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Fig. 4 | Clinical Epigenetics

Fig. 4

From: Epigenetic priming improves salvage chemotherapy in diffuse large B-cell lymphoma via endogenous retrovirus-induced cGAS-STING activation

Fig. 4

5-Azacytidine activates ERV expression in DLBCL cell lines. A ERV expression profiles are shown using a heatmap. B Histogram of the number of reads attributed to each of the 3220 ERV loci sorted in order of highest to lowest expressed ERVs for each cell line, x-axis: 3220 ERV loci in percentage scale, y-axis: scaled expression levels of ERVs in each cell line. C The total ERV locus number is shown using a bar chat. D The total ERV normalized expression is shown using a bar chat. E Venn diagram showing the number of baseline ERV, post-treatment ERV, and 5-azacytidine-induced ERV conditions in each cell line. F The number of 5-azacytidine-induced ERV loci in each cell line is shown using a bar chat. G The 5-azacytidine-induced ERV normalized expression level in each cell line is shown using a bar chat. H Correlation between the 5-azacytidine-induced ERV locus number and ERV expression. I–L The expression levels of several ERVs were detected using qPCR. I–L *p < 0.05, **p < 0.01 and ***p < 0.001 (two-way ANOVA). AZA: 5-azacytidine

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