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Table 2 Mean percent methylation levels at the differentially methylated CpG sites in the promoter region of the VEGF , FLT -1 and KDR genes

From: Differential placental methylation and expression of VEGF, FLT- 1 and KDR genes in human term and preterm preeclampsia

  Percent methylation (%)
CpG site Mean ± standard error
Normotensive Term PE Preterm PE
VEGF    
Mean promoter 5.1 ± 0.1 4.9 ± 0.1 4.7 ± 0.2*
CpG - 6.7 4.2 ± 0.2 3.7 ± 0.2 3.5 ± 0.4*
CpG – 8 7.1 ± 0.1 6.8 ± 0.1 6.4 ± 0.2**
CpG – 14 4.2 ± 0.3 4.9 ± 0.3 5.2 ± 0.4*
FLT -1  
CpG – 16 1.6 ± 0.2 0.8 ± 0.2** 1.2 ± 0.2
CpG – 17 3.2 ± 0.1 3.2 ± 0.1 2.7 ± 0.1*1
CpG – 24 1.1 ± 0.1 0.7 ± 0.1* 0.6 ± 0.1*
KDR    
CpG – 12.13 4.9 ± 0.7 7.6 ± 1.1* 8.2 ± 1.1*
  1. Values given are mean ± SE. PE, preeclampsia. *P <0.05; **P <0.01 compared to term; 1P <0.05 compared to term PE.