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Table 7 The effects of SNP, DNA methylation, and their interaction effects in selected models ( IL4 )

From: The interplay of DNA methylation over time with Th2 pathway genetic variants on asthma risk and temporal asthma transition

Model

Model frequency#

Parameter

 

Effects at age 10 (n = 34); Log-OR (P value)

Effects at age 18 (n = 233); Log-OR (P value)$

6

532

cg23943829

 

−2.17 (1.00)

−3.60 (0.009)

rs2070874

AG

−22.16 (1.00)

−4.97 (0.4)

GG

Ref.

Ref.

cg23943829* rs2070874

AG

2.17 (1.00)

2.61 (0.4)

GG

Ref.

Ref.

7

669

cg23943829

 

−1.60 (0.64)

−4.47 (0.003)

rs2243250

AG

−21.18 (1.00)

−6.75 (0.2)

GG

Ref.

Ref.

cg23943829* rs2243250

AG

1.60 (1.00)

3.84 (0.1)

GG

Ref.

Ref.

  1. #The frequency is based on 1,000 bootstrap samples.
  2. $P values significant at the 0.01 level at age 18 are in bold font.