Table 4 Enriched KEGG pathways from predicted targets of top DM microRNAs

Predicted targeted pathways of hypomethylated miRs

Glioma

45

6.42%

1.9269

0.0001

Axon guidance

77

10.99%

1.6102

0.0003

Pathways in cancer

166

23.69%

1.3653

0.0004

Endocytosis

101

14.41%

1.4808

0.0011

Insulin-signaling pathway

77

10.99%

1.5386

0.0040

ErbB-signaling pathway

54

7.71%

1.6744

0.0056

Neurotrophin-signaling pathway

71

10.13%

1.5446

0.0086

Chronic myeloid leukemia

47

6.71%

1.6905

0.0185

SNARE interactions in vesicular transport

28

4.00%

1.9877

0.0253

Predicted targeted pathways of hypermethylated miRs

Endocytosis

133

14.32%

1.4482

0.0000

MAPK-signaling pathway

178

19.17%

1.3357

0.0000

Neurotrophin-signaling pathway

92

9.91%

1.4865

0.0001

Axon guidance

95

10.23%

1.4755

0.0001

Pathways in cancer

211

22.73%

1.2889

0.0001

Chronic myeloid leukemia

59

6.35%

1.5761

0.0011

ErbB-signaling pathway

65

7.00%

1.4969

0.0061

Apoptosis

65

7.00%

1.4969

0.0061

Regulation of actin cytoskeleton

140

15.08%

1.3046

0.0074

Adherens junction

58

6.25%

1.5092

0.0147

Glioma

49

5.28%

1.5583

0.0196

Focal adhesion

130

14.00%

1.2958

0.0275