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Table 4 Enriched KEGG pathways from predicted targets of top DM microRNAs

From: Genome-scale hypomethylation in the cord blood DNAs associated with early onset preeclampsia

  Count Percent of genes Fold enrichment P value (FDR)
Predicted targeted pathways of hypomethylated miRs     
Glioma 45 6.42% 1.9269 0.0001
Axon guidance 77 10.99% 1.6102 0.0003
Pathways in cancer 166 23.69% 1.3653 0.0004
Endocytosis 101 14.41% 1.4808 0.0011
Insulin-signaling pathway 77 10.99% 1.5386 0.0040
ErbB-signaling pathway 54 7.71% 1.6744 0.0056
Neurotrophin-signaling pathway 71 10.13% 1.5446 0.0086
Chronic myeloid leukemia 47 6.71% 1.6905 0.0185
SNARE interactions in vesicular transport 28 4.00% 1.9877 0.0253
Predicted targeted pathways of hypermethylated miRs     
Endocytosis 133 14.32% 1.4482 0.0000
MAPK-signaling pathway 178 19.17% 1.3357 0.0000
Neurotrophin-signaling pathway 92 9.91% 1.4865 0.0001
Axon guidance 95 10.23% 1.4755 0.0001
Pathways in cancer 211 22.73% 1.2889 0.0001
Chronic myeloid leukemia 59 6.35% 1.5761 0.0011
ErbB-signaling pathway 65 7.00% 1.4969 0.0061
Apoptosis 65 7.00% 1.4969 0.0061
Regulation of actin cytoskeleton 140 15.08% 1.3046 0.0074
Adherens junction 58 6.25% 1.5092 0.0147
Glioma 49 5.28% 1.5583 0.0196
Focal adhesion 130 14.00% 1.2958 0.0275
  1. SNARE soluble NSF attachment protein receptor, MAPK mitogen-activated protein kinase.