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Table 1 Distribution of significant and highly specific smoking-associated CpGs (smCpGs) among blood cell types and replication in published epigenome-wide association studies

From: Epigenomic profiling of isolated blood cell types reveals highly specific B cell smoking signatures and links to disease risk

Cell type

(Sample na)

CpGs at BF

(Percent specific to this cell type)

Highly specific among BF

(Percent highly specific)b

FDR 5%

(Percent specific to this cell type)

BF replicatedc

Replicated highly cell-type-specificb

B cell (CD19+)

(NS = 69, SM = 64)c

111

(82.0%)

80

(72.1%)

3096

(93.4%)

62

(56%)

36

(45%)

Granulocyte (CD15+)

(NS = 67, SM = 63)

96

(42.7%)

26

(27.1%)

986

(74.2%)

84

(88%)

16

(62%)

Monocyte (CD14+)

(NS = 71, SM = 62)

83

(33.7%)

12

(14.5%)

501

(54.1%)

78

(94%)

10

(83%)

Natural killer cell (CD56+)

(NS = 68, SM = 58)

19

(36.8%)

5

(26.3%)

482

(78.8%)

17

(90%)

4

(80%)

CD4T cell (CD4+)

(NS = 67, SM = 60)

12

(66.7%)

5

(41.7%)

45

(62.2%)

12

(100%)

5

(100%)

CD8T cell (CD8+)

(NS = 68, SM = 60)

5

(20.0%)

1

(20%)

10

(30.0%)

4

(80%)

0

(0%)

All cell types

238

(73.9%)

129

(54.2%)

4655

(93.5%)

171

(72%)

71

(55%)

  1. BF Bonferroni, FDR false discovery rate
  2. aThe maximal sample size of any cell type is NS = 71 and SM = 64. DNA amount, or data quality eliminated some samples from analysis. Six subjects only have a WB sample, without any cell type
  3. bHighly specific were > 104 p value difference in one cell type relative to all other cell types
  4. cReplication comparison from the following references [13, 33,34,35,36,37,38,39]
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Clinical Epigenetics

ISSN: 1868-7083

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