Suppression of hepatitis B virus (HBV) replication using microRNA (miRNA)-like molecules. A. Stem-loop structures of hsa-miRs containing antiviral target sequences. B. HBV transcripts and corresponding target sequences on the covalently closed circular DNA (cccDNA). C. Hepatitis B surface antigen (HBsAg) assessment upon hepatitis B virus met murine hepatocytes (HBV-Met) treatment with candidate miRs. D. Gene expression analyses in HBV-Met treated with miRNA-30 L-X1 versus untreated HBV-Met. Statistics and coloring correspond to Figure 1A-G.