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Fig. 8 | Clinical Epigenetics

Fig. 8

From: Epigenetic priming improves salvage chemotherapy in diffuse large B-cell lymphoma via endogenous retrovirus-induced cGAS-STING activation

Fig. 8

Epigenetic priming-induced chemosensitization is a potential solution for the unmet needs of salvage chemotherapy. 5-azacytidine epigenetic priming improved platinum-based salvage chemotherapy in DLBCL via ERV-induced cGAS-STING activation rather than via dsRNA sensor activation, cGAS-STING activation is likely involved over dsRNA detection due to the putatively high levels of reverse transcriptase in DLBCL cells, and the cGAS/STING deficiency could impair the chemosensitizing effect

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Clinical Epigenetics

ISSN: 1868-7083

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