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  1. Parthenogenetic mosaicism is an extremely rare condition identified only in five subjects to date. The previous studies indicate that this condition is mediated by parthenogenetic activation and is free from a...

    Authors: Yohei Masunaga, Masayo Kagami, Fumiko Kato, Takeshi Usui, Takako Yonemoto, Kazuo Mishima, Maki Fukami, Kazushi Aoto, Hirotomo Saitsu and Tsutomu Ogata
    Citation: Clinical Epigenetics 2021 13:73
  2. The development of new biomarkers with diagnostic, prognostic and therapeutic prominence will greatly enhance the management of breast cancer (BC). Several reports suggest the involvement of the histone acetyl...

    Authors: Wafaa S. Ramadan, Iman M. Talaat, Mahmood Y. Hachim, Annette Lischka, Timo Gemoll and Raafat El-Awady
    Citation: Clinical Epigenetics 2021 13:72
  3. Testicular germ cell tumors (TGCTs) are among the most common solid malignancies in young-adult men, and currently most mortality is due to metastatic disease and emergence of resistance to cisplatin. There is...

    Authors: João Lobo, Vera Constâncio, Pedro Leite-Silva, Rita Guimarães, Mariana Cantante, Isaac Braga, Joaquina Maurício, Leendert H. J. Looijenga, Rui Henrique and Carmen Jerónimo
    Citation: Clinical Epigenetics 2021 13:70
  4. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Holly Russell, Katarzyna Kedzierska, Daniel D. Buchanan, Rachael Thomas, Emma Tham, Miriam Mints, Anne Keränen, Graham G. Giles, Melissa C. Southey, Roger L. Milne, Ian Tomlinson, David Church, Amanda B. Spurdle, Tracy A. O’Mara and Annabelle Lewis
    Citation: Clinical Epigenetics 2021 13:69

    The original article was published in Clinical Epigenetics 2020 12:102

  5. Poor family emotional health (FEH) during childhood is prevalent and impactful, and likely confers similar neurodevelopmental risks as other adverse social environments. Pointed FEH study efforts are underdeve...

    Authors: J. R. Pfeiffer, Angela C. Bustamante, Grace S. Kim, Don Armstrong, Annchen R. Knodt, Karestan C. Koenen, Ahmad R. Hariri and Monica Uddin
    Citation: Clinical Epigenetics 2021 13:68
  6. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Sara Gombert, Mathias Rhein, Andreas Winterpacht, Tino Münster, Thomas Hillemacher, Andreas Leffler and Helge Frieling
    Citation: Clinical Epigenetics 2021 13:67

    The original article was published in Clinical Epigenetics 2019 12:1

  7. Despite impressive efforts invested in epigenetic research in the last 50 years, clinical applications are still lacking. Only a few university hospital centers currently use epigenetic biomarkers at the bedsi...

    Authors: Federica Sarno, Giuditta Benincasa, Markus List, Albert-Lazlo Barabasi, Jan Baumbach, Fortunato Ciardiello, Sebastiano Filetti, Kimberly Glass, Joseph Loscalzo, Cinzia Marchese, Bradley A. Maron, Paola Paci, Paolo Parini, Enrico Petrillo, Edwin K. Silverman, Antonella Verrienti…
    Citation: Clinical Epigenetics 2021 13:66
  8. Several studies show that childhood and adulthood asthma and its symptoms can be modulated through epigenetic modifications. Epigenetic changes are inheritable modifications that can modify the gene expression...

    Authors: Mojgan Sheikhpour, Mobina Maleki, Maryam Ebrahimi Vargoorani and Vahid Amiri
    Citation: Clinical Epigenetics 2021 13:65
  9. Previous studies have shown that DNA methylation (DNAm) is associated with body mass index (BMI). However, it is unknown whether DNAm at pre-adolescence is associated with BMI status transition from pre- to po...

    Authors: Jiajing Wang, Hongmei Zhang, Faisal I. Rezwan, Caroline Relton, S. Hasan Arshad and John W. Holloway
    Citation: Clinical Epigenetics 2021 13:64
  10. Epigenetic alterations are known contributors to cancer development and aggressiveness. Additional to alterations in cancer cells, aberrant epigenetic marks are present in cells of the tumor microenvironment, ...

    Authors: Iris Lodewijk, Sandra P. Nunes, Rui Henrique, Carmen Jerónimo, Marta Dueñas and Jesús M. Paramio
    Citation: Clinical Epigenetics 2021 13:63
  11. Enhancer of zeste homolog 2 inhibitors (EZH2i) have garnered increased attention owing to their anticancer activity by targeting EZH2, a well-known cancer-promoting factor. However, some lymphomas are resistan...

    Authors: Chen Li, Yan Wang, Yueqing Gong, Tengrui Zhang, Jiaqi Huang, Zhen Tan and Lixiang Xue
    Citation: Clinical Epigenetics 2021 13:62
  12. Hypertrophic cardiomyopathy (HCM) is the most common genetic disease of the cardiac muscle, frequently caused by mutations in MYBPC3. However, little is known about the upstream pathways and key regulators causin...

    Authors: J. Pei, M. Schuldt, E. Nagyova, Z. Gu, S. el Bouhaddani, L. Yiangou, M. Jansen, J. J. A. Calis, L. M. Dorsch, C. Snijders Blok, N. A. M. van den Dungen, N. Lansu, B. J. Boukens, I. R. Efimov, M. Michels, M. C. Verhaar…
    Citation: Clinical Epigenetics 2021 13:61
  13. DNA methylation is a key epigenetic modification that can directly affect gene regulation. DNA methylation is highly influenced by environmental factors such as cigarette smoking, which is causally related to ...

    Authors: Chen Yao, Roby Joehanes, Rory Wilson, Toshiko Tanaka, Luigi Ferrucci, Anja Kretschmer, Holger Prokisch, Katharina Schramm, Christian Gieger, Annette Peters, Melanie Waldenberger, Carola Marzi, Christian Herder and Daniel Levy
    Citation: Clinical Epigenetics 2021 13:60
  14. Lead, a known neurotoxicant, has previously received attention in Parkinson’s disease (PD) research, but epidemiologic studies have been limited in sample size and findings are equivocal. We generated two meth...

    Authors: Kimberly C. Paul, Steve Horvath, Irish Del Rosario, Jeff M. Bronstein and Beate Ritz
    Citation: Clinical Epigenetics 2021 13:59
  15. Valproic acid (VPA) is one of the most commonly used anti-epileptic drugs with pharmacological actions on GABA and blocking voltage-gated ion channels. VPA also inhibits histone deacetylase (HDAC) activity. Su...

    Authors: Sebastian Lunke, Scott Maxwell, Ishant Khurana, Harikrishnan K.N., Jun Okabe, Keith Al-Hasani and Assam El-Osta
    Citation: Clinical Epigenetics 2021 13:58
  16. Low birthweight has been repeatedly associated with long-term adverse health outcomes and many non-communicable diseases. Our aim was to look-up cord blood birthweight-associated CpG sites identified by the PA...

    Authors: Chiara Moccia, Maja Popovic, Elena Isaevska, Valentina Fiano, Morena Trevisan, Franca Rusconi, Silvia Polidoro and Lorenzo Richiardi
    Citation: Clinical Epigenetics 2021 13:57
  17. An intronic GGGGCC (G4C2) hexanucleotide repeat expansion (HRE) in the C9ORF72 gene is the most common cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), referred to as C9ALS/FTD. No ...

    Authors: Esteban Quezada, Claudio Cappelli, Iván Diaz, Nur Jury, Nicholas Wightman, Robert H. Brown Jr., Martín Montecino and Brigitte van Zundert
    Citation: Clinical Epigenetics 2021 13:56
  18. Cardiovascular disease (CVD) is the leading cause of mortality among US adults. African Americans have higher burden of CVD morbidity and mortality compared to any other racial group. Identifying biomarkers fo...

    Authors: Farah Ammous, Wei Zhao, Scott M. Ratliff, Thomas H. Mosley, Lawrence F. Bielak, Xiang Zhou, Patricia A. Peyser, Sharon L. R. Kardia and Jennifer A. Smith
    Citation: Clinical Epigenetics 2021 13:55
  19. Non-small cell lung carcinoma (NSCLC) is a leading cause of cancer-related death and represents a major health burden worldwide. Current therapies for NSCLC include chemotherapy, immunotherapy, and targeted mo...

    Authors: Claudia Dominici, Nicolas Sgarioto, Zhenbao Yu, Laura Sesma-Sanz, Jean-Yves Masson, Stéphane Richard and Noël J.-M. Raynal
    Citation: Clinical Epigenetics 2021 13:54
  20. Intervertebral disc degeneration (IDD) is a major cause of lower back pain. This study aimed at exploring the effects of histone deacetylase 4 (HDAC4) and its upstream and downstream signaling molecules on IDD...

    Authors: Lin Xiao, Dongping Gong, Loufeng Liang, Anwei Liang, Huaxin Liang, Xiayi Xu and Hongli Teng
    Citation: Clinical Epigenetics 2021 13:53
  21. The promoter hypermethylation of the methylguanine-DNA methyltransferase gene is a frequently used biomarker in daily clinical practice as it is associated with a favorable prognosis in glioblastoma patients t...

    Authors: Rocio Rosas-Alonso, Julian Colmenarejo-Fernandez, Olga Pernia, Carlos Rodriguez-Antolín, Isabel Esteban, Ismael Ghanem, Dario Sanchez-Cabrero, Itsaso Losantos-Garcia, Sara Palacios-Zambrano, Gema Moreno-Bueno, Javier de Castro, Virginia Martinez-Marin and Inmaculada Ibanez-de-Caceres
    Citation: Clinical Epigenetics 2021 13:52
  22. Hirschsprung disease (HSCR, OMIM 142623) is a rare congenital disorder that results from a failure to fully colonize the gut by enteric precursor cells (EPCs) derived from the neural crest. Such incomplete gut...

    Authors: Leticia Villalba-Benito, Daniel López-López, Ana Torroglosa, Carlos S. Casimiro-Soriguer, Berta Luzón-Toro, Raquel María Fernández, María José Moya-Jiménez, Guillermo Antiñolo, Joaquín Dopazo and Salud Borrego
    Citation: Clinical Epigenetics 2021 13:51
  23. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Alejandra Sandoval-Bórquez, Iva Polakovicova, Nicolás Carrasco-Véliz, Lorena Lobos-González, Ismael Riquelme, Gonzalo Carrasco-Avino, Carolina Bizama, Enrique Norero, Gareth I. Owen, Juan C. Roa and Alejandro H. Corvalán
    Citation: Clinical Epigenetics 2021 13:50

    The original article was published in Clinical Epigenetics 2017 9:114

  24. Altered DNA methylation patterns play important roles in cancer development and progression. We examined whether expression levels of genes directly or indirectly involved in DNA methylation and demethylation ...

    Authors: Suleyman Vural, Alida Palmisano, William C. Reinhold, Yves Pommier, Beverly A. Teicher and Julia Krushkal
    Citation: Clinical Epigenetics 2021 13:49
  25. DNA methylation age (mAge), a methylation biomarker for the aging process, might serve as a more accurate predictor of morbidity and aging status than chronological age. We evaluated the role of multiple facto...

    Authors: Anat Yaskolka Meir, Maria Keller, Stephan H. Bernhart, Ehud Rinott, Gal Tsaban, Hila Zelicha, Alon Kaplan, Dan Schwarzfuchs, Ilan Shelef, Yftach Gepner, Jun Li, Yifei Lin, Matthias Blüher, Uta Ceglarek, Michael Stumvoll, Peter F. Stadler…
    Citation: Clinical Epigenetics 2021 13:48
  26. Maternal smoking affects more than half a million pregnancies each year in the US and is known to result in fetal growth restriction as measured by lower birthweight and its associated long-term consequences. ...

    Authors: Richard Xu, Xiumei Hong, Boyang Zhang, Wanyu Huang, Wenpin Hou, Guoying Wang, Xiaobin Wang, Tak Igusa, Liming Liang and Hongkai Ji
    Citation: Clinical Epigenetics 2021 13:47
  27. Assessing functional ability is an important component of understanding healthy aging. Objective measures of functional ability include grip strength, gait speed, sit-to-stand time, and 6-min walk distance. Us...

    Authors: Curtis L. Petersen, Brock C. Christensen and John A. Batsis
    Citation: Clinical Epigenetics 2021 13:46
  28. Chromatin modifiers and their implications in oncogenesis have been an exciting area of cancer research. These are enzymes that modify chromatin via post-translational modifications such as methylation, acetyl...

    Authors: Benjamin J. Bernard, Nupur Nigam, Kyunghee Burkitt and Vassiliki Saloura
    Citation: Clinical Epigenetics 2021 13:45
  29. Trimethylation of lysine 27 and dimethylation of lysine 9 of histone-H3 catalyzed by the histone methyltransferases EZH2 and G9a impede gene transcription in cancer. Our human bronchial epithelial (HBEC) pre-m...

    Authors: Carmen S. Tellez, Maria A. Picchi, Daniel Juri, Kieu Do, Dhimant H. Desai, Shantu G. Amin, Julie A. Hutt, Piotr T. Filipczak and Steven A. Belinsky
    Citation: Clinical Epigenetics 2021 13:44
  30. Epigenetic alterations may contribute to early detection of cancer. We evaluated the association of blood DNA methylation with lymphatic–hematopoietic cancers and, for comparison, with solid cancers. We also e...

    Authors: Arce Domingo-Relloso, Tianxiao Huan, Karin Haack, Angela L. Riffo-Campos, Daniel Levy, M. Daniele Fallin, Mary Beth Terry, Ying Zhang, Dorothy A. Rhoades, Miguel Herreros-Martinez, Esther Garcia-Esquinas, Shelley A. Cole, Maria Tellez-Plaza and Ana Navas-Acien
    Citation: Clinical Epigenetics 2021 13:43
  31. Cardiovascular health (CVH) has been defined by the American Heart Association (AHA) as the presence of the “Life’s Simple 7” ideal lifestyle and clinical factors. CVH is known to predict longevity and freedom...

    Authors: Tess D. Pottinger, Sadiya S. Khan, Yinan Zheng, Wei Zhang, Hilary A. Tindle, Matthew Allison, Gretchen Wells, Aladdin H. Shadyab, Rami Nassir, Lisa Warsinger Martin, JoAnn E. Manson, Donald M. Lloyd-Jones, Philip Greenland, Andrea A. Baccarelli, Eric A. Whitsel and Lifang Hou
    Citation: Clinical Epigenetics 2021 13:42
  32. Type 2 diabetes (T2D) is a heterogeneous disease with well-known genetic and environmental risk factors contributing to its prevalence. Epigenetic mechanisms related to changes in DNA methylation (DNAm), may a...

    Authors: Diana L. Juvinao-Quintero, Riccardo E. Marioni, Carolina Ochoa-Rosales, Tom C. Russ, Ian J. Deary, Joyce B. J. van Meurs, Trudy Voortman, Marie-France Hivert, Gemma C. Sharp, Caroline L. Relton and Hannah R. Elliott
    Citation: Clinical Epigenetics 2021 13:40
  33. In this review, we were interested to identify the wide universe of enzymes associated with epigenetic modifications, whose gene expression is regulated by miRNAs with a high relative abundance in Crohn's dise...

    Authors: Cecilia Fernández-Ponce, Roberto Navarro Quiroz, Anderson Díaz Perez, Gustavo Aroca Martinez, Andrés Cadena Bonfanti, Antonio Acosta Hoyos, Lorena Gómez Escorcia, Sandra Hernández Agudelo, Christian Orozco Sánchez, José Villarreal Camacho, Linda Atencio Ibarra, Jose Consuegra Machado, Alberto Espinoza Garavito, Francisco García-Cózar and Elkin Navarro Quiroz
    Citation: Clinical Epigenetics 2021 13:39
  34. Lung cancer is the leading cause of cancer-related death in most western countries in both, males and females, accounting for roughly 20–25% of all cancer deaths. For choosing the most appropriate therapy regi...

    Authors: Torsten Goldmann, Bernhard Schmitt, Julia Müller, Maren Kröger, Swetlana Scheufele, Sebastian Marwitz, Dörte Nitschkowski, Marc A. Schneider, Michael Meister, Thomas Muley, Michael Thomas, Christian Kugler, Klaus F. Rabe, Reiner Siebert, Martin Reck and Ole Ammerpohl
    Citation: Clinical Epigenetics 2021 13:38
  35. BRG1 (encoded by SMARCA4) is a catalytic component of the SWI/SNF chromatin remodelling complex, with key roles in modulating DNA accessibility. Dysregulation of BRG1 is observed, but functionally uncharacterised...

    Authors: Katherine A. Giles, Cathryn M. Gould, Joanna Achinger-Kawecka, Scott G. Page, Georgia R. Kafer, Samuel Rogers, Phuc-Loi Luu, Anthony J. Cesare, Susan J. Clark and Phillippa C. Taberlay
    Citation: Clinical Epigenetics 2021 13:37
  36. Smoking remains one of the leading preventable causes of death. Smoking leaves a strong signature on the blood methylome as shown in multiple studies using the Infinium HumanMethylation450 BeadChip. Here, we e...

    Authors: C. Christiansen, J. E. Castillo-Fernandez, A. Domingo-Relloso, W. Zhao, J. S. El-Sayed Moustafa, P.-C. Tsai, J. Maddock, K. Haack, S. A. Cole, S. L. R. Kardia, M. Molokhia, M. Suderman, C. Power, C. Relton, A. Wong, D. Kuh…
    Citation: Clinical Epigenetics 2021 13:36
  37. Epigenetic inactivation of O6-methylguanine DNA-methyltransferase (MGMT) is associated with increased sensitivity to alkylating chemotherapeutic agents in glioblastoma patients. The genetic background underlying

    Authors: Lijie Wang, Afsaneh Mohammadnejad, Weilong Li, Jesper Lund, Shuxia Li, Signe Clemmensen, Maria Timofeeva, Mette Soerensen, Jonas Mengel-From, Kaare Christensen, Jacob Hjelmborg and Qihua Tan
    Citation: Clinical Epigenetics 2021 13:35
  38. Glycosylation, one of the most fundamental post-translational modifications, is altered in cancer and is subject in part, to epigenetic regulation. As there are many epigenetic-targeted therapies currently in ...

    Authors: Gordon Greville, Esther Llop, Jane Howard, Stephen F. Madden, Antoinette S. Perry, Rosa Peracaula, Pauline M. Rudd, Amanda McCann and Radka Saldova
    Citation: Clinical Epigenetics 2021 13:34
  39. Although R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) remains the standard chemotherapy regimen for diffuse large B cell lymphoma (DLBCL) patients, not all patients are respon...

    Authors: Hang-Yu Chen, Wei-Long Zhang, Lei Zhang, Ping Yang, Fang Li, Ze-Ruo Yang, Jing Wang, Meng Pang, Yun Hong, Changjian Yan, Wei Li, Jia Liu, Nuo Xu, Long Chen, Xiu-Bing Xiao, Yan Qin…
    Citation: Clinical Epigenetics 2021 13:33
  40. There is an unmet need for noninvasive markers specific for kidney transplant rejection. Such a marker may eventually overcome the need for a transplant biopsy. In this pilot study, the potential of circulatin...

    Authors: Jeroen G. H. P. Verhoeven, Carla C. Baan, Annemiek M. A. Peeters, Marian C. Clahsen-van Groningen, Daan Nieboer, Mariëlle Herzog, Marc Eccleston, Dennis A. Hesselink and Karin Boer
    Citation: Clinical Epigenetics 2021 13:32
  41. Transcription factor B cell lymphoma 6 (BCL6) is a master regulator of T follicular helper (Tfh) cells, which play a crucial role in the pathogenesis of systemic lupus erythematosus (SLE). However, the mechani...

    Authors: Limin Liu, Longyuan Hu, Linxuan Yang, Sujie Jia, Pei Du, Xiaoli Min, Jiali Wu, Haijing Wu, Hai Long, Qianjin Lu and Ming Zhao
    Citation: Clinical Epigenetics 2021 13:31
  42. Whereas duplications in 11p15.5 covering both imprinting centers (ICs) and their subordinated genes account for up to 1% of Beckwith–Wiedemann and Silver–Russell syndrome patients (BWS, SRS), the deletions in ...

    Authors: Thomas Eggermann, Matthias Begemann and Lutz Pfeiffer
    Citation: Clinical Epigenetics 2021 13:30
  43. Pneumococcal infections are a major cause of morbidity and mortality in young children and immaturity of the immune system partly underlies poor vaccine responses seen in the young. Emerging evidence suggests ...

    Authors: Sara Pischedda, Daniel O’Connor, Benjamin P. Fairfax, Antonio Salas, Federico Martinon-Torres, Andrew J. Pollard and Johannes Trück
    Citation: Clinical Epigenetics 2021 13:29
  44. Patients suffering from the BCR-ABL1-negative myeloproliferative disease prefibrotic primary myelofibrosis (pre-PMF) have a certain risk for progression to myelofibrosis. Accurate risk estimation for this fibroti...

    Authors: Ulrich Lehmann, Helge Stark, Stephan Bartels, Jerome Schlue, Guntram Büsche and Hans Kreipe
    Citation: Clinical Epigenetics 2021 13:28
  45. Prior work in mice has shown that some retrotransposed elements remain substantially methylated during DNA methylation reprogramming of germ cells. In the pig, however, information about this process is scarce...

    Authors: Isabel Gómez-Redondo, Benjamín Planells, Sebastián Cánovas, Elena Ivanova, Gavin Kelsey and Alfonso Gutiérrez-Adán
    Citation: Clinical Epigenetics 2021 13:27
  46. Early detection of colorectal carcinoma (CRC) would help to identify tumors when curative treatments are available and beneficial. However, current screening methods for CRC, e.g., colonoscopy, may affect pati...

    Authors: Jinke Sui, Xianrui Wu, Chenyang Wang, Guoqiang Wang, Chengcheng Li, Jing Zhao, Yuzi Zhang, Jianxing Xiang, Yu Xu, Weiqi Nian, Fuao Cao, Guanyu Yu, Zheng Lou, Liqiang Hao, Lianjie Liu, Bingsi Li…
    Citation: Clinical Epigenetics 2021 13:26
  47. Epigenetic therapies may modulate the tumor microenvironment. We evaluated the safety and optimal sequence of combination DNA methyltransferase inhibitor guadecitabine with a granulocyte macrophage-colony-stim...

    Authors: Katherine M. Bever, Dwayne L. Thomas II, Jiajia Zhang, Ernie A. Diaz Rivera, Gary L. Rosner, Qingfeng Zhu, Julie M. Nauroth, Brian Christmas, Elizabeth D. Thompson, Robert A. Anders, Carol Judkins, Meizheng Liu, Elizabeth M. Jaffee, Nita Ahuja, Lei Zheng and Nilofer S. Azad
    Citation: Clinical Epigenetics 2021 13:25
  48. Fabry disease (FD) is a rare X-linked disease caused by mutations in GLA gene with consequent lysosomal accumulation of globotriaosylceramide (Gb3). Women with FD often show highly heterogeneous symptoms that ...

    Authors: Teodolinda Di Risi, Roberta Vinciguerra, Mariella Cuomo, Rosa Della Monica, Eleonora Riccio, Sirio Cocozza, Massimo Imbriaco, Giovanni Duro, Antonio Pisani and Lorenzo Chiariotti
    Citation: Clinical Epigenetics 2021 13:24
  49. The neuropeptide oxytocin regulates mammalian social behavior. Disruptions in oxytocin signaling are a feature of many psychopathologies. One commonly studied biomarker for oxytocin involvement in psychiatric ...

    Authors: Joshua S. Danoff, Kelly L. Wroblewski, Andrew J. Graves, Graham C. Quinn, Allison M. Perkeybile, William M. Kenkel, Travis S. Lillard, Hardik I. Parikh, Hudson F. Golino, Simon G. Gregory, C. Sue Carter, Karen L. Bales and Jessica J. Connelly
    Citation: Clinical Epigenetics 2021 13:23