Table 3 Indices of methyl donor status in blood and tissues from ApoE mice fed a control (C) or high fat (HF) diet depleted of folic acid (F−) or folic acid and vitamins B6 and B12 (F−B−) for 16 weeks

87.8 ± 4.8^a

16.2 ± 1.5^b

14.9 ± 0.9^b

104.9 ± 5.5^c

15.5 ± 1.7^b

15.0 ± 1.4^b

498.9 ± 42.9^a

163.5 ± 8.9^b

184.7 ± 6.8^b

507.9 ± 26.0^a

149.6 ± 9.7^b

193.3 ± 18.7^b

106.0 ± 8.0^a

47.1 ± 2.8^b

50.2 ± 3.6^b

117.1 ± 8.3^a

42.0 ± 2.3^b

41.1 ± 1.6^b

24.8 ± 2.3^a

15.3 ± 1.0^b

6.8 ± 0.1^c

25.6 ± 3.0^a

12.5 ± 0.5^d

6.1 ± 0.5^c

22.5 ± 1.0^a,c

22.0 ± 0.6^a,c

7.2 ± 0.7^b

24.9 ± 1.6^a

20.5 ± 1.1^c

6.9 ± 1.0^b

1.49 ± 0.05^a

1.43 ± 0.11^a

0.96 ± 0.04^b

1.38 ± 0.09^a

1.18 ± 0.09^c

0.84 ± 0.04^b

100.2 ± 9.2^a

50.7 ± 4.0^b

43.7 ± 2.6^c

84.1 ± 4.7^d

47.6 ± 6.7^b

36.1 ± 1.8^c

50.4 ± 2.3^a

71.6 ± 3.1^b

86.1 ± 4.3^c

47.6 ± 3.1^a

68.1 ± 3.8^b

89.7 ± 4.4^c