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Fig. 4 | Clinical Epigenetics

Fig. 4

From: E3 ubiquitin ligase RNF180 prevents excessive PCDH10 methylation to suppress the proliferation and metastasis of gastric cancer cells by promoting ubiquitination of DNMT1

Fig. 4

PCDH10 overexpression inhibits the migratory and invasive abilities of GC cells in vitro and in vivo. A Transwell assay was performed to determine the effects of PCDH10 overexpression on cellular invasion and migration. B Representative bioluminescence images of the different groups are shown at 8 weeks after tail vein injection (left). The radiance was collected and calculated (right). C Representative hematoxylin and eosin (H&E) staining images of lung tissue sections from different groups (left). The number of lung metastatic foci was calculated (right). Scale bars: 200 μm (main) and 50 μm (insert). D Heatmap showing differentially expressed genes in PCDH10-overexpressing HGC27 cells. E The interaction diagram of proteins involved cell growth, cytokine-mediated signaling pathway, and cell-substrate adhesion. F The significantly dysregulated pathways among PCDH10 overexpression and control groups in different KEGG categories. G RT-PCR analysis of target genes in indicated cells. *p < 0.05, ***p < 0.001, ****p < 0.0001, N.S. Not significant

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