Table 2 LINE-1 methylation levels in normal mucosa and aberrant crypt foci for each of the three groups of subjects
Healthy controls (n = 70) | Adenoma (n = 42) | Colon cancer (n = 35) | P valuea | |
|---|---|---|---|---|
Normal rectal mucosa, n/N | 62/70 | 31/42 | 24/35 | 0.107 |
Median (IQR) | 76.73% (73.23 to 78.22) | 75.34% (73.7 to 77.2) | 77.06% (75.04 to 79.23) | |
Normal descending colon mucosa, n/N | 42/70 | 38/42 | 21/35 | 0.147 |
Median (IQR) | 77.67% (75.84 to 80.18) | 78.45% (77.37 to 79.92) | 80.30% (77.19 to 81.39) | |
Aberrant crypt foci, n/N | 68/70 | 38/42 | 24/35 | 0.409 |
Median (IQR) | 79.41% (77.24 to 81.58) | 80.32% (77.45 to 82.82) | 81.37% (77.48 to 83.14) | |
Dysplastic aberrant crypt foci, n/N | 15 | 11 | 9 | 0.32 |
Median (IQR) | 80.58% (78.54 to 82.37) | 80.99% (79.15 to 83.07) | 82.74% (79.83 to 83.43) | |
Hyperplastic aberrant crypt foci, n/N | 53 | 27 | 24 | 0.812 |
Median (IQR) | 79.32% (76.94 to 81.54) | 79.59% (76.80 to 82.22) | 80.02% (76.50 to 82.55) |