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Table 1 Histone deacetylases

From: Histone deacetylase inhibitors: clinical implications for hematological malignancies

Class HDAC HDACs yeast HDACs mammalian Length Mechanism of deacetylation Tissue expression
Class I RPD3 HDAC1 482 Zn2+ dependent Ubiquitous
HDAC2 488
HDAC3 428
HDAC8 377
Class II HDA1 HDAC4 1084 Zn2+ dependent Restricted
HDAC5 1122
HDAC6 1215
HDAC7 912
HDAC9 1011
HDAC10 669
Class III SIR2 SIRT1 747 NAD+ dependent ND
HST1 SIRT2 373
HST2 SIRT3 399
HST3 SIRT4 314
HST4 SIRT5 310
  SIRT6 355
  SIRT7 400
Class IV RPD3 HDAC11 347 Zn2+ dependent Ubiquitous