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  1. Content type: Review

    The myeloproliferative neoplasms (MPNs) are a group of clonal hematological malignancies characterized by a hypercellular bone marrow and a tendency to develop thrombotic complications and to evolve to myelofi...

    Authors: John Mascarenhas, Nitin Roper, Pratima Chaurasia and Ronald Hoffman

    Citation: Clinical Epigenetics 2011 2:50

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  2. Content type: Review

    Head and neck cancer (HNC) is a heterogenous and complex entity including diverse anatomical sites and a variety of tumor types displaying unique characteristics and different etilogies. Both environmental and...

    Authors: Semra Demokan and Nejat Dalay

    Citation: Clinical Epigenetics 2011 2:45

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  3. Content type: Review

    Chemoresistance is one of the major hurdles to overcome for the successful treatment of breast cancer. At present, there are several mechanisms proposed to explain drug resistance to chemotherapeutic agents, i...

    Authors: Kristy R. Kutanzi, Olga V. Yurchenko, Frederick A. Beland, Vasyl’ F. Checkhun and Igor P. Pogribny

    Citation: Clinical Epigenetics 2011 2:40

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  4. Content type: Original Article

    DNA methylation plays an integral role in development and aging through epigenetic regulation of genome function. DNA methyltransferase 1 (Dnmt1) is the most prevalent DNA methyltransferase that maintains geno...

    Authors: Liang Liu, Thomas van Groen, Inga Kadish, Yuanyuan Li, Deli Wang, Smitha R. James, Adam R. Karpf and Trygve O. Tollefsbol

    Citation: Clinical Epigenetics 2011 2:42

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  5. Content type: Review

    Epigenetic mechanisms are thought to play a major role in the pathogenesis of the major psychoses (schizophrenia and bipolar disorder), and they may be the link between the environment and the genome in the pa...

    Authors: Jacob Peedicayil

    Citation: Clinical Epigenetics 2011 2:38

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  6. Content type: Original Article

    5-azacytidine (AZA) has become standard treatment for patients with higher-risk myelodysplastic syndrome (MDS). Response rate is about 50% and response duration is limited. Histone deactylase (HDAC) inhibitors...

    Authors: Andrea Kuendgen, Gesine Bug, Oliver G. Ottmann, Detlef Haase, Julie Schanz, Barbara Hildebrandt, Kathrin Nachtkamp, Judith Neukirchen, Ariane Dienst, Rainer Haas, Ulrich Germing and Norbert Gattermann

    Citation: Clinical Epigenetics 2011 2:31

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  7. Content type: Review

    Fermentation of glucose to lactate in the presence of sufficient oxygen, known as aerobic glycolysis or Warburg effect, is a universal phenotype of cancer cells. Understanding its origin and role in cellular i...

    Authors: Paike Jayadeva Bhat, Lalit Darunte, Venkatesh Kareenhalli, Jaswandi Dandekar and Abhay Kumar

    Citation: Clinical Epigenetics 2011 2:30

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  8. Content type: Review

    About 15–20% of human cancers worldwide have viral etiology. Emerging data clearly indicate that several human DNA and RNA viruses, such as human papillomavirus, Epstein–Barr virus, Kaposi’s sarcoma-associated...

    Authors: Elzbieta Poreba, Justyna Karolina Broniarczyk and Anna Gozdzicka-Jozefiak

    Citation: Clinical Epigenetics 2011 2:26

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  9. Content type: Review

    Cyclin D1 is a cell cycle machine, a sensor of extracellular signals and plays an important role in G1-S phase progression. The human cyclin D1 promoter contains multiple transcription factor binding sites suc...

    Authors: Zhi-yi Guo, Xiao-hui Hao, Fei-Fei Tan, Xin Pei, Li-Mei Shang, Xue-lian Jiang and Fang Yang

    Citation: Clinical Epigenetics 2011 2:18

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  10. Content type: Review

    The bioactive vitamin D (VD) metabolite, 1,25-dihydroxyvitamin D3 regulates essential pathways of cellular metabolism and differentiation via its nuclear receptor (VDR). Molecular mechanisms which are known to pl...

    Authors: Heidrun Karlic and Franz Varga

    Citation: Clinical Epigenetics 2011 2:21

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  11. Content type: Review

    Histone deacetylases (HDACs) are homologous to prokaryotic enzymes that removed acetyl groups from non-histone proteins before the evolution of eukaryotic histones. Enzymes inherited from prokaryotes or from a...

    Authors: Gregory W. Peek and Trygve O. Tollefsbol

    Citation: Clinical Epigenetics 2011 2:20

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  12. Content type: Review

    Epigenetic marks are well recognized as heritable chemical modifications of DNA and chromatin that induce chromatin structural changes thereby affecting gene activity. A lesser-known phenomenon is the pervasiv...

    Authors: Emily L. Putiri and Keith D. Robertson

    Citation: Clinical Epigenetics 2010 2:17

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  13. Content type: Review

    Considering psychiatry as a medical discipline, a diagnosis identifying a disorder should lead to an effective therapy. Such presumed causality is the basis of evidence-based psychiatry. We examined the streng...

    Authors: Drozdstoy Stojanov, Jakob Korf, Peter de Jonge and Georgi Popov

    Citation: Clinical Epigenetics 2010 2:14

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  14. Content type: Review

    There exist two paradigms about the nature of cancer. According to the generally accepted one, cancer is a by-product of design limitations of a multi-cellular organism (Greaves, Nat Rev Cancer 7:213–221, 2007...

    Authors: Anatoly V. Lichtenstein

    Citation: Clinical Epigenetics 2010 1:10

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  15. Content type: Review

    Aging is the natural trace that time leaves behind on life during blossom and maturation, culminating in senescence and death. This process is accompanied by a decline in the healthy function of multiple organ...

    Authors: Susanne Voelter-Mahlknecht and Ulrich Mahlknecht

    Citation: Clinical Epigenetics 2010 1:8

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  16. Content type: Review

    Histone modifications have widely been implicated in cancer development and progression and are potentially reversible by drug treatments. The N-terminal tails of each histone extend outward through the DNA st...

    Authors: Francesco Paolo Tambaro, Carmela Dell’Aversana, Vincenzo Carafa, Angela Nebbioso, Branka Radic, Felicetto Ferrara and Lucia Altucci

    Citation: Clinical Epigenetics 2010 1:6

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  17. Content type: Original Article

    This study examined molecular (DNA hypermethylation), clinical, histopathological, demographical, smoking, and alcohol variables to assess diagnosis (early versus late stage) and prognosis (survival) outcomes ...

    Authors: Josena K. Stephen, Kang Mei Chen, Veena Shah, Shaleta Havard, Alissa Kapke, Mei Lu, Michael S. Benninger and Maria J. Worsham

    Citation: Clinical Epigenetics 2010 1:5

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  18. Content type: Original article

    The analysis and visualisation of research data in an environment which is most similar to living conditions belong to the most challenging claims of present scientific research endeavours. To date, the effect...

    Authors: Christian-Lars Dransfeld, Hamed Alborzinia, Stefan Wölfl and Ulrich Mahlknecht

    Citation: Clinical Epigenetics 2010 1:4

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  19. Content type: Review

    Chromatin remodeling and gene expression are regulated by histone deacetylases (HDACs) that condense the chromatin structure by deacetylating histones. HDACs comprise a group of enzymes that are responsible fo...

    Authors: Georges Herbein and Daniel Wendling

    Citation: Clinical Epigenetics 2010 1:3

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  20. Content type: Review

    microRNAs are endogenous noncoding RNAs that are implicated in gene regulation. More recently, miRNAs have been shown to play a pivotal role in multiple cellular processes that interfere with tumorigenesis. He...

    Authors: Salma Essa, N. Denzer, U. Mahlknecht, R. Klein, E. M. Collnot and J. Reichrath

    Citation: Clinical Epigenetics 2010 1:1

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