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Table 2 The basic characteristics of all the enrolled participants

From: SOCS1 methylation level is associated with prognosis in patients with acute-on-chronic hepatitis B liver failure

Variable

ACHBLF group (n = 80)

CHB group (n = 60)

HC group (n = 30)

GC group (n = 45)

CM group (n = 35)

Male (%)

31 (68.9)

25 (71.4)

43 (61.4)

19 (63.3)

Age (years)

44.0 (32.0–51.5)

45.0 (37.0–57.0)

42.0 (34.0–48.5)

36.5 (28.3–42.8)

HBeAg + (%)

20 (44.4)

18 (51.4)

28 (46.7)

NA

Log10 [HBV DNA]

4.3 (3.3–5.9)

4.3 (3.9–6.7)

4.5 (3.2–5.5)

NA

ALT (U/L)

238.0 (136.5–513.0)

150.0 (101.0–373.0)

90.0 (56.5–148.5)

18.0 (12.8–23.0)

AST (U/L)

164.0 (94.0–310.5)

130.0 (85.0–179.0)

65.5 (38.5–91.5)

18.0 (15.8–23.0)

TBIL (mg/dL)

12.5 (10.8–19.4)

13.3 (10.4–22.8)

0.9 (0.7–1.1)

0.7 (0.5–0.8)

ALB (g/L)

30.8 (28.6–36.0)

32.7 (28.9–35.7)

42.8 (40.4–45.9)

49.5 (47.2–51.3)

Cr (mg./dL)

0.7 (0.6–0.9)

0.8 (0.6–0.9)

0.7 (0.6–0.8)

0.7 (0.6–0.8)

INR

1.7 (1.6–1.9)

1.8 (1.6–2.1)

1.0 (1.0–1.1)

1.0 (1.0–1.1)

PTA (%)

35.0 (30.0–37.5)

34.0 (30.0–38.0)

83.5 (73.5–97.0)

96.0 (88.8–104.0)

MELD score

19.8 (18.2–22.8)

20.6 (18.7–25.1)

NA

NA

SOCS1 methylation level

23.8 (7.9–61.6)

34.2 (2.4–71.7)

1.8 (1.0–3.0)

0.8 (0.6–1.3)

  1. ACHBLF acute-on-chronic hepatitis B liver failure, CHB chronic hepatitis B, HCs healthy controls, GC glucocorticoid, CM conservative medical, HBeAg hepatitis B e antigen, ALT alanine aminotransferase, AST aspartate aminotransferase, TBIL total bilirubin, ALB albumin, Cr creatinine, INR international normalized ratio, PTA prothrombin time activity, MELD model for end-stage liver disease, NA not available
  2. Quantitative variables were expressed as the median (centile 25; centile 75). Categorical variables were expressed as number (%)