Table 3 Representative peripheral blood B cell genes differentially expressed in smokers
Gene | Description | FDR | FC | Functions and ontologies |
|---|---|---|---|---|
GPR15 | G protein-coupled receptor 15 | 1.35E−34 | 12.20 | Anti-inflammatory, chronic smoking biomarker |
HOMER3 | Homer scaffold protein 3 | 2.69 E−11 | 2.51 | Negative regulation of T-cell activation, NFAT inhibition |
GPR55 | G protein-coupled receptor 55 | 5.52 E−10 | 2.19 | Cannabinoid receptor, nicotine use disorder |
MGAT3 | Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase | 6.90 E−06 | 1.83 | Glycoprotein oligosaccharide biosynthesis, N-glycosylation |
ARHGAP6 | Rho GTPase activating protein 6 | 9.08 E−05 | 2.22 | Actin cytoskeleton, cell morphology |
ETV7 | ETS variant transcription factor 7 | 1.37 E−03 | 2.44 | Transcriptional repressor |
ITGAL | Integrin subunit alpha L | 1.37 E−03 | 1.28 | ICAM receptor, leukocyte adhesion and transmigration, lymphopoiesis, lymphocyte-mediated cytotoxicity |
NCALD | Neurocalcin delta | 1.39 E−03 | 3.13 | Calcium ion binding, cytosolic neuronal calcium sensor |
STEAP3 | STEAP3 metalloreductase | 1.39 E−03 | 1.79 | Erythrocyte iron homeostasis |
HFE | Homeostatic iron regulator | 1.80 E−03 | 1.58 | Iron homeostasis, homology with MHC class I |
FOXP1 | Forkhead box P1 | 3.11 E−03 | − 1.26 | Transcriptional regulator, B cell differentiation |
AK8 | Adenylate kinase 8 | 6.26 E−03 | 2.44 | Transfer terminal phosphate group to nucleoside |
NFE2L3 | NFE2 like bZIP transcription factor 3 | 6.26 E−03 | 1.60 | Erythrocyte-specific globin gene expression, lymphoma |
MFN1 | mitofusin 1 | 6.39 E−03 | − 1.25 | Mitochondrial clustering and fusion |
AICDA | Activation induced cytidine deaminase | 7.10 E−03 | 2.22 | B cell somatic hypermutation, gene conversion, and class-switch recombination |
CPAMD8 | C3 and PZP like alpha-2-macroglobulin domain containing 8 | 7.10 E−03 | 2.33 | Complement, innate immunity |
SLC46A1 | Solute carrier family 46 member 1 | 7.10 E−03 | 1.38 | Proton-coupled folate transporter |
TRERF1 | Transcriptional regulating factor 1 | 7.87 E−03 | 1.69 | Transcriptional activator of CYP11A1 |
MYH10 | Myosin heavy chain 10 | 1.22 E−02 | − 2.09 | B cell development, proliferation, and antibody response |
IGLC7 | Immunoglobulin lambda constant 7 | 1.23 E−02 | 2.18 | Immunoglobulin light chain production |
L1CAM | L1 cell adhesion molecule | 1.23 E−02 | 1.50 | Neuronal migration and axonal growth, brain development |
RARA | Retinoic acid receptor alpha | 1.32 E−02 | 1.31 | B cell growth and class-switch, T cell immunity |
TRPS1 | Transcriptional repressor GATA binding 1 | 1.32 E−02 | − 1.28 | Cell cycle, chondrocyte proliferation, breast cancer marker |
BBC3 | BCL2 binding component 3 | 1.57 E−02 | 1.61 | Apoptosis, regulation of memory B cell survival |
MAPK11 | Mitogen-activated protein kinase 11 | 1.66 E−−02 | 1.78 | MAPK signal transducer, inflammation, T cell immunity |
CD82 | CD82 molecule | 1.75 E−02 | 1.25 | CD4/CD8 associated, TCR/CD3 pathway costimulation |
MTARC2 | Mitochondrial amidoxime reducing component 2 | 1.83 E−02 | 1.68 | N-oxygenated molecule reduction, drug metabolism |
BMF* | Bcl2 modifying factor | 2.20 E−02 | 1.38 | Apoptosis, prevent autoimmunity, B cell homeostasis |
CCR10 | C–C motif chemokine receptor 9 | 2.92 E−02 | 2.59 | Homing and migration of B cells, CCL27 receptor |
ABCB4* | ATP binding cassette subfamily B member 4 | 3.00 E−02 | − 1.33 | Biliary lipid secretion, B cell adaptive immune response |
MYL9* | Myosin light chain 9 | 3.40 E−02 | 1.95 | T cell CD69 ligand, lung inflammatory immune response |
TICAM1 | Toll like receptor adaptor molecule 1 | 3.41 E−02 | 1.29 | TLR adaptor, innate immunity against pathogens, anti-viral |
ARHGAP32* | Rho GTPase activating protein 24 | 3.65 E−02 | − 1.54 | Neuronal cell differentiation |
RARG | Retinoic acid receptor gamma | 3.65 E−02 | 1.33 | B cell growth and class-switch, T cell immunity |
MAPK12 | Mitogen-activated protein kinase 12 | 4.57 E−02 | 2.13 | MAPK signal transducer, inflammation, muscle growth, |
CD226* | CD226 molecule | 4.62 E−02 | 1.69 | Cytotoxicity, T cell proliferation, autoimmune diseases |
PARP3* | Poly(ADP-ribose) polymerase family member 3 | 4.71 E−02 | 1.28 | DNA damage repair, regulation of class switch recombination |
GPR132 | G protein-coupled receptor 15 | 4.86 E−02 | 1.26 | Oxidized free fatty acid receptor, mitosis, hematopoiesis |
ITGA3* | Integrin subunit alpha 3 | 5.61 E−02 | 1.55 | Matrix degradation, endothelial cell migration |
CCR9* | C–C motif chemokine receptor 10 | 8.03 E−02 | − 2.29 | T cell selection and migration, HIV-1 infection. CCL25 receptor |
COL18A1* | Collagen type XVIII alpha 1 chain | 1.38 E−01 | 1.86 | Extracellular matrix, MAPK signaling, angiogenesis inhibition |
IGHE* | Immunoglobulin heavy constant epsilon | 1.66 E−01 | 2.32 | IgE heavy chain constant region production |
VAV3* | Vav guanine nucleotide exchange factor 3 | 1.68 E−01 | − 1.22 | Angiogenesis, B cell receptor activation and development |
CCL4* | C–C motif chemokine ligand 4 | 2.15 E−01 | − 2.31 | B cell receptor pathway activation biomarker, CCR5 ligand |