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Fig. 4 | Clinical Epigenetics

Fig. 4

From: Combined inhibition of histone deacetylase and cytidine deaminase improves epigenetic potency of decitabine in colorectal adenocarcinomas

Fig. 4

Chromosomal distribution of drug-responsive tumor-suppressor miRNAs. A Shown is the upregulation of tumor-suppressor miRNAs induced by the decitabine and PBA treatment of Caco-2 cells (A1) and the combined decitabine/PBA treatment (A2). Note, 19 out of 23 upregulated miRNAs are located on chromosome 19. B The chromosomal distribution of significantly regulated miRNAs following decitabine (B1), PBA (B2) and the combined drug treatment (B3). C Repression of tumor-suppressor miRNAs (miR-138–1-3p, -1224-5p and 4274) following decitabine treatment. PBA and the combined decitabine/PBA treatment recovered expression of repressed tumor suppressor miRNAs

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Clinical Epigenetics

ISSN: 1868-7083

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