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  1. High expression of immune checkpoints in tumor microenvironment plays significant roles in inhibiting anti-tumor immunity, which is associated with poor prognosis and cancer progression. Major epigenetic modif...

    Authors: Varun Sasidharan Nair, Haytham El Salhat, Rowaida Z. Taha, Anne John, Bassam R. Ali and Eyad Elkord

    Citation: Clinical Epigenetics 2018 10:78

    Content type: Research

    Published on:

  2. An increased incidence of imprint-associated disorders has been reported in babies born from assisted reproductive technology (ART). However, previous studies supporting an association between ART and an alter...

    Authors: D. Gentilini, E. Somigliana, L. Pagliardini, E. Rabellotti, P. Garagnani, L. Bernardinelli, E. Papaleo, M. Candiani, A. M. Di Blasio and P. Viganò

    Citation: Clinical Epigenetics 2018 10:77

    Content type: Research

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  3. Primary testing for high-risk HPV (hrHPV) is increasingly implemented in cervical cancer screening programs. Many hrHPV-positive women, however, harbor clinically irrelevant infections, demanding additional di...

    Authors: Iris Babion, Barbara C. Snoek, Putri W. Novianti, Annelieke Jaspers, Nienke van Trommel, Daniëlle A. M. Heideman, Chris J. L. M. Meijer, Peter J. F. Snijders, Renske D. M. Steenbergen and Saskia M. Wilting

    Citation: Clinical Epigenetics 2018 10:76

    Content type: Research

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  4. Many genome- and epigenome-wide association studies (GWAS and EWAS) and studies of promoter methylation of candidate genes for inflammatory bowel disease (IBD) have demonstrated significant associations betwee...

    Authors: Marija Klasić, Dora Markulin, Aleksandar Vojta, Ivana Samaržija, Ivan Biruš, Paula Dobrinić, Nicholas T. Ventham, Irena Trbojević-Akmačić, Mirna Šimurina, Jerko Štambuk, Genadij Razdorov, Nicholas A. Kennedy, Jack Satsangi, Ana M. Dias, Salome Pinho, Vito Annese…

    Citation: Clinical Epigenetics 2018 10:75

    Content type: Research

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  5. After publication of the original article [1], it came to the publishers’ attention that the below author’s corrections provided at the proofing stage had been misinterpreted.

    Authors: Catherine Le Stunff, Anne-Laure Castell, Nicolas Todd, Clémence Mille, Marie-Pierre Belot, Nathalie Frament, Sylvie Brailly-Tabard, Alexandra Benachi, Delphine Fradin and Pierre Bougnères

    Citation: Clinical Epigenetics 2018 10:74

    Content type: Correction

    Published on:

    The original article was published in Clinical Epigenetics 2018 10:57

  6. Mislabeled, contaminated or poorly performing samples can threaten power in methylation microarray analyses or even result in spurious associations. We describe a set of quality checks for the popular Illumina...

    Authors: Jonathan A. Heiss and Allan C. Just

    Citation: Clinical Epigenetics 2018 10:73

    Content type: Methodology

    Published on:

  7. Active demethylation of 5-methyl-2′-deoxycytidine (5-mdC) in DNA occurs by oxidation to 5-(hydroxymethyl)-2′-deoxycytidine (5-hmdC) and further oxidation to 5-formyl-2′-deoxycytidine (5-fdC) and 5-carboxy-2′-d...

    Authors: Tomasz Dziaman, Daniel Gackowski, Jolanta Guz, Kinga Linowiecka, Magdalena Bodnar, Marta Starczak, Ewelina Zarakowska, Martyna Modrzejewska, Anna Szpila, Justyna Szpotan, Maciej Gawronski, Anna Labejszo, Ariel Liebert, Zbigniew Banaszkiewicz, Maria Klopocka, Marek Foksinski…

    Citation: Clinical Epigenetics 2018 10:72

    Content type: Research

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  8. Current standard methods used to detect and monitor bladder cancer (BC) are invasive or have low sensitivity. This study aimed to develop a urine methylation biomarker classifier for BC monitoring and validate...

    Authors: Antoine G. van der Heijden, Lourdes Mengual, Mercedes Ingelmo-Torres, Juan J. Lozano, Cindy C. M. van Rijt-van de Westerlo, Montserrat Baixauli, Bogdan Geavlete, Cristian Moldoveanud, Cosmin Ene, Colin P. Dinney, Bogdan Czerniak, Jack A. Schalken, Lambertus A. L. M. Kiemeney, Maria J. Ribal, J. Alfred Witjes and Antonio Alcaraz

    Citation: Clinical Epigenetics 2018 10:71

    Content type: Research

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  10. Reduced expression of retinoic acid-induced 2 (RAI2) was found in breast cancer. The regulation and function of RAI2 in human colorectal cancer (CRC) remain unclear.

    Authors: Wenji Yan, Kongming Wu, James G. Herman, Xiuduan Xu, Yunsheng Yang, Guanghai Dai and Mingzhou Guo

    Citation: Clinical Epigenetics 2018 10:69

    Content type: Research

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  11. Methylated genes detected in sputum are promise biomarkers for lung cancer. Yet the current PCR technologies for quantification of DNA methylation and diagnostic value of the sputum biomarkers are not sufficie...

    Authors: Yun Su, Hong Bin Fang and Feng Jiang

    Citation: Clinical Epigenetics 2018 10:68

    Content type: Research

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  12. Transplantation of human hematopoietic stem cells into immunodeficient mice provides a powerful in vivo model system to gain functional insights into hematopoietic differentiation. So far, it remains unclear i...

    Authors: Joana Frobel, Susann Rahmig, Julia Franzen, Claudia Waskow and Wolfgang Wagner

    Citation: Clinical Epigenetics 2018 10:67

    Content type: Short report

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  13. To investigate the relationship between early-life stress and glucocorticoid receptor (GR) gene methylation, which may result in long-lasting neurodevelopmental impairment, we performed a longitudinal analysis...

    Authors: Masato Kantake, Natsuki Ohkawa, Tomohiro Iwasaki, Naho Ikeda, Atsuko Awaji, Nobutomo Saito, Hiromichi Shoji and Toshiaki Shimizu

    Citation: Clinical Epigenetics 2018 10:66

    Content type: Research

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  14. The objective of this study was to discover DNA methylation biomarkers for detecting non-small lung cancer (NSCLC) in bronchial washings and understanding the association between DNA methylation and smoking ce...

    Authors: Sang-Won Um, Yujin Kim, Bo Bin Lee, Dongho Kim, Kyung-Jong Lee, Hong Kwan Kim, Joungho Han, Hojoong Kim, Young Mog Shim and Duk-Hwan Kim

    Citation: Clinical Epigenetics 2018 10:65

    Content type: Research

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  16. Cell-free circulating tumour-derived DNA (ctDNA) can be detected by testing for methylated BCAT1 and IKZF1 DNA, which has proven sensitivity for colorectal cancer (CRC). A prospective correlative biomarker study ...

    Authors: Erin L. Symonds, Susanne K. Pedersen, David H. Murray, Maher Jedi, Susan E. Byrne, Philippa Rabbitt, Rohan T. Baker, Dawn Bastin and Graeme P. Young

    Citation: Clinical Epigenetics 2018 10:63

    Content type: Research

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  17. The changes that occur during puberty have been implicated in susceptibility to a wide range of diseases later in life, many of which are characterized by sex-specific differences in prevalence. Both genetic a...

    Authors: Emma E. Thompson, Jessie Nicodemus-Johnson, Kyung Won Kim, James E. Gern, Daniel J. Jackson, Robert F. Lemanske and Carole Ober

    Citation: Clinical Epigenetics 2018 10:62

    Content type: Research

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  19. Lack of vitamin D (VD) has been associated with colorectal cancer (CRC). VD has anti-inflammatory effects and regulates several cellular pathways by means of its receptor, including epigenetic modifications. A...

    Authors: Daniel Castellano-Castillo, Sonsoles Morcillo, Mercedes Clemente-Postigo, Ana Belén Crujeiras, Jose Carlos Fernandez-García, Esperanza Torres, Francisco José Tinahones and Manuel Macias-Gonzalez

    Citation: Clinical Epigenetics 2018 10:60

    Content type: Research

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  21. Exposure to endocrine-disrupting chemicals can alter normal physiology and increase susceptibility to non-communicable diseases like obesity. Especially the prenatal and early postnatal period is highly vulner...

    Authors: Kristin M. Junge, Beate Leppert, Susanne Jahreis, Dirk K. Wissenbach, Ralph Feltens, Konrad Grützmann, Loreen Thürmann, Tobias Bauer, Naveed Ishaque, Matthias Schick, Melanie Bewerunge-Hudler, Stefan Röder, Mario Bauer, Angela Schulz, Michael Borte, Kathrin Landgraf…

    Citation: Clinical Epigenetics 2018 10:58

    Content type: Research

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  22. There are many reasons to think that epigenetics is a key determinant of fetal growth variability across the normal population. Since IGF1 and INS genes are major determinants of intrauterine growth, we examined ...

    Authors: Catherine Le Stunff, Anne-Laure Castell, Nicolas Todd, Clémence Mille, Marie-Pierre Belot, Nathalie Frament, Sylvie Brailly-Tabard, Alexandra Benachi, Delphine Fradin and Pierre Bougnères

    Citation: Clinical Epigenetics 2018 10:57

    Content type: Research

    Published on:

    The Correction to this article has been published in Clinical Epigenetics 2018 10:74

  23. Recently, epigenetic age acceleration—or older epigenetic age in comparison to chronological age—has been robustly associated with mortality and various morbidities. However, accelerated epigenetic aging has n...

    Authors: Marguerite R. Irvin, Stella Aslibekyan, Anh Do, Degui Zhi, Bertha Hidalgo, Steven A. Claas, Vinodh Srinivasasainagendra, Steve Horvath, Hemant K. Tiwari, Devin M. Absher and Donna K. Arnett

    Citation: Clinical Epigenetics 2018 10:56

    Content type: Research

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  24. IgE-mediated sensitization may be epigenetically programmed in utero, but early childhood environment may further alter complex traits and disease phenotypes through epigenetic plasticity. However, the epigeno...

    Authors: Cheng Peng, Andres Cardenas, Sheryl L. Rifas-Shiman, Marie-France Hivert, Diane R. Gold, Thomas A. Platts-Mills, Xihong Lin, Emily Oken, Andrea A. Baccarelli, Augusto A. Litonjua and Dawn L. DeMeo

    Citation: Clinical Epigenetics 2018 10:55

    Content type: Research

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  25. Periprostatic adipose tissue (PPAT) has been recognized to associate with prostate cancer (PCa) aggressiveness and progression. Here, we sought to investigate whether excess adiposity modulates the methylome o...

    Authors: Yan Cheng, Cátia Monteiro, Andreia Matos, Jiaying You, Avelino Fraga, Carina Pereira, Victoria Catalán, Amaia Rodríguez, Javier Gómez-Ambrosi, Gema Frühbeck, Ricardo Ribeiro and Pingzhao Hu

    Citation: Clinical Epigenetics 2018 10:54

    Content type: Research

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  26. Colorectal cancer is the fourth cause of cancer-related deaths worldwide, though detection at early stages associates with good prognosis. Thus, there is a clear demand for novel non-invasive tests for the ear...

    Authors: María Gallardo-Gómez, Sebastian Moran, María Páez de la Cadena, Vicenta Soledad Martínez-Zorzano, Francisco Javier Rodríguez-Berrocal, Mar Rodríguez-Girondo, Manel Esteller, Joaquín Cubiella, Luis Bujanda, Antoni Castells, Francesc Balaguer, Rodrigo Jover and Loretta De Chiara

    Citation: Clinical Epigenetics 2018 10:53

    Content type: Research

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  27. Staging and pathological grading systems are convenient but imperfect predictors of recurrence in head and neck squamous cell carcinoma (HNSCC). Identifying biomarkers for HNSCC that will progress and cause de...

    Authors: Kiyoshi Misawa, Masato Mima, Atsushi Imai, Daiki Mochizuki, Yuki Misawa, Shiori Endo, Ryuji Ishikawa, Takeharu Kanazawa and Hiroyuki Mineta

    Citation: Clinical Epigenetics 2018 10:52

    Content type: Research

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  28. Breast cancer is the most frequent cancer among women worldwide. Biomarkers for early detection and prognosis of these patients are needed. We hypothesized that deafness, autosomal dominant 5 (DFNA5) may be a val...

    Authors: Lieselot Croes, Matthias Beyens, Erik Fransen, Joe Ibrahim, Wim Vanden Berghe, Arvid Suls, Marc Peeters, Patrick Pauwels, Guy Van Camp and Ken Op de Beeck

    Citation: Clinical Epigenetics 2018 10:51

    Content type: Research

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  29. The prevalence of respiratory allergy in children is increasing. Epigenetic DNA methylation changes are plausible underlying molecular mechanisms.

    Authors: Sabine A. S. Langie, Matthieu Moisse, Katarzyna Szarc vel Szic, Ellen Van Der Plas, Gudrun Koppen, Sofie De Prins, Tijs Louwies, Vera Nelen, Guy Van Camp, Diether Lambrechts, Greet Schoeters, Wim Vanden Berghe and Patrick De Boever

    Citation: Clinical Epigenetics 2018 10:50

    Content type: Research

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  30. The high prevalence of obesity among US adults has resulted in significant increases in associated metabolic disorders such as diabetes, dyslipidemia, and high blood pressure. Together, these disorders constit...

    Authors: Tomi Akinyemiju, Anh N. Do, Amit Patki, Stella Aslibekyan, Degui Zhi, Bertha Hidalgo, Hemant K. Tiwari, Devin Absher, Xin Geng, Donna K. Arnett and Marguerite R. Irvin

    Citation: Clinical Epigenetics 2018 10:49

    Content type: Research

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  31. The etiology and pathogenesis of pre-eclampsia (PE) is unclear, and there is no ideal early clinical biomarker for prediction of PE. The competing endogenous RNA (ceRNA) hypothesis is a new approach to uncover...

    Authors: Xiaopeng Hu, Junping Ao, Xinyue Li, Huijuan Zhang, Ji Wu and Weiwei Cheng

    Citation: Clinical Epigenetics 2018 10:48

    Content type: Research

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  32. The long non-coding RNA H19 plays a crucial role in solid tumor initiation and progression. However, the potential role of H19 and its clinical significance in acute myeloid leukemia (AML) remain largely elusive.

    Authors: Ting-juan Zhang, Jing-dong Zhou, Wei Zhang, Jiang Lin, Ji-chun Ma, Xiang-mei Wen, Qian Yuan, Xi-xi Li, Zi-jun Xu and Jun Qian

    Citation: Clinical Epigenetics 2018 10:47

    Content type: Research

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  33. Genetic variants within the fatty acid desaturase (FADS) gene cluster (human Chr11) are important regulators of long-chain (LC) polyunsaturated fatty acid (PUFA) biosynthesis in the liver and consequently have be...

    Authors: Elaheh Rahbar, Charlotte Mae K. Waits, Edward H. Kirby Jr., Leslie R. Miller, Hannah C. Ainsworth, Tao Cui, Susan Sergeant, Timothy D. Howard, Carl D. Langefeld and Floyd H. Chilton

    Citation: Clinical Epigenetics 2018 10:46

    Content type: Research

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  34. Monosomy of the X chromosome is the most frequent genetic abnormality in human as it is present in approximately 2% of all conceptions, although 99% of these embryos are spontaneously miscarried. In postnatal ...

    Authors: Francisco Álvarez-Nava and Roberto Lanes

    Citation: Clinical Epigenetics 2018 10:45

    Content type: Review

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  35. Kidney cancer and clear cell renal carcinoma (ccRCC) are the 16th most common cause of death worldwide. ccRCC is often metastasized at diagnosis, and surgery remains the main treatment; therefore, early diagno...

    Authors: Elisa Cocco, Manuela Leo, Claudia Canzonetta, Serena Di Vito, Antonello Mai, Dante Rotili, Arianna Di Napoli, Andrea Vecchione, Cosimo De Nunzio, Patrizia Filetici and Antonella Stoppacciaro

    Citation: Clinical Epigenetics 2018 10:44

    Content type: Research

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  36. To identify aberrant promoter methylation of genomic loci encoding microRNA (mgmiR) in head and neck squamous cell carcinoma (HNSCC) and to evaluate a biomarker panel of mgmiRs to improve the diagnostic accura...

    Authors: Yu Cao, Katherine Green, Steve Quattlebaum, Ben Milam, Ling Lu, Dexiang Gao, Hui He, Ningning Li, Liwei Gao, Francis Hall, Matthew Whinery, Elyse Handley, Yi Ma, Tao Xu, Feng Jin, Jing Xiao…

    Citation: Clinical Epigenetics 2018 10:43

    Content type: Research

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  37. DNMT3A gene mutation has been associated with poor prognosis in acute myeloid leukemia, but its clinical implications in myelodysplastic syndrome (MDS) and dynamic changes during disease progression remain contro...

    Authors: Ming-En Lin, Hsin-An Hou, Cheng-Hong Tsai, Shang-Ju Wu, Yuan-Yeh Kuo, Mei-Hsuan Tseng, Ming-Chih Liu, Chia-Wen Liu, Wen-Chien Chou, Chien-Yuan Chen, Jih-Luh Tang, Ming Yao, Chi-Cheng Li, Shang-Yi Huang, Bor-Sheng Ko, Szu-Chun Hsu…

    Citation: Clinical Epigenetics 2018 10:42

    Content type: Research

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  38. KDM lysine demethylase family members are related to lung cancer clinical outcomes and are potential biomarkers for chemotherapeutics. However, little is known about epigenetic alterations in KDM genes and their ...

    Authors: Yongyue Wei, Junya Liang, Ruyang Zhang, Yichen Guo, Sipeng Shen, Li Su, Xihong Lin, Sebastian Moran, Åslaug Helland, Maria M. Bjaanæs, Anna Karlsson, Maria Planck, Manel Esteller, Thomas Fleischer, Johan Staaf, Yang Zhao…

    Citation: Clinical Epigenetics 2018 10:41

    Content type: Research

    Published on:

  39. Prostate cancer (PCa) is a major cause of morbidity and mortality in men worldwide. MicroRNAs are globally downregulated in PCa, especially in poorly differentiated tumors. Nonetheless, the underlying mechanis...

    Authors: João Ramalho-Carvalho, Céline S. Gonçalves, Inês Graça, David Bidarra, Eva Pereira-Silva, Sofia Salta, Maria Inês Godinho, Antonio Gomez, Manel Esteller, Bruno M. Costa, Rui Henrique and Carmen Jerónimo

    Citation: Clinical Epigenetics 2018 10:40

    Content type: Research

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  40. Fibroblast growth factor receptor 2 (FGFR2) gene encodes a protein of the fibroblast growth factor receptor family. FGFR2 gene expression is associated with the regulation of implantation process of placenta whic...

    Authors: Fu-Ying Tian, Xi-Meng Wang, Chuanbo Xie, Bo Zhao, Zhongzheng Niu, Lijun Fan, Marie-France Hivert and Wei-Qing Chen

    Citation: Clinical Epigenetics 2018 10:39

    Content type: Research

    Published on:

  41. Methylation measures quantified by microarray techniques can be affected by systematic variation due to the technical processing of samples, which may compromise the accuracy of the measurement process and con...

    Authors: Flavie Perrier, Alexei Novoloaca, Srikant Ambatipudi, Laura Baglietto, Akram Ghantous, Vittorio Perduca, Myrto Barrdahl, Sophia Harlid, Ken K. Ong, Alexia Cardona, Silvia Polidoro, Therese Haugdahl Nøst, Kim Overvad, Hanane Omichessan, Martijn Dollé, Christina Bamia…

    Citation: Clinical Epigenetics 2018 10:38

    Content type: Methodology

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  42. Early pulmonary oxygen exposure is one of the most important factors implicated in the development of bronchopulmonary dysplasia (BPD).

    Authors: Cho-Ming Chao, Rhea van den Bruck, Samantha Lork, Janica Merkle, Laura Krampen, Patrick P Weil, Malik Aydin, Saverio Bellusci, Andreas C. Jenke and Jan Postberg

    Citation: Clinical Epigenetics 2018 10:37

    Content type: Research

    Published on:

  43. After publication of the original article [1], it came to the authors’ attention that a reference was omitted from the Background.

    Authors: Yuzhu Wang, Tao He, James G. Herman, Enqiang Linghu, Yunsheng Yang, François Fuks, Fuyou Zhou, Linjie Song and Mingzhou Guo

    Citation: Clinical Epigenetics 2018 10:36

    Content type: Correction

    Published on:

    The original article was published in Clinical Epigenetics 2017 9:115

  44. Biomarkers that can predict the prognosis of colorectal cancer (CRC) patients and that can stratify high-risk early stage patients from low-risk early stage patients are urgently needed for better management o...

    Authors: Muriel X. G. Draht, Danny Goudkade, Alexander Koch, Heike I. Grabsch, Matty P. Weijenberg, Manon van Engeland, Veerle Melotte and Kim M. Smits

    Citation: Clinical Epigenetics 2018 10:35

    Content type: Review

    Published on:

  45. 5,10-Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in one-carbon metabolism that ensures the availability of methyl groups for methylation reactions. Two single-nucleotide polymorphisms (SNPs) in...

    Authors: Giulia F. Del Gobbo, E. Magda Price, Courtney W. Hanna and Wendy P. Robinson

    Citation: Clinical Epigenetics 2018 10:34

    Content type: Research

    Published on:

  47. Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease of the lungs that is currently the fourth leading cause of death worldwide. Genetic factors account for only a small amount of COPD risk,...

    Authors: Rachel L. Clifford, Nick Fishbane, Jamie Patel, Julia L. MacIsaac, Lisa M. McEwen, Andrew J. Fisher, Corry-Anke Brandsma, Parameswaran Nair, Michael S. Kobor, Tillie-Louise Hackett and Alan J. Knox

    Citation: Clinical Epigenetics 2018 10:32

    Content type: Research

    Published on:

  48. Few biological markers are associated with survival after relapse of B-cell precursor acute lymphoblastic leukemia (BCP-ALL). In pediatric T-cell ALL, we have identified promoter-associated methylation alterat...

    Authors: Magnus Borssén, Jessica Nordlund, Zahra Haider, Mattias Landfors, Pär Larsson, Jukka Kanerva, Kjeld Schmiegelow, Trond Flaegstad, Ólafur Gísli Jónsson, Britt-Marie Frost, Josefine Palle, Erik Forestier, Mats Heyman, Magnus Hultdin, Gudmar Lönnerholm and Sofie Degerman

    Citation: Clinical Epigenetics 2018 10:31

    Content type: Short report

    Published on:

  49. DNA methylation is an important epigenetic modification, associated with gene expression. 5-Methylcytosine and 5-hydroxymethylcytosine are two epigenetic hallmarks that maintain the equilibrium of epigenetic r...

    Authors: Yimin Zhu, Hanlin Lu, Dandan Zhang, Meiyan Li, Xiaohui Sun, Ledong Wan, Dan Yu, Yiping Tian, Hongchuan Jin, Aifen Lin, Fei Gao and Maode Lai

    Citation: Clinical Epigenetics 2018 10:30

    Content type: Research

    Published on:

  50. Hepatoblastoma (HB) is the most common liver tumor of childhood and occurs predominantly within the first 3 years of life. In accordance to its early manifestation, HB has been described to display an extremel...

    Authors: Alexander Beck, Franziska Trippel, Alexandra Wagner, Saskia Joppien, Max Felle, Christian Vokuhl, Thomas Schwarzmayr, Tim M. Strom, Dietrich von Schweinitz, Gernot Längst and Roland Kappler

    Citation: Clinical Epigenetics 2018 10:27

    Content type: Research

    Published on:

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