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Fig. 5 | Clinical Epigenetics

Fig. 5

From: Epigenetic priming improves salvage chemotherapy in diffuse large B-cell lymphoma via endogenous retrovirus-induced cGAS-STING activation

Fig. 5

5-Azacytidine induces chemosensitization mediated by the cGAS-STING axis. A–H The expression levels of target proteins were measured using Western blotting and RNA-sequencing data. MDA5, RIG-I, cGAS, and STING are encoded by the IFIH1, DDX58, MB21D1, and TMEM173 genes, respectively. I Pearson correlation between the dsDNA sensor activation level and cisplatin sensitivity. J Pearson correlation between cGAS-STING activation and the chemosensitization effect. K, L The expression and phosphorylation levels of IRF3 and IκBα were measured using western blotting

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Clinical Epigenetics

ISSN: 1868-7083

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