Skip to main content

Table 2 List of genes in which altered expression can lead to epigenetic deregulation in MPNs

From: Epigenetic abnormalities in myeloproliferative neoplasms: a target for novel therapeutic strategies

Gene Abbreviation MPN subtype Reference
10–11 translocation-2 TET2 ET, PV, PMF, MF-BP Hussein et al. (2010); Schaub et al. (2010); Tefferi et al. (2009b)
Additional sex combs like 1 ASXL1 ET, PMF, MF-BP Carbuccia et al. (2009)
Enhancer of zeste homolog 2 EZH2 MDS/MPN, PMF, MF-BP Ernst et al. (2010)
Isocitrate dehydrogenase 1 and 2 IDH1/2 ET, PV, PMF, MF-BP Green and Beer (2010); Pardanani et al. (2010c); Tefferi et al. (2010)
Ikaros family zinc finger 1 IKZF1 MF-BP Jager et al. (2010)
Janus-associated kinase 2 JAK2V617F ET, PV, PMF, MF-BP Nischal et al. (2010); Dawson et al. (2009)
Protein arginine methyltransferase 5 PRMT5 PV Liu et al. (2011)