Table 3 Adjusted log-linear regression model of the interaction of genetic variants and DNA methylation of the IL4R gene on asthma at age 18 years

Intercept

19.59

−12.78

51.97

0.25

cg09791102

−26.97

−63.62

9.67

0.14

rs3024685

CC

−102.45

−158.51

−46.40

0.0003

CT

−38.48

−80.71

3.75

0.07

TT

Reference

cg09791102* rs3024685

CC

115.54

53.18

177.91

0.0003

CT

43.90

−3.45

91.27

0.06

TT

Reference

rs3024622

CC

−1.24

−3.45

0.95

0.26

CG

−0.14

−1.00

0.72

0.74

GG

Reference

rs12102586

TT

2.41

0.29

4.53

0.02

CT

0.65

−0.24

1.55

0.15

CC

Reference

rs16976728

TT

−0.53

−2.03

0.95

0.48

CT

0.16

−0.78

1.11

0.72

CC

Reference

Maternal smoking during pregnancy

0.43

−0.40

1.26

0.31

Maternal history of asthma

0.53

−0.41

1.49

0.26

Body mass index at age 18 years (kg/m²)

0.05

−0.009

0.12

0.09

Breastfeeding duration (weeks)

0.02

−0.004

0.04

0.11