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Table 2 Interaction of methylation at cg13566430 and rs1800925 genotypes on FEV 1 /FVC and DRS

From: Interaction of prenatal maternal smoking, interleukin 13 genetic variants and DNA methylation influencing airflow and airway reactivity

  

FEV1/FVC

DRS

  

Estimate

95% CI

P

Estimate

95% CI

P

Main effects

       

cg13566430

 

0.175

−0.166 to 0.517

0.313

−0.568

−2.361 to 1.226

0.533

rs20541

AA

0.020

−0.024 to 0.064

0.369

−0.075

−0.278 to 0.129

0.469

 

AG

0.006

−0.014 to 0.026

0.548

0.036

−0.076 to 0.149

0.523

 

GG

 

Reference

  

Reference

 

rs1800925

TT

0.030

−0.019 to 0.079

0.231

0.299

0.045 to 0.554

0.021

 

CT

−0.001

−0.021 to 0.019

−0.001

−0.026

−0.134 to 0.083

0.644

 

CC

 

Reference

  

Reference

 

Interaction

       

rs1800925

TT

−0.412

−0.855 to 0.030

0.068

3.989

1.194 to 6.785

0.005

 

CT

−0.134

−0.296 to 0.028

0.106

0.124

−0.733 to 0.982

0.775

 

CC

 

Reference

  

Reference

 

cg13566430

 

0.174

−0.301 to 0.648

0.472

0.624

−1.926 to 3.174

0.629

rs1800925× cg13566430

TT

3.274

0.114 to 6.434

0.042

−27.497

−48.283 to −6.710

0.010

 

CT

0.799

−0.114 to 1.712

0.086

−0.809

−5.661 to 4.043

0.742

 

CC

 

Reference

  

Reference

 
  1. DRS, dose response slope; FEV1, forced expiratory volume in 1 second; FVC, forced vital capacity.
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Clinical Epigenetics

ISSN: 1868-7083

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