Table 2 Mean percent methylation levels at the differentially methylated CpG sites in the promoter region of the VEGF , FLT -1 and KDR genes

CpG site

Normotensive

Term PE

Preterm PE

VEGF

Mean promoter

5.1 ± 0.1

4.9 ± 0.1

4.7 ± 0.2*

CpG - 6.7

4.2 ± 0.2

3.7 ± 0.2

3.5 ± 0.4*

CpG – 8

7.1 ± 0.1

6.8 ± 0.1

6.4 ± 0.2**

CpG – 14

4.2 ± 0.3

4.9 ± 0.3

5.2 ± 0.4*

FLT -1

CpG – 16

1.6 ± 0.2

0.8 ± 0.2**

1.2 ± 0.2

CpG – 17

3.2 ± 0.1

3.2 ± 0.1

2.7 ± 0.1*¹

CpG – 24

1.1 ± 0.1

0.7 ± 0.1*

0.6 ± 0.1*

KDR

CpG – 12.13

4.9 ± 0.7

7.6 ± 1.1*

8.2 ± 1.1*