E3 ubiquitin ligase RNF180 prevents excessive PCDH10 methylation to suppress the proliferation and metastasis of gastric cancer cells by promoting ubiquitination of DNMT1

Table 2 Correlations between PCDH10 and clinicopathological features in 142 gastric cancer patients in IHC database

Variable	Number of patients	Chi-square value		p value*
Variable	PCDH10^Low	PCDH10^High		p value*
Gender
Male	64	19	0.489	0.484
Female	50	9	0.489	0.484
Age, years
≤ 60	59	13	1.819	0.177
> 60	55	15	1.819	0.177
Tumor location
Upper third	28	7	1.866	0.610
Middle third	11	4
Lower third	57	12
> 2/3 stomach	18	5
Tumor size, cm
≤ 4	33	14	4.089	0.043
> 4	81	14	4.089	0.043
Lauren classification
intestinal	53	19	1.398	0.237
diffuse	61	9	1.398	0.237
Type of gastrectomy
Distal subtotal	57	12	0.146	0.930
Proximal subtotal	14	4
Total	43	12
pT stage
T2	5	2	1.605	0.828
T3	3	2
T4a	97	24
T4b	9	0
pN stage
N0	10	5	10.237	0.029*
N1	10	5
N2	19	9
N3a	50	6
N3b	25	3

A chi-square test was used for comparing groups between low and high PCDH10 expression
*p < 0.05 was considered significant

ISSN: 1868-7083