Fig. 7

PCDH10 expression is positively correlated with RNF180 and negatively associated with DNMT1 expression in human gastric cancer (GC) tissues. A Representative immunohistochemical images of PCDH10, RNF180, and DNMT1 in GC tissues and adjacent non-tumorous tissues. Scale bars: 200 μm (main) and 20 μm (insert). B The correlation between PCDH10 expression and RNF180 or DNMT1 expression in GC tissues. C Kaplan–Meier survival curves for overall postoperative survival and cumulative death hazard showed that GC patients with high-expression of DNMT1 and low expression of PCDH10 showed poorer prognosis. D Kaplan–Meier survival curves for overall postoperative survival and cumulative death hazard showed that GC patients with low-expression of both DNMT1 and PCDH10 showed poorer prognosis. E The predictive accuracy for overall survival based on the iAUC with 1000 × bootstrap resampling for the five parameters is shown as a box plot. The iAUC indicates integrated area under the ROC curve. F Model depicting the mechanism through which RNF180 regulate PCDH10 expression via the ubiquitin-dependent degradation of DNMT1, this model is created with https://www.biorender.com/