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  1. High dietary glycaemic index (GI) and load (GL) have been associated with increased risk of various cardiometabolic conditions. Among the molecular potential mechanisms underlying this relationship, DNA methyl...

    Authors: Fabrizia Noro, Federica Santonastaso, Annalisa Marotta, Marialaura Bonaccio, Sabatino Orlandi, Alfonsina Tirozzi, Simona Costanzo, Amalia De Curtis, Francesco Gianfagna, Augusto Di Castelnuovo, Furio Brighenti, Chiara Cerletti, Maria Benedetta Donati, Giovanni de Gaetano, Licia Iacoviello, Alessandro Gialluisi…
    Citation: Clinical Epigenetics 2022 14:189
  2. DNA methylation profiling of circulating cell-free DNA (cfDNA) has rapidly become a promising strategy for biomarker identification and development. The cell-type-specific nature of DNA methylation patterns an...

    Authors: Ricardo Martins-Ferreira, Bárbara Leal, João Chaves, Laura Ciudad, Raquel Samões, António Martins da Silva, Paulo Pinho Costa and Esteban Ballestar
    Citation: Clinical Epigenetics 2022 14:188
  3. BDNF exon IV promoter methylation is a potential biomarker for treatment response to antidepressants in MDD. We have previously shown CpG-87 methylation as a successful biomarker for the prediction of non-resp...

    Authors: Hansi Pathak, Anton Borchert, Sara Garaali, Alexandra Burkert and Helge Frieling
    Citation: Clinical Epigenetics 2022 14:187
  4. To assess the genetic and epigenetic effects promoted by Bisphenol A (BPA) exposure in adolescent males from the Spanish INMA-Granada birth cohort, and in human cells.

    Authors: Shereen Cynthia D’Cruz, Chunxiang Hao, Martin Labussiere, Vicente Mustieles, Carmen Freire, Louis Legoff, Laura Magnaghi-Jaulin, Alicia Olivas-Martinez, Andrea Rodriguez-Carrillo, Christian Jaulin, Arthur David, Mariana F. Fernandez and Fatima Smagulova
    Citation: Clinical Epigenetics 2022 14:186
  5. It has been suggested that antenatal exposure to environmental endocrine disruptors is responsible for adverse trends in male reproductive health, including male infertility, impaired semen quality, cryptorchi...

    Authors: Ludwig Stenz, Matthias Beyens, Mark E. Gill, Ariane Paoloni-Giacobino and Christian De Geyter
    Citation: Clinical Epigenetics 2022 14:185
  6. Hepatocellular carcinoma (HCC) is an extensive heterogeneous disease where epigenetic factors contribute to its pathogenesis. Polycomb group (PcG) proteins are a group of subunits constituting various macro-mo...

    Authors: Yunong Fu, Kaibo Yang, Kunjin Wu, Hai Wang, Qinglin Li, Fengping Zhang, Kun Yang, Qing Yao, Xiaohua Ma, Yujie Deng, Jingyao Zhang, Chang Liu and Kai Qu
    Citation: Clinical Epigenetics 2022 14:184
  7. Non-genetic disease inheritance and offspring phenotype are substantially influenced by germline epigenetic programming, including genomic imprinting. Loss of Polycomb Repressive Complex 2 (PRC2) function in o...

    Authors: Ellen G. Jarred, Zhipeng Qu, Tesha Tsai, Ruby Oberin, Sigrid Petautschnig, Heidi Bildsoe, Stephen Pederson, Qing-hua Zhang, Jessica M. Stringer, John Carroll, David K. Gardner, Maarten Van den Buuse, Natalie A. Sims, William T. Gibson, David L. Adelson and Patrick S. Western
    Citation: Clinical Epigenetics 2022 14:183
  8. Chromatin structural organization, gene expression and proteostasis are intricately regulated in a wide range of biological processes, both physiological and pathological. Protein acetylation, a major post-tra...

    Authors: Federica Donnarumma, Valeria Tucci, Concetta Ambrosino, Lucia Altucci and Vincenzo Carafa
    Citation: Clinical Epigenetics 2022 14:182
  9. Overproduction of cAMP-responsive element modulator α (CREMα) in total T cells from patients with systemic lupus erythematosus (SLE) can inhibit IL-2 and increase IL-17A. These ultimately promote progression o...

    Authors: Shuangyan Luo, Huilin Zhang, Yuming Xie, Junke Huang, Danhong Luo and Qing Zhang
    Citation: Clinical Epigenetics 2022 14:181
  10. Nodal mature T-cell lymphomas (nMTCL) comprises a heterogeneous group of rare malignancies with aggressive biological behavior and poor prognosis. Epigenetic phenomena, including mutations in genes that contro...

    Authors: Luís Alberto de Pádua Covas Lage, Hebert Fabrício Culler, Guilherme Carneiro Barreto, Cadiele Oliana Reichert, Débora Levy, Renata de Oliveira Costa, Vanderson Rocha and Juliana Pereira
    Citation: Clinical Epigenetics 2022 14:180
  11. Konzo, a disease characterized by sudden, irreversible spastic paraparesis, affecting up to 10% of the population in some regions of Sub-Saharan Africa during outbreaks, is strongly associated with dietary exp...

    Authors: Kristen Kocher, Surajit Bhattacharya, Matthew S. Bramble, Daniel Okitundu-Luwa, Dieudonne Mumba Ngoyi, Desire Tshala-Katumbay and Eric Vilain
    Citation: Clinical Epigenetics 2022 14:179
  12. Breast cancer (BC) is the most frequently diagnosed cancer and a leading cause of death among women worldwide. Early BC is potentially curable, but the mortality rates still observed among BC patients demonstr...

    Authors: Joana Dias Apolónio, João S. Dias, Mónica Teotónio Fernandes, Martin Komosa, Tatiana Lipman, Cindy H. Zhang, Ricardo Leão, Donghyun Lee, Nuno Miguel Nunes, Ana-Teresa Maia, José L. Morera, Luis Vicioso, Uri Tabori and Pedro Castelo-Branco
    Citation: Clinical Epigenetics 2022 14:178
  13. The prevalence of type 2 diabetes has dramatically increased in the past years. Increasing evidence supports that blood DNA methylation, the best studied epigenetic mark, is related to diabetes risk. Few prosp...

    Authors: Arce Domingo-Relloso, Matthew O. Gribble, Angela L. Riffo-Campos, Karin Haack, Shelley A. Cole, Maria Tellez-Plaza, Jason G. Umans, Amanda M. Fretts, Ying Zhang, M. Daniele Fallin, Ana Navas-Acien and Todd M. Everson
    Citation: Clinical Epigenetics 2022 14:177
  14. Obesity is a multifactorial and chronic condition of growing universal concern. It has recently been reported that bariatric surgery is a more successful treatment for severe obesity than other noninvasive int...

    Authors: Fazlur Rahman Talukdar, David Israel Escobar Marcillo, Ruhina Shirin Laskar, Alexei Novoloaca, Cyrille Cuenin, Paolo Sbraccia, Lorenza Nisticò, Valeria Guglielmi, Tarik Gheit, Massimo Tommasino, Eugenia Dogliotti, Paola Fortini and Zdenko Herceg
    Citation: Clinical Epigenetics 2022 14:176
  15. Host innate immune cells have been identified as key players in the early eradication of Mycobacterium tuberculosis and in the maintenance of an anti-mycobacterial immune memory, which we and others have shown ar...

    Authors: Isabelle Pehrson, Shumaila Sayyab, Jyotirmoy Das, Nina Idh, Jakob Paues, Melissa Méndez-Aranda, César Ugarte-Gil and Maria Lerm
    Citation: Clinical Epigenetics 2022 14:175
  16. DNA methylation (5-mC) is being widely recognized as an alternative in the detection of sequence variants in the diagnosis of some rare neurodevelopmental and imprinting disorders. Identification of alteration...

    Authors: Robin Grolaux, Alexis Hardy, Catharina Olsen, Sonia Van Dooren, Guillaume Smits and Matthieu Defrance
    Citation: Clinical Epigenetics 2022 14:174
  17. There is considerable evidence that epigenetic mechanisms and DNA methylation are critical drivers of immune cell lineage differentiation and activation. However, there has been limited coordinated investigati...

    Authors: Ze Zhang, Rondi Butler, Devin C. Koestler, Shelby Bell-Glenn, Gayathri Warrier, Annette M. Molinaro, Brock C. Christensen, John K. Wiencke, Karl T. Kelsey and Lucas A. Salas
    Citation: Clinical Epigenetics 2022 14:173
  18. Post-acute COVID-19 syndrome (PACS) has been defined as symptoms persisting after clearance of a COVID-19 infection. We have previously demonstrated that alterations in DNA methylation (DNAm) status persist in...

    Authors: Frida Nikesjö, Shumaila Sayyab, Lovisa Karlsson, Eirini Apostolou, Anders Rosén, Kristofer Hedman and Maria Lerm
    Citation: Clinical Epigenetics 2022 14:172
  19. Currently, human papillomavirus (HPV) positivity represents a strong prognostic factor for both reduced risk of relapse and improved survival in patients with oropharyngeal squamous cell carcinoma (OPSCC). How...

    Authors: Mariateresa Casarotto, Valentina Lupato, Giorgio Giurato, Roberto Guerrieri, Sandro Sulfaro, Annamaria Salvati, Elisa D’Angelo, Carlo Furlan, Anna Menegaldo, Lorena Baboci, Barbara Montico, Irene Turturici, Riccardo Dolcetti, Salvatore Romeo, Vittorio Baggio, Stefania Corrado…
    Citation: Clinical Epigenetics 2022 14:171
  20. Dystonia is a rare movement disorder, in which patients suffer from involuntary twisting movements or abnormal posturing. Next to these motor symptoms, patients have a high prevalence of psychiatric comorbidit...

    Authors: Elze R. Timmers, Torsten Plösch, Marenka Smit, Ingrid H. Hof, Rikst Nynke Verkaik-Schakel, Marina A. J. Tijssen, Tom J. de Koning and Klary E. Niezen-Koning
    Citation: Clinical Epigenetics 2022 14:170
  21. Silicosis is one of the most severe occupational diseases worldwide and is characterized by silicon nodules and diffuse pulmonary fibrosis. However, specific treatments for silicosis are still lacking at prese...

    Authors: Haoyu Yin, Yujia Xie, Pei Gu, Wei Li, Yingdie Zhang, Yuxin Yao, Weihong Chen and Jixuan Ma
    Citation: Clinical Epigenetics 2022 14:169
  22. In recent years, non-alcoholic steatohepatitis (NASH) has become the main cause of hepatocellular carcinoma (HCC). As a means of improving the treatment of NASH-related HCCs based on early detection, this stud...

    Authors: Junko Kuramoto, Eri Arai, Mao Fujimoto, Ying Tian, Yuriko Yamada, Takuya Yotani, Satomi Makiuchi, Noboru Tsuda, Hidenori Ojima, Moto Fukai, Yosuke Seki, Kazunori Kasama, Nobuaki Funahashi, Haruhide Udagawa, Takao Nammo, Kazuki Yasuda…
    Citation: Clinical Epigenetics 2022 14:168
  23. The death rate of lung cancer (LC) ranks first in the world. Changes of DNA methylation in peripheral blood may be related to malignant tumors. It is necessary to explore blood-based biomarkers of methylation ...

    Authors: Yifei Fang, Yunhui Qu, Longtao Ji, Hao Sun, Jiaqi Li, Yutong Zhao, Feifei Liang, Zhi Wang, Jiao Su, Jingjing Liu, Liping Dai and Songyun Ouyang
    Citation: Clinical Epigenetics 2022 14:167
  24. Of the only 20% of patients with resectable pancreatic ductal adenocarcinoma (rPDA), cancer recurs in 80% of cases. Epigenetic dysregulation is an early hallmark of cancer cells acquiring metastatic potential,...

    Authors: Thatcher R. Heumann, Marina Baretti, Elizabeth A. Sugar, Jennifer N. Durham, Sheila Linden, Tamara Y. Lopez-Vidal, James Leatherman, Leslie Cope, Anup Sharma, Colin D. Weekes, Peter J. O’Dwyer, Kim A. Reiss, Dulabh K. Monga, Nita Ahuja and Nilofer S. Azad
    Citation: Clinical Epigenetics 2022 14:166
  25. Epigenetic age is a DNA methylation-based biomarker of aging that is accurate across the lifespan and a range of cell types. The difference between epigenetic age and chronological age, termed age acceleration...

    Authors: Rong Jiang, Elizabeth R. Hauser, Lydia Coulter Kwee, Svati H. Shah, Jessica A. Regan, Janet L. Huebner, Virginia B. Kraus, William E. Kraus and Cavin K. Ward-Caviness
    Citation: Clinical Epigenetics 2022 14:165
  26. The role of JAM3 in different tumors is controversial. The epigenetic regulation and the mechanism of JAM3 remain to be elucidated in human esophageal cancer (EC).

    Authors: Weili Yang, Chao Guo, James G. Herman, Cheng Zhu, Honghui Lv, Xiaomo Su, Lirong Zhang, Meiying Zhang and Mingzhou Guo
    Citation: Clinical Epigenetics 2022 14:164
  27. DNA methylation (5-mC) signals in cell-free DNA (cfDNA) of cancer patients represent promising biomarkers for minimally invasive tumor detection. The high abundance of cancer-associated 5-mC alterations permit...

    Authors: Florian Janke, Arlou Kristina Angeles, Anja Lisa Riediger, Simone Bauer, Martin Reck, Albrecht Stenzinger, Marc A. Schneider, Thomas Muley, Michael Thomas, Petros Christopoulos and Holger Sültmann
    Citation: Clinical Epigenetics 2022 14:163
  28. We screened out several hypermethylated solute carrier (SLC) family genes in acute myeloid leukemia by reduced representation bisulfite sequencing. SLC22A3 encodes an organic cation transport protein, which is cr...

    Authors: Yu Gu, Zi-jun Xu, Jing-dong Zhou, Xiang-mei Wen, Ye Jin, Qian Yuan, Pei-hui Xia, Yuan Feng, Lei Yang, Jiang Lin and Jun Qian
    Citation: Clinical Epigenetics 2022 14:162
  29. Parent of origin-specific allelic expression of imprinted genes is epigenetically controlled. In cancer, imprinted genes undergo both genomic and epigenomic alterations, including frequent copy number changes....

    Authors: Julia Krushkal, Suleyman Vural, Travis L. Jensen, George Wright and Yingdong Zhao
    Citation: Clinical Epigenetics 2022 14:161
  30. Recurrence represents a well-known poor prognostic factor for colorectal cancer (CRC) patients. This study aimed to establish an effective prognostic prediction model based on noninvasive circulating tumor DNA...

    Authors: Xin Yang, Xiaofeng Wen, Qin Guo, Yunfeng Zhang, Zhenxing Liang, Qian Wu, Zhihao Li, Weimei Ruan, Zhujia Ye, Hong Wang, Zhiwei Chen, Jian-Bing Fan, Ping Lan, Huashan Liu and Xianrui Wu
    Citation: Clinical Epigenetics 2022 14:160
  31. The epigenetic regulation of the renin–angiotensin–aldosterone system (RAAS) potentially plays a role in the pathophysiology underlying the high burden of hypertension in sub-Saharan Africans (SSA). Here we re...

    Authors: Eva L. van der Linden, Adrienne Halley, Karlijn A. C. Meeks, Felix Chilunga, Charles Hayfron-Benjamin, Andrea Venema, Ingrid M. Garrelds, A. H. Jan Danser, Bert-Jan van den Born, Peter Henneman and Charles Agyemang
    Citation: Clinical Epigenetics 2022 14:159
  32. Epigenome-wide association studies (EWAS) have helped to define the associations between DNA methylation and many clinicopathologic and developmental traits. Since DNA methylation is affected by genetic variat...

    Authors: Shaobo Li, Nicholas Mancuso, Catherine Metayer, Xiaomei Ma, Adam J. de Smith and Joseph L. Wiemels
    Citation: Clinical Epigenetics 2022 14:158
  33. High caloric diet and lack of physical activity are considered main causes of NAFLD, and a change in the diet is still the only effective treatment of this disease. However, molecular mechanism of the effectiv...

    Authors: Katarzyna Ewa Sokolowska, Dominika Maciejewska-Markiewicz, Jan Bińkowski, Joanna Palma, Olga Taryma-Leśniak, Katarzyna Kozlowska-Petriczko, Konrad Borowski, Magdalena Baśkiewicz-Hałasa, Viktoria Hawryłkowicz, Patrycja Załęcka, Marcin Ufnal, Dominik Strapagiel, Justyna Jarczak, Karolina Skonieczna-Żydecka, Karina Ryterska, Bogusław Machaliński…
    Citation: Clinical Epigenetics 2022 14:157
  34. The protocadherin proteins are cell adhesion molecules at the crossroad of signaling pathways playing a major role in neuronal development. It is now understood that their role as signaling hubs is not only im...

    Authors: Arnaud Carrier, Cécile Desjobert, Valérie Lobjois, Lise Rigal, Florence Busato, Jörg Tost, Miquel Ensenyat-Mendez, Diego M. Marzese, Anne Pradines, Gilles Favre, Laurence Lamant, Luisa Lanfrancone, Chantal Etievant, Paola B. Arimondo and Joëlle Riond
    Citation: Clinical Epigenetics 2022 14:156
  35. Smoking and alcohol consumption may compromise health by way of epigenetic modifications. Epigenetic signatures of alcohol and tobacco consumption could provide insights into the reversibility of phenotypic ch...

    Authors: Jonviea D. Chamberlain, Sébastien Nusslé, Laurence Chapatte, Cassandre Kinnaer, Dusan Petrovic, Sylvain Pradervand, Murielle Bochud, Sarah E. Harris, Janie Corley, Simon R. Cox and Semira Gonseth Nusslé
    Citation: Clinical Epigenetics 2022 14:155
  36. DNA methylation is an important epigenetic mechanism that regulates gene expression. To date, most DNA methylation studies have focussed on CpG islands in the gene promoter region, and the mechanism of methyla...

    Authors: Qi Wang, Fei Xiong, Guanhua Wu, Wenzheng Liu, Junsheng Chen, Bing Wang and Yongjun Chen
    Citation: Clinical Epigenetics 2022 14:154
  37. Physiological maternal stress response, such as imbalance in the glucocorticoid pathway and immune system seems to be mediated by DNA methylation (DNAm) and might translate intrauterine stress exposures into p...

    Authors: Verônica Euclydes, Catarina Gomes, Gisele Gouveia, Vinicius Daguano Gastaldi, Arthur Sant’Anna Feltrin, Caroline Camilo, Rossana Pulcineli Vieira, Aloísio Felipe-Silva, Sandra Grisi, Günther Fink, Alexandra Brentani and Helena Brentani
    Citation: Clinical Epigenetics 2022 14:152
  38. Children born after assisted reproductive technologies (ART) differ in birthweight from those naturally conceived. It has been hypothesized that this might be explained by epigenetic mechanisms. We examined wh...

    Authors: Ellen Ø. Carlsen, Yunsung Lee, Per Magnus, Astanand Jugessur, Christian M. Page, Haakon E. Nustad, Siri E. Håberg, Rolv T. Lie and Maria C. Magnus
    Citation: Clinical Epigenetics 2022 14:151
  39. Cervical screening using primary human papilloma virus (HPV) testing and cytology is being implemented in several countries. Cytology as triage for colposcopy referral suffers from several shortcomings. HPV te...

    Authors: Chiara Herzog, Karin Sundström, Allison Jones, Iona Evans, James E. Barrett, Jiangrong Wang, Elisa Redl, Lena Schreiberhuber, Laura Costas, Sonia Paytubi, Lukas Dostalek, Michal Zikan, David Cibula, Gaby Sroczynski, Uwe Siebert, Joakim Dillner…
    Citation: Clinical Epigenetics 2022 14:150
  40. Sarcomas are a heterogeneous group of rare malignant tumors with more than 100 subtypes. Accurate diagnosis remains challenging due to a lack of characteristic molecular or histomorphological hallmarks. A DNA ...

    Authors: Siyer Roohani, Felix Ehret, Eilís Perez, David Capper, Armin Jarosch, Anne Flörcken, Sven Märdian, Daniel Zips and David Kaul
    Citation: Clinical Epigenetics 2022 14:149
  41. The molecular pathogenesis of T-cell large granular lymphocytic leukemia (T-LGLL), a mature T-cell leukemia arising commonly from T-cell receptor αβ-positive CD8+ memory cytotoxic T cells, is only partly understo...

    Authors: Patricia Johansson, Teresa Laguna, Julio Ossowski, Vera Pancaldi, Martina Brauser, Ulrich Dührsen, Lara Keuneke, Ana Queiros, Julia Richter, José I. Martín-Subero, Reiner Siebert, Brigitte Schlegelberger, Ralf Küppers, Jan Dürig, Eva M. Murga Penas, Enrique Carillo-de Santa Pau…
    Citation: Clinical Epigenetics 2022 14:148

    The Publisher Correction to this article has been published in Clinical Epigenetics 2023 15:3

  42. Proline/arginine-rich end leucine-rich repeat protein (PRELP) is a member of the small leucine-rich proteoglycan family of extracellular matrix proteins, which is markedly suppressed in the majority of early-s...

    Authors: Kanto Shozu, Syuzo Kaneko, Norio Shinkai, Ai Dozen, Hirofumi Kosuge, Makoto Nakakido, Hidenori Machino, Ken Takasawa, Ken Asada, Masaaki Komatsu, Kouhei Tsumoto, Shin-Ichi Ohnuma and Ryuji Hamamoto
    Citation: Clinical Epigenetics 2022 14:147
  43. Genomic imprinting is an epigenetic phenomenon of monoallelic gene expression pattern depending on parental origin. In humans, congenital imprinting disruptions resulting from genetic or epigenetic mechanisms ...

    Authors: Yunqi Chao, Yifang Qin, Xinyi Zou, Xiangzhi Wang, Chenxi Hu, Fangling Xia and Chaochun Zou
    Citation: Clinical Epigenetics 2022 14:146
  44. Epigenetics includes a complex set of processes that alter gene activity without modifying the DNA sequence, which ultimately determines how the genetic information common to all the cells of an organism is us...

    Authors: Giulia Robusti, Alessandro Vai, Tiziana Bonaldi and Roberta Noberini
    Citation: Clinical Epigenetics 2022 14:145
  45. Epigenetic modifications offer compelling evidence of the environmental etiology of complex diseases. Social and biographical conditions, as well as material exposures, all modulate our biology with consequenc...

    Authors: Luca Chiapperino and Francesco Paneni
    Citation: Clinical Epigenetics 2022 14:144

    The Correspondence to this article has been published in Epigenetics Communications 2023 3:4

    The Correspondence to this article has been published in Epigenetics Communications 2023 3:2

  46. Imprinting disorders, which affect growth, development, metabolism and neoplasia risk, are caused by genetic or epigenetic changes to genes that are expressed from only one parental allele. Disease may result ...

    Authors: Deborah Mackay, Jet Bliek, Masayo Kagami, Jair Tenorio-Castano, Arrate Pereda, Frédéric Brioude, Irène Netchine, Dzhoy Papingi, Elisa de Franco, Margaret Lever, Julie Sillibourne, Paola Lombardi, Véronique Gaston, Maithé Tauber, Gwenaelle Diene, Eric Bieth…
    Citation: Clinical Epigenetics 2022 14:143
  47. Arterial hypertension represents a worldwide health burden and a major risk factor for cardiovascular morbidity and mortality. Hypertension can be primary (primary hypertension, PHT), or secondary to endocrine...

    Authors: Roberta Armignacco, Parminder S. Reel, Smarti Reel, Anne Jouinot, Amandine Septier, Cassandra Gaspar, Karine Perlemoine, Casper K. Larsen, Lucas Bouys, Leah Braun, Anna Riester, Matthias Kroiss, Fidéline Bonnet-Serrano, Laurence Amar, Anne Blanchard, Anne-Paule Gimenez-Roqueplo…
    Citation: Clinical Epigenetics 2022 14:142
  48. Cryopreservation has important application in assisted reproductive technology (ART). The vitrification technique has been widely used in the cryopreservation of oocytes and embryos, as a large number of clini...

    Authors: Huanhuan Chen, Lei Zhang, Li Meng, Linlin Liang and Cuilian Zhang
    Citation: Clinical Epigenetics 2022 14:141