Table 1 Histone deacetylases
From: Histone deacetylase inhibitors: clinical implications for hematological malignancies
Class HDAC | HDACs yeast | HDACs mammalian | Length | Mechanism of deacetylation | Tissue expression |
|---|---|---|---|---|---|
Class I | RPD3 | HDAC1 | 482 | Zn2+ dependent | Ubiquitous |
HDAC2 | 488 | ||||
HDAC3 | 428 | ||||
HDAC8 | 377 | ||||
Class II | HDA1 | HDAC4 | 1084 | Zn2+ dependent | Restricted |
HDAC5 | 1122 | ||||
HDAC6 | 1215 | ||||
HDAC7 | 912 | ||||
HDAC9 | 1011 | ||||
HDAC10 | 669 | ||||
Class III | SIR2 | SIRT1 | 747 | NAD+ dependent | ND |
HST1 | SIRT2 | 373 | |||
HST2 | SIRT3 | 399 | |||
HST3 | SIRT4 | 314 | |||
HST4 | SIRT5 | 310 | |||
| Â | SIRT6 | 355 | |||
| Â | SIRT7 | 400 | |||
Class IV | RPD3 | HDAC11 | 347 | Zn2+ dependent | Ubiquitous |