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  1. Development of cardiovascular disease (CVD), including coronary artery disease, arrhythmia, and ischemic stroke, depends on environmental and genetic factors. To investigate the epigenetic basis of myocardial ...

    Authors: Masahiro Nakatochi, Sahoko Ichihara, Ken Yamamoto, Keiko Naruse, Shigeki Yokota, Hiroyuki Asano, Tatsuaki Matsubara and Mitsuhiro Yokota
    Citation: Clinical Epigenetics 2017 9:54
  2. Targeting checkpoint inhibitors using monoclonal antibodies results in significantly better outcome of cancer patients compared to conventional chemotherapy. However, the current companion diagnostics to predi...

    Authors: Sebastian Marwitz, Swetlana Scheufele, Sven Perner, Martin Reck, Ole Ammerpohl and Torsten Goldmann
    Citation: Clinical Epigenetics 2017 9:51
  3. DIRAS1 is a new member of the Ras gene family. It was described as a potential tumor suppressor in human glioblastomas and esophageal cancer. The role of DIRAS1 in colorectal cancer re...

    Authors: Ruipan Zheng, Dan Gao, Tao He, Meiying Zhang, Xiaomei Zhang, Enqiang Linghu, Lixin Wei and Mingzhou Guo
    Citation: Clinical Epigenetics 2017 9:50
  4. A recent study has shown that it is possible to accurately estimate gestational age (GA) at birth from the DNA methylation (DNAm) of fetal umbilical cord blood/newborn blood spots. This DNAm GA predictor may p...

    Authors: Polina Girchenko, Jari Lahti, Darina Czamara, Anna K. Knight, Meaghan J. Jones, Anna Suarez, Esa Hämäläinen, Eero Kajantie, Hannele Laivuori, Pia M. Villa, Rebecca M. Reynolds, Michael S. Kobor, Alicia K. Smith, Elisabeth B. Binder and Katri Räikkönen
    Citation: Clinical Epigenetics 2017 9:49
  5. Epigenetic mechanisms provide an interface between environmental factors and the genome and are known to play a role in complex diseases such as obesity. These mechanisms, including DNA methylation, influence ...

    Authors: Donia Macartney-Coxson, Miles C. Benton, Ray Blick, Richard S. Stubbs, Ronald D. Hagan and Michael A. Langston
    Citation: Clinical Epigenetics 2017 9:48
  6. DNA methylation is an important epigenetic mechanism involved in gene regulation, with alterations in DNA methylation in the nuclear genome being linked to numerous complex diseases. Mitochondrial DNA methylat...

    Authors: Matthew Devall, Rebecca G. Smith, Aaron Jeffries, Eilis Hannon, Matthew N. Davies, Leonard Schalkwyk, Jonathan Mill, Michael Weedon and Katie Lunnon
    Citation: Clinical Epigenetics 2017 9:47
  7. The CpG island methylator phenotype (CIMP) in stage III colon cancer (CRC) has been associated with improved survival after treatment with adjuvant irinotecan-based chemotherapy. In this analysis, we determine...

    Authors: Stacey A. Cohen, Ming Yu, Kelsey Baker, Mary Redman, Chen Wu, Tai J. Heinzerling, Ralph M. Wirtz, Elpida Charalambous, George Pentheroudakis, Vassiliki Kotoula, Konstantine T. Kalogeras, George Fountzilas and William M. Grady
    Citation: Clinical Epigenetics 2017 9:46
  8. Papillary thyroid carcinoma (PTC) is a common endocrine neoplasm with a recent increase in incidence in many countries. Although PTC has been explored by gene expression and DNA methylation studies, the regula...

    Authors: Caroline Moraes Beltrami, Mariana Bisarro dos Reis, Mateus Camargo Barros-Filho, Fabio Albuquerque Marchi, Hellen Kuasne, Clóvis Antônio Lopes Pinto, Srikant Ambatipudi, Zdenko Herceg, Luiz Paulo Kowalski and Silvia Regina Rogatto
    Citation: Clinical Epigenetics 2017 9:45
  9. The early detection of type 1 diabetes (T1D) largely depends on a reliable approach to monitor β cell loss. An effective way to evaluate the decline of β cell mass would allow early preventative intervention t...

    Authors: Kuo Zhang, Guigao Lin, Yanxi Han, Jiehong Xie and Jinming Li
    Citation: Clinical Epigenetics 2017 9:44
  10. Omega-3 polyunsaturated fatty acids (n-3 FAs) have several beneficial effects on cardiovascular (CV) disease risk factors. These effects on CV risk profile may be mediated by several factors, including epigene...

    Authors: Bénédicte L. Tremblay, Frédéric Guénard, Iwona Rudkowska, Simone Lemieux, Patrick Couture and Marie-Claude Vohl
    Citation: Clinical Epigenetics 2017 9:43
  11. Goblet cell metaplasia, a common feature of chronic obstructive pulmonary disease (COPD), is associated with mucus hypersecretion which contributes to the morbidity and mortality among patients. Transcription ...

    Authors: J. Song, I. H. Heijink, L. E. M. Kistemaker, M. Reinders-Luinge, W. Kooistra, J. A. Noordhoek, R. Gosens, C. A. Brandsma, W. Timens, P. S. Hiemstra, M. G. Rots and M. N. Hylkema
    Citation: Clinical Epigenetics 2017 9:42
  12. Subjects born with low birth weight (LBW) display a more energy-conserving response to fasting compared with normal birth weight (NBW) subjects. However, the molecular mechanisms explaining these metabolic dif...

    Authors: Line Hjort, Sine W. Jørgensen, Linn Gillberg, Elin Hall, Charlotte Brøns, Jan Frystyk, Allan A. Vaag and Charlotte Ling
    Citation: Clinical Epigenetics 2017 9:40
  13. Epigenetics changes have been shown to be affected by cigarette smoking. Cigarette smoke (CS)-mediated DNA methylation can potentially affect several cellular and pathophysiological processes, acute exacerbati...

    Authors: Isaac K. Sundar, Qiangzong Yin, Brian S. Baier, Li Yan, Witold Mazur, Dongmei Li, Martha Susiarjo and Irfan Rahman
    Citation: Clinical Epigenetics 2017 9:38
  14. Offspring of women with diabetes in pregnancy are at increased risk of type 2 diabetes mellitus (T2DM), potentially mediated by epigenetic mechanisms. The adipokines leptin, adiponectin, and resistin (genes: LEP,...

    Authors: Azadeh Houshmand-Oeregaard, Ninna S. Hansen, Line Hjort, Louise Kelstrup, Christa Broholm, Elisabeth R. Mathiesen, Tine D. Clausen, Peter Damm and Allan Vaag
    Citation: Clinical Epigenetics 2017 9:37
  15. Long non-coding RNAs (lncRNAs) have emerged as key players in a remarkably variety of biological processes and pathologic conditions, including cancer. Next-generation sequencing technologies and bioinformatic...

    Authors: Pelayo G. de Lena, Abel Paz-Gallardo, Jesús M. Paramio and Ramón García-Escudero
    Citation: Clinical Epigenetics 2017 9:36
  16. Prenatal environmental conditions may influence disease risk in later life. We previously found a gene-environment interaction between the paraoxonase 1 (PON1) Q192R genotype and prenatal pesticide exposure leadi...

    Authors: Ken Declerck, Sylvie Remy, Christine Wohlfahrt-Veje, Katharina M. Main, Guy Van Camp, Greet Schoeters, Wim Vanden Berghe and Helle R. Andersen
    Citation: Clinical Epigenetics 2017 9:35
  17. DNA methylation is the most studied epigenetic modification due to its role in regulating gene expression, and its involvement in the pathogenesis of cancer and several diseases upon aberrations in methylation...

    Authors: Teresia Kling, Anna Wenger, Stephan Beck and Helena Carén
    Citation: Clinical Epigenetics 2017 9:33
  18. Determining the role of DNA methylation in various biological processes is dependent on the accurate representation of often highly complex patterns. Accurate representation is dependent on unbiased PCR amplif...

    Authors: Ida L. M. Candiloro, Thomas Mikeska and Alexander Dobrovic
    Citation: Clinical Epigenetics 2017 9:31
  19. Dysregulation in post-translational modifications of histones and their modifiers are now well-recognized as a hallmark of cancer and can be used as biomarkers and potential therapeutic targets for disease pro...

    Authors: Divya Reddy, Bharat Khade, Riddhi Pandya and Sanjay Gupta
    Citation: Clinical Epigenetics 2017 9:30
  20. Genetics explains a small proportion of variance in body mass index at the population level. Epigenetics, commonly measured by gene methylation, holds promise for understanding obesity risk factors and mechani...

    Authors: Jocelyn Dunstan, Joseph P. Bressler, Timothy H. Moran, Jonathan S. Pollak, Annemarie G. Hirsch, Lisa Bailey-Davis, Thomas A. Glass and Brian S. Schwartz
    Citation: Clinical Epigenetics 2017 9:29
  21. Intrauterine exposure to gestational diabetes mellitus (GDM) confers a lifelong increased risk for metabolic and other complex disorders to the offspring. GDM-induced epigenetic modifications modulating gene r...

    Authors: Larissa Haertle, Nady El Hajj, Marcus Dittrich, Tobias Müller, Indrajit Nanda, Harald Lehnen and Thomas Haaf
    Citation: Clinical Epigenetics 2017 9:28
  22. Authors: Guadalupe Quiñonez-Silva, Mercedes Dávalos-Salas, Félix Recillas-Targa, Patricia Ostrosky-Wegman, Diego Arenas Aranda and Luis Benítez-Bribiesca
    Citation: Clinical Epigenetics 2017 9:27

    The original article was published in Clinical Epigenetics 2016 8:1

  23. Colorectal cancers (CRCs) undergo distinct genetic and epigenetic alterations. Expression of mutL homolog 1 (MLH1), a mismatch repair gene that corrects DNA replication errors, is lost in up to 15% of sporadic tu...

    Authors: Andrea J. Savio, Miralem Mrkonjic, Mathieu Lemire, Steven Gallinger, Julia A. Knight and Bharat Bapat
    Citation: Clinical Epigenetics 2017 9:26
  24. Conventional tubular adenomas are frequently detected in patients undergoing average risk screening colonoscopy and are over-represented in patients who will develop colorectal cancer (CRC). Whether features o...

    Authors: Alice Chu Jiang, Lela Buckingham, William Barbanera, Amoah Yeboah Korang, Faraz Bishesari and Joshua Melson
    Citation: Clinical Epigenetics 2017 9:25

    The Erratum to this article has been published in Clinical Epigenetics 2017 9:76

  25. Colorectal cancer (CRC) is the third most common cancer worldwide. If detected at an early stage, prognosis is good. Despite increasing evidence for the benefits of implemented screening programs, such as scre...

    Authors: Jonathan Alexander Heiss and Hermann Brenner
    Citation: Clinical Epigenetics 2017 9:24
  26. MiRNA expression markers are well characterized in colorectal cancer (CRC), but less is known about miRNA expression profiles in colorectal adenomas. Genome-wide miRNA and mRNA expression analyses were conduct...

    Authors: Zsófia Brigitta Nagy, Barnabás Wichmann, Alexandra Kalmár, Orsolya Galamb, Barbara Kinga Barták, Sándor Spisák, Zsolt Tulassay and Béla Molnár
    Citation: Clinical Epigenetics 2017 9:22
  27. Cerebral white matter hyperintensities (WMH) on magnetic resonance imaging (MRI) are part of the spectrum of brain vascular injury accompanying aging and are associated with a substantial risk of stroke and de...

    Authors: Abhay Raina, Xiaoping Zhao, Megan L. Grove, Jan Bressler, Rebecca F. Gottesman, Weihua Guan, James S. Pankow, Eric Boerwinkle, Thomas H. Mosley and Myriam Fornage
    Citation: Clinical Epigenetics 2017 9:21
  28. Human aging is associated with profound changes in one of the major epigenetic mechanisms, DNA methylation. Some of these changes occur in a clock-like fashion, i.e., correlating with the calendar age of an in...

    Authors: Tapio Nevalainen, Laura Kananen, Saara Marttila, Juulia Jylhävä, Nina Mononen, Mika Kähönen, Olli T. Raitakari, Antti Hervonen, Marja Jylhä, Terho Lehtimäki and Mikko Hurme
    Citation: Clinical Epigenetics 2017 9:20
  29. Lung disease progression is variable among cystic fibrosis (CF) patients and depends on DNA mutations in the CFTR gene, polymorphic variations in disease modifier genes, and environmental exposure. The contributi...

    Authors: Milena Magalhães, Isabelle Rivals, Mireille Claustres, Jessica Varilh, Mélodie Thomasset, Anne Bergougnoux, Laurent Mely, Sylvie Leroy, Harriet Corvol, Loïc Guillot, Marlène Murris, Emmanuelle Beyne, Davide Caimmi, Isabelle Vachier, Raphaël Chiron and Albertina De Sario
    Citation: Clinical Epigenetics 2017 9:19
  30. Alteration of DNA methylation (5-methylcytosine, 5mC) patterns represents one of the causes of tumorigenesis and cancer progression. Tet proteins can oxidise 5mC to 5-hydroxymethylcytosine (5hmC), 5-formylcyto...

    Authors: Ashley Ramsawhook, Lara Lewis, Beth Coyle and Alexey Ruzov
    Citation: Clinical Epigenetics 2017 9:18
  31. Multiple myeloma (MM) is a hematological malignancy, which remains incurable because most patients eventually relapse or become refractory to current treatments. Due to heterogeneity within the cancer cell mic...

    Authors: Mark E. Issa, Farnaz Sedigheh Takhsha, Chandra Sekhar Chirumamilla, Claudina Perez-Novo, Wim Vanden Berghe and Muriel Cuendet
    Citation: Clinical Epigenetics 2017 9:17
  32. Maternal nutrition during pregnancy and infant nutrition in the early postnatal period (lactation) are critically involved in the development and health of the newborn infant. The Maternal Nutrition and Offspr...

    Authors: Sara Pauwels, Manosij Ghosh, Radu Corneliu Duca, Bram Bekaert, Kathleen Freson, Inge Huybrechts, Sabine A. S. Langie, Gudrun Koppen, Roland Devlieger and Lode Godderis
    Citation: Clinical Epigenetics 2017 9:16
  33. DNA methylation is a key epigenetic mechanism that is suggested to be associated with blood lipid levels. We aimed to identify CpG sites at which DNA methylation levels are associated with blood levels of trig...

    Authors: Kim V. E. Braun, Klodian Dhana, Paul S. de Vries, Trudy Voortman, Joyce B. J. van Meurs, Andre G. Uitterlinden, Albert Hofman, Frank B. Hu, Oscar H. Franco and Abbas Dehghan
    Citation: Clinical Epigenetics 2017 9:15
  34. We analyzed placental DNA methylation levels at repeated sequences (LINE1 elements) and all CCGG sites (the LUMA assay) to study the effect of modifiable clinical or laboratory procedures involved in in vitro fer...

    Authors: Jayashri Ghosh, Christos Coutifaris, Carmen Sapienza and Monica Mainigi
    Citation: Clinical Epigenetics 2017 9:14
  35. Oral squamous cell carcinoma (OSCC) is one of the common malignancies in Southeast Asia. Epigenetic changes, mainly the altered DNA methylation, have been implicated in many cancers. Considering the varied env...

    Authors: Baidehi Basu, Joyeeta Chakraborty, Aditi Chandra, Atul Katarkar, Jadav Ritesh Kumar Baldevbhai, Debjit Dhar Chowdhury, Jay Gopal Ray, Keya Chaudhuri and Raghunath Chatterjee
    Citation: Clinical Epigenetics 2017 9:13
  36. Molecular biomarkers assisting risk-group assignment and subsequent treatment stratification are urgently needed for patients with squamous cell cancer of the head and neck region (HNSCC). Aberrant methylation...

    Authors: Verena Sailer, Emily Eva Holmes, Heidrun Gevensleben, Diane Goltz, Freya Dröge, Alina Franzen, Jörn Dietrich, Glen Kristiansen, Friedrich Bootz, Andreas Schröck and Dimo Dietrich
    Citation: Clinical Epigenetics 2017 9:12
  37. Population based epigenetic association studies of disease and exposures are becoming more common with the availability of economical genome-wide technologies for interrogation of the methylome, such as the Il...

    Authors: Rachel D. Edgar, Meaghan J. Jones, Wendy P. Robinson and Michael S. Kobor
    Citation: Clinical Epigenetics 2017 9:11
  38. Differentially methylated regions (DMRs) within DNA isolated from whole blood can be used to estimate the proportions of circulating leukocyte subtypes. We use the term “immunomethylomics” to describe the appl...

    Authors: John K. Wiencke, Devin C. Koestler, Lucas A. Salas, Joseph L. Wiemels, Ritu P. Roy, Helen M. Hansen, Terri Rice, Lucie S. McCoy, Paige M. Bracci, Annette M. Molinaro, Karl T. Kelsey, Margaret R. Wrensch and Brock C. Christensen
    Citation: Clinical Epigenetics 2017 9:10
  39. There is a growing interest in simple molecular biomarkers for biological aging. Age-associated DNA methylation (DNAm) changes at specific CG dinucleotides can be combined into epigenetic age predictors to est...

    Authors: Yan Zhang, Jan Hapala, Hermann Brenner and Wolfgang Wagner
    Citation: Clinical Epigenetics 2017 9:9
  40. Bladder cancer (BC) is one of the most common cancers in the western world and ranks as the most expensive to manage, due to the need for cystoscopic examination. BC shows frequent changes in DNA methylation, ...

    Authors: Andrew Feber, Pawan Dhami, Liqin Dong, Patricia de Winter, Wei Shen Tan, Mónica Martínez-Fernández, Dirk S. Paul, Antony Hynes-Allen, Sheida Rezaee, Pratik Gurung, Simon Rodney, Ahmed Mehmood, Felipe Villacampa, Federico de la Rosa, Charles Jameson, Kar Keung Cheng…
    Citation: Clinical Epigenetics 2017 9:8
  41. Cadherin-like protein 22 (CDH22) is a transmembrane glycoprotein involved in cell-cell adhesion and metastasis. Its role in cancer is controversial because it has been described as being upregulated in colorec...

    Authors: Esperanza Martín-Sánchez, Saioa Mendaza, Ane Ulazia-Garmendia, Iñaki Monreal-Santesteban, Alicia Córdoba, Francisco Vicente-García, Idoia Blanco-Luquin, Susana De La Cruz, Ana Aramendia and David Guerrero-Setas
    Citation: Clinical Epigenetics 2017 9:7
  42. Panic disorder (PD) is considered to be a multifactorial disorder emerging from interactions among multiple genetic and environmental factors. To date, although genetic studies reported several susceptibility ...

    Authors: Mihoko Shimada-Sugimoto, Takeshi Otowa, Taku Miyagawa, Tadashi Umekage, Yoshiya Kawamura, Miki Bundo, Kazuya Iwamoto, Mamoru Tochigi, Kiyoto Kasai, Hisanobu Kaiya, Hisashi Tanii, Yuji Okazaki, Katsushi Tokunaga and Tsukasa Sasaki
    Citation: Clinical Epigenetics 2017 9:6
  43. A report of the 6th Epigenomics of Common Diseases Conference held at the Wellcome Genome Campus in Hinxton, Cambridge, UK, on 1–4 November 2016.

    Authors: Euan J. Rodger and Aniruddha Chatterjee
    Citation: Clinical Epigenetics 2017 9:5
  44. RRx-001, a dinitroazetidine derivative, is a novel anticancer agent currently in phase II clinical trials. It mediates immunomodulatory effects either directly through polarization of tumor associated macropha...

    Authors: Hongjuan Zhao, Shoucheng Ning, Rosalie Nolley, Jan Scicinski, Bryan Oronsky, Susan J. Knox and Donna M. Peehl
    Citation: Clinical Epigenetics 2017 9:4
  45. Allergic rhinitis is a common chronic disorder characterized by immunoglobulin E-mediated inflammation. To identify new genes associated with this trait, we performed genome- and epigenome-wide association stu...

    Authors: Andréanne Morin, Michel Laviolette, Tomi Pastinen, Louis-Philippe Boulet and Catherine Laprise
    Citation: Clinical Epigenetics 2017 9:3