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  1. Imprinting disorders are a group of congenital diseases which are characterized by molecular alterations affecting differentially methylated regions (DMRs). To date, at least twelve imprinting disorders have b...

    Authors: Thomas Eggermann, Elzem Yapici, Jet Bliek, Arrate Pereda, Matthias Begemann, Silvia Russo, Pierpaola Tannorella, Luciano Calzari, Guiomar Perez de Nanclares, Paola Lombardi, I. Karen Temple, Deborah Mackay, Andrea Riccio, Masayo Kagami, Tsutomu Ogata, Pablo Lapunzina…
    Citation: Clinical Epigenetics 2022 14:41
  2. Ambient air pollutant (AAP) exposure is associated with adverse pregnancy outcomes, such as preeclampsia, preterm labor, and low birth weight. Previous studies have shown methylation of immune genes associate ...

    Authors: Juan Aguilera, Xiaorui Han, Shu Cao, John Balmes, Fred Lurmann, Tim Tyner, Liza Lutzker, Elizabeth Noth, S. Katharine Hammond, Vanitha Sampath, Trevor Burt, P. J. Utz, Purvesh Khatri, Nima Aghaeepour, Holden Maecker, Mary Prunicki…
    Citation: Clinical Epigenetics 2022 14:40
  3. This work is aimed at improving the understanding of cardiometabolic syndrome pathophysiology and its relationship with thrombosis by generating a multi-omic disease signature.

    Authors: Denis Seyres, Alessandra Cabassi, John J. Lambourne, Frances Burden, Samantha Farrow, Harriet McKinney, Joana Batista, Carly Kempster, Maik Pietzner, Oliver Slingsby, Thong Huy Cao, Paulene A. Quinn, Luca Stefanucci, Matthew C. Sims, Karola Rehnstrom, Claire L. Adams…
    Citation: Clinical Epigenetics 2022 14:39
  4. Psoriasis is a chronic and hyperproliferative skin disease featured by hyperkeratosis with parakeratosis, Munro micro-abscess, elongation of rete pegs, granulosa thinning, and lymphocyte infiltration. We previ...

    Authors: Xiaoqing Xu, Xianfa Tang, Yuxi Zhang, Zhaobing Pan, Qingping Wang, Lili Tang, Caihong Zhu, Hui Cheng and Fusheng Zhou
    Citation: Clinical Epigenetics 2022 14:38
  5. DNA methylation alterations have emerged as hallmarks of cancer and have been proposed as screening, prognostic, and predictive biomarkers. Traditional approaches for methylation analysis have relied on bisulf...

    Authors: Tamara S. Rodems, Duane S. Juang, Charlotte N. Stahlfeld, Cole S. Gilsdorf, Tim E. G. Krueger, Erika Heninger, Shuang G. Zhao, Jamie M. Sperger, David J. Beebe, Michael C. Haffner and Joshua M. Lang
    Citation: Clinical Epigenetics 2022 14:37
  6. Authors: Yan Wang, Liangying Dan, Qianqian Li, Lili Li, Lan Zhong, Bianfei Shao, Fang Yu, Sanxiu He, Shaorong Tian, Jin He, Qian Xiao, Thomas C. Putti, Xiaoqian He, Yixiao Feng, Yong Lin and Tingxiu Xiang
    Citation: Clinical Epigenetics 2022 14:36

    The original article was published in Clinical Epigenetics 2019 11:184

  7. Long non-coding RNAs (LncRNAs) are widely known for their various functions in cancer from tumor initiation to tumor progression and metastasis. Gliomas are the most prevalent primary forms of brain tumor, cla...

    Authors: Ali Mamivand, Shiva Bayat, Abolfazl Maghrouni, Sasan Shabani, Alireza Khoshnevisan, Hiva Saffar and Mina Tabrizi
    Citation: Clinical Epigenetics 2022 14:35
  8. Epigenetic posttranslational modifications are critical for fine-tuning gene expression in various biological processes. SETD8 is so far the only known lysyl methyltransferase in mammalian cells to produce mon...

    Authors: Libo Xu, Ling Zhang, Jicheng Sun, Xindan Hu, Dhan V. Kalvakolanu, Hui Ren and Baofeng Guo
    Citation: Clinical Epigenetics 2022 14:34
  9. Epstein–Barr virus DNA viral load is used as a surrogate marker to start Rituximab in transplant recipients at risk of developing PTLD. However, an elevated EBV DNAemia does not discriminate lymphoproliferatio...

    Authors: Chloé Borde, Frédérique Quignon, Corinne Amiel, Joël Gozlan, Vincent Marechal and Eolia Brissot
    Citation: Clinical Epigenetics 2022 14:33
  10. Recent studies have suggested that folic acid can restore abnormal DNA methylation and monocyte subset shifts caused by hyperhomocysteinemia (HHcy) and hyperlipidemia (HL). However, the exact mechanism of acti...

    Authors: Yang Xiang, Bin Liang, Xiaokang Zhang, Xueping Qiu, Qianyun Deng, Li Yu, Hong Yu, Zhibing Lu and Fang Zheng
    Citation: Clinical Epigenetics 2022 14:32
  11. Age is one of the strongest risk factors for the development of breast cancer, however, the underlying etiology linking age and breast cancer remains unclear. We have previously observed links between epigenet...

    Authors: Mariya Rozenblit, Erin Hofstatter, Zuyun Liu, Tess O’Meara, Anna Maria Storniolo, Disha Dalela, Vineet Singh, Lajos Pusztai and Morgan Levine
    Citation: Clinical Epigenetics 2022 14:30
  12. Physical activity impacts immune homeostasis and leads to rapid and marked increase in cell-free DNA (cfDNA). However, the origin of cfDNA during exercise remains elusive and it is unknown if physical activity...

    Authors: Elmo W. I. Neuberger, Stephanie Sontag, Alexandra Brahmer, Keito F. A. Philippi, Markus P. Radsak, Wolfgang Wagner and Perikles Simon
    Citation: Clinical Epigenetics 2022 14:29
  13. We tested the ability of a novel DNA methylation biomarker set to distinguish metastatic pancreatic cancer cases from benign pancreatic cyst patients and to monitor tumor dynamics using quantitative DNA methyl...

    Authors: Lukas Vrba, Bernard W. Futscher, Marc Oshiro, George S. Watts, Emmanuel Menashi, Charles Hu, Hytham Hammad, Daniel R. Pennington, Umamaheshwari Golconda, Hemanth Gavini, Denise J. Roe, Rachna T. Shroff and Mark A. Nelson
    Citation: Clinical Epigenetics 2022 14:28
  14. Myeloid-derived suppressor cells (MDSCs), which include monocytic (mMDSCs) and granulocytic (gMDSCs) cells, are an immunosuppressive, heterogeneous population of cells upregulated in cancer and other pathologi...

    Authors: Isabella Berglund-Brown, Emily Nissen, Devin C. Koestler, Rondi A. Butler, Melissa N. Eliot, James F. Padbury, Lucas A. Salas, Annette M. Molinaro, Brock C. Christensen, John K. Wiencke and Karl T. Kelsey
    Citation: Clinical Epigenetics 2022 14:27
  15. Promoter methylation of the DNA repair gene O6-methylguanine-DNA methyltransferase (MGMT) is an acknowledged predictive epigenetic marker in glioblastoma multiforme and anaplastic astrocytoma. Patients with methy...

    Authors: Sascha Tierling, Wiebke M. Jürgens-Wemheuer, Alea Leismann, Julia Becker-Kettern, Michael Scherer, Arne Wrede, David Breuskin, Steffi Urbschat, Christoph Sippl, Joachim Oertel, Walter J. Schulz-Schaeffer and Jörn Walter
    Citation: Clinical Epigenetics 2022 14:26
  16. DNA methylation is an epigenetic mark that is influenced by underlying genetic profile, environment, and ageing. In addition to X-linked DNA methylation, sex-specific methylation patterns are widespread across...

    Authors: Rebecca Shepherd, Ingrid Bretherton, Ken Pang, Toby Mansell, Anna Czajko, Bowon Kim, Amanda Vlahos, Jeffrey D. Zajac, Richard Saffery, Ada Cheung and Boris Novakovic
    Citation: Clinical Epigenetics 2022 14:24
  17. Early detection of esophageal cancer is critical to improve survival. Whilst studies have identified biomarkers, their interpretation and validity is often confounded by cell-type heterogeneity.

    Authors: Alok K. Maity, Timothy C. Stone, Vanessa Ward, Amy P. Webster, Zhen Yang, Aine Hogan, Hazel McBain, Margaraet Duku, Kai Man Alexander Ho, Paul Wolfson, David G. Graham, Stephan Beck, Andrew E. Teschendorff and Laurence B. Lovat
    Citation: Clinical Epigenetics 2022 14:23
  18. Multiple studies have reported the prognostic impact of DNA methylation changes in acute myeloid leukemia (AML). However, these epigenetic markers have not been thoroughly validated and therefore are still not...

    Authors: Šárka Šestáková, Ela Cerovská, Cyril Šálek, Dávid Kundrát, Ivana Ježíšková, Adam Folta, Jiří Mayer, Zdeněk Ráčil, Petr Cetkovský and Hana Remešová
    Citation: Clinical Epigenetics 2022 14:22
  19. Genome-wide association studies have identified several breast cancer susceptibility loci. However, biomarkers for risk assessment are still missing. Here, we investigated cancer-related molecular changes dete...

    Authors: Natascia Marino, Rana German, Ram Podicheti, Douglas B. Rusch, Pam Rockey, Jie Huang, George E. Sandusky, Constance J. Temm, Sandra Althouse, Kenneth P. Nephew, Harikrishna Nakshatri, Jun Liu, Ashley Vode, Sha Cao and Anna Maria V. Storniolo
    Citation: Clinical Epigenetics 2022 14:21
  20. Although kidney transplantation improves patient survival and quality of life, long-term results are hampered by both immune- and non-immune-mediated complications. Current biomarkers of post-transplant compli...

    Authors: Iacopo Cristoferi, Tommaso Antonio Giacon, Karin Boer, Myrthe van Baardwijk, Flavia Neri, Manuela Campisi, Hendrikus J. A. N. Kimenai, Marian C. Clahsen - van Groningen, Sofia Pavanello, Lucrezia Furian and Robert C. Minnee
    Citation: Clinical Epigenetics 2022 14:20
  21. The development of accurate urinary biomarkers for non-invasive and cost-effective detection of primary and recurrent bladder tumours is recognized as one of the major clinical needs in bladder cancer diagnostics

    Authors: Anouk E. Hentschel, Irene J. Beijert, Judith Bosschieter, Paul C. Kauer, André N. Vis, Birgit I. Lissenberg-Witte, R. Jeroen A. van Moorselaar, Renske D. M. Steenbergen and Jakko A. Nieuwenhuijzen
    Citation: Clinical Epigenetics 2022 14:19
  22. Lymph node metastasis (LNM) is an important factor for both treatment and prognosis of early gastric cancer (EGC). Current methods are insufficient to evaluate LNM in EGC due to suboptimal accuracy. Herein, we...

    Authors: Shang Chen, Yanqi Yu, Tao Li, Weimei Ruan, Jun Wang, Quanzhou Peng, Yingdian Yu, Tianfeng Cao, Wenyuan Xue, Xin Liu, Zhiwei Chen, Jiang Yu and Jian-Bing Fan
    Citation: Clinical Epigenetics 2022 14:18
  23. GrimAge acceleration (GAA), an epigenetic marker that represents physiologic aging, is associated with atherosclerotic cardiovascular disease. However, the associations between early adulthood lipid levels and...

    Authors: Tao Gao, John T. Wilkins, Yinan Zheng, Brian T. Joyce, David R. Jacobs Jr., Pamela J. Schreiner, Steve Horvath, Philip Greenland, Donald Lloyd-Jones and Lifang Hou
    Citation: Clinical Epigenetics 2022 14:16
  24. Lung cancer is one of most common cancers worldwide, with a 5-year survival rate of less than 20%, which is mainly due to late-stage diagnosis. Noninvasive methods using 5-hydroxymethylation of cytosine (5hmC)...

    Authors: Xinlei Hu, Kai Luo, Hui Shi, Xiaoqin Yan, Ruichen Huang, Bi Zhao, Jun Zhang, Dan Xie and Wei Zhang
    Citation: Clinical Epigenetics 2022 14:15
  25. Non-muscle-invasive bladder cancer (NMIBC) patients receive frequent monitoring because ≥ 70% will have recurrent disease. However, screening is invasive, expensive, and associated with significant morbidity m...

    Authors: Ji-Qing Chen, Lucas A. Salas, John K. Wiencke, Devin C. Koestler, Annette M. Molinaro, Angeline S. Andrew, John D. Seigne, Margaret R. Karagas, Karl T. Kelsey and Brock C. Christensen
    Citation: Clinical Epigenetics 2022 14:14
  26. Different functional somatic syndromes (FSS), fibromyalgia (FMS) and other unexplained painful conditions share many common clinical traits and are characterized by troubling and functionally disabling somatic...

    Authors: Johannes Achenbach, Mathias Rhein, Alexander Glahn, Helge Frieling and Matthias Karst
    Citation: Clinical Epigenetics 2022 14:13
  27. Prenatal alcohol exposure (PAE) is associated with a range of adverse offspring neurodevelopmental outcomes. Several studies suggest that PAE modifies DNA methylation in offspring cells and tissues, providing ...

    Authors: Mitchell Bestry, Martyn Symons, Alexander Larcombe, Evelyne Muggli, Jeffrey M. Craig, Delyse Hutchinson, Jane Halliday and David Martino
    Citation: Clinical Epigenetics 2022 14:12
  28. Heart failure with preserved ejection fraction (HFpEF), affected collectively by genetic and environmental factors, is the common subtype of chronic heart failure. Although the available risk assessment method...

    Authors: Xuetong Zhao, Yang Sui, Xiuyan Ruan, Xinyue Wang, Kunlun He, Wei Dong, Hongzhu Qu and Xiangdong Fang
    Citation: Clinical Epigenetics 2022 14:11
  29. DNA methylation, an epigenetic mechanism modulated by lifestyle and environmental factors, may be an important biomarker of complex diseases including cardiovascular diseases (CVD) and subclinical atherosclero...

    Authors: Farah Ammous, Wei Zhao, Lisha Lin, Scott M. Ratliff, Thomas H. Mosley, Lawrence F. Bielak, Xiang Zhou, Patricia A. Peyser, Sharon L. R. Kardia and Jennifer A. Smith
    Citation: Clinical Epigenetics 2022 14:10
  30. DNA methylation studies have associated methylation levels at different CpG sites or genomic regions with lung function. Moreover, genetic ancestry has been associated with lung function in Latinos. However, n...

    Authors: Esther Herrera-Luis, Annie Li, Angel C. Y. Mak, Javier Perez-Garcia, Jennifer R. Elhawary, Sam S. Oh, Donglei Hu, Celeste Eng, Kevin L. Keys, Scott Huntsman, Kenneth B. Beckman, Luisa N. Borrell, Jose Rodriguez-Santana, Esteban G. Burchard and Maria Pino-Yanes
    Citation: Clinical Epigenetics 2022 14:9
  31. Despite significant advances in the treatment and care of people with HIV (PWH), several challenges remain in our understanding of disease pathogenesis to improve patient care. HIV infection can modify the hos...

    Authors: Boghuma K. Titanji, Marta Gwinn, Vincent C. Marconi and Yan V. Sun
    Citation: Clinical Epigenetics 2022 14:8
  32. Basal-like breast cancer (BLBC) is one of the most aggressive malignant diseases in women with an increased metastatic behavior and poor prognosis compared to other molecular subtypes of breast cancer. Resista...

    Authors: Garyfallia Pantelaiou-Prokaki, Iga Mieczkowska, Geske E. Schmidt, Sonja Fritzsche, Evangelos Prokakis, Julia Gallwas and Florian Wegwitz
    Citation: Clinical Epigenetics 2022 14:7
  33. The prevalence of cardiometabolic disease (CMD) is rising globally, with environmentally induced epigenetic changes suggested to play a role. Few studies have investigated epigenetic associations with CMD risk...

    Authors: Elie Antoun, Prachand Issarapu, Chiara di Gravio, Smeeta Shrestha, Modupeh Betts, Ayden Saffari, Sirazul A. Sahariah, Alagu Sankareswaran, Manisha Arumalla, Andrew M. Prentice, Caroline H. D. Fall, Matt J. Silver, Giriraj R. Chandak and Karen A. Lillycrop
    Citation: Clinical Epigenetics 2022 14:6
  34. Type II germ cell tumors (GCT) are the most common solid cancers in males of age 15 to 35 years. Treatment of these tumors includes cisplatin-based therapy achieving high cure rates, but also leading to late t...

    Authors: Melanie R. Müller, Aaron Burmeister, Margaretha A. Skowron, Alexa Stephan, Felix Bremmer, Gamal A. Wakileh, Patrick Petzsch, Karl Köhrer, Peter Albers and Daniel Nettersheim
    Citation: Clinical Epigenetics 2022 14:5
  35. High-risk human papillomavirus (HR-HPV) infection is the main cause of cervical cancer, but additional alterations are necessary for its development. Abnormal DNA methylation has an important role in the origi...

    Authors: Jaqueline Loaeza-Loaeza, Berenice Illades-Aguiar, Oscar del Moral-Hernández, Yaneth Castro-Coronel, Marco A. Leyva-Vázquez, Roberto Dircio-Maldonado, Julio Ortiz-Ortiz and Daniel Hernández-Sotelo
    Citation: Clinical Epigenetics 2022 14:4
  36. DNA mismatch repair proficient (pMMR) metastatic colorectal cancer (mCRC) is not responsive to pembrolizumab monotherapy. DNA methyltransferase inhibitors can promote antitumor immune responses. This clinical ...

    Authors: Chaoyuan Kuang, Yongseok Park, Ryan C. Augustin, Yan Lin, Douglas J. Hartman, Lindsey Seigh, Reetesh K. Pai, Weijing Sun, Nathan Bahary, James Ohr, John C. Rhee, Stanley M. Marks, H. Scott Beasley, Yongli Shuai, James G. Herman, Hassane M. Zarour…
    Citation: Clinical Epigenetics 2022 14:3
  37. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a typical neurodegenerative disease associated with mitochondrial dysfunction. Methylation of the D-loop ...

    Authors: Jiewen Zhang, Junkui Shang, Fengyu Wang, Xuejing Huo, Ruihua Sun, Zhixia Ren, Wan Wang, Miaomiao Yang, Gai Li, Dandan Gao, Ruijie Liu, Pingping Bai, Shuyi Wang, Yanliang Wang and Xi Yan
    Citation: Clinical Epigenetics 2022 14:2
  38. Epigenetic clocks are biomarkers of ageing derived from DNA methylation levels at a subset of CpG sites. The difference between age predicted by these clocks and chronological age, termed “epigenetic age accel...

    Authors: Rhona A. Beynon, Suzanne M. Ingle, Ryan Langdon, Margaret May, Andy Ness, Richard M. Martin, Matthew Suderman, Kate Ingarfield, Riccardo E. Marioni, Daniel L. McCartney, Tim Waterboer, Michael Pawlita, Caroline Relton, George Davey Smith and Rebecca C. Richmond
    Citation: Clinical Epigenetics 2022 14:1
  39. Circulating tumor DNA (ctDNA) is a promising diagnostic and prognostic marker for many cancers and has been actively investigated in recent years. Previous studies have already demonstrated the potential use o...

    Authors: Wu-Hao Lin, Jian Xiao, Zi-Yi Ye, Da-Liang Wei, Xiao-Hui Zhai, Rui-Hua Xu, Zhao-Lei Zeng and Hui-Yan Luo
    Citation: Clinical Epigenetics 2021 13:232
  40. The role of breastfeeding in modulating epigenetic factors has been suggested as a possible mechanism conferring its benefits on child development but it lacks evidence. Using extensive DNA methylation data fr...

    Authors: Laurent Briollais, Denis Rustand, Catherine Allard, Yanyan Wu, Jingxiong Xu, Samyukta Govinda Rajan, Marie-France Hivert, Myriam Doyon, Luigi Bouchard, Patrick O. McGowan, Steven Matthews and Steven Lye
    Citation: Clinical Epigenetics 2021 13:231
  41. Body mass index (BMI), a well-known risk factor for poor cardiovascular outcomes, is associated with differential DNA methylation (DNAm). Similarly, metabolic health has also been associated with changes in DN...

    Authors: Whitney L. Do, Steve Nguyen, Jie Yao, Xiuqing Guo, Eric A. Whitsel, Ellen Demerath, Jerome I. Rotter, Stephen S. Rich, Leslie Lange, Jingzhong Ding, David Van Den Berg, Yongmei Liu, Anne E. Justice, Weihua Guan, Steve Horvath, Themistocles L. Assimes…
    Citation: Clinical Epigenetics 2021 13:230
  42. The characteristics of programmed cell death protein-1 (PD-L1) expression, tumor-infiltrating lymphocytes (TILs), and tumor microenvironment (TME) in lung adenocarcinoma (LUAD) patients are closely related to ...

    Authors: Fenglong Bie, He Tian, Nan Sun, Ruochuan Zang, Moyan Zhang, Peng Song, Lei Liu, Yue Peng, Guangyu Bai, Bolun Zhou and Shugeng Gao
    Citation: Clinical Epigenetics 2021 13:229
  43. Dysregulation of fibroblast growth factor receptor (FGFR) signaling pathway has been observed in head and neck squamous cell carcinoma (HNSCC) and is a promising therapeutic target for selective tyrosine kinase i...

    Authors: Yilin Bao, Jennis Gabrielpillai, Jörn Dietrich, Romina Zarbl, Sebastian Strieth, Friederike Schröck and Dimo Dietrich
    Citation: Clinical Epigenetics 2021 13:228
  44. Women with a history of complications of pregnancy, including hypertensive disorders, gestational diabetes or an infant fetal growth restriction or preterm birth, are at higher risk for cardiovascular disease ...

    Authors: Emily W. Harville, Pashupati P. Mishra, Mika Kähönen, Emma Raitoharju, Saara Marttila, Olli Raitakari and Terho Lehtimäki
    Citation: Clinical Epigenetics 2021 13:227
  45. Neoadjuvant chemotherapy (NAC) is used to treat triple-negative breast cancer (TNBC) prior to resection. Biomarkers that accurately predict a patient’s response to NAC are needed to individualise therapy and a...

    Authors: Braydon Meyer, Samuel Clifton, Warwick Locke, Phuc-Loi Luu, Qian Du, Dilys Lam, Nicola J. Armstrong, Beena Kumar, Niantao Deng, Kate Harvey, Alex Swarbrick, Vinod Ganju, Susan J. Clark, Ruth Pidsley and Clare Stirzaker
    Citation: Clinical Epigenetics 2021 13:226
  46. Deregulated methylation of tumor suppressor genes is a hallmark event in colorectal cancer (CRC) carcinogenesis. UNC5 receptors, down-regulated in various human malignancies due to epigenetic alterations, have be...

    Authors: Dong Dong, Runshi Zhang, Jie Shao, Aimin Zhang, Yichao Wang, Yunli Zhou and Yueguo Li
    Citation: Clinical Epigenetics 2021 13:225
  47. Metformin and weight loss relationships with epigenetic age measures—biological aging biomarkers—remain understudied. We performed a post-hoc analysis of a randomized controlled trial among overweight/obese br...

    Authors: Jamaji C. Nwanaji-Enwerem, Felicia Fei-Lei Chung, Lars Van der Laan, Alexei Novoloaca, Cyrille Cuenin, Harriet Johansson, Bernardo Bonanni, Alan E. Hubbard, Martyn T. Smith, Sheri J. Hartman, Andres Cardenas, Dorothy D. Sears and Zdenko Herceg
    Citation: Clinical Epigenetics 2021 13:224