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Fig. 1 | Clinical Epigenetics

Fig. 1

From: Capturing sex-specific and hypofertility-linked effects of assisted reproductive technologies on the cord blood DNA methylome

Fig. 1

ART/hypofertility differentially affects genome-wide DNA methylation in the cord blood of male and female infants. A Total number of hypomethylated and hypermethylated DMCs between ART and control groups when all, only male and only female samples were used for comparison. B Methylation differences at DMCs between ART and control groups, with pie charts summarizing the proportion of DMCs demonstrating less than 10%, between 10 and 20% and greater than 20% methylation differences. C Distribution of DMCs within genomic regions (top), repetitive elements (middle) and CpG-rich regions (bottom) in comparison to all captured sites genome-wide. D Gene Ontology analysis of all genic DMCs was performed. Pie charts demonstrating the categorical distribution of all significant biological processes for the ART versus Control analysis in males and females and selected terms are shown. The number of observed genes associated with each term is indicated within bars. Enrichment is defined as the proportion of observed genes compared to the number annotated within the whole dataset and is indicated by bar colour. The dotted line represents the significance threshold: weighted Fisher’s p value < 0.01

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