Articles

Genome-wide DNA methylation profiling is able to identify prefibrotic PMF cases at risk for progression to myelofibrosis

Patients suffering from the BCR-ABL1-negative myeloproliferative disease prefibrotic primary myelofibrosis (pre-PMF) have a certain risk for progression to myelofibrosis. Accurate risk estimation for this fibroti...

Authors: Ulrich Lehmann, Helge Stark, Stephan Bartels, Jerome Schlue, Guntram Büsche and Hans Kreipe

Genome-wide DNA methylation dynamics during epigenetic reprogramming in the porcine germline

Prior work in mice has shown that some retrotransposed elements remain substantially methylated during DNA methylation reprogramming of germ cells. In the pig, however, information about this process is scarce...

Authors: Isabel Gómez-Redondo, Benjamín Planells, Sebastián Cánovas, Elena Ivanova, Gavin Kelsey and Alfonso Gutiérrez-Adán

Discovery and validation of methylation signatures in blood-based circulating tumor cell-free DNA in early detection of colorectal carcinoma: a case–control study

Early detection of colorectal carcinoma (CRC) would help to identify tumors when curative treatments are available and beneficial. However, current screening methods for CRC, e.g., colonoscopy, may affect pati...

Authors: Jinke Sui, Xianrui Wu, Chenyang Wang, Guoqiang Wang, Chengcheng Li, Jing Zhao, Yuzi Zhang, Jianxing Xiang, Yu Xu, Weiqi Nian, Fuao Cao, Guanyu Yu, Zheng Lou, Liqiang Hao, Lianjie Liu, Bingsi Li…

A feasibility study of combined epigenetic and vaccine therapy in advanced colorectal cancer with pharmacodynamic endpoint

Epigenetic therapies may modulate the tumor microenvironment. We evaluated the safety and optimal sequence of combination DNA methyltransferase inhibitor guadecitabine with a granulocyte macrophage-colony-stim...

Authors: Katherine M. Bever, Dwayne L. Thomas II, Jiajia Zhang, Ernie A. Diaz Rivera, Gary L. Rosner, Qingfeng Zhu, Julie M. Nauroth, Brian Christmas, Elizabeth D. Thompson, Robert A. Anders, Carol Judkins, Meizheng Liu, Elizabeth M. Jaffee, Nita Ahuja, Lei Zheng and Nilofer S. Azad

DNA methylation impact on Fabry disease

Fabry disease (FD) is a rare X-linked disease caused by mutations in GLA gene with consequent lysosomal accumulation of globotriaosylceramide (Gb3). Women with FD often show highly heterogeneous symptoms that ...

Authors: Teodolinda Di Risi, Roberta Vinciguerra, Mariella Cuomo, Rosa Della Monica, Eleonora Riccio, Sirio Cocozza, Massimo Imbriaco, Giovanni Duro, Antonio Pisani and Lorenzo Chiariotti

Genetic, epigenetic, and environmental factors controlling oxytocin receptor gene expression

The neuropeptide oxytocin regulates mammalian social behavior. Disruptions in oxytocin signaling are a feature of many psychopathologies. One commonly studied biomarker for oxytocin involvement in psychiatric ...

Authors: Joshua S. Danoff, Kelly L. Wroblewski, Andrew J. Graves, Graham C. Quinn, Allison M. Perkeybile, William M. Kenkel, Travis S. Lillard, Hardik I. Parikh, Hudson F. Golino, Simon G. Gregory, C. Sue Carter, Karen L. Bales and Jessica J. Connelly

Identification and validation of methylated differentially expressed miRNAs and immune infiltrate profile in EBV-associated gastric cancer

The recent discovery of cancer/tissue specificity of miRNA has indicated its great potential as a therapeutic target. In Epstein–Barr virus-associated gastric cancer (EBVaGC), host genes are affected by extens...

Authors: Mansheng Zhu, Qixiang Liang, Tao Chen, Qian Kong, Gengtai Ye, Shitong Yu, Xunjun Li, Qinglie He, Hao Liu, Yanfeng Hu, Jiang Yu and Guoxin Li

Loss of H3K27 methylation identifies poor outcomes in adult-onset acute leukemia

Acute leukemia is an epigenetically heterogeneous disease. The intensity of treatment is currently guided by cytogenetic and molecular genetic risk classifications; however these incompletely predict outcomes,...

Authors: A. D. van Dijk, F. W. Hoff, Y. H. Qiu, J. Chandra, E. Jabbour, E. S. J. M. de Bont, T. M. Horton and S. M. Kornblau

MethCORR infers gene expression from DNA methylation and allows molecular analysis of ten common cancer types using fresh-frozen and formalin-fixed paraffin-embedded tumor samples

Transcriptional analysis is widely used to study the molecular biology of cancer and hold great biomarker potential for clinical patient stratification. Yet, accurate transcriptional profiling requires RNA of ...

Authors: Trine B. Mattesen, Claus L. Andersen and Jesper B. Bramsen

Profile of copper-associated DNA methylation and its association with incident acute coronary syndrome

Acute coronary syndrome (ACS) is a cardiac emergency with high mortality. Exposure to high copper (Cu) concentration has been linked to ACS. However, whether DNA methylation contributes to the association betw...

Authors: Pinpin Long, Qiuhong Wang, Yizhi Zhang, Xiaoyan Zhu, Kuai Yu, Haijing Jiang, Xuezhen Liu, Min Zhou, Yu Yuan, Kang Liu, Jing Jiang, Xiaomin Zhang, Meian He, Huan Guo, Weihong Chen, Jing Yuan…

Hypoxia promotes the metastasis of pancreatic cancer through regulating NOX4/KDM5A-mediated histone methylation modification changes in a HIF1A-independent manner

Hypoxia is a characteristic of the tumor microenvironments within pancreatic cancer (PC), which has been linked to its malignancy. Recently, hypoxia has been reported to regulate the activity of important carc...

Authors: Hongzhen Li, Chunyan Peng, Chenhui Zhu, Shuang Nie, Xuetian Qian, Zhao Shi, Mengyue Shi, Yan Liang, Xiwei Ding, Shu Zhang, Bin Zhang, Xihan Li, Guifang Xu, Ying Lv, Lei Wang, Helmut Friess…

Male obesity impacts DNA methylation reprogramming in sperm

Male obesity has profound effects on morbidity and mortality, but relatively little is known about the impact of obesity on gametes and the potential for adverse effects of male obesity to be passed to the nex...

Authors: Sanaz Keyhan, Emily Burke, Rose Schrott, Zhiqing Huang, Carole Grenier, Thomas Price, Doug Raburn, David L. Corcoran, Adelheid Soubry, Catherine Hoyo and Susan K. Murphy

Identification and validation of obesity-related gene LEP methylation as a prognostic indicator in patients with acute myeloid leukemia

Obesity confers enhanced risk for multiple diseases including cancer. The DNA methylation alterations in obesity-related genes have been implicated in several human solid tumors. However, the underlying role a...

Authors: Ting-juan Zhang, Zi-jun Xu, Yu Gu, Ji-chun Ma, Xiang-mei Wen, Wei Zhang, Zhao-qun Deng, Jun Qian, Jiang Lin and Jing-dong Zhou

CAMK2N1/RUNX3 methylation is an independent prognostic biomarker for progression-free and overall survival of platinum-sensitive epithelial ovarian cancer patients

To date, no predictive or prognostic molecular biomarkers except BRCA mutations are clinically established for epithelial ovarian cancer (EOC) despite being the deadliest gynecological malignancy. Aim of this bio...

Authors: Karolin Heinze, Matthias Rengsberger, Mieczyslaw Gajda, Lars Jansen, Linea Osmers, Leticia Oliveira-Ferrer, Barbara Schmalfeldt, Matthias Dürst, Norman Häfner and Ingo B. Runnebaum

Evaluation of a panel of tumor-specific differentially-methylated DNA regions in IRF4, IKZF1 and BCAT1 for blood-based detection of colorectal cancer

Differentially-methylated regions (DMRs) are characteristic of colorectal cancer (CRC) and some occur more frequently than common mutations. This study aimed to evaluate the clinical utility of assaying circul...

Authors: Graeme P. Young, Erin L. Symonds, Hans Jørgen Nielsen, Linnea Ferm, Ib J. Christensen, Evelien Dekker, Manon van der Vlugt, Rosalie C. Mallant-Hent, Nicky Boulter, Betty Yu, Michelle Chan, Gregor Tevz, Lawrence C. LaPointe and Susanne K. Pedersen

Epigenetic modifications in muscle regeneration and progression of Duchenne muscular dystrophy

Duchenne muscular dystrophy (DMD) is a multisystemic disorder that affects 1:5000 boys. The severity of the phenotype varies dependent on the mutation site in the DMD gene and the resultant dystrophin expression ...

Authors: Anna Rugowska, Alicja Starosta and Patryk Konieczny

Identification of DNA methylation signatures associated with poor outcome in lower-risk Stage, Size, Grade and Necrosis (SSIGN) score clear cell renal cell cancer

Despite using prognostic algorithms and standard surveillance guidelines, 17% of patients initially diagnosed with low risk clear cell renal cell carcinoma (ccRCC) ultimately relapse and die of recurrent disea...

Authors: Louis Y. El Khoury, Shuang Fu, Ryan A. Hlady, Ryan T. Wagner, Liguo Wang, Jeanette E. Eckel-Passow, Erik P. Castle, Melissa L. Stanton, R. Houston Thompson, Alexander S. Parker, Thai H. Ho and Keith D. Robertson

Association of variably methylated tumour DNA regions with overall survival for invasive lobular breast cancer

Tumour DNA methylation profiling has shown potential to refine disease subtyping and improve the diagnosis and prognosis prediction of breast cancer. However, limited data exist regarding invasive lobular brea...

Authors: Medha Suman, Pierre-Antoine Dugué, Ee Ming Wong, JiHoon Eric Joo, John L. Hopper, Tu Nguyen-Dumont, Graham G. Giles, Roger L. Milne, Catriona McLean and Melissa C. Southey

BRD4 inhibition alleviates mechanical stress-induced TMJ OA-like pathological changes and attenuates TREM1-mediated inflammatory response

The aim of this paper was to investigate the protective effects of bromodomain containing 4 (BRD4) inhibition on the temporomandibular joint osteoarthritis (TMJ OA) induced by compressive mechanical stress and...

Authors: Ziwei Huang, Ren Yang, Lu Zhang, Mengjiao Zhu, Caixia Zhang, Juan Wen and Huang Li

Different methylation signatures at diagnosis in patients with high-risk myelodysplastic syndromes and secondary acute myeloid leukemia predict azacitidine response and longer survival

Epigenetic therapy, using hypomethylating agents (HMA), is known to be effective in the treatment of high-risk myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) patients who are not suitable for...

Authors: M. Cabezón, R. Malinverni, J. Bargay, B. Xicoy, S. Marcé, A. Garrido, M. Tormo, L. Arenillas, R. Coll, J. Borras, M. J. Jiménez, M. Hoyos, D. Valcárcel, L. Escoda, F. Vall-Llovera, A. Garcia…

Childhood DNA methylation as a marker of early life rapid weight gain and subsequent overweight

High early postnatal weight gain has been associated with childhood adiposity; however, the mechanism remains unknown. DNA methylation is a hypothesised mechanism linking early life exposures and subsequent di...

Authors: N. Robinson, H. Brown, Elie Antoun, Keith M. Godfrey, Mark A. Hanson, Karen A. Lillycrop, Sarah R. Crozier, Robert Murray, M. S. Pearce, C. L. Relton, V. Albani and J. A. McKay

DNA methylation and lipid metabolism: an EWAS of 226 metabolic measures

The discovery of robust and trans-ethnically replicated DNA methylation markers of metabolic phenotypes, has hinted at a potential role of epigenetic mechanisms in lipid metabolism. However, DNA methylation an...

Authors: Monica del C. Gomez-Alonso, Anja Kretschmer, Rory Wilson, Liliane Pfeiffer, Ville Karhunen, Ilkka Seppälä, Weihua Zhang, Kirstin Mittelstraß, Simone Wahl, Pamela R. Matias-Garcia, Holger Prokisch, Sacha Horn, Thomas Meitinger, Luis R. Serrano-Garcia, Sylvain Sebert, Olli Raitakari…

Sperm DNA methylation epimutation biomarker for paternal offspring autism susceptibility

Autism spectrum disorder (ASD) has increased over tenfold over the past several decades and appears predominantly associated with paternal transmission. Although genetics is anticipated to be a component of AS...

Authors: Nicolás Garrido, Fabio Cruz, Rocio Rivera Egea, Carlos Simon, Ingrid Sadler-Riggleman, Daniel Beck, Eric Nilsson, Millissia Ben Maamar and Michael K. Skinner

Pre-adolescence DNA methylation is associated with lung function trajectories from pre-adolescence to adulthood

The pattern of lung function development from pre-adolescence to adulthood plays a significant role in the pathogenesis of respiratory diseases. Inconsistent findings in genetic studies on lung function trajec...

Authors: Shadia Khan Sunny, Hongmei Zhang, Fawaz Mzayek, Caroline L. Relton, Susan Ring, A. John Henderson, Susan Ewart, John W. Holloway and S. Hasan Arshad

Developmental cannabidiol exposure increases anxiety and modifies genome-wide brain DNA methylation in adult female mice

Use of cannabidiol (CBD), the primary non-psychoactive compound found in cannabis, has recently risen dramatically, while relatively little is known about the underlying molecular mechanisms of its effects. Pr...

Authors: Nicole M. Wanner, Mathia Colwell, Chelsea Drown and Christopher Faulk

Integrated analysis reveals the alterations that LMNA interacts with euchromatin in LMNA mutation-associated dilated cardiomyopathy

Dilated cardiomyopathy (DCM) is a serious cardiac heterogeneous pathological disease, which may be caused by mutations in the LMNA gene. Lamins interact with not only lamina-associated domains (LADs) but also ...

Authors: Xiaolin Zhang, Xiuli Shao, Ruijia Zhang, Rongli Zhu and Rui Feng

DNA methylation epi-signature is associated with two molecularly and phenotypically distinct clinical subtypes of Phelan-McDermid syndrome

Phelan-McDermid syndrome is characterized by a range of neurodevelopmental phenotypes with incomplete penetrance and variable expressivity. It is caused by a variable size and breakpoint microdeletions in the ...

Authors: L. C. Schenkel, E. Aref-Eshghi, K. Rooney, J. Kerkhof, M. A. Levy, H. McConkey, R. C. Rogers, K. Phelan, S. M. Sarasua, L. Jain, R. Pauly, L. Boccuto, B. DuPont, G. Cappuccio, N. Brunetti-Pierri, C. E. Schwartz…

Micro-RNA-125a mediates the effects of hypomethylating agents in chronic myelomonocytic leukemia

Chronic myelomonocytic leukemia (CMML) is an aggressive hematopoietic malignancy that arises from hematopoietic stem and progenitor cells (HSPCs). Patients with CMML are frequently treated with epigenetic ther...

Authors: Johannes Lorenz Berg, Bianca Perfler, Stefan Hatzl, Marie-Christina Mayer, Sonja Wurm, Barbara Uhl, Andreas Reinisch, Ingeborg Klymiuk, Sascha Tierling, Gudrun Pregartner, Gerhard Bachmaier, Andrea Berghold, Klaus Geissler, Martin Pichler, Gerald Hoefler, Herbert Strobl…

High-resolution analyses of human sperm dynamic methylome reveal thousands of novel age-related epigenetic alterations

Children of aged fathers are at a higher risk of developing mental disorders. Alterations in sperm DNA methylation have been implicated as a potential cause. However, age-dependent modifications of the germ ce...

Authors: Mingju Cao, Xiaojian Shao, Peter Chan, Warren Cheung, Tony Kwan, Tomi Pastinen and Bernard Robaire

Reproductive technologies, female infertility, and the risk of imprinting-related disorders

Epidemiological studies suggest that singletons born from assisted reproductive technologies (ART) have a high risk of adverse perinatal outcomes, specifically for imprinting disorders. Because ART processes t...

Authors: Patricia Fauque, Jacques De Mouzon, Aviva Devaux, Sylvie Epelboin, Marie-José Gervoise-Boyer, Rachel Levy, Morgane Valentin, Géraldine Viot, Arianne Bergère, Claire De Vienne, Philippe Jonveaux and Fabienne Pessione

Global hypermethylation of intestinal epithelial cells is a hallmark feature of neonatal surgical necrotizing enterocolitis

Necrotizing enterocolitis (NEC) remains one of the overall leading causes of death in premature infants, and the pathogenesis is unpredictable and not well characterized. The aim of our study was to determine ...

Authors: Misty Good, Tianjiao Chu, Patricia Shaw, Lora McClain, Austin Chamberlain, Carlos Castro, Jamie M. Rimer, Belgacem Mihi, Qingqing Gong, Lila S. Nolan, Krista Cooksey, Laura Linneman, Pranjal Agrawal, David N. Finegold and David Peters

Longitudinal data in peripheral blood confirm that PM20D1 is a quantitative trait locus (QTL) for Alzheimer’s disease and implicate its dynamic role in disease progression

While Alzheimer’s disease (AD) remains one of the most challenging diseases to tackle, genome-wide genetic/epigenetic studies reveal many disease-associated risk loci, which sheds new light onto disease herita...

Authors: Qi Wang, Yinghua Chen, Benjamin Readhead, Kewei Chen, Yi Su, Eric M. Reiman and Joel T. Dudley

DNA methylation changes in metabolic and immune-regulatory pathways in blood and lymph node CD4 + T cells in response to SIV infections

The molecular mechanisms underlying HIV-induced inflammation, which persists even during effective long-term treatment, remain incompletely defined. Here, we studied pathogenic and nonpathogenic simian immunod...

Authors: Simon P. Jochems, Beatrice Jacquelin, Nicolas Tchitchek, Florence Busato, Fabien Pichon, Nicolas Huot, Yi Liu, Mickaël J. Ploquin, Elodie Roché, Rémi Cheynier, Nathalie Dereuddre-Bosquet, Christiane Stahl-Henning, Roger Le Grand, Jorg Tost and Michaela Müller-Trutwin

DNA methylation patterns of β-globin cluster in β-thalassemia patients

Reactivation of fetal hemoglobin (HbF, α₂γ₂) holds a therapeutic target for β-thalassemia and sickle cell disease. Although many HbF regulators have been identified, the methylation patterns in β-globin cluster d...

Authors: Xiuqin Bao, Yangjin Zuo, Diyu Chen and Cunyou Zhao

Epigenetic regulation of inflammation in periodontitis: cellular mechanisms and therapeutic potential

Epigenetic mechanisms, namely DNA and histone modifications, are critical regulators of immunity and inflammation which have emerged as potential targets for immunomodulating therapies. The prevalence and sign...

Authors: Krzysztof T. Jurdziński, Jan Potempa and Aleksander M. Grabiec

Developmental programming in human umbilical cord vein endothelial cells following fetal growth restriction

Fetal growth restriction (FGR) is associated with an increased susceptibility for various noncommunicable diseases in adulthood, including cardiovascular and renal disease. During FGR, reduced uteroplacental b...

Authors: Fieke Terstappen, Jorg J. A. Calis, Nina D. Paauw, Jaap A. Joles, Bas B. van Rijn, Michal Mokry, Torsten Plösch and A. Titia Lely

Whole blood DNA methylation aging markers predict colorectal cancer survival: a prospective cohort study

Blood DNA methylation-based aging algorithms predict mortality in the general population. We investigated the prognostic value of five established DNA methylation aging algorithms for patients with colorectal ...

Authors: Xīn Gào, Yan Zhang, Daniel Boakye, Xiangwei Li, Jenny Chang-Claude, Michael Hoffmeister and Hermann Brenner

Epigenetic modification mechanisms involved in keloid: current status and prospect

Keloid, a common dermal fibroproliferative disorder, is benign skin tumors characterized by the aggressive fibroblasts proliferation and excessive accumulation of extracellular matrix. However, common therapeu...

Authors: Wenchang Lv, Yuping Ren, Kai Hou, Weijie Hu, Yi Yi, Mingchen Xiong, Min Wu, Yiping Wu and Qi Zhang

Mitochondrial metabolism and DNA methylation: a review of the interaction between two genomes

Mitochondria are controlled by the coordination of two genomes: the mitochondrial and the nuclear DNA. As such, variations in nuclear gene expression as a consequence of mutations and epigenetic modifications ...

Authors: Amanda F. C. Lopes

Dynamic changes in chromatin accessibility, altered adipogenic gene expression, and total versus de novo fatty acid synthesis in subcutaneous adipose stem cells of normal-weight polycystic ovary syndrome (PCOS) women during adipogenesis: evidence of cellular programming

Normal-weight polycystic ovary syndrome (PCOS) women exhibit adipose resistance in vivo accompanied by enhanced subcutaneous (SC) abdominal adipose stem cell (ASC) development to adipocytes with accelerated li...

Authors: Karen L. Leung, Smriti Sanchita, Catherine T. Pham, Brett A. Davis, Mariam Okhovat, Xiangming Ding, Phillip Dumesic, Tristan R. Grogan, Kevin J. Williams, Marco Morselli, Feiyang Ma, Lucia Carbone, Xinmin Li, Matteo Pellegrini, Daniel A. Dumesic and Gregorio D. Chazenbalk

DNA methylation signatures to predict the cervicovaginal microbiome status

The composition of the microbiome plays an important role in human health and disease. Whether there is a direct association between the cervicovaginal microbiome and the host’s epigenome is largely unexplored.

Authors: Nuno R. Nené, James Barrett, Allison Jones, Iona Evans, Daniel Reisel, John F. Timms, Tobias Paprotka, Andreas Leimbach, Dorella Franchi, Nicoletta Colombo, Line Bjørge, Michal Zikan, David Cibula and Martin Widschwendter

High-fat diet-induced and genetically inherited obesity differentially alters DNA methylation profile in the germline of adult male rats

Paternal obesity has been associated with reduced live birth rates. It could lead to inheritance of metabolic disturbances to the offspring through epigenetic mechanisms. However, obesity is a multifactorial d...

Authors: Sharvari S. Deshpande, Harishankar Nemani, Gandhimathi Arumugam, Avinash Ravichandran and Nafisa H. Balasinor

Correction to: Combining the differentiating effect of panobinostat with the apoptotic effect of arsenic trioxide leads to significant survival benefit in a model of t(8;21) acute myeloid leukemia

An amendment to this paper has been published and can be accessed via the original article.

Authors: Jessica M. Salmon, Michael Bots, Eva Vidacs, Kym L. Stanley, Peter Atadja, Johannes Zuber and Ricky W. Johnstone

Altered immune phenotype and DNA methylation in panic disorder

Multiple studies have related psychiatric disorders and immune alterations. Panic disorder (PD) has been linked with changes in leukocytes distributions in several small studies using different methods for imm...

Authors: Curtis L. Petersen, Ji-Qing Chen, Lucas A. Salas and Brock C. Christensen

Epigenetic profiling of Italian patients identified methylation sites associated with hereditary transthyretin amyloidosis

Hereditary transthyretin (TTR) amyloidosis (hATTR) is a rare life-threatening disorder caused by amyloidogenic coding mutations located in TTR gene. To understand the high phenotypic variability observed among ca...

Authors: Antonella De Lillo, Gita A. Pathak, Flavio De Angelis, Marco Di Girolamo, Marco Luigetti, Mario Sabatelli, Federico Perfetto, Sabrina Frusconi, Dario Manfellotto, Maria Fuciarelli and Renato Polimanti

5-Hydroxymethylation highlights the heterogeneity in keratinization and cell junctions in head and neck cancers

Head and neck squamous cell carcinoma (HNSCC) is the sixth most prevalent cancer worldwide, with human papillomavirus (HPV)-related HNSCC rising to concerning levels. Extensive clinical, genetic and epigenetic...

Authors: Siyu Liu, Marcell Costa de Medeiros, Evan M. Fernandez, Katie R. Zarins, Raymond G. Cavalcante, Tingting Qin, Gregory T. Wolf, Maria E. Figueroa, Nisha J. D’Silva, Laura S. Rozek and Maureen A. Sartor

Assessment of MGMT methylation status using high-performance liquid chromatography in newly diagnosed glioblastoma

The utility of O⁶-methylguanine-DNA methyltransferase (MGMT) gene promoter methylation status as a prognostic marker in patients with glioblastoma (GBM) has been established. However, the number of CpG sites that...

Authors: Mitsuto Hanihara, Kunio Miyake, Atsushi Watanabe, Yuriko Yamada, Naoki Oishi, Tomoyuki Kawataki, Takeshi Inukai, Tetsuo Kondo and Hiroyuki Kinouchi

The tumor suppressor Zinc finger protein 471 suppresses breast cancer growth and metastasis through inhibiting AKT and Wnt/β-catenin signaling

Zinc-finger protein 471 (ZNF471) is a member of the Krüppel-associated box domain zinc finger protein (KRAB-ZFP) family. ZNF471 is methylated in squamous cell carcinomas of tongue, stomach and esophageal. However...

Authors: Chunfang Tao, Juan Luo, Jun Tang, Danfeng Zhou, Shujun Feng, Zhu Qiu, Thomas C. Putti, Tingxiu Xiang, Qiao Tao, Lili Li and Guosheng Ren

Epimutations in human sperm from patients with impaired spermatogenesis

Authors: Joana Marques, Filipa Carvalho, Alberto Barros and Mário Sousa

Triage of hrHPV-positive women: comparison of two commercial methylation-specific PCR assays

High-risk human papillomavirus (hrHPV)-based screening is becoming increasingly important, either by supplementing or replacing the traditional cytology-based cervical Pap smear. However, hrHPV screening lacks...

Authors: Carolin Dippmann, Martina Schmitz, Kristina Wunsch, Stefanie Schütze, Katrin Beer, Christiane Greinke, Hans Ikenberg, Heike Hoyer, Ingo B. Runnebaum, Alfred Hansel and Matthias Dürst