E3 ubiquitin ligase RNF180 prevents excessive PCDH10 methylation to suppress the proliferation and metastasis of gastric cancer cells by promoting ubiquitination of DNMT1

Table 1 Univariate and multivariate analyses of factors associated with overall survival

Variable	No. of patients	Univariate analysis		Multivariate analysis
Variable	No. of patients	5-year OS	p value	HR (95% CI)	p value
Gender
Male	83	27.7	0.852
Female	59	25.4	0.852
Age, years
≤ 60	72	33.3	0.016	1.627 (1.042–2.539)	0.032
> 60	70	20.0	0.016	1.627 (1.042–2.539)	0.032
Tumor location
Upper third	35	28.6	0.069
Middle third	15	28.8
Lower third	69	40.0
> 2/3 stomach	23	17.4
Tumor size, cm
≤ 4	48	41.7	0.002	1.282 (0.818–2.008)	0.278
> 4	94	19.1	0.002	1.282 (0.818–2.008)	0.278
Lauren classification
Intestinal	72	37.5	0.002	0.695 (0.394–1.224)	0.207
Diffuse	70	15.1
Type of gastrectomy
Distal subtotal	71	28.2	0.403
Proximal subtotal	18	33.3
Total	53	22.6
pT stage
T2	7	42.9	0.009	1.020 (0.615–1.691)	0.939
T3	5	60.0
T4a	121	25.6
T4b	9	11.1
pN stage
N0	15	80.0	< 0.001	1.556 (1.240–1.953)	< 0.001
N1	15	40.0
N2	28	17.9
N3a	56	23.2
N3b	28	7.1
PCDH10 expression level (%)
Low	113	21.2	0.001	1.959 (1.060–3.620)	0.032
High	29	41.8	0.001	1 (Ref)	0.032

CI Confidence interval; HR hazard ratio; No. Number; OS Overall survival; Ref Reference
Variables with p values less than 0.1 were included in the multivariate analysis

ISSN: 1868-7083