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Table 1 Description of the control and ART/hypofertile groups

From: Capturing sex-specific and hypofertility-linked effects of assisted reproductive technologies on the cord blood DNA methylome

 

Control group

n = 36

ART/hypofertile group

n = 37

p Value

Maternal age in years

34.1 (3.3)

33.8 (4.5)

0.70

Paternal age in years

36.7 (5.3)

37.7 (7.1)a

0.48

Maternal BMI

24.5 (5.0)b

24.8 (5.1)c

0.81

Smoking status during pregnancy

(S/SSP/NSd)

3/7/26

3/5/29

0.79

Obstetrical issues (M/Fe)

 Normal

27 (14/13)

25 (14/11)

0.30

 Prematurity alone

5 (1/4)

2 (0/2)

 Gestational diabetes (GD) alone

2 (1/1)

4 (4/0)

 Pre-eclampsia alone

2 (1/1)

2 (0/2)

 Pre-eclampsia + prematurity

0

3 (1/2)

 Pre-eclampsia + GD

0

1 (0/1)

Delivery route (Vaginal/C section)

26/10

23/14

0.46

Gestational age in weeksf

38.7 (1.6)

38.6 (1.6)

0.79

Infant sex (M/Fe)

17/19

19/18

0.82

ART/hypofertile subgroupg

 In vivo (> 1 yr/IUI)

17 (8/9)

 In vitro (IVF/ICSI)

20 (4/16)

  1. a1 Paternal age unknown
  2. b1 BMI unknown
  3. c5 BMI unknown
  4. dS, smoking during pregnancy; SSP, stopped smoking before pregnancy; NS, no smoking
  5. eM, male; F, female
  6. f10 were considered to be premature (< 37 weeks gestational age at delivery): 7/10 were delivered at 36 weeks (4 control and 3 ART/hypofertile) and 3/10 were delivered at 35 weeks (1 control and 2 ART/hypofertile)
  7. g > 1 yr, spontaneous pregnancy after > 1 year of unprotected intercourse; IUI, intrauterine insemination; IVF, in vitro fertilization; ICSI, intracytoplasmic sperm injection
  8. For numerical variables, mean (SD) is shown and two-tailed unpaired t test was performed to compare groups
  9. For categorical variables, N is shown and Fisher’s exact test or chi-square test was performed to compare groups