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  1. Despite penile carcinoma (PeCa) being a relatively rare neoplasm, it remains an important public health issue for poor and developing countries. Contrary to most tumors, limited data are available for markers ...

    Authors: Hellen Kuasne, Ilce Mara de Syllos Cólus, Ariane Fidelis Busso, Hector Hernandez-Vargas, Mateus Camargo Barros-Filho, Fabio Albuquerque Marchi, Cristovam Scapulatempo-Neto, Eliney Ferreira Faria, Ademar Lopes, Gustavo Cardoso Guimarães, Zdenko Herceg and Silvia Regina Rogatto

    Citation: Clinical Epigenetics 2015 7:46

    Content type: Research

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  2. In this letter to the editor, we respond to the recent publication by Philibert et al. Methylation array data can simultaneously identify individuals and convey protected health information: an unrecognized ethic...

    Authors: Yann Joly, Stephanie OM Dyke, Warren A Cheung, Mark A Rothstein and Tomi Pastinen

    Citation: Clinical Epigenetics 2015 7:45

    Content type: Letter to the Editor

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  3. Alcohol is a well-known risk factor for hepatocellular carcinoma (HCC), but the mechanisms underlying the alcohol-related hepatocarcinogenesis are still poorly understood. Alcohol alters the provision of methy...

    Authors: Silvia Udali, Patrizia Guarini, Andrea Ruzzenente, Alberto Ferrarini, Alfredo Guglielmi, Valentina Lotto, Paola Tononi, Patrizia Pattini, Sara Moruzzi, Tommaso Campagnaro, Simone Conci, Oliviero Olivieri, Roberto Corrocher, Massimo Delledonne, Sang-Woon Choi and Simonetta Friso

    Citation: Clinical Epigenetics 2015 7:43

    Content type: Research

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  4. Prostate cancer (PCa), a highly incident and heterogeneous malignancy, mostly affects men from developed countries. Increased knowledge of the biological mechanisms underlying PCa onset and progression are cri...

    Authors: Pedro Costa-Pinheiro, João Ramalho-Carvalho, Filipa Quintela Vieira, Jorge Torres-Ferreira, Jorge Oliveira, Céline S Gonçalves, Bruno M Costa, Rui Henrique and Carmen Jerónimo

    Citation: Clinical Epigenetics 2015 7:42

    Content type: Research

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  5. We, and others, have demonstrated previously that there are differences in DNA methylation and transcript levels of a number of genes in cord blood and placenta between children conceived using assisted reprod...

    Authors: Sisi Song, Jayashri Ghosh, Monica Mainigi, Nahid Turan, Rachel Weinerman, May Truongcao, Christos Coutifaris and Carmen Sapienza

    Citation: Clinical Epigenetics 2015 7:41

    Content type: Research

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  6. Neuroendocrine prostate cancer (NEPC) is a highly aggressive subtype of prostate cancer (PCa) for which the median survival remains less than a year. Current treatments are only palliative in nature, and the l...

    Authors: Pier-Luc Clermont, Dong Lin, Francesco Crea, Rebecca Wu, Hui Xue, Yuwei Wang, Kelsie L Thu, Wan L Lam, Colin C Collins, Yuzhuo Wang and Cheryl D Helgason

    Citation: Clinical Epigenetics 2015 7:40

    Content type: Research

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  7. The current epidemic of obesity and associated diseases calls for swift actions to better understand the mechanisms by which genetics and environmental factors affect metabolic health in humans. Monozygotic (M...

    Authors: Miina Ollikainen, Khadeeja Ismail, Kristina Gervin, Anjuska Kyllönen, Antti Hakkarainen, Jesper Lundbom, Elina A Järvinen, Jennifer R Harris, Nina Lundbom, Aila Rissanen, Robert Lyle, Kirsi H Pietiläinen and Jaakko Kaprio

    Citation: Clinical Epigenetics 2015 7:39

    Content type: Research

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  8. Epigenetic changes in DNA methylation could regulate the expression of several allergy-related genes. We investigated whether tolerance acquisition in children with immunoglobulin E (IgE)-mediated cow’s milk a...

    Authors: Roberto Berni Canani, Lorella Paparo, Rita Nocerino, Linda Cosenza, Vincenza Pezzella, Margherita Di Costanzo, Mario Capasso, Valentina Del Monaco, Valeria D’Argenio, Luigi Greco and Francesco Salvatore

    Citation: Clinical Epigenetics 2015 7:38

    Content type: Research

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  9. Both forms of facioscapulohumeral muscular dystrophy (FSHD) are associated with aberrant epigenetic regulation of the chromosome 4q35 D4Z4 macrosatellite. Chromatin changes due to large deletions of heterochro...

    Authors: Takako I Jones, Oliver D King, Charis L Himeda, Sachiko Homma, Jennifer C J Chen, Mary Lou Beermann, Chi Yan, Charles P Emerson Jr, Jeffrey B Miller, Kathryn R Wagner and Peter L Jones

    Citation: Clinical Epigenetics 2015 7:37

    Content type: Research

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  10. Type 2 diabetes mellitus (T2D) is highly prevalent in Middle-Eastern and North African Arab populations, but the molecular basis for this susceptibility is unknown. Altered DNA methylation levels were reported...

    Authors: Gidon Toperoff, Jeremy D Kark, Dvir Aran, Hisham Nassar, Wiessam Abu Ahmad, Ronit Sinnreich, Dima Azaiza, Benjamin Glaser and Asaf Hellman

    Citation: Clinical Epigenetics 2015 7:35

    Content type: Research

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  11. Age-related changes in DNA methylation occurring in blood leukocytes during early childhood may reflect epigenetic maturation. We hypothesized that some of these changes involve gene networks of critical relev...

    Authors: Nathalie Acevedo, Lovisa E Reinius, Morana Vitezic, Vittorio Fortino, Cilla Söderhäll, Hanna Honkanen, Riitta Veijola, Olli Simell, Jorma Toppari, Jorma Ilonen, Mikael Knip, Annika Scheynius, Heikki Hyöty, Dario Greco and Juha Kere

    Citation: Clinical Epigenetics 2015 7:34

    Content type: Research

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  12. The progressively older population in developed countries is reflected in an increase in the number of people suffering from age-related chronic inflammatory diseases such as metabolic syndrome, diabetes, hear...

    Authors: Katarzyna Szarc vel Szic, Ken Declerck, Melita Vidaković and Wim Vanden Berghe

    Citation: Clinical Epigenetics 2015 7:33

    Content type: Review

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  13. This study was aimed at investigating if the effect of RARβ2 hypermethylation on recurrence-free survival (RFS) in non-small cell lung cancer (NSCLC) depends on one’s smoking status and specific interacting prote...

    Authors: Yujin Kim, DongHao Jin, Bo Bin Lee, Eun Yoon Cho, Joungho Han, Young Mog Shim and Duk-Hwan Kim

    Citation: Clinical Epigenetics 2015 7:32

    Content type: Research

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  14. Histone to protamine exchange and the hyperacetylation of the remaining histones are hallmarks of spermiogenesis. Acetylation of histone H4 at lysine 12 (H4K12ac) was observed prior to full decondensation of s...

    Authors: Markus Vieweg, Katerina Dvorakova-Hortova, Barbora Dudkova, Przemyslaw Waliszewski, Marie Otte, Berthold Oels, Amir Hajimohammad, Heiko Turley, Martin Schorsch, Hans-Christian Schuppe, Wolfgang Weidner, Klaus Steger and Agnieszka Paradowska-Dogan

    Citation: Clinical Epigenetics 2015 7:31

    Content type: Research

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  15. Recent studies have demonstrated that DNA polymorphisms in the solute carrier family 30 member 8 (SLC30A8) gene confer the risk susceptibility to type 2 diabetes (T2D). The present study aimed to analyze DNA meth...

    Authors: Norhashimah Abu Seman, Wan Nazaimoon Wan Mohamud, Claes-Göran Östenson, Kerstin Brismar and Harvest F Gu

    Citation: Clinical Epigenetics 2015 7:30

    Content type: Research

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  16. Demethylation process is necessary for the expression of various factors involved in chemotherapy cytotoxicity or resistance. Platinum-resistant cells may have reduced expression of the copper/platinum transpo...

    Authors: Apostolia M Tsimberidou, Rabih Said, Kirk Culotta, Ignacio Wistuba, Jaroslav Jelinek, Siqing Fu, Gerald Falchook, Aung Naing, Sarina Piha-Paul, Ralph Zinner, Zahid H Siddik, Guangan He, Kenneth Hess, David J Stewart, Razelle Kurzrock and Jean-Pierre J Issa

    Citation: Clinical Epigenetics 2015 7:29

    Content type: Research

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  17. The clinical utility of DNA methylation as a predictive or prognostic biomarker requires scalable resequencing protocols for bisulfite-converted DNA. Key features of any validation method should be adaptabilit...

    Authors: Darren Korbie, Erica Lin, David Wall, Shalima S Nair, Clare Stirzaker, Sue J Clark and Matt Trau

    Citation: Clinical Epigenetics 2015 7:28

    Content type: Methodology

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  18. Phthalates may increase the asthma risk in children. Mechanisms underlying this association remain to be addressed. This study assesses the effect of phthalate exposures on epigenetic changes and the role of e...

    Authors: I-Jen Wang, Wilfried JJ Karmaus, Su-Lien Chen, John W Holloway and Susan Ewart

    Citation: Clinical Epigenetics 2015 7:27

    Content type: Research

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  19. The Editors of Clinical Epigenetics would like to thank all our reviewers who have contributed to the journal in volume 6 (2014).

    Authors: Ulrich Mahlknecht

    Citation: Clinical Epigenetics 2015 7:26

    Content type: Reviewer acknowledgement

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  20. Chronic liver injury can lead to the development of liver fibrosis and cirrhosis but only in a minority of patients. Currently, it is not clear which factors determine progression to fibrosis. We investigated ...

    Authors: Müjdat Zeybel, Timothy Hardy, Stuart M Robinson, Christopher Fox, Quentin M Anstee, Thomas Ness, Steven Masson, John C Mathers, Jeremy French, Steve White and Jelena Mann

    Citation: Clinical Epigenetics 2015 7:25

    Content type: Research

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  21. The pathogenesis of systemic lupus erythematosus (SLE) has not yet been completely elucidated. One of the hallmarks of SLE is the production of autoantibodies by uncontrolled over-activated B cells. Early B ce...

    Authors: Shuangyan Luo, Yu Liu, Gongping Liang, Ming Zhao, Haijing Wu, Yunsheng Liang, Xiangning Qiu, Yixin Tan, Yong Dai, Susan Yung, Tak-Mao Chan and Qianjin Lu

    Citation: Clinical Epigenetics 2015 7:24

    Content type: Research

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  22. Imprinting disorders (IDs) are a group of eight rare but probably underdiagnosed congenital diseases affecting growth, development and metabolism. They are caused by similar molecular changes affecting regulat...

    Authors: Thomas Eggermann, Irène Netchine, I Karen Temple, Zeynep Tümer, David Monk, Deborah Mackay, Karin Grønskov, Andrea Riccio, Agnès Linglart and Eamonn R Maher

    Citation: Clinical Epigenetics 2015 7:23

    Content type: Review

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  23. Even if genetics play an important role, individual variation in stature remains unexplained at the molecular level. Indeed, genome-wide association study (GWAS) have revealed hundreds of variants that contrib...

    Authors: Meriem Ouni, Yasemin Gunes, Marie-Pierre Belot, Anne-Laure Castell, Delphine Fradin and Pierre Bougnères

    Citation: Clinical Epigenetics 2015 7:22

    Content type: Research

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  24. Preeclampsia is one of the leading causes of fetal and maternal morbidity and mortality worldwide. Preterm babies of mothers with early onset preeclampsia (EOPE) are at higher risks for various diseases later ...

    Authors: Travers Ching, James Ha, Min-Ae Song, Maarit Tiirikainen, Janos Molnar, Marla J Berry, Dena Towner and Lana X Garmire

    Citation: Clinical Epigenetics 2015 7:21

    Content type: Research

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  25. Altered expression of microRNAs (miRNAs) commonly accompanies colorectal (CRC) and endometrial carcinoma (EC) development, but the underlying mechanisms and clinicopathological correlations remain to be clarif...

    Authors: Sippy Kaur, Johanna E Lotsari, Sam Al-Sohaily, Janindra Warusavitarne, Maija RJ Kohonen-Corish and Päivi Peltomäki

    Citation: Clinical Epigenetics 2015 7:20

    Content type: Research

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  26. Primary cells enter replicative senescence after a limited number of cell divisions. This process needs to be considered in cell culture experiments, and it is particularly important for regenerative medicine....

    Authors: Sonja Hänzelmann, Fabian Beier, Eduardo G Gusmao, Carmen M Koch, Sebastian Hummel, Iryna Charapitsa, Sylvia Joussen, Vladimir Benes, Tim H Brümmendorf, George Reid, Ivan G Costa and Wolfgang Wagner

    Citation: Clinical Epigenetics 2015 7:19

    Content type: Research

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  27. Hypomethylation of long interspersed element (LINE)-1 has been observed in tumorigenesis when using degenerate assays, which provide an average across all repeats. However, it is unknown whether individual LIN...

    Authors: Nicole Nüsgen, Wolfgang Goering, Albertas Dauksa, Arijit Biswas, Muhammad Ahmer Jamil, Ioanna Dimitriou, Amit Sharma, Heike Singer, Rolf Fimmers, Holger Fröhlich, Johannes Oldenburg, Antanas Gulbinas, Wolfgang A Schulz and Osman El-Maarri

    Citation: Clinical Epigenetics 2015 7:17

    Content type: Research

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  28. Neuroblastoma (NB) is the most common extracranial pediatric solid tumor with a highly variable clinical course, ranging from spontaneous regression to life-threatening disease. Survival rates for high-risk NB...

    Authors: Yania Yáñez, Elena Grau, Virginia C Rodríguez-Cortez, David Hervás, Enrique Vidal, Rosa Noguera, Miguel Hernández, Vanessa Segura, Adela Cañete, Ana Conesa, Jaime Font de Mora and Victoria Castel

    Citation: Clinical Epigenetics 2015 7:16

    Content type: Research

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  29. Hepatocellular carcinoma (HCC) is among the most frequent human malignancies and a major cause of cancer-related death worldwide. It is characterized by late detection and fast progression, and it is believed ...

    Authors: Marie-Pierre Lambert, Pierre-Benoit Ancey, Davide Degli Esposti, Marie-Pierre Cros, Athena Sklias, Jean-Yves Scoazec, David Durantel, Hector Hernandez-Vargas and Zdenko Herceg

    Citation: Clinical Epigenetics 2015 7:15

    Content type: Research

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  30. The dietary supply of methyl donors such as folate, vitamin B12, betaine, methionine, and choline is essential for normal growth, development, and physiological functions through the life course. Both human and a...

    Authors: Antonysunil Adaikalakoteswari, Sarah Finer, Philip D Voyias, Ciara M McCarthy, Manu Vatish, Jonathan Moore, Melissa Smart-Halajko, Nahla Bawazeer, Nasser M Al-Daghri, Philip G McTernan, Sudhesh Kumar, Graham A Hitman, Ponnusamy Saravanan and Gyanendra Tripathi

    Citation: Clinical Epigenetics 2015 7:14

    Content type: Research

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  31. Recent genome-wide analysis has shown that DNA methylation spans long stretches of chromosome regions consisting of clusters of contiguous CpG islands or gene families. Hypermethylation of various gene cluster...

    Authors: Rohit R Jadhav, Zhenqing Ye, Rui-Lan Huang, Joseph Liu, Pei-Yin Hsu, Yi-Wen Huang, Leticia B Rangel, Hung-Cheng Lai, Juan Carlos Roa, Nameer B Kirma, Tim Hui-Ming Huang and Victor X Jin

    Citation: Clinical Epigenetics 2015 7:13

    Content type: Research

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  32. The prevalence of chronic diseases such as cancer, type 2 diabetes, metabolic syndrome (MetS), and cardiovascular disease increases with age in all populations. Epigenetic features are hypothesized to play imp...

    Authors: Omar Ali, Diana Cerjak, Jack W Kent Jr, Roland James, John Blangero, Melanie A Carless and Yi Zhang

    Citation: Clinical Epigenetics 2015 7:12

    Content type: Research

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  33. We present a method that utilizes DNA methylation profiling for prediction of the cytogenetic subtypes of acute lymphoblastic leukemia (ALL) cells from pediatric ALL patients. The primary aim of our study was ...

    Authors: Jessica Nordlund, Christofer L Bäcklin, Vasilios Zachariadis, Lucia Cavelier, Johan Dahlberg, Ingegerd Öfverholm, Gisela Barbany, Ann Nordgren, Elin Övernäs, Jonas Abrahamsson, Trond Flaegstad, Mats M Heyman, Ólafur G Jónsson, Jukka Kanerva, Rolf Larsson, Josefine Palle…

    Citation: Clinical Epigenetics 2015 7:11

    Content type: Research

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  34. Long non-coding RNAs (lncRNA) play an important role in carcinogenesis; knowledge on lncRNA expression in renal cell carcinoma is rudimental. As a basis for biomarker development, we aimed to explore the lncRN...

    Authors: Jasmine JC Blondeau, Mario Deng, Isabella Syring, Sarah Schrödter, Doris Schmidt, Sven Perner, Stefan C Müller and Jörg Ellinger

    Citation: Clinical Epigenetics 2015 7:10

    Content type: Research

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  35. An adverse intrauterine environment leads to permanent physiological changes including vascular tone regulation, potentially influencing the risk for adult vascular diseases. We therefore aimed to monitor resp...

    Authors: Jan Postberg, Miriam Kanders, Sakeh Forcob, Rhea Willems, Valerie Orth, Kai Oliver Hensel, Patrick Philipp Weil, Stefan Wirth and Andreas Christoph Jenke

    Citation: Clinical Epigenetics 2015 7:9

    Content type: Research

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  36. Transgenerational epigenetic inheritance has gained increased attention due to the possibility that exposure to environmental contaminants induce diseases that propagate across generations through epigenomic a...

    Authors: Carlos Guerrero-Bosagna and Per Jensen

    Citation: Clinical Epigenetics 2015 7:8

    Content type: Letter to the Editor

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  37. Modification of DNA by methylation of cytosines at CpG dinucleotides is a widespread phenomenon that leads to changes in gene expression, thereby influencing and regulating many biological processes. Recent te...

    Authors: Shaza B Zaghlool, Mashael Al-Shafai, Wadha A Al Muftah, Pankaj Kumar, Mario Falchi and Karsten Suhre

    Citation: Clinical Epigenetics 2015 7:6

    Content type: Research

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  38. The in vitro analysis of the hypomethylation of imprinting control region 1 (ICR1) within the IGF2/H19 locus is challenged by the mosaic distribution of the epimutation in tissues from children with Silver-Russel...

    Authors: Doreen Heckmann, Christina Urban, Karin Weber, Kai Kannenberg and Gerhard Binder

    Citation: Clinical Epigenetics 2015 7:5

    Content type: Research

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  39. Studies of methylation biomarkers for cervical cancer often involved only few randomly selected CpGs per candidate gene analyzed by methylation-specific PCR-based methods, with often inconsistent results from ...

    Authors: Xiaoyi Tian, Di Chen, Ran Zhang, Jun Zhou, Xiaozhong Peng, Xiaolin Yang, Xiuru Zhang and Zhi Zheng

    Citation: Clinical Epigenetics 2015 7:4

    Content type: Research

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  40. DNA methylation was suggested as the promising biomarker for lung cancer diagnosis. However, it is a great challenge to search for the optimal combination of methylation biomarkers to obtain maximum diagnostic...

    Authors: Shicheng Guo, Fengyang Yan, Jibin Xu, Yang Bao, Ji Zhu, Xiaotian Wang, Junjie Wu, Yi Li, Weilin Pu, Yan Liu, Zhengwen Jiang, Yanyun Ma, Xiaofeng Chen, Momiao Xiong, Li Jin and Jiucun Wang

    Citation: Clinical Epigenetics 2015 7:3

    Content type: Research

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  41. One of the most frequently found abnormalities in acute myeloid leukemia (AML) is the t(8;21)(q22;q22) translocation, which is seen in around 15% of patients. This translocation results in the production of th...

    Authors: Jessica M Salmon, Michael Bots, Eva Vidacs, Kym L Stanley, Peter Atadja, Johannes Zuber and Ricky W Johnstone

    Citation: Clinical Epigenetics 2015 7:2

    Content type: Short report

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  42. The dysregulation of transforming growth factor-β (TGF-β) signaling plays a crucial role in ovarian carcinogenesis and in maintaining cancer stem cell properties. Classified as a member of the ATP-binding cass...

    Authors: Jian-Liang Chou, Rui-Lan Huang, Jacqueline Shay, Lin-Yu Chen, Sheng-Jie Lin, Pearlly S Yan, Wei-Ting Chao, Yi-Hui Lai, Yen-Ling Lai, Tai-Kuang Chao, Cheng-I Lee, Chien-Kuo Tai, Shu-Fen Wu, Kenneth P Nephew, Tim H-M Huang, Hung-Cheng Lai…

    Citation: Clinical Epigenetics 2015 7:1

    Content type: Research

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  43. Splicing is more efficient when coupled with transcription and it has been proposed that nucleosomes enriched in exons are important for splice site recognition. Lynch syndrome is a familial cancer syndrome th...

    Authors: Mathew A Sloane, Luke B Hesson, Andrea C Nunez, Bryony A Thompson and Robyn L Ward

    Citation: Clinical Epigenetics 2014 6:32

    Content type: Short report

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  44. DNA hypermethylation is reported as a frequent event and prognostic marker in head and neck squamous cell carcinomas (HNSCC). Methylation has been commonly assessed with non-quantitative methodologies, such as...

    Authors: Annette M Lim, Ida LM Candiloro, Nicholas Wong, Marnie Collins, Hongdo Do, Elena A Takano, Christopher Angel, Richard J Young, June Corry, David Wiesenfeld, Stephen Kleid, Elizabeth Sigston, Bernard Lyons, Danny Rischin, Benjamin Solomon and Alexander Dobrovic

    Citation: Clinical Epigenetics 2014 6:22

    Content type: Research

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  45. An important model of hepatocellular carcinoma (HCC) that has been described in southeast Asia includes the transition from chronic hepatitis B infection (CHB) to liver cirrhosis (LC) and, finally, to HCC. The...

    Authors: Yangxing Zhao, Feng Xue, Jinfeng Sun, Shicheng Guo, Hongyu Zhang, Bijun Qiu, Junfeng Geng, Jun Gu, Xiaoyu Zhou, Wei Wang, Zhenfeng Zhang, Ning Tang, Yinghua He, Jian Yu and Qiang Xia

    Citation: Clinical Epigenetics 2014 6:30

    Content type: Research

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