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  1. DNA methylation is involved in the regulation of gene expression and phenotypic variation, but the inter-relationship between genetic variation, DNA methylation and gene expression remains poorly understood. H...

    Authors: Anna Díez-Villanueva, Mireia Jordà, Robert Carreras-Torres, Henar Alonso, David Cordero, Elisabet Guinó, Xavier Sanjuan, Cristina Santos, Ramón Salazar, Rebeca Sanz-Pamplona and Victor Moreno

    Citation: Clinical Epigenetics 2021 13:162

    Content type: Research

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  2. Several studies have reported an association between male infertility and aberrant sperm DNA methylation patterns, in particular in imprinted genes. In a recent investigation based on whole methylome and deep ...

    Authors: Sara Di Persio, Elsa Leitão, Marius Wöste, Tobias Tekath, Jann-Frederik Cremers, Martin Dugas, Xiaolin Li, Gerd Meyer zu Hörste, Sabine Kliesch, Sandra Laurentino, Nina Neuhaus and Bernhard Horsthemke

    Citation: Clinical Epigenetics 2021 13:160

    Content type: Research

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  3. Early-stage lung cancers radiologically manifested as ground-glass opacities (GGOs) have been increasingly identified, among which pure GGO (pGGO) has a good prognosis after local resection. However, the optim...

    Authors: Ziqi Jia, Yadong Wang, Jianchao Xue, Xiaoying Yang, Zhongxing Bing, Chao Guo, Chao Gao, Zhenhuan Tian, Zhenzhen Zhang, Hualei Kong, Qiye He, Zhixi Su, Yiying Liu, Yang Song, Dianjing Liang, Naixin Liang…

    Citation: Clinical Epigenetics 2021 13:153

    Content type: Research

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  4. Prader–Willi syndrome is a rare genetic neurodevelopmental disorder caused by a paternal deficiency of maternally imprinted gene expression located in the chromosome 15q11–q13 region. Previous studies have dem...

    Authors: Juliette Salles, Sanaa Eddiry, Emmanuelle Lacassagne, Virginie Laurier, Catherine Molinas, Éric Bieth, Nicolas Franchitto, Jean-Pierre Salles and Maithé Tauber

    Citation: Clinical Epigenetics 2021 13:159

    Content type: Research

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  5. The multifactorial nature of non-alcoholic fatty liver disease cannot be explained solely by genetic factors. Recent evidence revealed that DNA methylation changes take place at proximal promoters within susce...

    Authors: Sara Diels, Bart Cuypers, Asta Tvarijonaviciute, Bruno Derudas, Evelien Van Dijck, An Verrijken, Luc F. Van Gaal, Kris Laukens, Philippe Lefebvre, Jose J. Ceron, Sven Francque, Wim Vanden Berghe and Wim Van Hul

    Citation: Clinical Epigenetics 2021 13:158

    Content type: Research

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  6. Dystonia is a clinically and genetically heterogeneous movement disorder characterized by sustained or intermittent muscle contractions causing abnormal, often repetitive, movements and/or postures. Heterozygo...

    Authors: Andrea Ciolfi, Aidin Foroutan, Alessandro Capuano, Lucia Pedace, Lorena Travaglini, Simone Pizzi, Marco Andreani, Evelina Miele, Federica Invernizzi, Chiara Reale, Celeste Panteghini, Maria Iascone, Marcello Niceta, Ralitza H. Gavrilova, Laura Schultz-Rogers, Emanuele Agolini…

    Citation: Clinical Epigenetics 2021 13:157

    Content type: Research

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  7. Aberrant DNA hypomethylation of the long interspersed nuclear elements (LINE-1 or L1) has been recognized as an early event of colorectal transformation. Simultaneous genetic and epigenetic analysis of colorec...

    Authors: Carla Debernardi, Laura Libera, Enrico Berrino, Nora Sahnane, Anna Maria Chiaravalli, Cristiana Laudi, Mattia Berselli, Anna Sapino, Fausto Sessa, Tiziana Venesio and Daniela Furlan

    Citation: Clinical Epigenetics 2021 13:154

    Content type: Research

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    The Correction to this article has been published in Clinical Epigenetics 2021 13:178

  8. Non-alcoholic fatty liver disease (NAFLD) is characterized by changes in cell composition that occur throughout disease pathogenesis, which includes the development of fibrosis in a subset of patients. DNA met...

    Authors: Nicholas D. Johnson, Xiumei Wu, Christopher D. Still, Xin Chu, Anthony T. Petrick, Glenn S. Gerhard, Karen N. Conneely and Johanna K. DiStefano

    Citation: Clinical Epigenetics 2021 13:152

    Content type: Research

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  9. Authors: David W. Chan, Wai-Yip Lam, Fushun Chen, Mingo M. H. Yung, Yau-Sang Chan, Wai-Sun Chan, Fangfang He, Stephanie S. Liu, Karen K. L. Chan, Benjamin Li and Hextan Y. S. Ngan

    Citation: Clinical Epigenetics 2021 13:151

    Content type: Correction

    Published on:

    The original article was published in Clinical Epigenetics 2021 13:142

  10. Glioblastoma (GBM) is the most aggressive primary brain tumor, having a poor prognosis and a median overall survival of less than two years. Over the last decade, numerous findings regarding the distinct molec...

    Authors: Borja Sesé, Miquel Ensenyat-Mendez, Sandra Iñiguez, Pere Llinàs-Arias and Diego M. Marzese

    Citation: Clinical Epigenetics 2021 13:150

    Content type: Review

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    The Correction to this article has been published in Clinical Epigenetics 2021 13:194

  11. There is a growing interest in the role of brain-derived neurotrophic factor (BDNF) in major depressive disorder (MDD). BDNF potentially exhibits opposite effects in the pathways linked to anhedonia and reward...

    Authors: J. Bakusic, E. Vrieze, M. Ghosh, D. A. Pizzagalli, B. Bekaert, S. Claes and L. Godderis

    Citation: Clinical Epigenetics 2021 13:149

    Content type: Research

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  12. Alveolar capillary dysplasia with or without misalignment of the pulmonary veins (ACD/MPV) is a lethal congenital lung disorder associated with a variety of heterozygous genomic alterations in the FOXF1 gene or i...

    Authors: Evelien Slot, Ruben Boers, Joachim Boers, Wilfred F. J. van IJcken, Dick Tibboel, Joost Gribnau, Robbert Rottier and Annelies de Klein

    Citation: Clinical Epigenetics 2021 13:148

    Content type: Research

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  13. The dilation of the aorta that occurs as a consequence of a congenitally bicuspid aortic valve (BAV) is associated with a risk of dissection, aneurysm or rupture. With progressive aortopathy, surgery is often ...

    Authors: Ashna Maredia, David Guzzardi, Mohammad Aleinati, Fatima Iqbal, Arshroop Khaira, Aiswarya Madhu, Xuemei Wang, Alex J. Barker, Patrick M. McCarthy, Paul W. M. Fedak and Steven C. Greenway

    Citation: Clinical Epigenetics 2021 13:147

    Content type: Research

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  14. Increasing evidence linking epigenetic mechanisms and different diseases, including cancer, has prompted in the last 15 years the investigation of histone post-translational modifications (PTMs) in clinical sa...

    Authors: Roberta Noberini, Evelyn Oliva Savoia, Stefania Brandini, Francesco Greco, Francesca Marra, Giovanni Bertalot, Giancarlo Pruneri, Liam A. McDonnell and Tiziana Bonaldi

    Citation: Clinical Epigenetics 2021 13:145

    Content type: Methodology

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  15. The PEPaNIC multicenter randomized controlled trial (RCT) has shown that early administration of supplemental parenteral nutrition (early-PN) as compared with withholding PN for 1 week (late-PN) induced long-t...

    Authors: An Jacobs, Fabian Güiza, Ines Verlinden, Karolijn Dulfer, Gonzalo Garcia Guerra, Koen Joosten, Sascha C. Verbruggen, Ilse Vanhorebeek and Greet Van den Berghe

    Citation: Clinical Epigenetics 2021 13:146

    Content type: Research

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  16. Non-coding RNA 886 (nc886) is coded from a maternally inherited metastable epiallele. We set out to investigate the determinants and dynamics of the methylation pattern at the nc886 epiallele and how this methyla...

    Authors: Saara Marttila, Leena E. Viiri, Pashupati P. Mishra, Brigitte Kühnel, Pamela R. Matias-Garcia, Leo-Pekka Lyytikäinen, Tiina Ceder, Nina Mononen, Wolfgang Rathmann, Juliane Winkelmann, Annette Peters, Mika Kähönen, Nina Hutri-Kähönen, Markus Juonala, Katriina Aalto-Setälä, Olli Raitakari…

    Citation: Clinical Epigenetics 2021 13:143

    Content type: Research

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  17. In contrast to stable genetic events, epigenetic changes are highly plastic and play crucial roles in tumor evolution and development. Epithelial ovarian cancer (EOC) is a highly heterogeneous disease that is ...

    Authors: David W. Chan, Wai-Yip Lam, Fushun Chen, Mingo M. H. Yung, Yau-Sang Chan, Wai-Sun Chan, Fangfang He, Stephanie S. Liu, Karen K. L. Chan, Benjamin Li and Hextan Y. S. Ngan

    Citation: Clinical Epigenetics 2021 13:142

    Content type: Research

    Published on:

    The Correction to this article has been published in Clinical Epigenetics 2021 13:151

  18. Primary or acquired chemoresistance is a key link in the high mortality rate of ovarian cancer. There is no reliable method to predict chemoresistance in ovarian cancer. We hypothesized that specific methylati...

    Authors: Li-yuan Feng, Bing-bing Yan, Yong-zhi Huang and Li Li

    Citation: Clinical Epigenetics 2021 13:141

    Content type: Research

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  19. Major depression has been recognized as the most commonly diagnosed psychiatric complication of mild traumatic brain injury (mTBI). Moreover, major depression is associated with poor outcomes following mTBI; h...

    Authors: Kuaikuai Duan, Andrew R. Mayer, Nicholas A. Shaff, Jiayu Chen, Dongdong Lin, Vince D. Calhoun, Dawn M. Jensen and Jingyu Liu

    Citation: Clinical Epigenetics 2021 13:140

    Content type: Research

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  20. Mutations in LMNA, encoding lamin A/C, lead to a variety of diseases known as laminopathies including dilated cardiomyopathy (DCM) and skeletal abnormalities. Though previous studies have investigated the dysregu...

    Authors: Julien L. P. Morival, Halida P. Widyastuti, Cecilia H. H. Nguyen, Michael V. Zaragoza and Timothy L. Downing

    Citation: Clinical Epigenetics 2021 13:139

    Content type: Research

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  21. Transcriptionally active chromatin is marked by tri-methylation of histone H3 at lysine 4 (H3K4me3) located after first exons and around transcription start sites. This epigenetic mark is typically restricted ...

    Authors: Tasnim H. Beacon, Geneviève P. Delcuve, Camila López, Gino Nardocci, Igor Kovalchuk, Andre J. van Wijnen and James R. Davie

    Citation: Clinical Epigenetics 2021 13:138

    Content type: Review

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  22. The role of epigenetics in inborn errors of metabolism (IEMs) is poorly investigated. Epigenetic changes can contribute to clinical heterogeneity of affected patients but could also be underestimated determini...

    Authors: Catia Cavicchi, Abderrahim Oussalah, Silvia Falliano, Lorenzo Ferri, Alessia Gozzini, Serena Gasperini, Serena Motta, Miriam Rigoldi, Giancarlo Parenti, Albina Tummolo, Concetta Meli, Francesca Menni, Francesca Furlan, Marta Daniotti, Sabrina Malvagia, Giancarlo la Marca…

    Citation: Clinical Epigenetics 2021 13:137

    Content type: Research

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  23. Equal dosage of X-linked genes between males and females is maintained by the X-inactivation of the second X chromosome in females through epigenetic mechanisms. Boys with aneuploidy of the X chromosome exhibi...

    Authors: Richard S. Lee, Sophia Q. Song, Henri M. Garrison-Desany, Jenny L. Carey, Patricia Lasutschinkow, Andrew Zabel, Joseph Bressler, Andrea Gropman and Carole Samango-Sprouse

    Citation: Clinical Epigenetics 2021 13:136

    Content type: Research

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  24. Environmental exposures may alter DNA methylation patterns of T helper cells. As T helper cells are instrumental for allergy development, changes in methylation patterns may constitute a mechanism of action fo...

    Authors: Johanna Huoman, David Martínez-Enguita, Elin Olsson, Jan Ernerudh, Lennart Nilsson, Karel Duchén, Mika Gustafsson and Maria C. Jenmalm

    Citation: Clinical Epigenetics 2021 13:135

    Content type: Research

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  25. X-chromosome inactivation (XCI) is a mechanism in which one of two X chromosomes in females is randomly inactivated in order to compensate for imbalance of gene dosage between sexes. However, about 15% of gene...

    Authors: Sayaka Kawashima, Atsushi Hattori, Erina Suzuki, Keiko Matsubara, Machiko Toki, Rika Kosaki, Yukihiro Hasegawa, Kazuhiko Nakabayashi, Maki Fukami and Masayo Kagami

    Citation: Clinical Epigenetics 2021 13:134

    Content type: Research

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  26. Patients with metastatic prostate cancer (PC) are treated with androgen deprivation therapy (ADT) that initially reduces metastasis growth, but after some time lethal castration-resistant PC (CRPC) develops. A...

    Authors: Erik Bovinder Ylitalo, Elin Thysell, Mattias Landfors, Maria Brattsand, Emma Jernberg, Sead Crnalic, Anders Widmark, Magnus Hultdin, Anders Bergh, Sofie Degerman and Pernilla Wikström

    Citation: Clinical Epigenetics 2021 13:133

    Content type: Research

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  27. Reproductive biology methods rely on in vitro follicle cultures from mature follicles obtained by hormonal stimulation for generating metaphase II oocytes to be fertilised and developed into a healthy embryo. ...

    Authors: Florence Naillat, Heba Saadeh, Joanna Nowacka-Woszuk, Lenka Gahurova, Fatima Santos, Shin-ichi Tomizawa and Gavin Kelsey

    Citation: Clinical Epigenetics 2021 13:132

    Content type: Research

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  28. Epigenome-wide association studies (EWAS) have provided opportunities to understand the role of epigenetic mechanisms in development and pathophysiology of many chronic diseases. However, an important limitati...

    Authors: Tianyuan Lu, Andres Cardenas, Patrice Perron, Marie-France Hivert, Luigi Bouchard and Celia M. T. Greenwood

    Citation: Clinical Epigenetics 2021 13:131

    Content type: Research

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  29. Epigenetic clocks are based on DNA methylation (DNAm). It has been suggested that these clocks are useable markers of biological aging and premature mortality. Because genetic factors explain variations in bot...

    Authors: Tiina Föhr, Katja Waller, Anne Viljanen, Riikka Sanchez, Miina Ollikainen, Taina Rantanen, Jaakko Kaprio and Elina Sillanpää

    Citation: Clinical Epigenetics 2021 13:128

    Content type: Research

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    The Correction to this article has been published in Clinical Epigenetics 2021 13:130

  30. The aetiology of inflammatory bowel disease (IBD) is related to genetics and epigenetics. Epigenetic regulation of the pathogenesis of IBD has not been well defined. Here, we investigated the role of H3K27ac e...

    Authors: Ya-Li Yu, Meng Chen, Hua Zhu, Ming-Xing Zhuo, Ping Chen, Yu-Juan Mao, Lian-Yun Li, Qiu Zhao, Min Wu and Mei Ye

    Citation: Clinical Epigenetics 2021 13:127

    Content type: Research

    Published on:

  31. Liver metastases can occur even in CRC patients who underwent curative surgery. While evidence suggested that adjuvant chemotherapy can help to reduce the occurrence of liver metastases for certain patients, i...

    Authors: Weihua Li, Lei Guo, Wanxiangfu Tang, Yutong Ma, Xiaonan Wang, Yang Shao, Hong Zhao and Jianming Ying

    Citation: Clinical Epigenetics 2021 13:126

    Content type: Research

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  32. Radiotherapy (RT) is one of the mainstay treatments for prostate cancer (PCa), a highly prevalent neoplasm among males worldwide. About 30% of newly diagnosed PCa patients receive RT with a curative intent. Ho...

    Authors: Catarina Macedo-Silva, Rosaria Benedetti, Fortunato Ciardiello, Salvatore Cappabianca, Carmen Jerónimo and Lucia Altucci

    Citation: Clinical Epigenetics 2021 13:125

    Content type: Review

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  33. Thoracic aortic dissection (TAD) is a severe disease with limited understandings in its pathogenesis. Altered DNA methylation has been revealed to be involved in many diseases etiology. Few studies have examin...

    Authors: Peiru Liu, Jing Zhang, Duo Du, Dandan Zhang, Zelin Jin, Wenqing Qiu, Xiushi Zhou, Shulong Dong, Mengyu Zhou, Heyu Zhao, Wei Zhang, Jiakang Ma, Shaoyang Sun, Weiguo Fu, Yun Liu and Lixin Wang

    Citation: Clinical Epigenetics 2021 13:124

    Content type: Research

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  34. Type 2 diabetes mellitus (T2DM) and hypothyroidism are two common endocrine diseases and the phenomenon that the prevalence of diabetes-related hypothyroidism shows a significant upward trend deserves further ...

    Authors: Jingyi Luo, Xiaoxia Wang, Li Yuan and Lixin Guo

    Citation: Clinical Epigenetics 2021 13:123

    Content type: Research

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  35. Resistance to DNA damaging chemotherapies leads to cancer treatment failure and poor patient prognosis. We investigated how genomic distribution of accessible chromatin sites is altered during acquisition of c...

    Authors: John Gallon, Erick Loomis, Edward Curry, Nicholas Martin, Leigh Brody, Ian Garner, Robert Brown and James M. Flanagan

    Citation: Clinical Epigenetics 2021 13:122

    Content type: Research

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  36. The difference between an individual's chronological and DNA methylation predicted age (DNAmAge), termed DNAmAge acceleration (DNAmAA), can capture life-long environmental exposures and age-related physiologic...

    Authors: Pamela R. Matías-García, Cavin K. Ward-Caviness, Laura M. Raffield, Xu Gao, Yan Zhang, Rory Wilson, Xīn Gào, Jana Nano, Andrew Bostom, Elena Colicino, Adolfo Correa, Brent Coull, Charles Eaton, Lifang Hou, Allan C. Just, Sonja Kunze…

    Citation: Clinical Epigenetics 2021 13:121

    Content type: Research

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  37. At present, after extensive studies in the field of cancer, cancer stem cells (CSCs) have been proposed as a major factor in tumor initiation, progression, metastasis, and recurrence. CSCs are a subpopulation ...

    Authors: Saeedeh Keyvani-Ghamsari, Khatereh Khorsandi, Azhar Rasul and Muhammad Khatir Zaman

    Citation: Clinical Epigenetics 2021 13:120

    Content type: Review

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  38. ZNF445, as well as ZFP57, is involved in the postfertilization methylation maintenance of multiple imprinting-associated differentially methylated regions (iDMRs). Thus, ZNF445 pathogenic variants are predicted t...

    Authors: Masayo Kagami, Kaori Hara-Isono, Keiko Matsubara, Kazuhiko Nakabayashi, Satoshi Narumi, Maki Fukami, Yumiko Ohkubo, Hirotomo Saitsu, Shuji Takada and Tsutomu Ogata

    Citation: Clinical Epigenetics 2021 13:119

    Content type: Research

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  39. There are no prior reports that compare differentially methylated regions of DNA in blood samples from COVID-19 patients to samples collected before the SARS-CoV-2 pandemic using a shared epigenotyping platfor...

    Authors: Joseph Balnis, Andy Madrid, Kirk J. Hogan, Lisa A. Drake, Hau C. Chieng, Anupama Tiwari, Catherine E. Vincent, Amit Chopra, Peter A. Vincent, Michael D. Robek, Harold A. Singer, Reid S. Alisch and Ariel Jaitovich

    Citation: Clinical Epigenetics 2021 13:118

    Content type: Research

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  40. Mutations in the POLE gene result in an ultra-hypermutated phenotype in colorectal cancer (CRC); however, the molecular characterisation of epigenetic alterations remains unclear. We examined the genetic and epig...

    Authors: Takashi Kawai, Akihiro Nyuya, Yoshiko Mori, Takehiro Tanaka, Hiroaki Tanioka, Kazuya Yasui, Toshiaki Toshima, Fumitaka Taniguchi, Kunitoshi Shigeyasu, Yuzo Umeda, Toshiyoshi Fujiwara, Makoto Okawaki, Yoshiyuki Yamaguchi, Ajay Goel and Takeshi Nagasaka

    Citation: Clinical Epigenetics 2021 13:117

    Content type: Research

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  41. The human endometrium is a highly dynamic tissue whose function is mainly regulated by the ovarian steroid hormones estradiol and progesterone. The serum levels of these and other hormones are associated with ...

    Authors: Alejandra Monserrat Retis-Resendiz, Ixchel Nayeli González-García, Moisés León-Juárez, Ignacio Camacho-Arroyo, Marco Cerbón and Edgar Ricardo Vázquez-Martínez

    Citation: Clinical Epigenetics 2021 13:116

    Content type: Review

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  42. Epigenetic modifications, such as DNA methylation, can influence the genetic susceptibility to type 2 diabetes mellitus (T2DM) and the progression of the disease. Our previous studies demonstrated that the reg...

    Authors: Michele Zampieri, Maria Giulia Bacalini, Ilaria Barchetta, Stefania Scalea, Flavia Agata Cimini, Laura Bertoccini, Stefano Tagliatesta, Giovanna De Matteis, Giuseppe Zardo, Maria Gisella Cavallo and Anna Reale

    Citation: Clinical Epigenetics 2021 13:114

    Content type: Research

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  43. Worldwide, colorectal cancer (CRC) is a deadly disease whose death rate ranks second among cancers though its incidence ranks third. Early CRC detection is key and is associated with improved survival outcomes...

    Authors: Farah J. Nassar, Zahraa S. Msheik, Rihab R. Nasr and Sally N. Temraz

    Citation: Clinical Epigenetics 2021 13:111

    Content type: Review

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  44. The aim of this study was to investigate the correspondence of different biological ageing estimates (i.e. epigenetic age) in blood and muscle tissue and their associations with physical activity (PA), physica...

    Authors: Elina Sillanpää, Aino Heikkinen, Anna Kankaanpää, Aini Paavilainen, Urho M. Kujala, Tuija H. Tammelin, Vuokko Kovanen, Sarianna Sipilä, Kirsi H. Pietiläinen, Jaakko Kaprio, Miina Ollikainen and Eija K. Laakkonen

    Citation: Clinical Epigenetics 2021 13:110

    Content type: Research

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