From: Pharmacokinetic and pharmacodynamic analysis of 5-aza-2’-deoxycytidine (decitabine) in the design of its dose-schedule for cancer therapy
Method (reference)
Dose-schedule
Plasma β half-life (minutes)
Clearance(ml/min/kg)
Bioassay[36]
25 to 100 mg/m2 1 hour inf q8 hours
35 +/− 5
126 +/− 21
LCMS[92]
15 mg/m2 3hour inf q8 hours
35
127-135
HPLC[90]
30 mg/m2 40 to 60 hours inf
10 to 15
-
