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  1. Epigenome-wide association studies (EWAS) have identified DNA methylation loci involved in adiposity. However, EWAS on adiposity in sub-Saharan Africans are lacking despite the high burden of adiposity among A...

    Authors: Karlijn A.C. Meeks, Peter Henneman, Andrea Venema, Tom Burr, Cecilia Galbete, Ina Danquah, Matthias B. Schulze, Frank P. Mockenhaupt, Ellis Owusu-Dabo, Charles N. Rotimi, Juliet Addo, Liam Smeeth, Silver Bahendeka, Joachim Spranger, Marcel M.A.M. Mannens, Mohammad H. Zafarmand…
    Citation: Clinical Epigenetics 2017 9:103
  2. Given that metformin is the most common pharmacological therapy for type 2 diabetes, understanding the function of this drug is of great importance. Hepatic metformin transporters are responsible for the pharm...

    Authors: Sonia García-Calzón, Alexander Perfilyev, Ville Männistö, Vanessa D. de Mello, Emma Nilsson, Jussi Pihlajamäki and Charlotte Ling
    Citation: Clinical Epigenetics 2017 9:102
  3. Occult hepatitis B virus infection (OBI) is an important risk factor of liver cirrhosis and hepatocellular carcinoma. Type 1 interferon (IFN) signaling-related miRNAs were significantly associated with hepatit...

    Authors: Yiying Wang, Peifu Zhu, Jing Qiu, Jie Wang, Huijuan Zhu, Yinwei Zhu, Lige Zhang, Jie Zhu, Xingxiang Liu and Chen Dong
    Citation: Clinical Epigenetics 2017 9:101
  4. Genome-wide association studies (GWASs) have identified dozens of loci associated with gout, but for most cases, the risk genes and the underlying molecular mechanisms contributing to these associations are un...

    Authors: Zaihua Zhu, Weida Meng, Peiru Liu, Xiaoxia Zhu, Yun Liu and Hejian Zou
    Citation: Clinical Epigenetics 2017 9:99
  5. Respiratory diseases hold several genome, epigenome, and transcriptional aberrations as a cause of the accumulated damage promoted by, among others, environmental risk factors. Such aberrations can also come a...

    Authors: Abril Marcela Herrera-Solorio, Leonel Armas-López, Oscar Arrieta, Joaquín Zúñiga, Patricia Piña-Sánchez and Federico Ávila-Moreno
    Citation: Clinical Epigenetics 2017 9:98
  6. Head and neck squamous cell carcinoma (HNSCC) is the sixth most prevalent cancer worldwide with rates of HPV-positive oropharyngeal squamous cell carcinoma (OPSCC) dramatically increasing. The overexpression o...

    Authors: Cameron D. Lindsay, Morris A. Kostiuk, Jeff Harris, Daniel A. O’Connell, Hadi Seikaly and Vincent L. Biron
    Citation: Clinical Epigenetics 2017 9:95
  7. Patients with early colorectal cancer (stages I–II) generally have a good prognosis, but a subgroup of 15–20% experiences relapse and eventually die of disease. Occult metastases have been suggested as a marke...

    Authors: Guro E. Lind, Marianne Guriby, Terje Ahlquist, Israr Hussain, Marine Jeanmougin, Kjetil Søreide, Hartwig Kørner, Ragnhild A. Lothe and Oddmund Nordgård
    Citation: Clinical Epigenetics 2017 9:97
  8. Obesity is a disease that is caused by genetic and environmental factors. However, epigenetic mechanisms of obesity are less well known. DNA methylation provides a mechanism whereby environmental factors can i...

    Authors: Samantha E. Day, Luis A. Garcia, Richard L. Coletta, Latoya E. Campbell, Tonya R. Benjamin, Elena A. De Filippis, James A. Madura II, Lawrence J. Mandarino, Lori R. Roust and Dawn K. Coletta
    Citation: Clinical Epigenetics 2017 9:96
  9. Werner syndrome is a progeroid disorder characterized by premature age-related phenotypes. Although it is well established that autosomal recessive mutations in the WRN gene is responsible for Werner syndrome,...

    Authors: T. Guastafierro, M. G. Bacalini, A. Marcoccia, D. Gentilini, S. Pisoni, A. M. Di Blasio, A. Corsi, C. Franceschi, D. Raimondo, A. Spanò, P. Garagnani and F. Bondanini
    Citation: Clinical Epigenetics 2017 9:92
  10. Aberrant CpG island methylation has been increasingly recognized as a common event in myelodysplastic syndrome (MDS). To date, most of the previous studies of miR-124 in MDS have focused on epigenetic changes ...

    Authors: Hong Wang, Tong-Tong Zhang, Song Jin, Hong Liu, Xiang Zhang, Chang-Geng Ruan, De-Pei Wu, Yue Han and Xiao-Qin Wang
    Citation: Clinical Epigenetics 2017 9:91
  11. Imprinted domains have been identified as targets for aberrant DNA methylation during carcinogenesis, but it remains unclear when these epigenetic alterations occur and how they contribute to tumor progression...

    Authors: Corey L. Bretz, Ingeborg M. Langohr and Joomyeong Kim
    Citation: Clinical Epigenetics 2017 9:90
  12. Cornelia de Lange syndrome (CdLS) is a multisystem developmental disorder frequently associated with heterozygous loss-of-function mutations of Nipped-B-like (NIPBL), the human homolog of Drosophila Nipped-B. NIP...

    Authors: Daniel A. Newkirk, Yen-Yun Chen, Richard Chien, Weihua Zeng, Jacob Biesinger, Ebony Flowers, Shimako Kawauchi, Rosaysela Santos, Anne L. Calof, Arthur D. Lander, Xiaohui Xie and Kyoko Yokomori
    Citation: Clinical Epigenetics 2017 9:89
  13. DNA methylation has started a recent revolution in genomics biology by identifying key biomarkers for multiple cancers, including oral squamous cell carcinoma (OSCC), the most common head and neck squamous cel...

    Authors: Sipeng Shen, Guanrong Wang, Qianwen Shi, Ruyang Zhang, Yang Zhao, Yongyue Wei, Feng Chen and David C. Christiani
    Citation: Clinical Epigenetics 2017 9:88
  14. Methylation quantitative trait loci (mQTLs) are the genetic variants that may affect the DNA methylation patterns of CpG sites. However, their roles in influencing the disturbances of smoking-related epigeneti...

    Authors: Xu Gao, Hauke Thomsen, Yan Zhang, Lutz Philipp Breitling and Hermann Brenner
    Citation: Clinical Epigenetics 2017 9:87
  15. Excess adiposity in childhood is associated with numerous adverse health outcomes. As this condition is difficult to treat once present, identification of risk early in life can help inform and implement strat...

    Authors: Jacob K. Kresovich, Yinan Zheng, Andres Cardenas, Brian T. Joyce, Sheryl L. Rifas-Shiman, Emily Oken, Matthew W. Gillman, Marie-France Hivert, Andrea A. Baccarelli and Lifang Hou
    Citation: Clinical Epigenetics 2017 9:86
  16. Oral squamous cell carcinoma (OSCC) is usually diagnosed at an advanced stage and is commonly preceded by oral premalignant lesions. The mortality rates have remained unchanged (50% within 5 years after diagno...

    Authors: Luca Morandi, Davide Gissi, Achille Tarsitano, Sofia Asioli, Andrea Gabusi, Claudio Marchetti, Lucio Montebugnoli and Maria Pia Foschini
    Citation: Clinical Epigenetics 2017 9:85
  17. Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal lung disorder of unknown origin with a highly variable and unpredictable clinical course. Polymorphisms and environmentally induced epigenetic variat...

    Authors: J. Guiot, I. Struman, V. Chavez, M. Henket, M. Herzog, K. Scoubeau, N. Hardat, B. Bondue, JL. Corhay, C. Moermans and R. Louis
    Citation: Clinical Epigenetics 2017 9:84
  18. Many conventional chemotherapeutic drugs are known to be involved in DNA damage, thus ultimately leading to apoptosis of leukemic cells. However, they fail to completely eliminate leukemia stem cells (LSCs) du...

    Authors: Yin Li, Yan Wang, Yong Zhou, Jie Li, Kai Chen, Leisi Zhang, Manman Deng, Suqi Deng, Peng Li and Bing Xu
    Citation: Clinical Epigenetics 2017 9:83
  19. Lysine-specific demethylase 1A (LSD1) is a key regulator of the androgen (AR) and estrogen receptors (ER), and LSD1 levels correlate with tumor aggressiveness. Here, we demonstrate that LSD1 regulates vitamin ...

    Authors: Sebastiano Battaglia, Ellen Karasik, Bryan Gillard, Jennifer Williams, Trisha Winchester, Michael T. Moser, Dominic J Smiraglia and Barbara A. Foster
    Citation: Clinical Epigenetics 2017 9:82
  20. Accumulating evidence suggests that tobacco smoking affects the susceptibility to and severity of chronic periodontitis. Epigenetics may explain the role of smoking in the development and progress of periodont...

    Authors: Young-Dan Cho, Pil-Jong Kim, Hong-Gee Kim, Yang-Jo Seol, Yong-Moo Lee, Young Ku, In-Chul Rhyu and Hyun-Mo Ryoo
    Citation: Clinical Epigenetics 2017 9:81
  21. The epithelial-to-mesenchymal transition (EMT) enables epithelial cancer cells to acquire mesenchymal features and contributes to metastasis and resistance to treatment. This process involves epigenetic reprog...

    Authors: Emilie Evanno, Julie Godet, Nathalie Piccirilli, Joëlle Guilhot, Serge Milin, Jean Marc Gombert, Benoit Fouchaq and Joëlle Roche
    Citation: Clinical Epigenetics 2017 9:80
  22. Frozen-thawed embryo transfer (FET) is increasingly available for the improvement of the success rate of assisted reproductive technologies other than fresh embryo transfer (ET). There have been numerous findi...

    Authors: Hitoshi Hiura, Hiromitsu Hattori, Norio Kobayashi, Hiroaki Okae, Hatsune Chiba, Naoko Miyauchi, Akane Kitamura, Hiroyuki Kikuchi, Hiroaki Yoshida and Takahiro Arima
    Citation: Clinical Epigenetics 2017 9:79
  23. Systemic lupus erythematosus (SLE) is a chronic relapsing–remitting autoimmune disease with highly heterogeneous phenotypes. Biomarkers with high sensitivity and specificity are useful for early diagnosis as w...

    Authors: Zijun Wang, Christopher Chang, Mou Peng and Qianjin Lu
    Citation: Clinical Epigenetics 2017 9:78
  24. Epidemiological studies have shown that long-term exposure to paracetamol during pregnancy is associated with attention-deficit/hyperactivity disorder (ADHD). The mechanism by which paracetamol may modulate th...

    Authors: Kristina Gervin, Hedvig Nordeng, Eivind Ystrom, Ted Reichborn-Kjennerud and Robert Lyle
    Citation: Clinical Epigenetics 2017 9:77
  25. Cord blood is a commonly used tissue in environmental, genetic, and epigenetic population studies due to its ready availability and potential to inform on a sensitive period of human development. However, the ...

    Authors: Alexander M. Morin, Evan Gatev, Lisa M. McEwen, Julia L. MacIsaac, David T. S. Lin, Nastassja Koen, Darina Czamara, Katri Räikkönen, Heather J. Zar, Karestan Koenen, Dan J. Stein, Michael S. Kobor and Meaghan J. Jones
    Citation: Clinical Epigenetics 2017 9:75
  26. Changes in DNA methylation, one of the most studied epigenetic mechanisms, are considered an initial marker for early cancer detection. We evaluated how availability of dietary factors (folates and vitamin B12...

    Authors: Hugo Sanchez, Mohammad B. Hossain, Lydia Lera, Sandra Hirsch, Cecilia Albala, Ricardo Uauy, Karin Broberg and Ana M. Ronco
    Citation: Clinical Epigenetics 2017 9:74
  27. Most DNA cancer methylation markers are based on the transcriptional regulation of the promoter-gene relationship. Recently, the importance of long-range interactions between distal CpGs and target genes has b...

    Authors: Seong-Min Park, Eun-Young Choi, Mingyun Bae, Jung Kyoon Choi and Youn-Jae Kim
    Citation: Clinical Epigenetics 2017 9:73
  28. The aim of this study was to explore the clinical utility of microRNAs (miRNAs) as improved markers of ovarian granulosa cell tumours (GCTs) for cancer diagnosis and prognosis prediction. Current histopatholog...

    Authors: Wei-Tzu Cheng, Roseanne Rosario, Anita Muthukaruppan, Michelle K Wilson, Kathryn Payne, Peter C. Fong, Andrew N. Shelling and Cherie Blenkiron
    Citation: Clinical Epigenetics 2017 9:72
  29. Although many genetic variants have been associated with multiple sclerosis (MS) risk, they do not explain all the disease risk and there remains uncertainty as to how these variants contribute to disease. DNA...

    Authors: Vicki E. Maltby, Rodney A. Lea, Katherine A. Sanders, Nicole White, Miles C. Benton, Rodney J. Scott and Jeannette Lechner-Scott
    Citation: Clinical Epigenetics 2017 9:71
  30. The DNA modification 5-hydroxymethylcytosine (5hmC) is now referred to as the sixth base of DNA with evidence of tissue-specific patterns and correlation with gene regulation and expression. This epigenetic ma...

    Authors: Noa Gilat, Tzlil Tabachnik, Amit Shwartz, Tamar Shahal, Dmitry Torchinsky, Yael Michaeli, Gil Nifker, Shahar Zirkin and Yuval Ebenstein
    Citation: Clinical Epigenetics 2017 9:70
  31. Aberrations in histone post-translational modifications (hPTMs) have been linked with various pathologies, including cancer, and could not only represent useful biomarkers but also suggest possible targetable ...

    Authors: Roberta Noberini, Rémi Longuespée, Cristina Richichi, Giancarlo Pruneri, Mark Kriegsmann, Giuliana Pelicci and Tiziana Bonaldi
    Citation: Clinical Epigenetics 2017 9:69
  32. The BDNF gene codes for brain-derived neurotrophic factor, a growth factor involved in neural development, cell differentiation, and synaptic plasticity. Present in both the brain and periphery, BDNF plays critic...

    Authors: Darlene A. Kertes, Samarth S. Bhatt, Hayley S. Kamin, David A. Hughes, Nicole C. Rodney and Connie J. Mulligan
    Citation: Clinical Epigenetics 2017 9:68
  33. Ageing is the main risk factor for human neurological disorders. Among the diverse molecular pathways that govern ageing, epigenetics can guide age-associated decline in part by regulating gene expression and ...

    Authors: Raúl Delgado-Morales, Roberto Carlos Agís-Balboa, Manel Esteller and María Berdasco
    Citation: Clinical Epigenetics 2017 9:67
  34. Fetal development largely depends on thyroid hormone availability and proper placental function with an important role played by placental mitochondria. The biological mechanisms by which thyroid hormones exer...

    Authors: Bram G. Janssen, Hyang-Min Byun, Harry A. Roels, Wilfried Gyselaers, Joris Penders, Andrea A. Baccarelli and Tim S. Nawrot
    Citation: Clinical Epigenetics 2017 9:66
  35. Physical activity is associated with improvement in lung function; however, pollution exposure during physical activity can lead to a transient reduction in lung function. This paradoxical relationship may be ...

    Authors: Stephanie Lovinsky-Desir, Kyung Hwa Jung, Jacqueline R. Jezioro, David Z. Torrone, Mariangels de Planell-Saguer, Beizhan Yan, Frederica P. Perera, Andrew G. Rundle, Matthew S. Perzanowski, Steven N. Chillrud and Rachel L. Miller
    Citation: Clinical Epigenetics 2017 9:65
  36. This study examined Sal-like protein (SALL)3 methylation profiles of head and neck cancer (HNSCC) patients at diagnosis and follow-up and evaluated their prognostic significance and value as a biomarker. SALL3 ex...

    Authors: Kiyoshi Misawa, Daiki Mochizuki, Atsushi Imai, Yuki Misawa, Shiori Endo, Masato Mima, Hideya Kawasaki, Thomas E. Carey and Takeharu Kanazawa
    Citation: Clinical Epigenetics 2017 9:64
  37. Epigenetic data could help identify risk factors for orofacial clefts, either by revealing a causal role for epigenetic mechanisms in causing clefts or by capturing information about causal genetic or environm...

    Authors: Gemma C. Sharp, Karen Ho, Amy Davies, Evie Stergiakouli, Kerry Humphries, Wendy McArdle, Jonathan Sandy, George Davey Smith, Sarah J. Lewis and Caroline L. Relton
    Citation: Clinical Epigenetics 2017 9:63
  38. Hypericin-mediated photodynamic therapy (HY-PDT) has recently captured increased attention as an alternative minimally invasive anticancer treatment, although cancer cells may acquire resistance. Therefore, co...

    Authors: Andrea Halaburková, Rastislav Jendželovský, Ján Kovaľ, Zdenko Herceg, Peter Fedoročko and Akram Ghantous
    Citation: Clinical Epigenetics 2017 9:62
  39. Asthma gene DNA methylation may underlie the effects of air pollution on airway inflammation. However, the temporality and individual susceptibility to environmental epigenetic regulation of asthma has not bee...

    Authors: Kyung Hwa Jung, Stephanie Lovinsky-Desir, Beizhan Yan, David Torrone, Jennifer Lawrence, Jacqueline R. Jezioro, Matthew Perzanowski, Frederica P. Perera, Steven N. Chillrud and Rachel L. Miller
    Citation: Clinical Epigenetics 2017 9:61
  40. Lung cancer is the leading cause of cancer-related deaths with 1.8 million new cases each year and poor 5-year prognosis. Promoter hypermethylation of tumour suppressors leads to their inactivation and thereby...

    Authors: Antje M. Richter, Steffen Kiehl, Nicole Köger, Janina Breuer, Thorsten Stiewe and Reinhard H. Dammann
    Citation: Clinical Epigenetics 2017 9:60
  41. Inclusion of new biomarkers to improve a personalized treatment approach for oropharyngeal squamous cell carcinoma (OPSCC) is urgently needed. Hypomethylation of the Long interspersed nucleotide element-1 (LIN...

    Authors: Carlo Furlan, Jerry Polesel, Luigi Barzan, Giovanni Franchin, Sandro Sulfaro, Salvatore Romeo, Francesca Colizzi, Aurora Rizzo, Vittorio Baggio, Vittorio Giacomarra, Angelo Paolo Dei Tos, Paolo Boscolo-Rizzo, Emanuela Vaccher, Riccardo Dolcetti, Luca Sigalotti and Elisabetta Fratta
    Citation: Clinical Epigenetics 2017 9:58
  42. In chronic lymphocytic leukemia (CLL), epigenomic and genomic studies have expanded the existing knowledge about the disease biology and led to the identification of potential biomarkers relevant for implement...

    Authors: Lata Rani, Nitin Mathur, Ritu Gupta, Ajay Gogia, Gurvinder Kaur, Jaspreet Kaur Dhanjal, Durai Sundar, Lalit Kumar and Atul Sharma
    Citation: Clinical Epigenetics 2017 9:57
  43. Numerous pulmonary diseases manifest with upper lobe predominance including cystic fibrosis, smoking-related chronic obstructive pulmonary disease, and tuberculosis. Zonal hypoxia, characteristic of these pulm...

    Authors: David A. Armstrong, Amanda B. Nymon, Carol S. Ringelberg, Corina Lesseur, Haley F. Hazlett, Louisa Howard, Carmen J. Marsit and Alix Ashare
    Citation: Clinical Epigenetics 2017 9:56
  44. Two molecular pathways promote the development of colorectal cancer (CRC). One is termed “microsatellite stable” (MSS) whereas the other is characterized by “microsatellite instability” (MSI or MIN). In additi...

    Authors: Tamotsu Sugai, Masakazu Yoshida, Makoto Eizuka, Noriyuki Uesugii, Wataru Habano, Kouki Otsuka, Akira Sasaki, Eiichiro Yamamoto, Takayuki Matsumoto and Hiromu Suzuki
    Citation: Clinical Epigenetics 2017 9:55
  45. Colonoscopy is currently widely accepted as the gold standard for detection of colorectal cancer (CRC) providing detection of up to 95% of pre-cancerous lesions during the procedure. However, certain limitatio...

    Authors: Jean-François Rahier, Anne Druez, Laurence Faugeras, Jean-Paul Martinet, Myriam Géhénot, Eléonore Josseaux, Marielle Herzog, Jake Micallef, Fabienne George, Monique Delos, Thierry De Ronde, Abdenor Badaoui and Lionel D’Hondt
    Citation: Clinical Epigenetics 2017 9:53