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  1. There exist two paradigms about the nature of cancer. According to the generally accepted one, cancer is a by-product of design limitations of a multi-cellular organism (Greaves, Nat Rev Cancer 7:213–221, 2007...

    Authors: Anatoly V. Lichtenstein
    Citation: Clinical Epigenetics 2010 1:10
  2. Histone modifications have widely been implicated in cancer development and progression and are potentially reversible by drug treatments. The N-terminal tails of each histone extend outward through the DNA st...

    Authors: Francesco Paolo Tambaro, Carmela Dell’Aversana, Vincenzo Carafa, Angela Nebbioso, Branka Radic, Felicetto Ferrara and Lucia Altucci
    Citation: Clinical Epigenetics 2010 1:6
  3. This study examined molecular (DNA hypermethylation), clinical, histopathological, demographical, smoking, and alcohol variables to assess diagnosis (early versus late stage) and prognosis (survival) outcomes ...

    Authors: Josena K. Stephen, Kang Mei Chen, Veena Shah, Shaleta Havard, Alissa Kapke, Mei Lu, Michael S. Benninger and Maria J. Worsham
    Citation: Clinical Epigenetics 2010 1:5
  4. The analysis and visualisation of research data in an environment which is most similar to living conditions belong to the most challenging claims of present scientific research endeavours. To date, the effect...

    Authors: Christian-Lars Dransfeld, Hamed Alborzinia, Stefan Wölfl and Ulrich Mahlknecht
    Citation: Clinical Epigenetics 2010 1:4
  5. Chromatin remodeling and gene expression are regulated by histone deacetylases (HDACs) that condense the chromatin structure by deacetylating histones. HDACs comprise a group of enzymes that are responsible fo...

    Authors: Georges Herbein and Daniel Wendling
    Citation: Clinical Epigenetics 2010 1:3
  6. microRNAs are endogenous noncoding RNAs that are implicated in gene regulation. More recently, miRNAs have been shown to play a pivotal role in multiple cellular processes that interfere with tumorigenesis. He...

    Authors: Salma Essa, N. Denzer, U. Mahlknecht, R. Klein, E. M. Collnot and J. Reichrath
    Citation: Clinical Epigenetics 2010 1:1