Skip to main content

Articles

Page 7 of 28

  1. Epigenetic mechanisms, namely DNA and histone modifications, are critical regulators of immunity and inflammation which have emerged as potential targets for immunomodulating therapies. The prevalence and sign...

    Authors: Krzysztof T. Jurdziński, Jan Potempa and Aleksander M. Grabiec
    Citation: Clinical Epigenetics 2020 12:186
  2. Fetal growth restriction (FGR) is associated with an increased susceptibility for various noncommunicable diseases in adulthood, including cardiovascular and renal disease. During FGR, reduced uteroplacental b...

    Authors: Fieke Terstappen, Jorg J. A. Calis, Nina D. Paauw, Jaap A. Joles, Bas B. van Rijn, Michal Mokry, Torsten Plösch and A. Titia Lely
    Citation: Clinical Epigenetics 2020 12:185
  3. Blood DNA methylation-based aging algorithms predict mortality in the general population. We investigated the prognostic value of five established DNA methylation aging algorithms for patients with colorectal ...

    Authors: Xīn Gào, Yan Zhang, Daniel Boakye, Xiangwei Li, Jenny Chang-Claude, Michael Hoffmeister and Hermann Brenner
    Citation: Clinical Epigenetics 2020 12:184
  4. Keloid, a common dermal fibroproliferative disorder, is benign skin tumors characterized by the aggressive fibroblasts proliferation and excessive accumulation of extracellular matrix. However, common therapeu...

    Authors: Wenchang Lv, Yuping Ren, Kai Hou, Weijie Hu, Yi Yi, Mingchen Xiong, Min Wu, Yiping Wu and Qi Zhang
    Citation: Clinical Epigenetics 2020 12:183
  5. Normal-weight polycystic ovary syndrome (PCOS) women exhibit adipose resistance in vivo accompanied by enhanced subcutaneous (SC) abdominal adipose stem cell (ASC) development to adipocytes with accelerated li...

    Authors: Karen L. Leung, Smriti Sanchita, Catherine T. Pham, Brett A. Davis, Mariam Okhovat, Xiangming Ding, Phillip Dumesic, Tristan R. Grogan, Kevin J. Williams, Marco Morselli, Feiyang Ma, Lucia Carbone, Xinmin Li, Matteo Pellegrini, Daniel A. Dumesic and Gregorio D. Chazenbalk
    Citation: Clinical Epigenetics 2020 12:181
  6. The composition of the microbiome plays an important role in human health and disease. Whether there is a direct association between the cervicovaginal microbiome and the host’s epigenome is largely unexplored.

    Authors: Nuno R. Nené, James Barrett, Allison Jones, Iona Evans, Daniel Reisel, John F. Timms, Tobias Paprotka, Andreas Leimbach, Dorella Franchi, Nicoletta Colombo, Line Bjørge, Michal Zikan, David Cibula and Martin Widschwendter
    Citation: Clinical Epigenetics 2020 12:180
  7. Paternal obesity has been associated with reduced live birth rates. It could lead to inheritance of metabolic disturbances to the offspring through epigenetic mechanisms. However, obesity is a multifactorial d...

    Authors: Sharvari S. Deshpande, Harishankar Nemani, Gandhimathi Arumugam, Avinash Ravichandran and Nafisa H. Balasinor
    Citation: Clinical Epigenetics 2020 12:179
  8. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Jessica M. Salmon, Michael Bots, Eva Vidacs, Kym L. Stanley, Peter Atadja, Johannes Zuber and Ricky W. Johnstone
    Citation: Clinical Epigenetics 2020 12:178

    The original article was published in Clinical Epigenetics 2015 7:2

  9. Multiple studies have related psychiatric disorders and immune alterations. Panic disorder (PD) has been linked with changes in leukocytes distributions in several small studies using different methods for imm...

    Authors: Curtis L. Petersen, Ji-Qing Chen, Lucas A. Salas and Brock C. Christensen
    Citation: Clinical Epigenetics 2020 12:177
  10. Hereditary transthyretin (TTR) amyloidosis (hATTR) is a rare life-threatening disorder caused by amyloidogenic coding mutations located in TTR gene. To understand the high phenotypic variability observed among ca...

    Authors: Antonella De Lillo, Gita A. Pathak, Flavio De Angelis, Marco Di Girolamo, Marco Luigetti, Mario Sabatelli, Federico Perfetto, Sabrina Frusconi, Dario Manfellotto, Maria Fuciarelli and Renato Polimanti
    Citation: Clinical Epigenetics 2020 12:176
  11. Head and neck squamous cell carcinoma (HNSCC) is the sixth most prevalent cancer worldwide, with human papillomavirus (HPV)-related HNSCC rising to concerning levels. Extensive clinical, genetic and epigenetic...

    Authors: Siyu Liu, Marcell Costa de Medeiros, Evan M. Fernandez, Katie R. Zarins, Raymond G. Cavalcante, Tingting Qin, Gregory T. Wolf, Maria E. Figueroa, Nisha J. D’Silva, Laura S. Rozek and Maureen A. Sartor
    Citation: Clinical Epigenetics 2020 12:175
  12. The utility of O6-methylguanine-DNA methyltransferase (MGMT) gene promoter methylation status as a prognostic marker in patients with glioblastoma (GBM) has been established. However, the number of CpG sites that...

    Authors: Mitsuto Hanihara, Kunio Miyake, Atsushi Watanabe, Yuriko Yamada, Naoki Oishi, Tomoyuki Kawataki, Takeshi Inukai, Tetsuo Kondo and Hiroyuki Kinouchi
    Citation: Clinical Epigenetics 2020 12:174
  13. Zinc-finger protein 471 (ZNF471) is a member of the Krüppel-associated box domain zinc finger protein (KRAB-ZFP) family. ZNF471 is methylated in squamous cell carcinomas of tongue, stomach and esophageal. However...

    Authors: Chunfang Tao, Juan Luo, Jun Tang, Danfeng Zhou, Shujun Feng, Zhu Qiu, Thomas C. Putti, Tingxiu Xiang, Qiao Tao, Lili Li and Guosheng Ren
    Citation: Clinical Epigenetics 2020 12:173

    The Correction to this article has been published in Clinical Epigenetics 2022 14:17

  14. High-risk human papillomavirus (hrHPV)-based screening is becoming increasingly important, either by supplementing or replacing the traditional cytology-based cervical Pap smear. However, hrHPV screening lacks...

    Authors: Carolin Dippmann, Martina Schmitz, Kristina Wunsch, Stefanie Schütze, Katrin Beer, Christiane Greinke, Hans Ikenberg, Heike Hoyer, Ingo B. Runnebaum, Alfred Hansel and Matthias Dürst
    Citation: Clinical Epigenetics 2020 12:171
  15. Patients with cardiovascular disease (CVD) and type 2 diabetes (DM2) have a high residual risk for experiencing a major adverse cardiac event. Dysregulation of epigenetic mechanisms of gene transcription in in...

    Authors: Sylwia Wasiak, Kim E. Dzobo, Brooke D. Rakai, Yannick Kaiser, Miranda Versloot, Mahnoush Bahjat, Stephanie C. Stotz, Li Fu, Michael Sweeney, Jan O. Johansson, Norman C. W. Wong, Erik S. G. Stroes, Jeffrey Kroon and Ewelina Kulikowski
    Citation: Clinical Epigenetics 2020 12:166
  16. Environmentally induced epigenetic changes can lead to health problems or disease, but the mechanisms involved remain unclear. Morphine can pass through the placental barrier leading to abnormal embryo develop...

    Authors: Iraia Muñoa-Hoyos, John A. Halsall, Manu Araolaza, Carl Ward, Idoia Garcia, Itziar Urizar-Arenaza, Marta Gianzo, Paloma Garcia, Bryan Turner and Nerea Subirán
    Citation: Clinical Epigenetics 2020 12:170
  17. Previous studies suggest the tumor suppressor role of long non-coding RNA (lncRNA) STXBP5-AS1 in cervical and gastric cancer, but its expression pattern and functional mechanism are still elusive in pancreatic ca...

    Authors: Shi Chen, Long Huang, Ge Li, Funan Qiu, Yaodong Wang, Can Yang, Jingjing Pan, Zhangwei Wu, Jiangzhi Chen and Yifeng Tian
    Citation: Clinical Epigenetics 2020 12:168
  18. Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a lifelong debilitating disease with a complex pathology not yet clearly defined. Susceptibility to ME/CFS involves genetic predisposition and exp...

    Authors: A. M. Helliwell, E. C. Sweetman, P. A. Stockwell, C. D. Edgar, A. Chatterjee and W. P. Tate
    Citation: Clinical Epigenetics 2020 12:167
  19. The incidence of endometrial cancer is rising, and current diagnostics often require invasive biopsy procedures. Urine may offer an alternative sample type, which is easily accessible and allows repetitive sel...

    Authors: Rianne van den Helder, Birgit M. M. Wever, Nienke E. van Trommel, Annina P. van Splunter, Constantijne H. Mom, Jenneke C. Kasius, Maaike C. G. Bleeker and Renske D. M. Steenbergen
    Citation: Clinical Epigenetics 2020 12:165
  20. Colon cancer (CC) is the third most common cancer worldwide, highlighting the importance of developing effective prevention strategies. Accumulating evidence supports that aspirin use reduces CC incidence. We ...

    Authors: Faiza Noreen, Anna Chaber-Ciopinska, Jaroslaw Regula, Primo Schär and Kaspar Truninger
    Citation: Clinical Epigenetics 2020 12:164
  21. Multiple myeloma (MM) is a heterogeneous plasma cell malignancy that remains challenging to cure. Global hypomethylation correlates with an aggressive phenotype of the disease, while hypermethylation is observ...

    Authors: Jean-Baptiste Alberge, Florence Magrangeas, Mirko Wagner, Soline Denié, Catherine Guérin-Charbonnel, Loïc Campion, Michel Attal, Hervé Avet-Loiseau, Thomas Carell, Philippe Moreau, Stéphane Minvielle and Aurélien A. Sérandour
    Citation: Clinical Epigenetics 2020 12:163
  22. Stool DNA testing is an emerging and attractive option for colorectal cancer (CRC) screening. We previously evaluated the feasibility of a stool DNA (sDNA) test of methylated SDC2 for CRC detection. The aim of th...

    Authors: Jianping Wang, Side Liu, Hui Wang, Lei Zheng, Changchun Zhou, Guoxin Li, Rongkang Huang, Huaiming Wang, Chujun Li, Xinjuan Fan, Xinhui Fu, Xinying Wang, Hongliang Guo, Jie Guan, Yanlai Sun, Xilin Song…
    Citation: Clinical Epigenetics 2020 12:162
  23. Gastric cancer (GC) is a digestive system cancer with a high mortality rate globally. Previous experiences and studies have provided clinicians with ample evidence to diagnose and treat patients with reasonabl...

    Authors: Tengda Li, Xin Chen, Mingli Gu, Anmei Deng and Cheng Qian
    Citation: Clinical Epigenetics 2020 12:161
  24. Elderly patients with diffuse large B-cell lymphoma (DLBCL) present with poor clinical outcome and intolerance to intensive chemotherapy. Histone deacetylase inhibitors (HDACIs) show anti-lymphoma activities a...

    Authors: Mu-Chen Zhang, Ying Fang, Li Wang, Shu Cheng, Di Fu, Yang He, Yan Zhao, Chao-Fu Wang, Xu-Feng Jiang, Qi Song, Peng-Peng Xu and Wei-Li Zhao
    Citation: Clinical Epigenetics 2020 12:160
  25. Imprinting disorders (IDs) show overlapping phenotypes, particularly in Silver–Russell syndrome (SRS), Temple syndrome (TS14), and Prader–Willi syndrome (PWS). These three IDs include fetal and postnatal growt...

    Authors: Kaori Hara-Isono, Keiko Matsubara, Tomoko Fuke, Kazuki Yamazawa, Kazuhito Satou, Nobuyuki Murakami, Shinji Saitoh, Kazuhiko Nakabayashi, Kenichiro Hata, Tsutomu Ogata, Maki Fukami and Masayo Kagami
    Citation: Clinical Epigenetics 2020 12:159
  26. DNA methylation-based biological age (DNAm age) is an important biomarker for adult health. Studies in specific age ranges have found widely varying results about its genetic and environmental causes of variat...

    Authors: Shuai Li, Tuong L. Nguyen, Ee Ming Wong, Pierre-Antoine Dugué, Gillian S. Dite, Nicola J. Armstrong, Jeffrey M. Craig, Karen A. Mather, Perminder S. Sachdev, Richard Saffery, Joohon Sung, Qihua Tan, Anbupalam Thalamuthu, Roger L. Milne, Graham G. Giles, Melissa C. Southey…
    Citation: Clinical Epigenetics 2020 12:158
  27. Tobacco smoking is a well-known modifiable risk factor for many chronic diseases, including cardiovascular disease (CVD). One of the proposed underlying mechanism linking smoking to disease is via epigenetic m...

    Authors: Silvana C. E. Maas, Michelle M. J. Mens, Brigitte Kühnel, Joyce B. J. van Meurs, André G. Uitterlinden, Annette Peters, Holger Prokisch, Christian Herder, Harald Grallert, Sonja Kunze, Melanie Waldenberger, Maryam Kavousi, Manfred Kayser and Mohsen Ghanbari
    Citation: Clinical Epigenetics 2020 12:157
  28. Epigenetics is a relatively new field of science that studies the genetic and non-genetic aspects related to heritable phenotypic changes, frequently caused by environmental and metabolic factors. In the host,...

    Authors: Sandra Atlante, Alessia Mongelli, Veronica Barbi, Fabio Martelli, Antonella Farsetti and Carlo Gaetano
    Citation: Clinical Epigenetics 2020 12:156
  29. A genome-wide study identified de novo DNA methylation alterations in leukocytes of children at paediatric intensive care unit (PICU) discharge, offering a biological basis for their impaired long-term developmen...

    Authors: Ines Verlinden, Fabian Güiza, Inge Derese, Pieter J. Wouters, Koen Joosten, Sascha C. Verbruggen, Greet Van den Berghe and Ilse Vanhorebeek
    Citation: Clinical Epigenetics 2020 12:155
  30. Variation in intercellular methylation patterns can complicate the use of methylation biomarkers for clinical diagnostic applications such as blood-based cancer testing. Here, we describe development and valid...

    Authors: Brendan F. Miller, Thomas R. Pisanic II, Gennady Margolin, Hanna M. Petrykowska, Pornpat Athamanolap, Alexander Goncearenco, Akosua Osei-Tutu, Christina M. Annunziata, Tza-Huei Wang and Laura Elnitski
    Citation: Clinical Epigenetics 2020 12:154
  31. Massively parallel sequencing of maternal cell-free DNA (cfDNA) is widely used to test fetal genetic abnormalities in non-invasive prenatal testing (NIPT). However, sequencing-based approaches are still of hig...

    Authors: Juozas Gordevičius, Milda Narmontė, Povilas Gibas, Kotryna Kvederavičiūtė, Vita Tomkutė, Priit Paluoja, Kaarel Krjutškov, Andres Salumets and Edita Kriukienė
    Citation: Clinical Epigenetics 2020 12:153
  32. Pathogenic CDKN1C gain-of-function variants on the maternal allele were initially reported as a cause of IMAGe syndrome characterized by intrauterine growth retardation, metaphyseal dysplasia, primary adrenal ins...

    Authors: Gerhard Binder, Julian Ziegler, Roland Schweizer, Wisam Habhab, Tobias B. Haack, Tilman Heinrich and Thomas Eggermann
    Citation: Clinical Epigenetics 2020 12:152
  33. Infants born very preterm are more likely to experience neonatal morbidities compared to their term peers. Variations in DNA methylation (DNAm) associated with these morbidities may yield novel information abo...

    Authors: Todd M. Everson, T. Michael O’Shea, Amber Burt, Karen Hermetz, Brian S. Carter, Jennifer Helderman, Julie A. Hofheimer, Elisabeth C. McGowan, Charles R. Neal, Steven L. Pastyrnak, Lynne M. Smith, Antoine Soliman, Sheri A. DellaGrotta, Lynne M. Dansereau, James F. Padbury, Barry M. Lester…
    Citation: Clinical Epigenetics 2020 12:151
  34. miR-342-3p, localized to 14q32, is a tumor suppressor miRNA implicated in carcinogenesis. Given the presence of a promotor-associated CpG island for its host gene, EVL, we hypothesized that intronic miR-342-3p is...

    Authors: Min Yue Zhang, George A. Calin, Kit San Yuen, Dong Yan Jin and Chor Sang Chim
    Citation: Clinical Epigenetics 2020 12:150
  35. Growing evidence shows that epigenetic modifications play a role in Alzheimer’s disease (AD). We performed an epigenome-wide association study (EWAS) to evaluate the DNA methylation differences using postmorte...

    Authors: Qingqin S. Li, Yu Sun and Tania Wang
    Citation: Clinical Epigenetics 2020 12:149
  36. Protein lysine methyltransferases (PKMTs) constitute a large family of approximately 50 chromatin modifiers that mono-, di- and/or tri-methylate lysine residues on histone and non-histone substrates. With the ...

    Authors: Theodore Vougiouklakis, Benjamin J. Bernard, Nupur Nigam, Kyunghee Burkitt, Yusuke Nakamura and Vassiliki Saloura
    Citation: Clinical Epigenetics 2020 12:146
  37. Mesenchymal fibroblasts are ubiquitous cells that maintain the extracellular matrix of organs. Within the lung, airway and parenchymal fibroblasts are crucial for lung development and are altered with disease,...

    Authors: Rachel L. Clifford, Chen Xi Yang, Nick Fishbane, Jamie Patel, Julia L. MacIsaac, Lisa M. McEwen, Sean T. May, Marcos Castellanos-Uribe, Parameswaran Nair, Ma’en Obeidat, Michael S. Kobor, Alan J. Knox and Tillie-Louise Hackett
    Citation: Clinical Epigenetics 2020 12:145
  38. Metabolically healthy obesity (MHO) is a considerably controversial concept as it is considered a transitory condition towards the development of different pathologies (type 2 diabetes, insulin resistance, or ...

    Authors: Cristina Gallardo-Escribano, Verónica Buonaiuto, M. Isabel Ruiz-Moreno, Antonio Vargas-Candela, Alberto Vilches-Perez, Javier Benitez-Porres, Angel Ramon Romance-Garcia, Alejandro Ruiz-Moreno, Ricardo Gomez-Huelgas and M. Rosa Bernal-Lopez
    Citation: Clinical Epigenetics 2020 12:144
  39. Accessible chromatin plays a central role in gene expression and chromatin architecture. Current accessible chromatin approaches depend on limited digestion/cutting and pasting adaptors at the accessible DNA, ...

    Authors: Hang Gyeong Chin, Zhiyi Sun, Udayakumar S. Vishnu, Pengying Hao, Paloma Cejas, George Spracklin, Pierre-Olivier Estève, Shuang-yong Xu, Henry W. Long and Sriharsa Pradhan
    Citation: Clinical Epigenetics 2020 12:143
  40. Epigenetic reprogramming using DNA demethylating drugs is a promising approach for cancer therapy, but its efficacy is highly dependent on the dosing regimen. Low-dose treatment for a prolonged period shows a ...

    Authors: Hideyuki Takeshima, Yukie Yoda, Mika Wakabayashi, Naoko Hattori, Satoshi Yamashita and Toshikazu Ushijima
    Citation: Clinical Epigenetics 2020 12:142
  41. Disruption of the hypothalamic–pituitary–adrenal (HPA) axis, a neuroendocrine system associated with the stress response, has been hypothesized to contribute to obesity development. This may be mediated throug...

    Authors: Tarryn Willmer, Julia H. Goedecke, Stephanie Dias, Johan Louw and Carmen Pheiffer
    Citation: Clinical Epigenetics 2020 12:141
  42. Cocaine use accelerates human immunodeficiency virus (HIV) progression and worsens HIV outcomes. We assessed whether DNA methylation in blood mediates the association between cocaine use and HIV severity in a ...

    Authors: Chang Shu, Amy C. Justice, Xinyu Zhang, Zuoheng Wang, Dana B. Hancock, Eric O. Johnson and Ke Xu
    Citation: Clinical Epigenetics 2020 12:140
  43. PADI6 is a component of the subcortical maternal complex, a group of proteins that is abundantly expressed in the oocyte cytoplasm, but is required for the correct development of early embryo. Maternal-effect ...

    Authors: Maria Vittoria Cubellis, Laura Pignata, Ankit Verma, Angela Sparago, Rosita Del Prete, Maria Monticelli, Luciano Calzari, Vincenzo Antona, Daniela Melis, Romano Tenconi, Silvia Russo, Flavia Cerrato and Andrea Riccio
    Citation: Clinical Epigenetics 2020 12:139
  44. Inflammation has been associated with higher rates of recurrence and mortality in head and neck cancer (HNC). While the biological mechanisms predisposing patients to heightened inflammatory states remain larg...

    Authors: Laura Moody, Sylvia L. Crowder, Andrew D. Fruge, Julie L. Locher, Wendy Demark-Wahnefried, Laura Q. Rogers, Ashley Delk-Licata, William R. Carroll, Sharon A. Spencer, Molly Black, John W. Erdman Jr, Hong Chen, Yuan-Xiang Pan and Anna E. Arthur
    Citation: Clinical Epigenetics 2020 12:138
  45. Mitochondrial dysregulation and aberrant epigenetic mechanisms have been frequently reported in neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), and several researchers suggested that...

    Authors: Andrea Stoccoro, Adam R. Smith, Lorena Mosca, Alessandro Marocchi, Francesca Gerardi, Christian Lunetta, Cristina Cereda, Stella Gagliardi, Katie Lunnon, Lucia Migliore and Fabio Coppedè
    Citation: Clinical Epigenetics 2020 12:137