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Table 3 GO terms that were enriched at a p-value < 0.001 among the top 250 CpGs from each EWAS of high NO2 exposure and high supplemental folic acid

From: Traffic-related air pollution and supplemental folic acid intake in relation to DNA methylation in granulosa cells

Exposure

GO ID

Description

p-value

NO2

GO:0006109

Regulation of carbohydrate metabolic process

2.35E−04

NO2

GO:0032271

Regulation of protein polymerization

4.15E−04

NO2

GO:2000463

Positive regulation of excitatory postsynaptic potential

6.07E−04

NO2

GO:0006887

Exocytosis

6.81E−04

NO2

GO:0016358

Dendrite development

9.46E−04

NO2

GO:0045121

Membrane raft

1.32E−05

NO2

GO:0098857

Membrane microdomain

1.36E−05

Folic acid

GO:0007611

Learning or memory

9.30E−05

Folic acid

GO:0044849

Estrous cycle

1.11E−04

Folic acid

GO:0050808

Synapse organization

1.60E−04

Folic acid

GO:0008361

Regulation of cell size

2.49E−04

Folic acid

GO:0050890

Cognition

2.81E−04

Folic acid

GO:0035584

Calcium-mediated signaling using intracellular calcium source

4.52E−04

Folic acid

GO:0090066

Regulation of anatomical structure size

5.73E−04

Folic acid

GO:0032535

Regulation of cellular component size

7.56E−04

Folic acid

GO:0050804

Modulation of chemical synaptic transmission

8.05E−04

Folic acid

GO:0099177

Regulation of trans-synaptic signaling

8.19E−04

Folic acid

GO:0043025

Neuronal cell body

1.58E−04

  1. High NO2 exposure was defined as > 34.1 ppb and low exposure was defined as < 11.7 ppb. High supplemental folic acid intake was defined as ≥ 800 µg/day and low intake was defined as < 400 µg/day
  2. EWAS, epigenome-wide association study; GO, gene ontology; NO2, nitrogen dioxide