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  1. The myeloproliferative neoplasms (MPNs) are a group of clonal hematological malignancies characterized by a hypercellular bone marrow and a tendency to develop thrombotic complications and to evolve to myelofi...

    Authors: John Mascarenhas, Nitin Roper, Pratima Chaurasia and Ronald Hoffman
    Citation: Clinical Epigenetics 2011 2:50
  2. Head and neck cancer (HNC) is a heterogenous and complex entity including diverse anatomical sites and a variety of tumor types displaying unique characteristics and different etilogies. Both environmental and...

    Authors: Semra Demokan and Nejat Dalay
    Citation: Clinical Epigenetics 2011 2:45
  3. Chemoresistance is one of the major hurdles to overcome for the successful treatment of breast cancer. At present, there are several mechanisms proposed to explain drug resistance to chemotherapeutic agents, i...

    Authors: Kristy R. Kutanzi, Olga V. Yurchenko, Frederick A. Beland, Vasyl’ F. Checkhun and Igor P. Pogribny
    Citation: Clinical Epigenetics 2011 2:40
  4. A sequence variant of histone H2A called H2AX is one of the key components of chromatin involved in DNA damage response induced by different genotoxic stresses. Phosphorylated H2AX (γH2AX) is rapidly concentra...

    Authors: Denis V. Firsanov, Liudmila V. Solovjeva and Maria P. Svetlova
    Citation: Clinical Epigenetics 2011 2:44
  5. Epigenetic mechanisms such as DNA hypermethylation and modifications of histone amino acids are known to play an important role in the control of gene expression both in normal human development and tumorigene...

    Authors: Christoph Oing, Edgar Jost, Edgar Dahl, Stefan Wilop, Tim H. Brümmendorf and Oliver Galm
    Citation: Clinical Epigenetics 2011 2:43
  6. Prostate cancer is a commonly diagnosed cancer in men and a leading cause of cancer deaths. Whilst the underlying mechanisms leading to prostate cancer are still to be determined, it is evident that both genet...

    Authors: Suyin P. Chin, Joanne L. Dickinson and Adele F. Holloway
    Citation: Clinical Epigenetics 2011 2:41
  7. DNA methylation plays an integral role in development and aging through epigenetic regulation of genome function. DNA methyltransferase 1 (Dnmt1) is the most prevalent DNA methyltransferase that maintains geno...

    Authors: Liang Liu, Thomas van Groen, Inga Kadish, Yuanyuan Li, Deli Wang, Smitha R. James, Adam R. Karpf and Trygve O. Tollefsbol
    Citation: Clinical Epigenetics 2011 2:42
  8. Elevated activation of the platelet-derived growth factor (PDGF) pathway, apoptosis evasion phenotype, and global DNA hypomethylation are hallmarks frequently observed in cancers, such as in low-grade glioma (...

    Authors: Emilie Debien, Eric Hervouet, Fabien Gautier, Philippe Juin, Francois M. Vallette and Pierre-Francois Cartron
    Citation: Clinical Epigenetics 2011 2:35
  9. Epigenetic mechanisms are thought to play a major role in the pathogenesis of the major psychoses (schizophrenia and bipolar disorder), and they may be the link between the environment and the genome in the pa...

    Authors: Jacob Peedicayil
    Citation: Clinical Epigenetics 2011 2:38
  10. Mucins are high molecular weight glycoproteins that play important roles in diagnostic and prognostic prediction and in carcinogenesis and tumor invasion. Regulation of expression of mucin genes has been studi...

    Authors: Norishige Yamada, Sho Kitamoto, Seiya Yokoyama, Tomofumi Hamada, Masamichi Goto, Hideaki Tsutsumida, Michiyo Higashi and Suguru Yonezawa
    Citation: Clinical Epigenetics 2011 2:37
  11. This review presents an epigenetic view on complex factors leading to development and perception of “genius.” There is increasing evidence which indicates that artistic creativity is influenced by epigenetic p...

    Authors: Heidrun Karlic and Pia Baurek
    Citation: Clinical Epigenetics 2011 2:33
  12. 5-azacytidine (AZA) has become standard treatment for patients with higher-risk myelodysplastic syndrome (MDS). Response rate is about 50% and response duration is limited. Histone deactylase (HDAC) inhibitors...

    Authors: Andrea Kuendgen, Gesine Bug, Oliver G. Ottmann, Detlef Haase, Julie Schanz, Barbara Hildebrandt, Kathrin Nachtkamp, Judith Neukirchen, Ariane Dienst, Rainer Haas, Ulrich Germing and Norbert Gattermann
    Citation: Clinical Epigenetics 2011 2:31
  13. Fermentation of glucose to lactate in the presence of sufficient oxygen, known as aerobic glycolysis or Warburg effect, is a universal phenotype of cancer cells. Understanding its origin and role in cellular i...

    Authors: Paike Jayadeva Bhat, Lalit Darunte, Venkatesh Kareenhalli, Jaswandi Dandekar and Abhay Kumar
    Citation: Clinical Epigenetics 2011 2:30
  14. Lymphocytes from the peripheral blood of patients with prostate cancer—the most frequent (noncutaneous) tumor in men—display epigenetic aberrations (altered modes of allelic replication) characteristic of the ...

    Authors: Samuel Cytron, Evgeni Stepnov, Igor Bounkin, Maya Mashevich, Aviva Dotan and Lydia Avivi
    Citation: Clinical Epigenetics 2011 2:29
  15. About 15–20% of human cancers worldwide have viral etiology. Emerging data clearly indicate that several human DNA and RNA viruses, such as human papillomavirus, Epstein–Barr virus, Kaposi’s sarcoma-associated...

    Authors: Elzbieta Poreba, Justyna Karolina Broniarczyk and Anna Gozdzicka-Jozefiak
    Citation: Clinical Epigenetics 2011 2:26
  16. S100 proteins are small, calcium-binding proteins whose genes are localized in a cluster on human chromosome 1. Through their ability to interact with various protein partners in a calcium-dependent manner, th...

    Authors: Wiesława Leśniak
    Citation: Clinical Epigenetics 2011 2:23
  17. Low folate intake is associated with vascular disease. Causality has been attributed to hyperhomocysteinemia. However, human intervention trials have failed to show the benefit of homocysteine-lowering therapi...

    Authors: Chris J. McNeil, John H. Beattie, M-J Gordon, Lynn P. Pirie and Susan J. Duthie
    Citation: Clinical Epigenetics 2011 2:22
  18. Cyclin D1 is a cell cycle machine, a sensor of extracellular signals and plays an important role in G1-S phase progression. The human cyclin D1 promoter contains multiple transcription factor binding sites suc...

    Authors: Zhi-yi Guo, Xiao-hui Hao, Fei-Fei Tan, Xin Pei, Li-Mei Shang, Xue-lian Jiang and Fang Yang
    Citation: Clinical Epigenetics 2011 2:18
  19. The bioactive vitamin D (VD) metabolite, 1,25-dihydroxyvitamin D3 regulates essential pathways of cellular metabolism and differentiation via its nuclear receptor (VDR). Molecular mechanisms which are known to pl...

    Authors: Heidrun Karlic and Franz Varga
    Citation: Clinical Epigenetics 2011 2:21
  20. Histone deacetylases (HDACs) are homologous to prokaryotic enzymes that removed acetyl groups from non-histone proteins before the evolution of eukaryotic histones. Enzymes inherited from prokaryotes or from a...

    Authors: Gregory W. Peek and Trygve O. Tollefsbol
    Citation: Clinical Epigenetics 2011 2:20
  21. Epigenetic marks are well recognized as heritable chemical modifications of DNA and chromatin that induce chromatin structural changes thereby affecting gene activity. A lesser-known phenomenon is the pervasiv...

    Authors: Emily L. Putiri and Keith D. Robertson
    Citation: Clinical Epigenetics 2010 2:17
  22. Considering psychiatry as a medical discipline, a diagnosis identifying a disorder should lead to an effective therapy. Such presumed causality is the basis of evidence-based psychiatry. We examined the streng...

    Authors: Drozdstoy Stojanov, Jakob Korf, Peter de Jonge and Georgi Popov
    Citation: Clinical Epigenetics 2010 2:14
  23. There exist two paradigms about the nature of cancer. According to the generally accepted one, cancer is a by-product of design limitations of a multi-cellular organism (Greaves, Nat Rev Cancer 7:213–221, 2007...

    Authors: Anatoly V. Lichtenstein
    Citation: Clinical Epigenetics 2010 1:10
  24. Aging is the natural trace that time leaves behind on life during blossom and maturation, culminating in senescence and death. This process is accompanied by a decline in the healthy function of multiple organ...

    Authors: Susanne Voelter-Mahlknecht and Ulrich Mahlknecht
    Citation: Clinical Epigenetics 2010 1:8
  25. Histone modifications have widely been implicated in cancer development and progression and are potentially reversible by drug treatments. The N-terminal tails of each histone extend outward through the DNA st...

    Authors: Francesco Paolo Tambaro, Carmela Dell’Aversana, Vincenzo Carafa, Angela Nebbioso, Branka Radic, Felicetto Ferrara and Lucia Altucci
    Citation: Clinical Epigenetics 2010 1:6
  26. This study examined molecular (DNA hypermethylation), clinical, histopathological, demographical, smoking, and alcohol variables to assess diagnosis (early versus late stage) and prognosis (survival) outcomes ...

    Authors: Josena K. Stephen, Kang Mei Chen, Veena Shah, Shaleta Havard, Alissa Kapke, Mei Lu, Michael S. Benninger and Maria J. Worsham
    Citation: Clinical Epigenetics 2010 1:5
  27. The analysis and visualisation of research data in an environment which is most similar to living conditions belong to the most challenging claims of present scientific research endeavours. To date, the effect...

    Authors: Christian-Lars Dransfeld, Hamed Alborzinia, Stefan Wölfl and Ulrich Mahlknecht
    Citation: Clinical Epigenetics 2010 1:4
  28. Chromatin remodeling and gene expression are regulated by histone deacetylases (HDACs) that condense the chromatin structure by deacetylating histones. HDACs comprise a group of enzymes that are responsible fo...

    Authors: Georges Herbein and Daniel Wendling
    Citation: Clinical Epigenetics 2010 1:3
  29. microRNAs are endogenous noncoding RNAs that are implicated in gene regulation. More recently, miRNAs have been shown to play a pivotal role in multiple cellular processes that interfere with tumorigenesis. He...

    Authors: Salma Essa, N. Denzer, U. Mahlknecht, R. Klein, E. M. Collnot and J. Reichrath
    Citation: Clinical Epigenetics 2010 1:1