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Figure 1 | Clinical Epigenetics

Figure 1

From: Pharmacokinetic and pharmacodynamic analysis of 5-aza-2’-deoxycytidine (decitabine) in the design of its dose-schedule for cancer therapy

Figure 1

Intracellular metabolism of 5-AZA-CdR. 5-AZA-CdR is transported into the cell by the equilibrative-nucleoside transport system. 5-AZA-CdR converts into its triphosphate form by phosphorylation and binds covalently to the DNA, where it blocks DNMTs and causes demethylation of DNA. 5-AZA-CdR, 5-aza-2′-deoxycytidine; DNMTs, DNA methyltransferases.

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Clinical Epigenetics

ISSN: 1868-7083

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