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  1. Individuals affected with autism often suffer additional co-morbidities such as intellectual disability. The genes contributing to autism cluster on a relatively limited number of cellular pathways, including ...

    Authors: Claudio Peter D’Incal, Kirsten Esther Van Rossem, Kevin De Man, Anthony Konings, Anke Van Dijck, Ludovico Rizzuti, Alessandro Vitriolo, Giuseppe Testa, Illana Gozes, Wim Vanden Berghe and R. Frank Kooy
    Citation: Clinical Epigenetics 2023 15:45
  2. Advanced maternal age (AMA) has increased in many high-income countries in recent decades. AMA is generally associated with a higher risk of various pregnancy complications, and the underlying molecular mechan...

    Authors: Meng Qin, Wei Chen, Lingyue Hua, Yan Meng, Jing Wang, Hanna Li, Rui Yang, Liying Yan and Jie Qiao
    Citation: Clinical Epigenetics 2023 15:44
  3. Epigenetic modifications are involved in the remodeling of the tumor microenvironment (TME) and the regulation of immune response. Nonetheless, the role of histone H4 methylation (H4M) modification in the TME ...

    Authors: Linyuan Yu, Tao Ji, Wei Liao, Yuyan Xu, Yinghao Fang, Qing Zhu, Jianmin Nie and Dinghua Yang
    Citation: Clinical Epigenetics 2023 15:43
  4. Clinical trials have shown zoledronic acid as a potent bisphosphonate in preventing bone loss, but with varying potency between patients. Human osteoclasts ex vivo reportedly displayed a variable sensitivity t...

    Authors: Qihua Tan, Anaïs Marie Julie Møller, Chuan Qiu, Jonna Skov Madsen, Hui Shen, Troels Bechmann, Jean-Marie Delaisse, Bjarne Winther Kristensen, Hong-Wen Deng, David Karasik and Kent Søe
    Citation: Clinical Epigenetics 2023 15:42
  5. The Infinium EPIC array measures the methylation status of > 850,000 CpG sites. The EPIC BeadChip uses a two-array design: Infinium Type I and Type II probes. These probe types exhibit different technical char...

    Authors: H. Welsh, C. M. P. F. Batalha, W. Li, K. L. Mpye, N. C. Souza-Pinto, M. S. Naslavsky and E. J. Parra
    Citation: Clinical Epigenetics 2023 15:41
  6. Molecular analyses have shown that tumours diagnosed as supratentorial primitive neuro-ectodermal tumours of the central nervous system (CNS-PNETs) in the past represent a heterogenous group of rare childhood ...

    Authors: Elizabeth Schepke, Maja Löfgren, Torsten Pietsch, Teresia Kling, Claes Nordborg, Thomas Olsson Bontell, Stefan Holm, Anders Öberg, Per Nyman, Marie Eliasson-Hofvander, Magnus Sabel, Birgitta Lannering and Helena Carén
    Citation: Clinical Epigenetics 2023 15:40
  7. Advances in understanding of cancer biology, genomics, epigenomics, and immunology have resulted in development of several therapeutic options that expand cancer care beyond traditional chemotherapy or radioth...

    Authors: Allison C. Rosenthal, Javier L. Munoz and J. C. Villasboas
    Citation: Clinical Epigenetics 2023 15:39
  8. Hypertension is a crucial risk factor for developing cardiovascular disease and reducing life expectancy. We aimed to detect DNA methylation (DNAm) variants potentially related to systolic blood pressure (SBP)...

    Authors: Weijing Wang, Jie Yao, Weilong Li, Yili Wu, Haiping Duan, Chunsheng Xu, Xiaocao Tian, Shuxia Li, Qihua Tan and Dongfeng Zhang
    Citation: Clinical Epigenetics 2023 15:38
  9. Despite its inconsistent response rate, decitabine, a demethylating agent, is often used as a non-intensive alternative therapeutic agent for acute myeloid leukemia (AML). It has been reported that relapsed/re...

    Authors: Shujiao He, Yan Li, Xuanren Shi, Lei Wang, Diya Cai, Jingfeng Zhou and Li Yu
    Citation: Clinical Epigenetics 2023 15:37
  10. Selenium, an essential trace element, has previously been investigated as a pro-apoptotic and DNA demethylation agent. It sensitizes the response to chemotherapy in patients who were refractory to cytotoxic ag...

    Authors: Lok Seng Chan, Johnson Liu, Molly S. C. Li, Lili Li, Qian Tao and Tony S. K. Mok
    Citation: Clinical Epigenetics 2023 15:36
  11. Imprinting disorders (ImpDis) comprise diseases which are caused by aberrant regulation of monoallelically and parent-of-origin-dependent expressed genes. A characteristic molecular change in ImpDis patients i...

    Authors: Larissa Bilo, Eguzkine Ochoa, Sunwoo Lee, Daniela Dey, Ingo Kurth, Florian Kraft, Fay Rodger, France Docquier, Ana Toribio, Leonardo Bottolo, Gerhard Binder, György Fekete, Miriam Elbracht, Eamonn R. Maher, Matthias Begemann and Thomas Eggermann
    Citation: Clinical Epigenetics 2023 15:35
  12. A growing body of research has emphasized 5-hydroxymethylcytosine (5hmC) as an important epigenetic mark. High-resolution methods to detect 5hmC require high sequencing depth and are therefore expensive. Many ...

    Authors: Jaywon Lee, Dongin Lee, Hwang-Phill Kim, Tae-You Kim and Duhee Bang
    Citation: Clinical Epigenetics 2023 15:34
  13. Immune cell proportions can be used to detect pathophysiological states and are also critical covariates in genomic analyses. The complete blood count (CBC) is the most common method of immune cell proportion ...

    Authors: Abner T. Apsley, Laura Etzel, Waylon J. Hastings, Christine C. Heim, Jennie G. Noll, Kieran J. O’Donnell, Hannah M. C. Schreier, Chad E. Shenk, Qiaofeng Ye and Idan Shalev
    Citation: Clinical Epigenetics 2023 15:33
  14. DNA methylation (DNAm) plays an important role in lipid metabolism, however, no epigenome-wide association study (EWAS) of lipid levels has been conducted among childhood cancer survivors. Here, we performed E...

    Authors: Qian Dong, Cheng Chen, Nan Song, Na Qin, Noel-Marie Plonski, Emily R. Finch, Kyla Shelton, John Easton, Heather Mulder, Emily Plyer, Geoffrey Neale, Emily Walker, Qian Li, I-Chan Huang, Jinghui Zhang, Hui Wang…
    Citation: Clinical Epigenetics 2023 15:32
  15. Exposure to indoor air pollution during pregnancy has been linked to neurodevelopmental delay in toddlers. Epigenetic modification, particularly DNA methylation (DNAm), may explain this link. In this study, we...

    Authors: Dakotah Feil, Sarina Abrishamcar, Grace M. Christensen, Aneesa Vanker, Nastassja Koen, Anna Kilanowski, Nadia Hoffman, Catherine J. Wedderburn, Kirsten A. Donald, Michael S. Kobor, Heather J. Zar, Dan J. Stein and Anke Hüls
    Citation: Clinical Epigenetics 2023 15:31
  16. PLCD1, located at 3p22, encodes an enzyme that mediates cellular metabolism and homeostasis, intracellular signal transduction and movement. PLCD1 plays a pivotal role in tumor suppression of several types of can...

    Authors: Jianlian Xie, Jun Zhou, Jiliang Xia, Ying Zeng, Guo Huang, Weihong Zeng, Tingyu Fan, Lili Li, Xi Zeng and Qian Tao
    Citation: Clinical Epigenetics 2023 15:30
  17. Glioblastoma (GBM, WHO grade IV) is an aggressive, primary brain tumor. Despite extensive tumor resection followed by radio- and chemotherapy, life expectancy of GBM patients did not improve over decades. Seve...

    Authors: Adria-Jaume Roura, Paulina Szadkowska, Katarzyna Poleszak, Michal J. Dabrowski, Aleksandra Ellert-Miklaszewska, Kamil Wojnicki, Iwona A. Ciechomska, Karolina Stepniak, Bozena Kaminska and Bartosz Wojtas
    Citation: Clinical Epigenetics 2023 15:29
  18. Intraductal papillary mucinous neoplasms (IPMNs), a type of cystic pancreatic cancer (PC) precursors, are increasingly identified on cross-sectional imaging and present a significant diagnostic challenge. Whil...

    Authors: Ankit Chhoda, Anup Sharma, Bethsebie Sailo, Haoyu Tang, Nensi Ruzgar, Wan Ying Tan, Lee Ying, Rishabh Khatri, Anand Narayanan, Shrikant Mane, Bony De Kumar, Laura D. Wood, Christine Iacobuzio-Donahue, Christopher L. Wolfgang, John W. Kunstman, Ronald R. Salem…
    Citation: Clinical Epigenetics 2023 15:28
  19. miRNAs are small non-coding RNAs that regulate gene expression and are linked to cancer development and progression. miRNA profiles are currently studied as new prognostic factors or therapeutic perspectives. ...

    Authors: Sara Mongiorgi, Alessia De Stefano, Stefano Ratti, Valentina Indio, Annalisa Astolfi, Irene Casalin, Andrea Pellagatti, Stefania Paolini, Sarah Parisi, Michele Cavo, Andrea Pession, James A. McCubrey, Pann-Ghill Suh, Lucia Manzoli, Jacqueline Boultwood, Carlo Finelli…
    Citation: Clinical Epigenetics 2023 15:27
  20. Early detection and prevention of precancerous lesions can significantly reduce the morbidity and mortality of colorectal cancer (CRC). Here, we developed new candidate CpG site biomarkers for CRC and evaluate...

    Authors: Yuguang Shen, Dongyang Wang, Tianli Yuan, Hongsheng Fang, Chen Zhu, Juan Qin, Xiaojing Xu, Cheng Zhang, Jiahua Liu, Yuanruohan Zhang, Zhoujin Wen, Jian Tang and Zheng Wang
    Citation: Clinical Epigenetics 2023 15:26
  21. Systemic sclerosis (SSc) is a multisystem autoimmune disorder that has an unclear etiology and disproportionately affects women and African Americans. Despite this, African Americans are dramatically underrepr...

    Authors: Peter C. Allen, Sarah Smith, Robert C. Wilson, Jena R. Wirth, Nathan H. Wilson, DeAnna Baker Frost, Jonathan Flume, Gary S. Gilkeson, Melissa A. Cunningham, Carl D. Langefeld, Devin M. Absher and Paula S. Ramos
    Citation: Clinical Epigenetics 2023 15:25
  22. Patients diagnosed with epithelial ovarian cancer (OC) have a 5-year survival rate of 49%. For early-stage disease, the 5-year survival rate is above 90%. However, advanced-stage disease accounts for most case...

    Authors: Simone Karlsson Terp, Malene Pontoppidan Stoico, Karen Dybkær and Inge Søkilde Pedersen
    Citation: Clinical Epigenetics 2023 15:24
  23. Insulin resistance (IR) is a well-established factor for breast cancer (BC) risk in postmenopausal women, but the interrelated molecular pathways on the methylome are not explicitly described. We conducted a p...

    Authors: Su Yon Jung, Parveen Bhatti and Matteo Pellegrini
    Citation: Clinical Epigenetics 2023 15:23
  24. N7-methylguanosine (m7G) modification has been reported to regulate RNA expression in multiple pathophysiological processes. However, little is known about its role and association with immune microenvironment in...

    Authors: Chaoqun Ma, Dingyuan Tu, Qiang Xu, Yan Wu, Xiaowei Song, Zhifu Guo and Xianxian Zhao
    Citation: Clinical Epigenetics 2023 15:22
  25. Accumulation of saturated fatty acids (SFAs) in the liver is known to induce hepatic steatosis and inflammation causing non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). Altho...

    Authors: Ratika Sehgal, Alexander Perfilyev, Ville Männistö, Jyrki Ågren, Emma Nilsson, Pirjo Käkelä, Charlotte Ling, Vanessa D. de Mello and Jussi Pihlajamäki
    Citation: Clinical Epigenetics 2023 15:21
  26. Pregnancy in women with multiple sclerosis (wwMS) is associated with a reduction of long-term disability progression. The mechanism that drives this effect is unknown, but converging evidence suggests a role f...

    Authors: Maria Pia Campagna, Alexandre Xavier, Jim Stankovich, Vicki E. Maltby, Mark Slee, Wei Z. Yeh, Trevor Kilpatrick, Rodney J. Scott, Helmut Butzkueven, Jeannette Lechner-Scott, Rodney A. Lea and Vilija G. Jokubaitis
    Citation: Clinical Epigenetics 2023 15:20
  27. Natural killer/T-cell lymphoma (NKTL) is a rare type of aggressive and heterogeneous non-Hodgkin's lymphoma (NHL) with a poor prognosis and limited therapeutic options. Therefore, there is an urgent need to ex...

    Authors: Jinghong Chen, Zhixiang Zuo, Yan Gao, Xiaosai Yao, Peiyong Guan, Yali Wang, Zhimei Li, Zhilong Liu, Jing Han Hong, Peng Deng, Jason Yongsheng Chan, Daryl Ming Zhe Cheah, Jingquan Lim, Kelila Xin Ye Chai, Burton Kuan Hui Chia, Jane Wan Lu Pang…
    Citation: Clinical Epigenetics 2023 15:19
  28. Oncogenic overexpression of integrin-β7 (ITGB7) in cases of high-risk multiple myeloma (MM) was reported to promote enhanced interactions between neoplastic plasma-B cells and stromal cells to develop cell-adhesi...

    Authors: Samrat Roy Choudhury, Stephanie D. Byrum, Duah Alkam, Cody Ashby, Fenghuang Zhan, Alan J. Tackett and Frits Van Rhee
    Citation: Clinical Epigenetics 2023 15:18
  29. People age biologically at different rates. Epigenetic clock-derived DNA methylation age acceleration (DNAmAA) is among the most promising markers proposed to assess the interindividual differences in biologic...

    Authors: Verena Laura Banszerus, Maximilian König, Ulf Landmesser, Valentin Max Vetter and Ilja Demuth
    Citation: Clinical Epigenetics 2023 15:16
  30. N-methyl-2-pyrrolidone (NMP) is an epigenetically active chemical fragment and organic solvent with numerous applications including use as a drug-delivery vehicle. Previously considered biologically inert, NMP .....

    Authors: Jake Shortt, Peter Galettis, Chan Y. Cheah, Joanne Davis, Mandy Ludford-Menting, Emma K. Link, Jennifer H. Martin, Rachel Koldej and David Ritchie
    Citation: Clinical Epigenetics 2023 15:15
  31. Renal cell carcinoma (RCC) is not sensitive to immunotherapy and has poor prognosis. DNA methylation regulates gene expression, and its abnormal changes are related to many human diseases. Recently, DNA methyl...

    Authors: Xiaonan Wang, Wancui Zhu, Qian Long, Enni Chen, Haohui Sun, Xiaodi Li, Hailin Xu, Weizhao Li, Pei Dong, Liru He, Miao Chen and Wuguo Deng
    Citation: Clinical Epigenetics 2023 15:14
  32. Collagen type XII alpha 1 chain (COL12A1) is associated with human cancer progression. Nevertheless, the expression pattern and the function of COL12A1 in intrahepatic cholangiocarcinoma (iCCA) remain unknown....

    Authors: Zengwei Tang, Yuan Yang, Qi Zhang and Tingbo Liang
    Citation: Clinical Epigenetics 2023 15:13

    The Correction to this article has been published in Clinical Epigenetics 2023 15:46

  33. Histone methylation modification plays an irreplaceable role in the wheezing diseases. The aim of this study was to explore whether azithromycin (AZM) attenuates post-inflammatory wheezing through inhibiting h...

    Authors: Shuqi Wu, Xiaochun Tian, Qian Mao and Chang Peng
    Citation: Clinical Epigenetics 2023 15:12
  34. Changes in gene-specific promoter methylation may result from aging and environmental influences. Atherosclerosis is associated with aging and environmental effects. Thus, promoter methylation profiling may be...

    Authors: Jee Yeon Kim, Jaroslav Jelinek, Young Ho Lee, Dae Hyun Kim, Keunsoo Kang, Su Hyun Ryu, Hye Rin Moon, Kwangjo Cho, Seo Hee Rha, Jae Kwan Cha, Jean-Pierre J. Issa and Jei Kim
    Citation: Clinical Epigenetics 2023 15:11
  35. Zinc finger and scan domain containing 18 (ZSCAN18) belongs to the zinc finger transcription factor superfamily, which consists of hundreds of members that play critical roles in all steps of tumorigenesis.

    Authors: Bin Li, Baoqing Ren, Gang Ma, Fenglin Cai, Pengliang Wang, Yi Zeng, Yong Liu, Li Zhang, Yang Yang, Han Liang, Rupeng Zhang and Jingyu Deng
    Citation: Clinical Epigenetics 2023 15:10
  36. In their attempt to fulfill the wish of having children, women who suffer from fertility issues often undergo assisted reproductive technologies such as ovarian stimulation, which has been associated with adve...

    Authors: Laura Saucedo-Cuevas, Elena Ivanova, Anamaria-Cristina Herta, Felix Krueger, Katy Billooye, Johan Smitz, Gavin Kelsey and Ellen Anckaert
    Citation: Clinical Epigenetics 2023 15:9
  37. Altered DNA-methylation affects biological ageing in adults and developmental processes in children. DNA-methylation is altered by environmental factors, trauma and illnesses. We hypothesised that paediatric c...

    Authors: Ines Verlinden, Grégoire Coppens, Ilse Vanhorebeek, Fabian Güiza, Inge Derese, Pieter J. Wouters, Koen F. Joosten, Sascha C. Verbruggen and Greet Van den Berghe
    Citation: Clinical Epigenetics 2023 15:8
  38. Accurate regulation of DNA methylation is necessary for normal cells to differentiate, develop and function. TET2 catalyzes stepwise DNA demethylation in hematopoietic cells. Mutations in the TET2 gene predispose...

    Authors: Aurora Taira, Kimmo Palin, Anna Kuosmanen, Niko Välimäki, Outi Kuittinen, Outi Kuismin, Eevi Kaasinen, Kristiina Rajamäki and Lauri A. Aaltonen
    Citation: Clinical Epigenetics 2023 15:7
  39. Modulating the epigenome has long been considered a potential opportunity for therapeutic intervention in numerous disease areas with several approved therapies marketed, primarily for cancer. Despite the over...

    Authors: Taylor Feehley, Charles W. O’Donnell, John Mendlein, Mahesh Karande and Thomas McCauley
    Citation: Clinical Epigenetics 2023 15:6
  40. Combination chemotherapy has contributed to increased survival from Hodgkin disease (HD) and testicular cancer (TC). However, questions concerning the quality of spermatozoa after treatment have arisen. While ...

    Authors: Donovan Chan, Kathleen Oros Klein, Antoni Riera-Escamilla, Csilla Krausz, Cristian O’Flaherty, Peter Chan, Bernard Robaire and Jacquetta M. Trasler
    Citation: Clinical Epigenetics 2023 15:5
  41. To explore the possible carcinogenesis and help better diagnose and treat patients with synchronous multiple primary lung cancers (sMPLC), we systematically investigated the genetic and DNA methylation profile...

    Authors: Fenglei Yu, Xiaojie Huang, Danting Zhou, Zhenyu Zhao, Fang Wu, Banglun Qian, Qiang Wang, Juan Chen, Qingchun Liang, Yi Jiang, Qi Ding, Qiongzhi He, Jingqun Tang, Xiang Wang, Wenliang Liu and Chen Chen
    Citation: Clinical Epigenetics 2023 15:4
  42. Authors: Patricia Johansson, Teresa Laguna, Julio Ossowski, Vera Pancaldi, Martina Brauser, Ulrich Dührsen, Lara Keuneke, Ana Queiros, Julia Richter, José I. Martín-Subero, Reiner Siebert, Brigitte Schlegelberger, Ralf Küppers, Jan Dürig, Eva M. Murga Penas, Enrique Carrillo-de Santa Pau…
    Citation: Clinical Epigenetics 2023 15:3

    The original article was published in Clinical Epigenetics 2022 14:148

  43. Epigenetic variants carried by circulating tumor DNA can be used as biomarkers for early detection of hepatocellular carcinoma (HCC) by noninvasive liquid biopsy. However, traditional methylation analysis meth...

    Authors: Ping Guo, Hailing Zheng, Yihan Li, Yuntong Li, Yue Xiao, Jin Zheng, Xingqiang Zhu, Huan Xu, Zhi He, Qian Zhang, Jinchun Chen, Mingshan Qiu, Min Jiang, Pingguo Liu and Hongliang Chen
    Citation: Clinical Epigenetics 2023 15:2
  44. Depression is a multifactorial disorder representing a significant public health burden. Previous studies have linked multiple single nucleotide polymorphisms with depressive phenotypes and suicidal behavior. ...

    Authors: Aleksandr V. Sokolov, Diana-Maria Manu, Didi O. T. Nordberg, Adrian D. E. Boström, Jussi Jokinen and Helgi B. Schiöth
    Citation: Clinical Epigenetics 2023 15:1
  45. Cardiac surgery and cardiopulmonary bypass induce a substantial immune and inflammatory response, the overactivation of which is associated with significant pulmonary, cardiovascular, and neurologic complicati...

    Authors: Matthew A. Fischer, Douglas J. Chapski, Elizabeth Soehalim, Dennis J. Montoya, Tristan Grogan, Matteo Pellegrini, Hua Cai, Richard J. Shemin and Thomas M. Vondriska
    Citation: Clinical Epigenetics 2022 14:195
  46. The variation in multiple sclerosis (MS) disease severity is incompletely explained by genetics, suggesting genetic and environmental interactions are involved. Moreover, the lack of prognostic biomarkers make...

    Authors: Maria Pia Campagna, Alexandre Xavier, Rodney A. Lea, Jim Stankovich, Vicki E. Maltby, Helmut Butzkueven, Jeannette Lechner-Scott, Rodney J. Scott and Vilija G. Jokubaitis
    Citation: Clinical Epigenetics 2022 14:194
  47. Epigenetic modifications in mammalian DNA are commonly manifested by DNA methylation. In the stomach, altered DNA methylation patterns have been observed following chronic Helicobacter pylori infections and in ga...

    Authors: Kristin Fritsche, Francesco Boccellato, Philipp Schlaermann, Max Koeppel, Christian Denecke, Alexander Link, Peter Malfertheiner, Ivo Gut, Thomas F. Meyer and Hilmar Berger
    Citation: Clinical Epigenetics 2022 14:193
  48. Fetal overgrowth “programs” an elevated risk of type 2 diabetes in adulthood. Epigenetic alterations may be a mechanism in programming the vulnerability. We sought to characterize genome-wide alterations in pl...

    Authors: Meng-Nan Yang, Rong Huang, Tao Zheng, Yu Dong, Wen-Juan Wang, Ya-Jie Xu, Vrati Mehra, Guang-Di Zhou, Xin Liu, Hua He, Fang Fang, Fei Li, Jian-Gao Fan, Jun Zhang, Fengxiu Ouyang, Laurent Briollais…
    Citation: Clinical Epigenetics 2022 14:192