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  1. Aberrant epigenetic modifications are described in an increasing number of pathological conditions, including neurodegenerative diseases, cardiovascular diseases, diabetes mellitus type 2, obesity and cancer. ...

    Authors: Christian Busch, Markus Burkard, Christian Leischner, Ulrich M. Lauer, Jan Frank and Sascha Venturelli

    Citation: Clinical Epigenetics 2015 7:64

    Content type: Review

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  2. Profound methylation of CpG islands constitutes a distinct molecular subtype of colorectal cancer (CRC). The frequencies of methylation in CRC vary according to clinico-pathological characteristics including s...

    Authors: Dae-Won Lee, Sae-Won Han, Yongjun Cha, Ye Young Rhee, Jeong Mo Bae, Nam-Yun Cho, Kyung-Hun Lee, Tae-Yong Kim, Do-Youn Oh, Seock-Ah Im, Yung-Jue Bang, Seung-Yong Jeong, Kyu Joo Park, Gyeong Hoon Kang and Tae-You Kim

    Citation: Clinical Epigenetics 2015 7:63

    Content type: Research

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  3. Classification of pediatric tumors into biologically defined subtypes is challenging, and multifaceted approaches are needed. For this aim, we developed a diagnostic classifier based on DNA methylation profiles.

    Authors: Anna Danielsson, Szilárd Nemes, Magnus Tisell, Birgitta Lannering, Claes Nordborg, Magnus Sabel and Helena Carén

    Citation: Clinical Epigenetics 2015 7:62

    Content type: Methodology

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  4. Although the etiology of primary biliary cirrhosis (PBC) remains enigmatic, there are several pieces of data supporting the thesis that a strong genetic predisposition and environmental factors interact to pro...

    Authors: Ana Lleo, Weici Zhang, Ming Zhao, Yixin Tan, Francesca Bernuzzi, Bochen Zhu, Qian Liu, Qiqun Tan, Federica Malinverno, Luca Valenti, Tingting Jiang, Lina Tan, Wei Liao, Ross Coppel, Pietro Invernizzi, Qianjin Lu…

    Citation: Clinical Epigenetics 2015 7:61

    Content type: Research

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  5. Mitochondrial alterations have been observed in subjects with metabolic disorders such as obesity and diabetes. Studies on animal models and cell cultures suggest aberrant glucose and lipid levels, and impaire...

    Authors: Louise D. Zheng, Leah E. Linarelli, Longhua Liu, Sarah S. Wall, Mark H. Greenawald, Richard W. Seidel, Paul A. Estabrooks, Fabio A. Almeida and Zhiyong Cheng

    Citation: Clinical Epigenetics 2015 7:60

    Content type: Research

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  6. Recent developments in genomic sequencing have advanced our understanding of the mutations underlying human malignancy. Melanoma is a prototype of an aggressive, genetically heterogeneous cancer notorious for ...

    Authors: Jonathan J. Lee, Lynette M. Sholl, Neal I. Lindeman, Scott R. Granter, Alvaro C. Laga, Priyanka Shivdasani, Gary Chin, Jason J. Luke, Patrick A. Ott, F. Stephen Hodi, Martin C. Mihm Jr., Jennifer Y. Lin, Andrew E. Werchniak, Harley A. Haynes, Nancy Bailey, Robert Liu…

    Citation: Clinical Epigenetics 2015 7:59

    Content type: Research

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  7. Carboplatin/paclitaxel (CP), with or without sorafenib, result in objective response rates of 18–20 % in unselected chemotherapy-naïve patients. Molecular predictors of survival and response to CP-based chemot...

    Authors: Liza C. Villaruz, Grace Huang, Marjorie Romkes, John M. Kirkwood, Shama C. Buch, Tomoko Nukui, Keith T. Flaherty, Sandra J. Lee, Melissa A. Wilson, Katherine L. Nathanson, Panayiotis V. Benos and Hussein A. Tawbi

    Citation: Clinical Epigenetics 2015 7:58

    Content type: Research

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  8. Tumour metastasis to the brain is a common and deadly development in certain cancers; 18–30 % of breast tumours metastasise to the brain. The contribution that gene silencing through epigenetic mechanisms play...

    Authors: Rajendra P. Pangeni, Prasanna Channathodiyil, David S. Huen, Lawrence W. Eagles, Balraj K. Johal, Dawar Pasha, Natasa Hadjistephanou, Oliver Nevell, Claire L. Davies, Ayobami I. Adewumi, Hamida Khanom, Ikroop S. Samra, Vanessa C. Buzatto, Preethi Chandrasekaran, Thoraia Shinawi, Timothy P. Dawson…

    Citation: Clinical Epigenetics 2015 7:57

    Content type: Research

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  9. The development of type-2 diabetes mellitus (T2DM) and its complications is largely due to the complex interaction between genetic factors and environmental influences, mainly dietary habits and lifestyle, whi...

    Authors: Francesco Prattichizzo, Angelica Giuliani, Artan Ceka, Maria Rita Rippo, Anna Rita Bonfigli, Roberto Testa, Antonio Domenico Procopio and Fabiola Olivieri

    Citation: Clinical Epigenetics 2015 7:56

    Content type: Review

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  10. Tobacco smoking, a risk factor for coronary artery disease (CAD), is known to modify DNA methylation. We hypothesized that tobacco smoking modifies methylation of the genes identified for CAD by genome-wide as...

    Authors: Rebecca V Steenaard, Symen Ligthart, Lisette Stolk, Marjolein J Peters, Joyce B van Meurs, Andre G Uitterlinden, Albert Hofman, Oscar H Franco and Abbas Dehghan

    Citation: Clinical Epigenetics 2015 7:54

    Content type: Research

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  11. Dysregulation of the epigenome is a common event in malignancy; however, deciphering the earliest cancer-associated epigenetic events remains a challenge. Cancer epigenome studies to date have primarily utilis...

    Authors: Warwick J Locke, Elena Zotenko, Clare Stirzaker, Mark D Robinson, Rebecca A Hinshelwood, Andrew Stone, Roger R Reddel, Lily I Huschtscha and Susan J Clark

    Citation: Clinical Epigenetics 2015 7:52

    Content type: Research

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  12. Current evidence supports the notion that environmental exposures are associated with DNA-methylation and expression changes that can impact human health. Our objective was to conduct a systematic review of ep...

    Authors: Adrian Ruiz-Hernandez, Chin-Chi Kuo, Pilar Rentero-Garrido, Wan-Yee Tang, Josep Redon, Jose M Ordovas, Ana Navas-Acien and Maria Tellez-Plaza

    Citation: Clinical Epigenetics 2015 7:55

    Content type: Review

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  13. The loss of 5-hydroxymethylcytosine (5hmC) has been identified as a novel epigenetic hallmark for melanoma. One of the known mechanisms underlying the loss of 5hmC is the decrease in expression of ten-eleven t...

    Authors: Christopher B Gustafson, Cuixia Yang, Kevin M Dickson, Hongwei Shao, Derek Van Booven, J William Harbour, Zhao-Jun Liu and Gaofeng Wang

    Citation: Clinical Epigenetics 2015 7:51

    Content type: Research

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  14. The interpretation of equivocal Papanicolaou (Pap) smear results remains challenging, even with the addition of the high-risk human papillomavirus test (HPV-HR). Recently, methylated zinc finger protein 582 (ZNF5...

    Authors: Yu-Ligh Liou, Yu Zhang, Yingzi Liu, Lanqin Cao, Chong-Zhen Qin, Tao-Lan Zhang, Chi-Feng Chang, Huei-Jen Wang, Shu-Yi Lin, Tang-Yuan Chu, Yi Zhang and Hong-Hao Zhou

    Citation: Clinical Epigenetics 2015 7:50

    Content type: Case study

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  15. The relevance of microRNAs (miRNAs) in adipose tissue is increasingly recognized, being intrinsically linked to different pathways, including obesity-related inflammation. In this study, we aimed to characteri...

    Authors: Francisco José Ortega, María Moreno, Josep María Mercader, José María Moreno-Navarrete, Núria Fuentes-Batllevell, Mònica Sabater, Wifredo Ricart and José Manuel Fernández-Real

    Citation: Clinical Epigenetics 2015 7:49

    Content type: Research

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  16. The Illumina Infinium HumanMethylation450 BeadChip is an array-based technology for analysing DNA methylation at approximately 475,000 differentially methylated cytosines across the human genome. Hitherto, the...

    Authors: Faisal I Rezwan, Louise E Docherty, Rebecca L Poole, Gabrielle A Lockett, S Hasan Arshad, John W Holloway, I Karen Temple and Deborah JG Mackay

    Citation: Clinical Epigenetics 2015 7:48

    Content type: Methodology

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  17. The birth weight of Black neonates in the United States is consistently smaller than that of their White counterparts. Epigenetic differences between the races may be involved in such disparities. The goal of ...

    Authors: Jennifer K Straughen, Levent Sipahi, Monica Uddin, Dawn P Misra and Vinod K Misra

    Citation: Clinical Epigenetics 2015 7:47

    Content type: Research

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  18. Despite penile carcinoma (PeCa) being a relatively rare neoplasm, it remains an important public health issue for poor and developing countries. Contrary to most tumors, limited data are available for markers ...

    Authors: Hellen Kuasne, Ilce Mara de Syllos Cólus, Ariane Fidelis Busso, Hector Hernandez-Vargas, Mateus Camargo Barros-Filho, Fabio Albuquerque Marchi, Cristovam Scapulatempo-Neto, Eliney Ferreira Faria, Ademar Lopes, Gustavo Cardoso Guimarães, Zdenko Herceg and Silvia Regina Rogatto

    Citation: Clinical Epigenetics 2015 7:46

    Content type: Research

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  19. In this letter to the editor, we respond to the recent publication by Philibert et al. Methylation array data can simultaneously identify individuals and convey protected health information: an unrecognized ethic...

    Authors: Yann Joly, Stephanie OM Dyke, Warren A Cheung, Mark A Rothstein and Tomi Pastinen

    Citation: Clinical Epigenetics 2015 7:45

    Content type: Letter to the Editor

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  20. Alcohol is a well-known risk factor for hepatocellular carcinoma (HCC), but the mechanisms underlying the alcohol-related hepatocarcinogenesis are still poorly understood. Alcohol alters the provision of methy...

    Authors: Silvia Udali, Patrizia Guarini, Andrea Ruzzenente, Alberto Ferrarini, Alfredo Guglielmi, Valentina Lotto, Paola Tononi, Patrizia Pattini, Sara Moruzzi, Tommaso Campagnaro, Simone Conci, Oliviero Olivieri, Roberto Corrocher, Massimo Delledonne, Sang-Woon Choi and Simonetta Friso

    Citation: Clinical Epigenetics 2015 7:43

    Content type: Research

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  21. Prostate cancer (PCa), a highly incident and heterogeneous malignancy, mostly affects men from developed countries. Increased knowledge of the biological mechanisms underlying PCa onset and progression are cri...

    Authors: Pedro Costa-Pinheiro, João Ramalho-Carvalho, Filipa Quintela Vieira, Jorge Torres-Ferreira, Jorge Oliveira, Céline S Gonçalves, Bruno M Costa, Rui Henrique and Carmen Jerónimo

    Citation: Clinical Epigenetics 2015 7:42

    Content type: Research

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  22. We, and others, have demonstrated previously that there are differences in DNA methylation and transcript levels of a number of genes in cord blood and placenta between children conceived using assisted reprod...

    Authors: Sisi Song, Jayashri Ghosh, Monica Mainigi, Nahid Turan, Rachel Weinerman, May Truongcao, Christos Coutifaris and Carmen Sapienza

    Citation: Clinical Epigenetics 2015 7:41

    Content type: Research

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  23. Neuroendocrine prostate cancer (NEPC) is a highly aggressive subtype of prostate cancer (PCa) for which the median survival remains less than a year. Current treatments are only palliative in nature, and the l...

    Authors: Pier-Luc Clermont, Dong Lin, Francesco Crea, Rebecca Wu, Hui Xue, Yuwei Wang, Kelsie L Thu, Wan L Lam, Colin C Collins, Yuzhuo Wang and Cheryl D Helgason

    Citation: Clinical Epigenetics 2015 7:40

    Content type: Research

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  24. The current epidemic of obesity and associated diseases calls for swift actions to better understand the mechanisms by which genetics and environmental factors affect metabolic health in humans. Monozygotic (M...

    Authors: Miina Ollikainen, Khadeeja Ismail, Kristina Gervin, Anjuska Kyllönen, Antti Hakkarainen, Jesper Lundbom, Elina A Järvinen, Jennifer R Harris, Nina Lundbom, Aila Rissanen, Robert Lyle, Kirsi H Pietiläinen and Jaakko Kaprio

    Citation: Clinical Epigenetics 2015 7:39

    Content type: Research

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  25. Epigenetic changes in DNA methylation could regulate the expression of several allergy-related genes. We investigated whether tolerance acquisition in children with immunoglobulin E (IgE)-mediated cow’s milk a...

    Authors: Roberto Berni Canani, Lorella Paparo, Rita Nocerino, Linda Cosenza, Vincenza Pezzella, Margherita Di Costanzo, Mario Capasso, Valentina Del Monaco, Valeria D’Argenio, Luigi Greco and Francesco Salvatore

    Citation: Clinical Epigenetics 2015 7:38

    Content type: Research

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  26. Both forms of facioscapulohumeral muscular dystrophy (FSHD) are associated with aberrant epigenetic regulation of the chromosome 4q35 D4Z4 macrosatellite. Chromatin changes due to large deletions of heterochro...

    Authors: Takako I Jones, Oliver D King, Charis L Himeda, Sachiko Homma, Jennifer C J Chen, Mary Lou Beermann, Chi Yan, Charles P Emerson Jr, Jeffrey B Miller, Kathryn R Wagner and Peter L Jones

    Citation: Clinical Epigenetics 2015 7:37

    Content type: Research

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  27. Type 2 diabetes mellitus (T2D) is highly prevalent in Middle-Eastern and North African Arab populations, but the molecular basis for this susceptibility is unknown. Altered DNA methylation levels were reported...

    Authors: Gidon Toperoff, Jeremy D Kark, Dvir Aran, Hisham Nassar, Wiessam Abu Ahmad, Ronit Sinnreich, Dima Azaiza, Benjamin Glaser and Asaf Hellman

    Citation: Clinical Epigenetics 2015 7:35

    Content type: Research

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  28. Age-related changes in DNA methylation occurring in blood leukocytes during early childhood may reflect epigenetic maturation. We hypothesized that some of these changes involve gene networks of critical relev...

    Authors: Nathalie Acevedo, Lovisa E Reinius, Morana Vitezic, Vittorio Fortino, Cilla Söderhäll, Hanna Honkanen, Riitta Veijola, Olli Simell, Jorma Toppari, Jorma Ilonen, Mikael Knip, Annika Scheynius, Heikki Hyöty, Dario Greco and Juha Kere

    Citation: Clinical Epigenetics 2015 7:34

    Content type: Research

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  29. The progressively older population in developed countries is reflected in an increase in the number of people suffering from age-related chronic inflammatory diseases such as metabolic syndrome, diabetes, hear...

    Authors: Katarzyna Szarc vel Szic, Ken Declerck, Melita Vidaković and Wim Vanden Berghe

    Citation: Clinical Epigenetics 2015 7:33

    Content type: Review

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  30. This study was aimed at investigating if the effect of RARβ2 hypermethylation on recurrence-free survival (RFS) in non-small cell lung cancer (NSCLC) depends on one’s smoking status and specific interacting prote...

    Authors: Yujin Kim, DongHao Jin, Bo Bin Lee, Eun Yoon Cho, Joungho Han, Young Mog Shim and Duk-Hwan Kim

    Citation: Clinical Epigenetics 2015 7:32

    Content type: Research

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  31. Histone to protamine exchange and the hyperacetylation of the remaining histones are hallmarks of spermiogenesis. Acetylation of histone H4 at lysine 12 (H4K12ac) was observed prior to full decondensation of s...

    Authors: Markus Vieweg, Katerina Dvorakova-Hortova, Barbora Dudkova, Przemyslaw Waliszewski, Marie Otte, Berthold Oels, Amir Hajimohammad, Heiko Turley, Martin Schorsch, Hans-Christian Schuppe, Wolfgang Weidner, Klaus Steger and Agnieszka Paradowska-Dogan

    Citation: Clinical Epigenetics 2015 7:31

    Content type: Research

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  32. Recent studies have demonstrated that DNA polymorphisms in the solute carrier family 30 member 8 (SLC30A8) gene confer the risk susceptibility to type 2 diabetes (T2D). The present study aimed to analyze DNA meth...

    Authors: Norhashimah Abu Seman, Wan Nazaimoon Wan Mohamud, Claes-Göran Östenson, Kerstin Brismar and Harvest F Gu

    Citation: Clinical Epigenetics 2015 7:30

    Content type: Research

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  33. Demethylation process is necessary for the expression of various factors involved in chemotherapy cytotoxicity or resistance. Platinum-resistant cells may have reduced expression of the copper/platinum transpo...

    Authors: Apostolia M Tsimberidou, Rabih Said, Kirk Culotta, Ignacio Wistuba, Jaroslav Jelinek, Siqing Fu, Gerald Falchook, Aung Naing, Sarina Piha-Paul, Ralph Zinner, Zahid H Siddik, Guangan He, Kenneth Hess, David J Stewart, Razelle Kurzrock and Jean-Pierre J Issa

    Citation: Clinical Epigenetics 2015 7:29

    Content type: Research

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  34. The clinical utility of DNA methylation as a predictive or prognostic biomarker requires scalable resequencing protocols for bisulfite-converted DNA. Key features of any validation method should be adaptabilit...

    Authors: Darren Korbie, Erica Lin, David Wall, Shalima S Nair, Clare Stirzaker, Sue J Clark and Matt Trau

    Citation: Clinical Epigenetics 2015 7:28

    Content type: Methodology

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  35. Phthalates may increase the asthma risk in children. Mechanisms underlying this association remain to be addressed. This study assesses the effect of phthalate exposures on epigenetic changes and the role of e...

    Authors: I-Jen Wang, Wilfried JJ Karmaus, Su-Lien Chen, John W Holloway and Susan Ewart

    Citation: Clinical Epigenetics 2015 7:27

    Content type: Research

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  36. The Editors of Clinical Epigenetics would like to thank all our reviewers who have contributed to the journal in volume 6 (2014).

    Authors: Ulrich Mahlknecht

    Citation: Clinical Epigenetics 2015 7:26

    Content type: Reviewer acknowledgement

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  37. Chronic liver injury can lead to the development of liver fibrosis and cirrhosis but only in a minority of patients. Currently, it is not clear which factors determine progression to fibrosis. We investigated ...

    Authors: Müjdat Zeybel, Timothy Hardy, Stuart M Robinson, Christopher Fox, Quentin M Anstee, Thomas Ness, Steven Masson, John C Mathers, Jeremy French, Steve White and Jelena Mann

    Citation: Clinical Epigenetics 2015 7:25

    Content type: Research

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  38. The pathogenesis of systemic lupus erythematosus (SLE) has not yet been completely elucidated. One of the hallmarks of SLE is the production of autoantibodies by uncontrolled over-activated B cells. Early B ce...

    Authors: Shuangyan Luo, Yu Liu, Gongping Liang, Ming Zhao, Haijing Wu, Yunsheng Liang, Xiangning Qiu, Yixin Tan, Yong Dai, Susan Yung, Tak-Mao Chan and Qianjin Lu

    Citation: Clinical Epigenetics 2015 7:24

    Content type: Research

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  39. Imprinting disorders (IDs) are a group of eight rare but probably underdiagnosed congenital diseases affecting growth, development and metabolism. They are caused by similar molecular changes affecting regulat...

    Authors: Thomas Eggermann, Irène Netchine, I Karen Temple, Zeynep Tümer, David Monk, Deborah Mackay, Karin Grønskov, Andrea Riccio, Agnès Linglart and Eamonn R Maher

    Citation: Clinical Epigenetics 2015 7:23

    Content type: Review

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  40. Even if genetics play an important role, individual variation in stature remains unexplained at the molecular level. Indeed, genome-wide association study (GWAS) have revealed hundreds of variants that contrib...

    Authors: Meriem Ouni, Yasemin Gunes, Marie-Pierre Belot, Anne-Laure Castell, Delphine Fradin and Pierre Bougnères

    Citation: Clinical Epigenetics 2015 7:22

    Content type: Research

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  41. Preeclampsia is one of the leading causes of fetal and maternal morbidity and mortality worldwide. Preterm babies of mothers with early onset preeclampsia (EOPE) are at higher risks for various diseases later ...

    Authors: Travers Ching, James Ha, Min-Ae Song, Maarit Tiirikainen, Janos Molnar, Marla J Berry, Dena Towner and Lana X Garmire

    Citation: Clinical Epigenetics 2015 7:21

    Content type: Research

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  42. Altered expression of microRNAs (miRNAs) commonly accompanies colorectal (CRC) and endometrial carcinoma (EC) development, but the underlying mechanisms and clinicopathological correlations remain to be clarif...

    Authors: Sippy Kaur, Johanna E Lotsari, Sam Al-Sohaily, Janindra Warusavitarne, Maija RJ Kohonen-Corish and Päivi Peltomäki

    Citation: Clinical Epigenetics 2015 7:20

    Content type: Research

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  43. Primary cells enter replicative senescence after a limited number of cell divisions. This process needs to be considered in cell culture experiments, and it is particularly important for regenerative medicine....

    Authors: Sonja Hänzelmann, Fabian Beier, Eduardo G Gusmao, Carmen M Koch, Sebastian Hummel, Iryna Charapitsa, Sylvia Joussen, Vladimir Benes, Tim H Brümmendorf, George Reid, Ivan G Costa and Wolfgang Wagner

    Citation: Clinical Epigenetics 2015 7:19

    Content type: Research

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  44. Hypomethylation of long interspersed element (LINE)-1 has been observed in tumorigenesis when using degenerate assays, which provide an average across all repeats. However, it is unknown whether individual LIN...

    Authors: Nicole Nüsgen, Wolfgang Goering, Albertas Dauksa, Arijit Biswas, Muhammad Ahmer Jamil, Ioanna Dimitriou, Amit Sharma, Heike Singer, Rolf Fimmers, Holger Fröhlich, Johannes Oldenburg, Antanas Gulbinas, Wolfgang A Schulz and Osman El-Maarri

    Citation: Clinical Epigenetics 2015 7:17

    Content type: Research

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  45. Hepatocellular carcinoma (HCC) is among the most frequent human malignancies and a major cause of cancer-related death worldwide. It is characterized by late detection and fast progression, and it is believed ...

    Authors: Marie-Pierre Lambert, Pierre-Benoit Ancey, Davide Degli Esposti, Marie-Pierre Cros, Athena Sklias, Jean-Yves Scoazec, David Durantel, Hector Hernandez-Vargas and Zdenko Herceg

    Citation: Clinical Epigenetics 2015 7:15

    Content type: Research

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  46. The dietary supply of methyl donors such as folate, vitamin B12, betaine, methionine, and choline is essential for normal growth, development, and physiological functions through the life course. Both human and a...

    Authors: Antonysunil Adaikalakoteswari, Sarah Finer, Philip D Voyias, Ciara M McCarthy, Manu Vatish, Jonathan Moore, Melissa Smart-Halajko, Nahla Bawazeer, Nasser M Al-Daghri, Philip G McTernan, Sudhesh Kumar, Graham A Hitman, Ponnusamy Saravanan and Gyanendra Tripathi

    Citation: Clinical Epigenetics 2015 7:14

    Content type: Research

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