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Fig. 2 | Clinical Epigenetics

Fig. 2

From: Histone lysine methyltransferase SMYD3 promotes oral squamous cell carcinoma tumorigenesis via H3K4me3-mediated HMGA2 transcription

Fig. 2

SMYD3 is upregulated in OSCC samples. A–H The box plots showed the distribution of SMYD3 expression in subtypes of TCGA-OSCC cohort. Numbers in parentheses indicate the sample size. I The location of CNV of SMYD3 on 23 chromosomes using the TCGA-OSCC cohort. J Deletion, diploid, copy number gain and amplification were involved in the deregulation of SMYD3 expression as analyzed by cBioPortal using TCGA-OSCC data. Numbers in parentheses indicate the sample size. K Correlation between SMYD3 CNV and mRNA expression. L Quantitative result of qRT-PCR of SMYD3 in 20 paired adjacent normal and OSCC tissues. M The protein levels of SMYD3 in 10 pairs of OSCC tissues (T) and adjacent normal tissues (N) measured by Western blotting. N Images of IHC staining for SMYD3 in normal tissues and different histologic grades of OSCC tissues (n = 131, from Stomatological Hospital of Shandong University and Shanghai Qutdo Biotech Company). Scale bars: 50 μm. O Quantification of SMYD3 IHC staining was correlated with that of H3K4me3 IHC staining in OSCC samples (n = 45, from Shanghai Qutdo Biotech Company)

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