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TableĀ 1 Epigenetic mechanisms of genetic instability

From: Epigenetic mechanisms and genome stability

Influence on repetitive elements Epigenetic involvement Molecular consequence
Direct Transcriptional repression of repetitive elements by DNA methylation Prevents DNA damage produced by DNA secondary structures or homologous recombination
Chromatin remodeling by DNMTs Chromatin condensation reduces DNA exposure to mutagenic factors or processes
Involvement of DNMTs in DNA repair DNMT1 interaction with the MMR machinery facilitates DNA repair
Indirect Hypermethylation of DNA repair genes (i.e., MMR) Reduced expression of genes required for genetic stability