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Section edited by Lucia Altucci, James Davie, Eamonn Maher, Adele Murrell, Trygve O Tollefsbol and Bryan Turner
This section welcomes articles from any discipline of clinical epigenetics not covered by the other journal sections.
Research
Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal lung disorder of unknown origin with a highly variable and unpredictable clinical course. Polymorphisms and environmentally induced epigenetic variat...
Clinical Epigenetics 2017 9:84
Published on: 15 August 2017
Research
Lysine-specific demethylase 1A (LSD1) is a key regulator of the androgen (AR) and estrogen receptors (ER), and LSD1 levels correlate with tumor aggressiveness. Here, we demonstrate that LSD1 regulates vitamin ...
Clinical Epigenetics 2017 9:82
Published on: 11 August 2017
Research
Accumulating evidence suggests that tobacco smoking affects the susceptibility to and severity of chronic periodontitis. Epigenetics may explain the role of smoking in the development and progress of periodont...
Clinical Epigenetics 2017 9:81
Published on: 10 August 2017
Research
Frozen-thawed embryo transfer (FET) is increasingly available for the improvement of the success rate of assisted reproductive technologies other than fresh embryo transfer (ET). There have been numerous findi...
Clinical Epigenetics 2017 9:79
Published on: 3 August 2017
Research
Goblet cell metaplasia, a common feature of chronic obstructive pulmonary disease (COPD), is associated with mucus hypersecretion which contributes to the morbidity and mortality among patients. Transcription ...
Clinical Epigenetics 2017 9:42
Published on: 24 April 2017
Research
Epigenetics changes have been shown to be affected by cigarette smoking. Cigarette smoke (CS)-mediated DNA methylation can potentially affect several cellular and pathophysiological processes, acute exacerbati...
Clinical Epigenetics 2017 9:38
Published on: 14 April 2017
Methodology
Determining the role of DNA methylation in various biological processes is dependent on the accurate representation of often highly complex patterns. Accurate representation is dependent on unbiased PCR amplif...
Clinical Epigenetics 2017 9:31
Published on: 4 April 2017
Short report
DNA methylation is the most studied epigenetic modification due to its role in regulating gene expression, and its involvement in the pathogenesis of cancer and several diseases upon aberrations in methylation...
Clinical Epigenetics 2017 9:33
Published on: 4 April 2017
Research
Lung disease progression is variable among cystic fibrosis (CF) patients and depends on DNA mutations in the CFTR gene, polymorphic variations in disease modifier genes, and environmental exposure. The contributi...
Clinical Epigenetics 2017 9:19
Published on: 14 February 2017
Short report
A report of the 6th Epigenomics of Common Diseases Conference held at the Wellcome Genome Campus in Hinxton, Cambridge, UK, on 1–4 November 2016.
Clinical Epigenetics 2017 9:5
Published on: 19 January 2017
Letter to the Editor
The study of DNA methylation in development and disease has ‘exploded’ as a field in recent years, with three major classes of measurement now routine. These encompass (i) locus-specific, (ii) genome-scale/wid...
Clinical Epigenetics 2017 9:2
Published on: 13 January 2017
Research
Environmentally influenced phenotypes, such as obesity and insulin resistance, can be transmitted over multiple generations. Epigenetic modifications, such as methylation of DNA cytosine-guanine (CpG) pairs, m...
Clinical Epigenetics 2016 8:124
Published on: 22 November 2016
Research
We present the first sequencing data using the combinatorial probe-anchor synthesis (cPAS)-based BGISEQ-500 sequencer. Applying cPAS, we investigated the repertoire of human small non-coding RNAs and compared it ...
Clinical Epigenetics 2016 8:123
Published on: 21 November 2016
Research
Molecular biomarkers that might help to distinguish between more aggressive and clinically insignificant prostate cancers (PCa) are still urgently needed. Aberrant DNA methylation as a common molecular alterat...
Clinical Epigenetics 2016 8:104
Published on: 26 September 2016
Review
SETD8/SET8/Pr-SET7/KMT5A is the only known lysine methyltransferase (KMT) that monomethylates lysine 20 of histone H4 (H4K20) in vivo. Lysine residues of non-histone proteins including proliferating cell nucle...
Clinical Epigenetics 2016 8:102
Published on: 22 September 2016
Methodology
Bisulfite (BS) conversion-based and methylation-sensitive restriction enzyme (MSRE)-based PCR methods have been the most commonly used techniques for locus-specific DNA methylation analysis. However, both meth...
Clinical Epigenetics 2016 8:101
Published on: 21 September 2016
Research
Colorectal cancer (CRC) appear to arise from precursor lesions in a well-characterized adenoma-carcinoma sequence. Significant efforts have been invested to develop biomarkers that identify early adenocarcinom...
Clinical Epigenetics 2016 8:100
Published on: 20 September 2016
Review
DNA methylation, through 5-methyl- and 5-hydroxymethylcytosine (5mC and 5hmC), is considered to be one of the principal interfaces between the genome and our environment, and it helps explain phenotypic variat...
Clinical Epigenetics 2016 8:92
Published on: 6 September 2016
Short report
DNA methylation is an essential epigenetic mark, controlled by DNA methyltransferase (DNMT) proteins, which regulates chromatin structure and gene expression throughout the genome. In this study, we describe a...
Clinical Epigenetics 2016 8:91
Published on: 5 September 2016
Research
In utero and early-life experienced environmental exposures are suggested to play an important role in many multifactorial diseases potentially mediated through lasting effects on the epigenome. As the epigeno...
Clinical Epigenetics 2016 8:81
Published on: 26 July 2016
