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Fig. 6 | Clinical Epigenetics

Fig. 6

From: Histone lysine methyltransferase SMYD3 promotes oral squamous cell carcinoma tumorigenesis via H3K4me3-mediated HMGA2 transcription

Fig. 6

HMGA2 is a key downstream effector for SMYD3-mediated functions. A, B Binding peak signal distribution locations in ChIP-seq. C Flow chart for screening 23 downstream target genes. D, E Univariate and multivariate Cox regression analyses of the 23 genes in the meta-GEO dataset. Hazard Ratio and P-values were displayed. F The distributions of functional similarities of three proteins were summarized as boxplots. G SMYD3 was co-expressed with HMGA2 in the meta-GEO dataset. H The variation of H3K4me3 binding peaks was mainly at the promoter regions (− 1 kb to the TSS) of HMGA2. I Quantification of qRT-PCR of SMYD3 was correlated with that of HMGA2 in collected 20 OSCC samples. J Quantification of SMYD3 IHC staining was correlated with that of HMGA2 IHC staining in OSCC samples (n = 131, from Stomatological Hospital of Shandong University and Shanghai Qutdo Biotech Company). K Quantification of HMGA2 IHC staining was correlated with that of H3K4me3 IHC staining in OSCC samples (n = 45, from Shanghai Qutdo Biotech Company)

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