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  1. Even if genetics play an important role, individual variation in stature remains unexplained at the molecular level. Indeed, genome-wide association study (GWAS) have revealed hundreds of variants that contrib...

    Authors: Meriem Ouni, Yasemin Gunes, Marie-Pierre Belot, Anne-Laure Castell, Delphine Fradin and Pierre Bougnères

    Citation: Clinical Epigenetics 2015 7:22

    Content type: Research

    Published on:

  2. Preeclampsia is one of the leading causes of fetal and maternal morbidity and mortality worldwide. Preterm babies of mothers with early onset preeclampsia (EOPE) are at higher risks for various diseases later ...

    Authors: Travers Ching, James Ha, Min-Ae Song, Maarit Tiirikainen, Janos Molnar, Marla J Berry, Dena Towner and Lana X Garmire

    Citation: Clinical Epigenetics 2015 7:21

    Content type: Research

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  3. Altered expression of microRNAs (miRNAs) commonly accompanies colorectal (CRC) and endometrial carcinoma (EC) development, but the underlying mechanisms and clinicopathological correlations remain to be clarif...

    Authors: Sippy Kaur, Johanna E Lotsari, Sam Al-Sohaily, Janindra Warusavitarne, Maija RJ Kohonen-Corish and Päivi Peltomäki

    Citation: Clinical Epigenetics 2015 7:20

    Content type: Research

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  4. Primary cells enter replicative senescence after a limited number of cell divisions. This process needs to be considered in cell culture experiments, and it is particularly important for regenerative medicine....

    Authors: Sonja Hänzelmann, Fabian Beier, Eduardo G Gusmao, Carmen M Koch, Sebastian Hummel, Iryna Charapitsa, Sylvia Joussen, Vladimir Benes, Tim H Brümmendorf, George Reid, Ivan G Costa and Wolfgang Wagner

    Citation: Clinical Epigenetics 2015 7:19

    Content type: Research

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  5. Hypomethylation of long interspersed element (LINE)-1 has been observed in tumorigenesis when using degenerate assays, which provide an average across all repeats. However, it is unknown whether individual LIN...

    Authors: Nicole Nüsgen, Wolfgang Goering, Albertas Dauksa, Arijit Biswas, Muhammad Ahmer Jamil, Ioanna Dimitriou, Amit Sharma, Heike Singer, Rolf Fimmers, Holger Fröhlich, Johannes Oldenburg, Antanas Gulbinas, Wolfgang A Schulz and Osman El-Maarri

    Citation: Clinical Epigenetics 2015 7:17

    Content type: Research

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  6. Neuroblastoma (NB) is the most common extracranial pediatric solid tumor with a highly variable clinical course, ranging from spontaneous regression to life-threatening disease. Survival rates for high-risk NB...

    Authors: Yania Yáñez, Elena Grau, Virginia C Rodríguez-Cortez, David Hervás, Enrique Vidal, Rosa Noguera, Miguel Hernández, Vanessa Segura, Adela Cañete, Ana Conesa, Jaime Font de Mora and Victoria Castel

    Citation: Clinical Epigenetics 2015 7:16

    Content type: Research

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  7. Hepatocellular carcinoma (HCC) is among the most frequent human malignancies and a major cause of cancer-related death worldwide. It is characterized by late detection and fast progression, and it is believed ...

    Authors: Marie-Pierre Lambert, Pierre-Benoit Ancey, Davide Degli Esposti, Marie-Pierre Cros, Athena Sklias, Jean-Yves Scoazec, David Durantel, Hector Hernandez-Vargas and Zdenko Herceg

    Citation: Clinical Epigenetics 2015 7:15

    Content type: Research

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  8. The dietary supply of methyl donors such as folate, vitamin B12, betaine, methionine, and choline is essential for normal growth, development, and physiological functions through the life course. Both human and a...

    Authors: Antonysunil Adaikalakoteswari, Sarah Finer, Philip D Voyias, Ciara M McCarthy, Manu Vatish, Jonathan Moore, Melissa Smart-Halajko, Nahla Bawazeer, Nasser M Al-Daghri, Philip G McTernan, Sudhesh Kumar, Graham A Hitman, Ponnusamy Saravanan and Gyanendra Tripathi

    Citation: Clinical Epigenetics 2015 7:14

    Content type: Research

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  9. Recent genome-wide analysis has shown that DNA methylation spans long stretches of chromosome regions consisting of clusters of contiguous CpG islands or gene families. Hypermethylation of various gene cluster...

    Authors: Rohit R Jadhav, Zhenqing Ye, Rui-Lan Huang, Joseph Liu, Pei-Yin Hsu, Yi-Wen Huang, Leticia B Rangel, Hung-Cheng Lai, Juan Carlos Roa, Nameer B Kirma, Tim Hui-Ming Huang and Victor X Jin

    Citation: Clinical Epigenetics 2015 7:13

    Content type: Research

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  10. The prevalence of chronic diseases such as cancer, type 2 diabetes, metabolic syndrome (MetS), and cardiovascular disease increases with age in all populations. Epigenetic features are hypothesized to play imp...

    Authors: Omar Ali, Diana Cerjak, Jack W Kent Jr, Roland James, John Blangero, Melanie A Carless and Yi Zhang

    Citation: Clinical Epigenetics 2015 7:12

    Content type: Research

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  11. We present a method that utilizes DNA methylation profiling for prediction of the cytogenetic subtypes of acute lymphoblastic leukemia (ALL) cells from pediatric ALL patients. The primary aim of our study was ...

    Authors: Jessica Nordlund, Christofer L Bäcklin, Vasilios Zachariadis, Lucia Cavelier, Johan Dahlberg, Ingegerd Öfverholm, Gisela Barbany, Ann Nordgren, Elin Övernäs, Jonas Abrahamsson, Trond Flaegstad, Mats M Heyman, Ólafur G Jónsson, Jukka Kanerva, Rolf Larsson, Josefine Palle…

    Citation: Clinical Epigenetics 2015 7:11

    Content type: Research

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  12. Long non-coding RNAs (lncRNA) play an important role in carcinogenesis; knowledge on lncRNA expression in renal cell carcinoma is rudimental. As a basis for biomarker development, we aimed to explore the lncRN...

    Authors: Jasmine JC Blondeau, Mario Deng, Isabella Syring, Sarah Schrödter, Doris Schmidt, Sven Perner, Stefan C Müller and Jörg Ellinger

    Citation: Clinical Epigenetics 2015 7:10

    Content type: Research

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  13. An adverse intrauterine environment leads to permanent physiological changes including vascular tone regulation, potentially influencing the risk for adult vascular diseases. We therefore aimed to monitor resp...

    Authors: Jan Postberg, Miriam Kanders, Sakeh Forcob, Rhea Willems, Valerie Orth, Kai Oliver Hensel, Patrick Philipp Weil, Stefan Wirth and Andreas Christoph Jenke

    Citation: Clinical Epigenetics 2015 7:9

    Content type: Research

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  14. Transgenerational epigenetic inheritance has gained increased attention due to the possibility that exposure to environmental contaminants induce diseases that propagate across generations through epigenomic a...

    Authors: Carlos Guerrero-Bosagna and Per Jensen

    Citation: Clinical Epigenetics 2015 7:8

    Content type: Letter to the Editor

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  15. Modification of DNA by methylation of cytosines at CpG dinucleotides is a widespread phenomenon that leads to changes in gene expression, thereby influencing and regulating many biological processes. Recent te...

    Authors: Shaza B Zaghlool, Mashael Al-Shafai, Wadha A Al Muftah, Pankaj Kumar, Mario Falchi and Karsten Suhre

    Citation: Clinical Epigenetics 2015 7:6

    Content type: Research

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  16. The in vitro analysis of the hypomethylation of imprinting control region 1 (ICR1) within the IGF2/H19 locus is challenged by the mosaic distribution of the epimutation in tissues from children with Silver-Russel...

    Authors: Doreen Heckmann, Christina Urban, Karin Weber, Kai Kannenberg and Gerhard Binder

    Citation: Clinical Epigenetics 2015 7:5

    Content type: Research

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  17. Studies of methylation biomarkers for cervical cancer often involved only few randomly selected CpGs per candidate gene analyzed by methylation-specific PCR-based methods, with often inconsistent results from ...

    Authors: Xiaoyi Tian, Di Chen, Ran Zhang, Jun Zhou, Xiaozhong Peng, Xiaolin Yang, Xiuru Zhang and Zhi Zheng

    Citation: Clinical Epigenetics 2015 7:4

    Content type: Research

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  18. DNA methylation was suggested as the promising biomarker for lung cancer diagnosis. However, it is a great challenge to search for the optimal combination of methylation biomarkers to obtain maximum diagnostic...

    Authors: Shicheng Guo, Fengyang Yan, Jibin Xu, Yang Bao, Ji Zhu, Xiaotian Wang, Junjie Wu, Yi Li, Weilin Pu, Yan Liu, Zhengwen Jiang, Yanyun Ma, Xiaofeng Chen, Momiao Xiong, Li Jin and Jiucun Wang

    Citation: Clinical Epigenetics 2015 7:3

    Content type: Research

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  19. One of the most frequently found abnormalities in acute myeloid leukemia (AML) is the t(8;21)(q22;q22) translocation, which is seen in around 15% of patients. This translocation results in the production of th...

    Authors: Jessica M Salmon, Michael Bots, Eva Vidacs, Kym L Stanley, Peter Atadja, Johannes Zuber and Ricky W Johnstone

    Citation: Clinical Epigenetics 2015 7:2

    Content type: Short report

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  20. The dysregulation of transforming growth factor-β (TGF-β) signaling plays a crucial role in ovarian carcinogenesis and in maintaining cancer stem cell properties. Classified as a member of the ATP-binding cass...

    Authors: Jian-Liang Chou, Rui-Lan Huang, Jacqueline Shay, Lin-Yu Chen, Sheng-Jie Lin, Pearlly S Yan, Wei-Ting Chao, Yi-Hui Lai, Yen-Ling Lai, Tai-Kuang Chao, Cheng-I Lee, Chien-Kuo Tai, Shu-Fen Wu, Kenneth P Nephew, Tim H-M Huang, Hung-Cheng Lai…

    Citation: Clinical Epigenetics 2015 7:1

    Content type: Research

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  21. Splicing is more efficient when coupled with transcription and it has been proposed that nucleosomes enriched in exons are important for splice site recognition. Lynch syndrome is a familial cancer syndrome th...

    Authors: Mathew A Sloane, Luke B Hesson, Andrea C Nunez, Bryony A Thompson and Robyn L Ward

    Citation: Clinical Epigenetics 2014 6:32

    Content type: Short report

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  22. DNA hypermethylation is reported as a frequent event and prognostic marker in head and neck squamous cell carcinomas (HNSCC). Methylation has been commonly assessed with non-quantitative methodologies, such as...

    Authors: Annette M Lim, Ida LM Candiloro, Nicholas Wong, Marnie Collins, Hongdo Do, Elena A Takano, Christopher Angel, Richard J Young, June Corry, David Wiesenfeld, Stephen Kleid, Elizabeth Sigston, Bernard Lyons, Danny Rischin, Benjamin Solomon and Alexander Dobrovic

    Citation: Clinical Epigenetics 2014 6:22

    Content type: Research

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  23. An important model of hepatocellular carcinoma (HCC) that has been described in southeast Asia includes the transition from chronic hepatitis B infection (CHB) to liver cirrhosis (LC) and, finally, to HCC. The...

    Authors: Yangxing Zhao, Feng Xue, Jinfeng Sun, Shicheng Guo, Hongyu Zhang, Bijun Qiu, Junfeng Geng, Jun Gu, Xiaoyu Zhou, Wei Wang, Zhenfeng Zhang, Ning Tang, Yinghua He, Jian Yu and Qiang Xia

    Citation: Clinical Epigenetics 2014 6:30

    Content type: Research

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  24. The two oppositely imprinted and expressed genes, DLK1 and MEG3, are located in the same gene cluster at 14q32. Previous studies in bladder cancer have suggested that tumor suppressor genes are located in this re...

    Authors: Annemarie Greife, Judith Knievel, Teodora Ribarska, Günter Niegisch and Wolfgang A Schulz

    Citation: Clinical Epigenetics 2014 6:29

    Content type: Research

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  25. Genome-wide methylation arrays are increasingly used tools in studies of complex medical disorders. Because of their expense and potential utility to the scientific community, current federal policy dictates t...

    Authors: Robert A Philibert, Nicolas Terry, Cheryl Erwin, Winter J Philibert, Steven RH Beach and Gene H Brody

    Citation: Clinical Epigenetics 2014 6:28

    Content type: Research

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  26. Elevated plasma levels of the branched-chain amino acid (BCAA) leucine are associated with obesity and insulin resistance (IR), and thus the propensity for type 2 diabetes mellitus development. However, other ...

    Authors: Aida Zarfeshani, Sherry Ngo and Allan M Sheppard

    Citation: Clinical Epigenetics 2014 6:27

    Content type: Research

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  27. Virus-host interactions result in altered gene expression profiles in host cell nuclei and enable virus particle production, thus obligatorily involving changes in their epigenomes. Neither such epigenome chan...

    Authors: Andreas C W Jenke, Kai O Hensel, Andreas Klein, Lisa Willuhn, Susanna Prax, Patrick P Weil, Theodor Winkler, Timo Deba, Valerie Orth, Armin Baiker, Stefan Wirth and Jan Postberg

    Citation: Clinical Epigenetics 2014 6:26

    Content type: Research

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  28. The pathogenesis and etiology of systemic sclerosis (SSc) are complex and poorly understood. To date, several studies have demonstrated that the activation of the immune system undoubtedly plays a pivotal role...

    Authors: YaoYao Wang, Ye Shu, YangFan Xiao, Qing Wang, Takuro Kanekura, YaPing Li, JiuCun Wang, Ming Zhao, QianJin Lu and Rong Xiao

    Citation: Clinical Epigenetics 2014 6:25

    Content type: Research

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  29. Aberrant crypt foci (ACF) are considered the first identifiable preneoplastic lesion in colorectal cancer (CRC), and have been proposed as a potential biomarker for CRC risk. Global DNA hypomethylation is an e...

    Authors: Isabel Quintanilla, Maria Lopez-Cerón, Mireya Jimeno, Miriam Cuatrecasas, Jennifer Muñoz, Leticia Moreira, Sabela Carballal, Maria Liz Leoz, Jordi Camps, Antoni Castells, Maria Pellisé and Francesc Balaguer

    Citation: Clinical Epigenetics 2014 6:24

    Content type: Short report

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  30. Facioscapulohumeral muscular dystrophy (FSHD) is linked to chromatin relaxation due to epigenetic changes at the 4q35 D4Z4 macrosatellite array. Molecular diagnostic criteria for FSHD are complex and involve a...

    Authors: Takako I Jones, Chi Yan, Peter C Sapp, Diane McKenna-Yasek, Peter B Kang, Colin Quinn, Johnny S Salameh, Oliver D King and Peter L Jones

    Citation: Clinical Epigenetics 2014 6:23

    Content type: Methodology

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  31. We have recently shown that T-antigen binding to Site I results in the replication-dependent introduction of H3K9me1 into SV40 chromatin late in infection. Since H3K9me2 and H3K9me3 are also present late in in...

    Authors: Les Kallestad, Kendra Christensen, Emily Woods and Barry Milavetz

    Citation: Clinical Epigenetics 2014 6:21

    Content type: Research

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  32. DNA methylation mediates gene silencing primarily by inducing repressive chromatin architecture via a common theme of interaction involving methyl-CpG binding (MBD) proteins, histone modifying enzymes and chro...

    Authors: Swayamsiddha Kar, Dipta Sengupta, Moonmoon Deb, Arunima Shilpi, Sabnam Parbin, Sandip Kumar Rath, Nibedita Pradhan, Madhumita Rakshit and Samir Kumar Patra

    Citation: Clinical Epigenetics 2014 6:20

    Content type: Research

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  33. The silencing of tumor suppressor genes (TSGs) by aberrant DNA methylation occurs frequently in acute myeloid leukemia (AML). This epigenetic alteration can be reversed by 5-aza-2’-deoxcytidine (decitabine, 5-...

    Authors: Richard L Momparler, Sylvie Côté, Louise F Momparler and Youssef Idaghdour

    Citation: Clinical Epigenetics 2014 6:19

    Content type: Research

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  34. Extensive reprogramming and dysregulation of DNA methylation is an important characteristic of pancreatic cancer (PC). Our study aimed to characterize the genomic methylation patterns in various genomic contex...

    Authors: Yangxing Zhao, Jinfeng Sun, Hongyu Zhang, Shicheng Guo, Jun Gu, Wei Wang, Ning Tang, Xiaoyu Zhou and Jian Yu

    Citation: Clinical Epigenetics 2014 6:18

    Content type: Research

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  35. The prevalence of asthma in girls increases after puberty. Previous studies have detected associations between sex hormones and asthma, as well as between sex hormones and T helper 2 (Th2) asthma-typical immun...

    Authors: Kranthi Guthikonda, Hongmei Zhang, Vikki G Nolan, Nelís Soto-Ramírez, Ali H Ziyab, Susan Ewart, Hasan S Arshad, Veeresh Patil, John W Holloway, Gabrielle A Lockett and Wilfried Karmaus

    Citation: Clinical Epigenetics 2014 6:17

    Content type: Research

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  36. Aberrant DNA methylation of promoter region CpG islands is an alternative mechanism that leads to genetic defects in the inactivation of tumor suppressor genes during myelomagenesis. The aim of this study was ...

    Authors: Giovanna Piras, Maria Monne, Angelo D Palmas, Anna Calvisi, Rosanna Asproni, Francesco Vacca, Laura Pilo, Attilio Gabbas and Giancarlo Latte

    Citation: Clinical Epigenetics 2014 6:16

    Content type: Short report

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  37. Chronic periodontitis represents a complex disease that is hard to control and is not completely understood. Evidence from past studies suggests that there is a key role for DNA methylation in the pathogenesis...

    Authors: Ana Paula De Souza, Aline Cristiane Planello, Marcelo Rocha Marques, Daniel Diniz De Carvalho and Sergio Roberto Peres Line

    Citation: Clinical Epigenetics 2014 6:15

    Content type: Research

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  38. Previous studies have suggested that DNA methylation contributes to coronary artery disease (CAD) risk variability. DNA hypermethylation at the ATP-binding cassette transporter A1 (ABCA1) gene, an important modul...

    Authors: Simon-Pierre Guay, Cécilia Légaré, Andrée-Anne Houde, Patrick Mathieu, Yohan Bossé and Luigi Bouchard

    Citation: Clinical Epigenetics 2014 6:14

    Content type: Research

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  39. Since tumor suppressor gene function may be lost through hypermethylation, we assessed whether the demethylating agent decitabine could increase tumor suppressor gene expression clinically. For fragile histidi...

    Authors: David J Stewart, Maria I Nunez, Jaroslav Jelinek, David Hong, Sanjay Gupta, Marcelo Aldaz, Jean-Pierre Issa, Razelle Kurzrock and Ignacio I Wistuba

    Citation: Clinical Epigenetics 2014 6:13

    Content type: Research

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  40. There is renewed interest towards understanding the host-pathogen interaction in the light of epigenetic modifications. Although epithelial tissue is the major site for host-pathogen interactions, there is han...

    Authors: Rahul Modak, Susweta Das Mitra, Madavan Vasudevan, Paramanandhan Krishnamoorthy, Manoj Kumar, Akshay V Bhat, Mani Bhuvana, Sankar K Ghosh, Bibek R Shome and Tapas K Kundu

    Citation: Clinical Epigenetics 2014 6:12

    Content type: Research

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  41. Beckwith-Wiedemann syndrome (BWS), a congenital overgrowth disorder with variable expressivity and a predisposition to tumorigenesis, results from disordered expression and/or function of imprinted genes at ch...

    Authors: Abdulla Ibrahim, Gail Kirby, Carol Hardy, Renuka P Dias, Louise Tee, Derek Lim, Jonathan Berg, Fiona MacDonald, Peter Nightingale and Eamonn R Maher

    Citation: Clinical Epigenetics 2014 6:11

    Content type: Research

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  42. Clinical observations have demonstrated that high levels of circulating insulin-like growth factor binding protein-1 (IGFBP-1) are associated with type 1 diabetes (T1D), whereas low serum IGFBP-1 levels are as...

    Authors: Tianwei Gu, Henrik Falhammar, Harvest F Gu and Kerstin Brismar

    Citation: Clinical Epigenetics 2014 6:10

    Content type: Research

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  43. Asthma is associated with allergic sensitization in about half of all cases, and asthma phenotypes can vary by age and sex. DNA methylation in the promoter of the allergy regulatory gene interferon gamma (IFNγ...

    Authors: Stephanie Lovinsky-Desir, Robert Ridder, David Torrone, Christina Maher, Surinder Narula, Melissa Scheuerman, David Merle, Meyer Kattan, Emily DiMango and Rachel L Miller

    Citation: Clinical Epigenetics 2014 6:9

    Content type: Research

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  44. Genetic effects on asthma of genes in the T-helper 2 (Th2) pathway may interact with epigenetic factors including DNA methylation. We hypothesized that interactions between genetic variants and methylation in ...

    Authors: Hongmei Zhang, Xin Tong, John W Holloway, Faisal I Rezwan, Gabrielle A Lockett, Veeresh Patil, Meredith Ray, Todd M Everson, Nelís Soto-Ramírez, S Hasan Arshad, Susan Ewart and Wilfried Karmaus

    Citation: Clinical Epigenetics 2014 6:8

    Content type: Research

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  45. Prenatal growth restriction and low birth weight have been linked to long-term alterations of health, presumably via adaptive modifications of the epigenome. Recent studies indicate a plasticity of the 11p15 e...

    Authors: Felix Schreiner, Bettina Gohlke, Sonja Stutte, Peter Bartmann, Kurt Hecher, Johannes Oldenburg, Osman El-Maarri and Joachim Woelfle

    Citation: Clinical Epigenetics 2014 6:6

    Content type: Research

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  46. Adenomatous polyposis coli (APC) has been reported to be a candidate tumor suppressor in many cancers. However, the diagnostic role of APC promoter methylation in non-small cell lung cancer (NSCLC) remains unclea...

    Authors: Shicheng Guo, Lixing Tan, Weilin Pu, Junjie Wu, Kuan Xu, Jinhui Wu, Qiang Li, Yanyun Ma, Jibin Xu, Li Jin and Jiucun Wang

    Citation: Clinical Epigenetics 2014 6:5

    Content type: Research

    Published on: