Figure 6

Differential response to E2 suppression and DAC activation of MT1 gene expression is seen in ERα + cell lines but not in ERα − cell lines. (A) Luciferase activity of ERE reporter vector normalized to Renilla reporter activity in luminal and basal breast cancer cell lines. (B) MT1 expression was carried out by RT-qPCR following E2 and/or DAC treatments as described in the Methods section.