Fig. 2

Genomic profiling and pathway enrichment analysis following decitabine, PBA and combined drug treatment of Caco-2 cells for 96 h. A Heat maps and principal component analysis (PCA) of genomic data after decitabine (A1), PBA (A2) and the combined drug treatment (A3) of Caco-2 cells. The data are compared to DMSO vehicle control treatment. B Metascape gene ontology terms and enriched pathways for up- and downregulated genes in response to decitabine (B1), PBA (B2) and the combined drug treatment (B3). Red colored histograms refer to enriched GO terms and pathways of upregulated genes. The blue colored histograms refer to enriched GO terms and pathways of downregulated genes. C A comparison of significantly enriched ontology terms and pathways associated with upregulated (C1) and downregulated genes (C2) in response to decitabine, PBA and the combined treatment of Caco-2 cells