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  1. The two oppositely imprinted and expressed genes, DLK1 and MEG3, are located in the same gene cluster at 14q32. Previous studies in bladder cancer have suggested that tumor suppressor genes are located in this re...

    Authors: Annemarie Greife, Judith Knievel, Teodora Ribarska, Günter Niegisch and Wolfgang A Schulz

    Citation: Clinical Epigenetics 2014 6:29

    Content type: Research

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  2. Genome-wide methylation arrays are increasingly used tools in studies of complex medical disorders. Because of their expense and potential utility to the scientific community, current federal policy dictates t...

    Authors: Robert A Philibert, Nicolas Terry, Cheryl Erwin, Winter J Philibert, Steven RH Beach and Gene H Brody

    Citation: Clinical Epigenetics 2014 6:28

    Content type: Research

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  3. Elevated plasma levels of the branched-chain amino acid (BCAA) leucine are associated with obesity and insulin resistance (IR), and thus the propensity for type 2 diabetes mellitus development. However, other ...

    Authors: Aida Zarfeshani, Sherry Ngo and Allan M Sheppard

    Citation: Clinical Epigenetics 2014 6:27

    Content type: Research

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  4. Virus-host interactions result in altered gene expression profiles in host cell nuclei and enable virus particle production, thus obligatorily involving changes in their epigenomes. Neither such epigenome chan...

    Authors: Andreas C W Jenke, Kai O Hensel, Andreas Klein, Lisa Willuhn, Susanna Prax, Patrick P Weil, Theodor Winkler, Timo Deba, Valerie Orth, Armin Baiker, Stefan Wirth and Jan Postberg

    Citation: Clinical Epigenetics 2014 6:26

    Content type: Research

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  5. The pathogenesis and etiology of systemic sclerosis (SSc) are complex and poorly understood. To date, several studies have demonstrated that the activation of the immune system undoubtedly plays a pivotal role...

    Authors: YaoYao Wang, Ye Shu, YangFan Xiao, Qing Wang, Takuro Kanekura, YaPing Li, JiuCun Wang, Ming Zhao, QianJin Lu and Rong Xiao

    Citation: Clinical Epigenetics 2014 6:25

    Content type: Research

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  6. Aberrant crypt foci (ACF) are considered the first identifiable preneoplastic lesion in colorectal cancer (CRC), and have been proposed as a potential biomarker for CRC risk. Global DNA hypomethylation is an e...

    Authors: Isabel Quintanilla, Maria Lopez-Cerón, Mireya Jimeno, Miriam Cuatrecasas, Jennifer Muñoz, Leticia Moreira, Sabela Carballal, Maria Liz Leoz, Jordi Camps, Antoni Castells, Maria Pellisé and Francesc Balaguer

    Citation: Clinical Epigenetics 2014 6:24

    Content type: Short report

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  7. Facioscapulohumeral muscular dystrophy (FSHD) is linked to chromatin relaxation due to epigenetic changes at the 4q35 D4Z4 macrosatellite array. Molecular diagnostic criteria for FSHD are complex and involve a...

    Authors: Takako I Jones, Chi Yan, Peter C Sapp, Diane McKenna-Yasek, Peter B Kang, Colin Quinn, Johnny S Salameh, Oliver D King and Peter L Jones

    Citation: Clinical Epigenetics 2014 6:23

    Content type: Methodology

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  8. We have recently shown that T-antigen binding to Site I results in the replication-dependent introduction of H3K9me1 into SV40 chromatin late in infection. Since H3K9me2 and H3K9me3 are also present late in in...

    Authors: Les Kallestad, Kendra Christensen, Emily Woods and Barry Milavetz

    Citation: Clinical Epigenetics 2014 6:21

    Content type: Research

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  9. DNA methylation mediates gene silencing primarily by inducing repressive chromatin architecture via a common theme of interaction involving methyl-CpG binding (MBD) proteins, histone modifying enzymes and chro...

    Authors: Swayamsiddha Kar, Dipta Sengupta, Moonmoon Deb, Arunima Shilpi, Sabnam Parbin, Sandip Kumar Rath, Nibedita Pradhan, Madhumita Rakshit and Samir Kumar Patra

    Citation: Clinical Epigenetics 2014 6:20

    Content type: Research

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  10. The silencing of tumor suppressor genes (TSGs) by aberrant DNA methylation occurs frequently in acute myeloid leukemia (AML). This epigenetic alteration can be reversed by 5-aza-2’-deoxcytidine (decitabine, 5-...

    Authors: Richard L Momparler, Sylvie Côté, Louise F Momparler and Youssef Idaghdour

    Citation: Clinical Epigenetics 2014 6:19

    Content type: Research

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  11. Extensive reprogramming and dysregulation of DNA methylation is an important characteristic of pancreatic cancer (PC). Our study aimed to characterize the genomic methylation patterns in various genomic contex...

    Authors: Yangxing Zhao, Jinfeng Sun, Hongyu Zhang, Shicheng Guo, Jun Gu, Wei Wang, Ning Tang, Xiaoyu Zhou and Jian Yu

    Citation: Clinical Epigenetics 2014 6:18

    Content type: Research

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  12. The prevalence of asthma in girls increases after puberty. Previous studies have detected associations between sex hormones and asthma, as well as between sex hormones and T helper 2 (Th2) asthma-typical immun...

    Authors: Kranthi Guthikonda, Hongmei Zhang, Vikki G Nolan, Nelís Soto-Ramírez, Ali H Ziyab, Susan Ewart, Hasan S Arshad, Veeresh Patil, John W Holloway, Gabrielle A Lockett and Wilfried Karmaus

    Citation: Clinical Epigenetics 2014 6:17

    Content type: Research

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  13. Aberrant DNA methylation of promoter region CpG islands is an alternative mechanism that leads to genetic defects in the inactivation of tumor suppressor genes during myelomagenesis. The aim of this study was ...

    Authors: Giovanna Piras, Maria Monne, Angelo D Palmas, Anna Calvisi, Rosanna Asproni, Francesco Vacca, Laura Pilo, Attilio Gabbas and Giancarlo Latte

    Citation: Clinical Epigenetics 2014 6:16

    Content type: Short report

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  14. Chronic periodontitis represents a complex disease that is hard to control and is not completely understood. Evidence from past studies suggests that there is a key role for DNA methylation in the pathogenesis...

    Authors: Ana Paula De Souza, Aline Cristiane Planello, Marcelo Rocha Marques, Daniel Diniz De Carvalho and Sergio Roberto Peres Line

    Citation: Clinical Epigenetics 2014 6:15

    Content type: Research

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  15. Previous studies have suggested that DNA methylation contributes to coronary artery disease (CAD) risk variability. DNA hypermethylation at the ATP-binding cassette transporter A1 (ABCA1) gene, an important modul...

    Authors: Simon-Pierre Guay, Cécilia Légaré, Andrée-Anne Houde, Patrick Mathieu, Yohan Bossé and Luigi Bouchard

    Citation: Clinical Epigenetics 2014 6:14

    Content type: Research

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  16. Since tumor suppressor gene function may be lost through hypermethylation, we assessed whether the demethylating agent decitabine could increase tumor suppressor gene expression clinically. For fragile histidi...

    Authors: David J Stewart, Maria I Nunez, Jaroslav Jelinek, David Hong, Sanjay Gupta, Marcelo Aldaz, Jean-Pierre Issa, Razelle Kurzrock and Ignacio I Wistuba

    Citation: Clinical Epigenetics 2014 6:13

    Content type: Research

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  17. There is renewed interest towards understanding the host-pathogen interaction in the light of epigenetic modifications. Although epithelial tissue is the major site for host-pathogen interactions, there is han...

    Authors: Rahul Modak, Susweta Das Mitra, Madavan Vasudevan, Paramanandhan Krishnamoorthy, Manoj Kumar, Akshay V Bhat, Mani Bhuvana, Sankar K Ghosh, Bibek R Shome and Tapas K Kundu

    Citation: Clinical Epigenetics 2014 6:12

    Content type: Research

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  18. Beckwith-Wiedemann syndrome (BWS), a congenital overgrowth disorder with variable expressivity and a predisposition to tumorigenesis, results from disordered expression and/or function of imprinted genes at ch...

    Authors: Abdulla Ibrahim, Gail Kirby, Carol Hardy, Renuka P Dias, Louise Tee, Derek Lim, Jonathan Berg, Fiona MacDonald, Peter Nightingale and Eamonn R Maher

    Citation: Clinical Epigenetics 2014 6:11

    Content type: Research

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  19. Clinical observations have demonstrated that high levels of circulating insulin-like growth factor binding protein-1 (IGFBP-1) are associated with type 1 diabetes (T1D), whereas low serum IGFBP-1 levels are as...

    Authors: Tianwei Gu, Henrik Falhammar, Harvest F Gu and Kerstin Brismar

    Citation: Clinical Epigenetics 2014 6:10

    Content type: Research

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  20. Asthma is associated with allergic sensitization in about half of all cases, and asthma phenotypes can vary by age and sex. DNA methylation in the promoter of the allergy regulatory gene interferon gamma (IFNγ...

    Authors: Stephanie Lovinsky-Desir, Robert Ridder, David Torrone, Christina Maher, Surinder Narula, Melissa Scheuerman, David Merle, Meyer Kattan, Emily DiMango and Rachel L Miller

    Citation: Clinical Epigenetics 2014 6:9

    Content type: Research

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  21. Genetic effects on asthma of genes in the T-helper 2 (Th2) pathway may interact with epigenetic factors including DNA methylation. We hypothesized that interactions between genetic variants and methylation in ...

    Authors: Hongmei Zhang, Xin Tong, John W Holloway, Faisal I Rezwan, Gabrielle A Lockett, Veeresh Patil, Meredith Ray, Todd M Everson, Nelís Soto-Ramírez, S Hasan Arshad, Susan Ewart and Wilfried Karmaus

    Citation: Clinical Epigenetics 2014 6:8

    Content type: Research

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  22. Prenatal growth restriction and low birth weight have been linked to long-term alterations of health, presumably via adaptive modifications of the epigenome. Recent studies indicate a plasticity of the 11p15 e...

    Authors: Felix Schreiner, Bettina Gohlke, Sonja Stutte, Peter Bartmann, Kurt Hecher, Johannes Oldenburg, Osman El-Maarri and Joachim Woelfle

    Citation: Clinical Epigenetics 2014 6:6

    Content type: Research

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  23. Adenomatous polyposis coli (APC) has been reported to be a candidate tumor suppressor in many cancers. However, the diagnostic role of APC promoter methylation in non-small cell lung cancer (NSCLC) remains unclea...

    Authors: Shicheng Guo, Lixing Tan, Weilin Pu, Junjie Wu, Kuan Xu, Jinhui Wu, Qiang Li, Yanyun Ma, Jibin Xu, Li Jin and Jiucun Wang

    Citation: Clinical Epigenetics 2014 6:5

    Content type: Research

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  24. DNA methylation is strongly associated with smoking status at multiple sites across the genome. Studies have largely been restricted to European origin individuals yet the greatest increase in smoking is occur...

    Authors: Hannah R Elliott, Therese Tillin, Wendy L McArdle, Karen Ho, Aparna Duggirala, Tim M Frayling, George Davey Smith, Alun D Hughes, Nish Chaturvedi and Caroline L Relton

    Citation: Clinical Epigenetics 2014 6:4

    Content type: Research

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  25. The Editors of Clinical Epigenetics would like to thank all our reviewers who have contributed to the journal in volume 5 (2013).

    Authors: Ulrich Mahlknecht

    Citation: Clinical Epigenetics 2014 6:3

    Content type: Reviewer Acknowledgement

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  26. In 31 solid tumor patients treated with the demethylating agent decitabine, we performed tumor biopsies before and after the first cycle of decitabine and used immunohistochemistry (IHC) to assess whether deci...

    Authors: David J Stewart, Maria I Nunez, Jaroslav Jelinek, David Hong, Sanjay Gupta, Jean-Pierre Issa, Ignacio I Wistuba and Razelle Kurzrock

    Citation: Clinical Epigenetics 2014 6:2

    Content type: Research

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  27. The mechanism of action of olanzapine in treating schizophrenia is not clear. This research reports the effects of a therapeutic equivalent treatment of olanzapine on DNA methylation in a rat model in vivo.

    Authors: Melkaye G Melka, Benjamin I Laufer, Patrick McDonald, Christina A Castellani, Nagalingam Rajakumar, Richard O’Reilly and Shiva M Singh

    Citation: Clinical Epigenetics 2014 6:1

    Content type: Research

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  28. Beckwith-Wiedemann syndrome (BWS) is a congenital overgrowth disorder associated with abnormalities in 11p15.5 imprinted genes. The most common cause is loss of methylation (epimutation) at the imprinting cont...

    Authors: Louise Tee, Derek HK Lim, Renuka P Dias, Marie-Odile Baudement, Amy A Slater, Gail Kirby, Tom Hancocks, Helen Stewart, Carol Hardy, Fiona Macdonald and Eamonn R Maher

    Citation: Clinical Epigenetics 2013 5:23

    Content type: Research

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  29. Asthma is characterized by airflow limitation and airway reactivity (AR). Interleukin-13 (IL-13) is involved in the pathogenesis of asthma. Two functional SNPs, rs20541 and rs1800925, of the IL-13 gene (IL13) hav...

    Authors: Veeresh K Patil, John W Holloway, Hongmei Zhang, Nelis Soto-Ramirez, Susan Ewart, S Hasan Arshad and Wilfried Karmaus

    Citation: Clinical Epigenetics 2013 5:22

    Content type: Short report

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  30. Prospective studies have shown that low levels of circulating insulin-like growth factor binding protein-1 (IGFBP-1) are associated with the risk of type 2 diabetes. In the present study, we investigated DNA m...

    Authors: Tianwei Gu, Harvest F Gu, Agneta Hilding, Louise K Sjöholm, Claes-Göran Östenson, Tomas J Ekström and Kerstin Brismar

    Citation: Clinical Epigenetics 2013 5:21

    Content type: Research

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  31. Insulin-like growth factor-binding protein 7 (IGFBP-7) is able to interact with insulin-like growth factor 1 (IGF-1) as well as insulin. Previous studies have suggested that serum IGFBP-7 levels may be associa...

    Authors: Harvest F Gu, Tianwei Gu, Agneta Hilding, Yiming Zhu, Lars Kärvestedt, Claes-Göran Östenson, Maode Lai, Masahiko Kutsukake, Jan Frystyk, Kazuhiro Tamura and Kerstin Brismar

    Citation: Clinical Epigenetics 2013 5:20

    Content type: Research

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  32. Smoking is the largest preventable cause of morbidity and mortality in the United States. In previous work, we demonstrated that altered DNA methylation at the aryl hydrocarbon receptor repressor (AHRR) is cor...

    Authors: Robert A Philibert, Steven R H Beach, Man-Kit Lei and Gene H Brody

    Citation: Clinical Epigenetics 2013 5:19

    Content type: Research

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  33. Epigenetic mechanisms are thought to be critical in mediating the role of the intrauterine environment on lifelong health and disease. Twin-twin transfusion syndrome (TTTS) is a rare condition wherein fetuses ...

    Authors: Carmen J Marsit, Devin C Koestler, Debra Watson-Smith, Charlotte M Boney, James F Padbury and Francois Luks

    Citation: Clinical Epigenetics 2013 5:18

    Content type: Research

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  34. A remarkable correspondence exists between the cytogenetic locations of the known fragile sites and frequently reported sites of hypermethylation. The best-known features of fragile sites are sequence motifs t...

    Authors: Steven S Smith

    Citation: Clinical Epigenetics 2013 5:17

    Content type: Hypothesis

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  35. Despite therapeutic advances in targeted therapy, metastatic renal cell carcinoma (RCC) remains incurable for the vast majority of patients. Key molecular events in the pathogenesis of RCC include inactivation...

    Authors: Christopher J Ricketts, Mark R Morris, Dean Gentle, Salwati Shuib, Michael Brown, Noel Clarke, Wenbin Wei, Paul Nathan, Farida Latif and Eamonn R Maher

    Citation: Clinical Epigenetics 2013 5:16

    Content type: Research

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  36. Epidemiological evidence indicates yet unknown epigenetic mechanisms underlying a propensity for overweight and type 2 diabetes. We analyzed the extent of methylation at lysine 4 and lysine 9 of histone H3 in ...

    Authors: Åsa Jufvas, Simon Sjödin, Kim Lundqvist, Risul Amin, Alexander V Vener and Peter Strålfors

    Citation: Clinical Epigenetics 2013 5:15

    Content type: Research

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  37. Authors: Athar Aziz, E Joanna Baxter, Carol Edwards, Clara Yujing Cheong, Mitsuteru Ito, Anthony Bench, Rebecca Kelley, Yvonne Silber, Philip A Beer, Keefe Chng, Marilyn B Renfree, Kirsten McEwen, Dionne Gray, Jyoti Nangalia, Ghulam J Mufti, Eva Hellstrom-Lindberg…

    Citation: Clinical Epigenetics 2013 5(Suppl 1):S5

    Content type: Meeting abstract

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    This article is part of a Supplement: Volume 5 Supplement 1

  38. Authors: Gabriella Ficz, Timothy A Hore, Fatima Santos, Heather J Lee, Wendy Dean, Julia Arand, Felix Krueger, David Oxley, Yu-Lee Paul, Jörn Walter, Simon J Cook, Simon Andrews, Miguel R Branco and Wolf Reik

    Citation: Clinical Epigenetics 2013 5(Suppl 1):S2

    Content type: Meeting abstract

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    This article is part of a Supplement: Volume 5 Supplement 1

  39. Prenatal alcohol exposure is known to result in fetal alcohol spectrum disorders, a continuum of physiological, behavioural, and cognitive phenotypes that include increased risk for anxiety and learning-associ...

    Authors: Randa L Stringer, Benjamin I Laufer, Morgan L Kleiber and Shiva M Singh

    Citation: Clinical Epigenetics 2013 5:14

    Content type: Short report

    Published on: