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Table 2 Multivariate cox analyses of disease outcome in MDS patients from the training cohort

From: LEP promoter methylation in the initiation and progression of clonal cytopenia of undetermined significance and myelodysplastic syndrome

Characteristic

Time to death

Time to progression

HR

95% CI

p value

HR

95% CI

p value

LEP promoter methylation

    Below cutoff

–

–

 

–

–

 

    Above cutoff

1.92

0.69, 5.38

0.214

4.36

1.03, 18.4

0.045

Sex

    Female

–

–

 

–

–

 

    Male

0.81

0.18, 3.59

0.782

3

0.53, 17.0

0.216

Age

1

0.96, 1.04

0.87

1

0.95, 1.06

0.921

Hgb

0.58

0.40, 0.85

0.005

1.2

0.87, 1.67

0.271

ANC

1.08

0.87, 1.33

0.497

1.22

0.97, 1.53

0.089

Platelets

1

0.99, 1.00

0.378

1

0.99, 1.00

0.58

IPSS-R

    Low

–

–

 

–

–

 

    Intermediate

1.51

0.40, 5.76

0.548

1.83

0.41, 8.27

0.432

High

2.32

0.45, 11.8

0.312

1.97

0.23, 17.0

0.539

BM blast %

1.18

0.99, 1.40

0.067

1.11

0.94, 1.30

0.211

  1. HR Hazard ratio, CI Confidence interval, Below cutoff mean LEP promoter methylation < 51.03%, Above cutoff mean LEP promoter methylation ≥ 51.03%, Hgb hemoglobin, ANC absolute neutrophil count, IPSS-R Revised International Prognostic Scoring System, BM bone marrow, MDS myelodysplastic syndrome
  2. Bold values denote statistical significance (p ≤ 0.05)
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Clinical Epigenetics

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