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Table 1 Clinical characteristics of child bearing group (female 19 to 39 years) from NDNS and pregnant women from Saudi population

From: Vitamin B12 insufficiency induces cholesterol biosynthesis by limiting s-adenosylmethionine and modulating the methylation of SREBF1 and LDLR genes

 

NDNS

Saudi cohort

Total

B 12 (ng/L)

Total

Maternal B 12 (ng/L)

n  = 315

>190 ( n  = 278)

≤190 ( n  = 37)

n  = 152

>190 ( n  = 84)

≤190 ( n  = 68)

Age (years)

31.2 ± 0.32

31.7 ± 0.34

30.5 ± 0.94

28.6 ± 0.43

28.5 ± 0.59

28.5 ± 0.62

BMI (kg/m2)

25.3 ± 0.29

25.2 ± 0.30

26.3 ± 1.0

26.75 ± 0.43

26.0 ± 0.55

27.8 ± 0.66*

WHR

0.77 ± 0.003

0.77 ± 0.003

0.79 ± 0.01

-

-

-

Total-C (mmol/L)

4.84 ± 0.06

4.79 ± 0.06

5.20 ± 0.21*

5.98 ± 0.09

5.80 ± 0.12

6.20 ± 0.15*

LDL-C (mmol/L)

3.58 ± 0.06

3.52 ± 0.06

4.01 ± 0.21**

3.02 ± 0.14

2.99 ± 0.18

3.14 ± 0.21

HDL-C (mmol/L)

1.26 ± 0.02

1.27 ± 0.02

1.19 ± 0.06

1.25 ± 0.03

1.25 ± 0.04

1.24 ± 0.04

Total-C:HDL ratio

4.11 ± 0.08

4.03 ± 0.08

4.70 ± 0.26**

5.11 ± 0.14

4.99 ± 0.18

5.29 ± 0.22

TG (mmol/L)

-

-

-

1.77 ± 0.05

1.64 ± 0.06

1.93 ± 0.07**

Folate (μg/L)

9.24 ± 0.21

9.35 ± 0.23

8.46 ± 0.51

10.4 ± 0.34

10.4 ± 0.49

10.5 ± 0.46

Homocysteine (μmol/L)

9.98 ± 0.21

9.78 ± 0.21

11.53 ± 0.65**

4.74 ± 0.13

4.45 ± 0.17

5.11 ± 0.21*

  1. P value compared to B12 (>190 ng/L) group; *P < 0.05; **P < 0.01. Continuous variables are mean ± SEM.