Figure 1
From: Expression profiling of DNA methylation-mediated epigenetic gene-silencing factors in breast cancer
The figure represents the MBD protein family comprising of five prominent nuclear proteins MeCP2, MBD1, MBD2, MBD3, and MBD4 and the protein partners they interact with such as histone deacetylases (HDACs) and chromatin remodeling complexes such as NuRD, SWI/SNF, and Mi-2. The figure also depicts the various hypermethylated promoters to which the different MBD proteins bind and mediate gene silencing in various cancer types. While MeCP2, MBD2, MBD3, and MBD4 interact with HDACs to bring about transcriptional repression, MBD1 binds with DNMT1 and acts to silence the hypermethylated promoter regions. Thus, together DNMT and MBD proteins supervise the epigenetic regulatory system to bring about transcriptional incompetence and lead to tumorigenic progression (Adapted from [26, 28, 29]).