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  1. The incidence of endometrial cancer is rising, and current diagnostics often require invasive biopsy procedures. Urine may offer an alternative sample type, which is easily accessible and allows repetitive sel...

    Authors: Rianne van den Helder, Birgit M. M. Wever, Nienke E. van Trommel, Annina P. van Splunter, Constantijne H. Mom, Jenneke C. Kasius, Maaike C. G. Bleeker and Renske D. M. Steenbergen
    Citation: Clinical Epigenetics 2020 12:165
  2. Colon cancer (CC) is the third most common cancer worldwide, highlighting the importance of developing effective prevention strategies. Accumulating evidence supports that aspirin use reduces CC incidence. We ...

    Authors: Faiza Noreen, Anna Chaber-Ciopinska, Jaroslaw Regula, Primo Schär and Kaspar Truninger
    Citation: Clinical Epigenetics 2020 12:164
  3. Multiple myeloma (MM) is a heterogeneous plasma cell malignancy that remains challenging to cure. Global hypomethylation correlates with an aggressive phenotype of the disease, while hypermethylation is observ...

    Authors: Jean-Baptiste Alberge, Florence Magrangeas, Mirko Wagner, Soline Denié, Catherine Guérin-Charbonnel, Loïc Campion, Michel Attal, Hervé Avet-Loiseau, Thomas Carell, Philippe Moreau, Stéphane Minvielle and Aurélien A. Sérandour
    Citation: Clinical Epigenetics 2020 12:163
  4. Stool DNA testing is an emerging and attractive option for colorectal cancer (CRC) screening. We previously evaluated the feasibility of a stool DNA (sDNA) test of methylated SDC2 for CRC detection. The aim of th...

    Authors: Jianping Wang, Side Liu, Hui Wang, Lei Zheng, Changchun Zhou, Guoxin Li, Rongkang Huang, Huaiming Wang, Chujun Li, Xinjuan Fan, Xinhui Fu, Xinying Wang, Hongliang Guo, Jie Guan, Yanlai Sun, Xilin Song…
    Citation: Clinical Epigenetics 2020 12:162
  5. Gastric cancer (GC) is a digestive system cancer with a high mortality rate globally. Previous experiences and studies have provided clinicians with ample evidence to diagnose and treat patients with reasonabl...

    Authors: Tengda Li, Xin Chen, Mingli Gu, Anmei Deng and Cheng Qian
    Citation: Clinical Epigenetics 2020 12:161
  6. Elderly patients with diffuse large B-cell lymphoma (DLBCL) present with poor clinical outcome and intolerance to intensive chemotherapy. Histone deacetylase inhibitors (HDACIs) show anti-lymphoma activities a...

    Authors: Mu-Chen Zhang, Ying Fang, Li Wang, Shu Cheng, Di Fu, Yang He, Yan Zhao, Chao-Fu Wang, Xu-Feng Jiang, Qi Song, Peng-Peng Xu and Wei-Li Zhao
    Citation: Clinical Epigenetics 2020 12:160
  7. Imprinting disorders (IDs) show overlapping phenotypes, particularly in Silver–Russell syndrome (SRS), Temple syndrome (TS14), and Prader–Willi syndrome (PWS). These three IDs include fetal and postnatal growt...

    Authors: Kaori Hara-Isono, Keiko Matsubara, Tomoko Fuke, Kazuki Yamazawa, Kazuhito Satou, Nobuyuki Murakami, Shinji Saitoh, Kazuhiko Nakabayashi, Kenichiro Hata, Tsutomu Ogata, Maki Fukami and Masayo Kagami
    Citation: Clinical Epigenetics 2020 12:159
  8. DNA methylation-based biological age (DNAm age) is an important biomarker for adult health. Studies in specific age ranges have found widely varying results about its genetic and environmental causes of variat...

    Authors: Shuai Li, Tuong L. Nguyen, Ee Ming Wong, Pierre-Antoine Dugué, Gillian S. Dite, Nicola J. Armstrong, Jeffrey M. Craig, Karen A. Mather, Perminder S. Sachdev, Richard Saffery, Joohon Sung, Qihua Tan, Anbupalam Thalamuthu, Roger L. Milne, Graham G. Giles, Melissa C. Southey…
    Citation: Clinical Epigenetics 2020 12:158
  9. Tobacco smoking is a well-known modifiable risk factor for many chronic diseases, including cardiovascular disease (CVD). One of the proposed underlying mechanism linking smoking to disease is via epigenetic m...

    Authors: Silvana C. E. Maas, Michelle M. J. Mens, Brigitte Kühnel, Joyce B. J. van Meurs, André G. Uitterlinden, Annette Peters, Holger Prokisch, Christian Herder, Harald Grallert, Sonja Kunze, Melanie Waldenberger, Maryam Kavousi, Manfred Kayser and Mohsen Ghanbari
    Citation: Clinical Epigenetics 2020 12:157
  10. Epigenetics is a relatively new field of science that studies the genetic and non-genetic aspects related to heritable phenotypic changes, frequently caused by environmental and metabolic factors. In the host,...

    Authors: Sandra Atlante, Alessia Mongelli, Veronica Barbi, Fabio Martelli, Antonella Farsetti and Carlo Gaetano
    Citation: Clinical Epigenetics 2020 12:156
  11. A genome-wide study identified de novo DNA methylation alterations in leukocytes of children at paediatric intensive care unit (PICU) discharge, offering a biological basis for their impaired long-term developmen...

    Authors: Ines Verlinden, Fabian Güiza, Inge Derese, Pieter J. Wouters, Koen Joosten, Sascha C. Verbruggen, Greet Van den Berghe and Ilse Vanhorebeek
    Citation: Clinical Epigenetics 2020 12:155
  12. Variation in intercellular methylation patterns can complicate the use of methylation biomarkers for clinical diagnostic applications such as blood-based cancer testing. Here, we describe development and valid...

    Authors: Brendan F. Miller, Thomas R. Pisanic II, Gennady Margolin, Hanna M. Petrykowska, Pornpat Athamanolap, Alexander Goncearenco, Akosua Osei-Tutu, Christina M. Annunziata, Tza-Huei Wang and Laura Elnitski
    Citation: Clinical Epigenetics 2020 12:154
  13. Massively parallel sequencing of maternal cell-free DNA (cfDNA) is widely used to test fetal genetic abnormalities in non-invasive prenatal testing (NIPT). However, sequencing-based approaches are still of hig...

    Authors: Juozas Gordevičius, Milda Narmontė, Povilas Gibas, Kotryna Kvederavičiūtė, Vita Tomkutė, Priit Paluoja, Kaarel Krjutškov, Andres Salumets and Edita Kriukienė
    Citation: Clinical Epigenetics 2020 12:153
  14. Pathogenic CDKN1C gain-of-function variants on the maternal allele were initially reported as a cause of IMAGe syndrome characterized by intrauterine growth retardation, metaphyseal dysplasia, primary adrenal ins...

    Authors: Gerhard Binder, Julian Ziegler, Roland Schweizer, Wisam Habhab, Tobias B. Haack, Tilman Heinrich and Thomas Eggermann
    Citation: Clinical Epigenetics 2020 12:152
  15. Infants born very preterm are more likely to experience neonatal morbidities compared to their term peers. Variations in DNA methylation (DNAm) associated with these morbidities may yield novel information abo...

    Authors: Todd M. Everson, T. Michael O’Shea, Amber Burt, Karen Hermetz, Brian S. Carter, Jennifer Helderman, Julie A. Hofheimer, Elisabeth C. McGowan, Charles R. Neal, Steven L. Pastyrnak, Lynne M. Smith, Antoine Soliman, Sheri A. DellaGrotta, Lynne M. Dansereau, James F. Padbury, Barry M. Lester…
    Citation: Clinical Epigenetics 2020 12:151
  16. miR-342-3p, localized to 14q32, is a tumor suppressor miRNA implicated in carcinogenesis. Given the presence of a promotor-associated CpG island for its host gene, EVL, we hypothesized that intronic miR-342-3p is...

    Authors: Min Yue Zhang, George A. Calin, Kit San Yuen, Dong Yan Jin and Chor Sang Chim
    Citation: Clinical Epigenetics 2020 12:150
  17. Growing evidence shows that epigenetic modifications play a role in Alzheimer’s disease (AD). We performed an epigenome-wide association study (EWAS) to evaluate the DNA methylation differences using postmorte...

    Authors: Qingqin S. Li, Yu Sun and Tania Wang
    Citation: Clinical Epigenetics 2020 12:149
  18. Protein lysine methyltransferases (PKMTs) constitute a large family of approximately 50 chromatin modifiers that mono-, di- and/or tri-methylate lysine residues on histone and non-histone substrates. With the ...

    Authors: Theodore Vougiouklakis, Benjamin J. Bernard, Nupur Nigam, Kyunghee Burkitt, Yusuke Nakamura and Vassiliki Saloura
    Citation: Clinical Epigenetics 2020 12:146
  19. Mesenchymal fibroblasts are ubiquitous cells that maintain the extracellular matrix of organs. Within the lung, airway and parenchymal fibroblasts are crucial for lung development and are altered with disease,...

    Authors: Rachel L. Clifford, Chen Xi Yang, Nick Fishbane, Jamie Patel, Julia L. MacIsaac, Lisa M. McEwen, Sean T. May, Marcos Castellanos-Uribe, Parameswaran Nair, Ma’en Obeidat, Michael S. Kobor, Alan J. Knox and Tillie-Louise Hackett
    Citation: Clinical Epigenetics 2020 12:145
  20. Metabolically healthy obesity (MHO) is a considerably controversial concept as it is considered a transitory condition towards the development of different pathologies (type 2 diabetes, insulin resistance, or ...

    Authors: Cristina Gallardo-Escribano, Verónica Buonaiuto, M. Isabel Ruiz-Moreno, Antonio Vargas-Candela, Alberto Vilches-Perez, Javier Benitez-Porres, Angel Ramon Romance-Garcia, Alejandro Ruiz-Moreno, Ricardo Gomez-Huelgas and M. Rosa Bernal-Lopez
    Citation: Clinical Epigenetics 2020 12:144
  21. Accessible chromatin plays a central role in gene expression and chromatin architecture. Current accessible chromatin approaches depend on limited digestion/cutting and pasting adaptors at the accessible DNA, ...

    Authors: Hang Gyeong Chin, Zhiyi Sun, Udayakumar S. Vishnu, Pengying Hao, Paloma Cejas, George Spracklin, Pierre-Olivier Estève, Shuang-yong Xu, Henry W. Long and Sriharsa Pradhan
    Citation: Clinical Epigenetics 2020 12:143
  22. Epigenetic reprogramming using DNA demethylating drugs is a promising approach for cancer therapy, but its efficacy is highly dependent on the dosing regimen. Low-dose treatment for a prolonged period shows a ...

    Authors: Hideyuki Takeshima, Yukie Yoda, Mika Wakabayashi, Naoko Hattori, Satoshi Yamashita and Toshikazu Ushijima
    Citation: Clinical Epigenetics 2020 12:142
  23. Disruption of the hypothalamic–pituitary–adrenal (HPA) axis, a neuroendocrine system associated with the stress response, has been hypothesized to contribute to obesity development. This may be mediated throug...

    Authors: Tarryn Willmer, Julia H. Goedecke, Stephanie Dias, Johan Louw and Carmen Pheiffer
    Citation: Clinical Epigenetics 2020 12:141
  24. Cocaine use accelerates human immunodeficiency virus (HIV) progression and worsens HIV outcomes. We assessed whether DNA methylation in blood mediates the association between cocaine use and HIV severity in a ...

    Authors: Chang Shu, Amy C. Justice, Xinyu Zhang, Zuoheng Wang, Dana B. Hancock, Eric O. Johnson and Ke Xu
    Citation: Clinical Epigenetics 2020 12:140
  25. PADI6 is a component of the subcortical maternal complex, a group of proteins that is abundantly expressed in the oocyte cytoplasm, but is required for the correct development of early embryo. Maternal-effect ...

    Authors: Maria Vittoria Cubellis, Laura Pignata, Ankit Verma, Angela Sparago, Rosita Del Prete, Maria Monticelli, Luciano Calzari, Vincenzo Antona, Daniela Melis, Romano Tenconi, Silvia Russo, Flavia Cerrato and Andrea Riccio
    Citation: Clinical Epigenetics 2020 12:139
  26. Inflammation has been associated with higher rates of recurrence and mortality in head and neck cancer (HNC). While the biological mechanisms predisposing patients to heightened inflammatory states remain larg...

    Authors: Laura Moody, Sylvia L. Crowder, Andrew D. Fruge, Julie L. Locher, Wendy Demark-Wahnefried, Laura Q. Rogers, Ashley Delk-Licata, William R. Carroll, Sharon A. Spencer, Molly Black, John W. Erdman Jr, Hong Chen, Yuan-Xiang Pan and Anna E. Arthur
    Citation: Clinical Epigenetics 2020 12:138
  27. Mitochondrial dysregulation and aberrant epigenetic mechanisms have been frequently reported in neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), and several researchers suggested that...

    Authors: Andrea Stoccoro, Adam R. Smith, Lorena Mosca, Alessandro Marocchi, Francesca Gerardi, Christian Lunetta, Cristina Cereda, Stella Gagliardi, Katie Lunnon, Lucia Migliore and Fabio Coppedè
    Citation: Clinical Epigenetics 2020 12:137
  28. Hepatitis B virus covalently closed circular DNA (HBV cccDNA) is assembled by histones and non-histones into a chromatin-like cccDNA minichromosome in the nucleus. The cellular histone acetyltransferase GCN5, ...

    Authors: Ying Yuan, Hongfeng Yuan, Guang Yang, Haolin Yun, Man Zhao, Zixian Liu, Lina Zhao, Yu Geng, Lei Liu, Jiapei Wang, Huihui Zhang, Yufei Wang and Xiao-dong Zhang
    Citation: Clinical Epigenetics 2020 12:135
  29. Intrauterine exposure to a disturbed maternal glucose metabolism is associated with adverse offspring outcomes. DNA methylation is a potential mechanism underlying these associations. We examined whether mater...

    Authors: Madelon L. Geurtsen, Vincent W. V. Jaddoe, Romy Gaillard and Janine F. Felix
    Citation: Clinical Epigenetics 2020 12:134
  30. Atrial natriuretic peptide (ANP), one of the main members of the natriuretic peptides system, has been associated with hypertension and related complications, but the underlying molecular mechanisms are not ve...

    Authors: Jing Li, Jinhua Zhu, Liyun Ren, Shengqi Ma, Bin Shen, Jia Yu, Rongyan Zhang, Mingzhi Zhang, Yan He and Hao Peng
    Citation: Clinical Epigenetics 2020 12:133
  31. Epigenetic mechanisms play an important role in the chemoresistance of acute myeloid leukemia (AML). The clinical response to epigenetic modifier-based chemotherapy in patients with relapsed/refractory AML (r/...

    Authors: Lixin Wang, Jianmin Luo, Guofeng Chen, Meiyun Fang, Xudong Wei, Yinghua Li, Zhuogang Liu, Yin Zhang, Sujun Gao, Jianliang Shen, Xin Wang, Xiaoning Gao, Wei Zhou, Yigai Ma, Hui Liu, Xinquan Li…
    Citation: Clinical Epigenetics 2020 12:132
  32. The number of tumor suppressor genes for which germline mutations have been linked to cancer risk is steadily increasing. However, while recent reports have linked constitutional normal tissue promoter methyla...

    Authors: Deepak B. Poduval, Elisabet Ognedal, Zuzana Sichmanova, Eivind Valen, Gjertrud T. Iversen, Laura Minsaas, Per E. Lønning and Stian Knappskog
    Citation: Clinical Epigenetics 2020 12:131
  33. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Kai Guo, Stephanie A. Eid, Sarah E. Elzinga, Crystal Pacut, Eva L. Feldman and Junguk Hur
    Citation: Clinical Epigenetics 2020 12:130

    The original article was published in Clinical Epigenetics 2020 12:123

  34. Alzheimer’s disease (AD) is the most common type of dementia, and patients with advanced AD frequently lose the ability to identify family members. The fusiform gyrus (FUS) of the brain is critical in facial r...

    Authors: Dingailu Ma, Irfete S. Fetahu, Mei Wang, Rui Fang, Jiahui Li, Hang Liu, Tobin Gramyk, Isabella Iwanicki, Sophie Gu, Winnie Xu, Li Tan, Feizhen Wu and Yujiang G. Shi
    Citation: Clinical Epigenetics 2020 12:129
  35. Preeclampsia (PE) is an obstetric disorder with significant morbidities for both the mother and fetus possibly caused by a failure of the placental trophoblast invasion. However, its pathophysiology largely re...

    Authors: Ji Hyae Lim, Yu-Jung Kang, Hye Jin Bak, Mi Sun Kim, Hyun Jung Lee, Dong Wook Kwak, You Jung Han, Moon Young Kim, Hyeyeon Boo, Shin Young Kim and Hyun Mee Ryu
    Citation: Clinical Epigenetics 2020 12:128
  36. We have previously developed a murine cellular system that models the transformation from melanocytes to metastatic melanoma cells. This model was established by cycles of anchorage impediment of melanocytes a...

    Authors: Hátylas Azevedo, Guilherme Cavalcante Pessoa, Francisca Nathália de Luna Vitorino, Jérémie Nsengimana, Julia Newton-Bishop, Eduardo Moraes Reis, Júlia Pinheiro Chagas da Cunha and Miriam Galvonas Jasiulionis
    Citation: Clinical Epigenetics 2020 12:127
  37. Although metabolic associate fatty liver disease (MAFLD) is associated with obesity, it can also occur in lean patients. MAFLD is more aggressive in lean patients compared to obese patients, with a higher risk...

    Authors: Diana Buzova, Andrea Maugeri, Antonio Liguori, Cecilia Napodano, Oriana Lo Re, Jude Oben, Anna Alisi, Antonio Gasbarrini, Antonio Grieco, Jan Cerveny, Luca Miele and Manlio Vinciguerra
    Citation: Clinical Epigenetics 2020 12:126
  38. Dyskeratosis congenita (DKC) and idiopathic aplastic anemia (AA) are bone marrow failure syndromes that share characteristics of premature aging with severe telomere attrition. Aging is also reflected by DNA m...

    Authors: Olivia Cypris, Monika Eipel, Julia Franzen, Corinna Rösseler, Vithurithra Tharmapalan, Chao-Chung Kuo, Margherita Vieri, Miloš Nikolić, Martin Kirschner, Tim H. Brümmendorf, Martin Zenke, Angelika Lampert, Fabian Beier and Wolfgang Wagner
    Citation: Clinical Epigenetics 2020 12:125
  39. Systemic sclerosis (SSc) is a rare connective tissue disease associated with rapid evolving interstitial lung disease (SSc-ILD), driving its mortality. Specific biomarkers associated with the evolution of the ...

    Authors: Julien Guiot, Monique Henket, Béatrice Andre, Marielle Herzog, Nathalie Hardat, Makon-Sebastien Njock, Catherine Moermans, Michel Malaise and Renaud Louis
    Citation: Clinical Epigenetics 2020 12:124
  40. Diabetic peripheral neuropathy (DPN) is the most common complication of type 2 diabetes (T2D). Although the cellular and molecular mechanisms of DPN are poorly understood, we and others have shown that altered...

    Authors: Kai Guo, Stephanie A. Eid, Sarah E. Elzinga, Crystal Pacut, Eva L. Feldman and Junguk Hur
    Citation: Clinical Epigenetics 2020 12:123

    The Correction to this article has been published in Clinical Epigenetics 2020 12:130

  41. DNA methylation biomarkers in stool may have applications in early colorectal cancer (CRC) detection; however, their association with stages of CRC carcinogenesis or their performance in detecting various stag...

    Authors: Janhavi R. Raut, Zhong Guan, Petra Schrotz-King and Hermann Brenner
    Citation: Clinical Epigenetics 2020 12:122
  42. Children conceived by assisted reproductive technologies (ART) have a moderate risk for a number of adverse events and conditions. The question whether this additional risk is associated with specific procedur...

    Authors: Julie Barberet, Fatima Barry, Cécile Choux, Magali Guilleman, Sara Karoui, Raymond Simonot, Céline Bruno and Patricia Fauque
    Citation: Clinical Epigenetics 2020 12:121
  43. Advanced biological aging, as measured by epigenetic aging indices, is associated with early mortality and morbidity. Associations between maternal epigenetic aging indices in pregnancy and pregnancy outcomes,...

    Authors: Kharah M. Ross, Judith E. Carroll, Steve Horvath, Calvin J. Hobel, Mary E. Coussons-Read and Christine Dunkel Schetter
    Citation: Clinical Epigenetics 2020 12:120
  44. Polycyclic aromatic hydrocarbon (PAH)-rich substances like cigarette smoke and PM2.5 induce aryl hydrocarbon receptor (AHR)-mediated aryl hydrocarbon receptor repressor (AHRR) methylation. AHRR cg05575921 and coa...

    Authors: Disline Manli Tantoh, Ming-Chi Wu, Chun-Chao Chuang, Pei-Hsin Chen, Yeu Sheng Tyan, Oswald Ndi Nfor, Wen-Yu Lu and Yung-Po Liaw
    Citation: Clinical Epigenetics 2020 12:117
  45. Individuals of the same chronological age display different rates of biological ageing. A number of measures of biological age have been proposed which harness age-related changes in DNA methylation profiles. ...

    Authors: Robert F. Hillary, Anna J. Stevenson, Daniel L. McCartney, Archie Campbell, Rosie M. Walker, David M. Howard, Craig W. Ritchie, Steve Horvath, Caroline Hayward, Andrew M. McIntosh, David J. Porteous, Ian J. Deary, Kathryn L. Evans and Riccardo E. Marioni
    Citation: Clinical Epigenetics 2020 12:115